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  1. Article ; Online: Ingested foreign body causing a silent perforation of the bowel.

    Kroon, Hidde M / Mullen, Dean

    BMJ case reports

    2021  Volume 14, Issue 1

    MeSH term(s) Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Humans ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Male ; Middle Aged ; Omentum/injuries ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global cost of postoperative ileus following abdominal surgery: meta-analysis.

    Traeger, Luke / Koullouros, Michalis / Bedrikovetski, Sergei / Kroon, Hidde M / Moore, James W / Sammour, Tarik

    BJS open

    2023  Volume 7, Issue 3

    Abstract: Background: Following abdominal surgery, postoperative ileus is a common complication significantly increasing patient morbidity and cost of hospital admission. This is the first systematic review aimed at determining the average global hospital cost ... ...

    Abstract Background: Following abdominal surgery, postoperative ileus is a common complication significantly increasing patient morbidity and cost of hospital admission. This is the first systematic review aimed at determining the average global hospital cost per patient associated with postoperative ileus.
    Methods: A systematic search of electronic databases was performed from January 2000 to March 2023. Studies included compared patients undergoing abdominal surgery who developed postoperative ileus to those who did not, focusing on costing data. The primary outcome was the total cost of inpatient stay. Risk of bias was assessed using the Newcastle-Ottawa assessment tool. Summary meta-analysis was performed.
    Results: Of the 2071 studies identified, 88 papers were assessed for full eligibility. The systematic review included nine studies (2005-2022), investigating 1 860 889 patients undergoing general, colorectal, gynaecological and urological surgery. These studies showed significant variations in the definition of postoperative ileus. Six studies were eligible for meta-analysis showing an increase of €8233 (95 per cent c.i. (5176 to 11 290), P < 0.0001, I2 = 95.5 per cent) per patient with postoperative ileus resulting in a 66.3 per cent increase in total hospital costs (95 per cent c.i. (34.8 to 97.9), P < 0.0001, I2 = 98.4 per cent). However, there was significant bias between studies. Five colorectal-surgery-specific studies showed an increase of €7242 (95 per cent c.i. (4502 to 9983), P < 0.0001, I2 = 86.0 per cent) per patient with postoperative ileus resulting in a 57.3 per cent increase in total hospital costs (95 per cent c.i. (36.3 to 78.3), P < 0.0001, I2 = 85.7 per cent).
    Conclusion: The global financial burden of postoperative ileus following abdominal surgery is significant. While further multicentre data using a uniform postoperative ileus definition would be useful, reducing the incidence and impact of postoperative ileus are a priority to mitigate healthcare-related costs, and improve patient outcomes.
    MeSH term(s) Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Hospitalization ; Digestive System Surgical Procedures/adverse effects ; Ileus/epidemiology ; Ileus/etiology ; Colorectal Neoplasms/complications
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad054
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  3. Article ; Online: ASO Author Reflection: Lateral Pelvic Lymph Nodes in Rectal Cancer-Not All Are Created Equal.

    Kroon, Hidde M / Kusters, Miranda / Sammour, Tarik

    Annals of surgical oncology

    2021  Volume 29, Issue 2, Page(s) 1204–1205

    MeSH term(s) Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Pelvis/pathology ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2021-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10815-3
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    Zs.A 4042: Show issues Location:
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  4. Article ; Online: Use of Acetylcholinesterase Inhibitors in Reducing Time to Gastrointestinal Function Recovery following Abdominal Surgery: A Systematic Review.

    Traeger, Luke / Dudi-Venkata, Nagendra / Bedrikovetski, Sergei / Kroon, Hidde M / Moore, James W / Sammour, Tarik

    Digestive surgery

    2023  Volume 41, Issue 1, Page(s) 12–23

    Abstract: Introduction: Postoperative ileus (POI) is a significant complication following abdominal surgery, increasing morbidity and mortality. The cholinergic anti-inflammatory response is one of the major pathways involved in developing POI, but current ... ...

    Abstract Introduction: Postoperative ileus (POI) is a significant complication following abdominal surgery, increasing morbidity and mortality. The cholinergic anti-inflammatory response is one of the major pathways involved in developing POI, but current recommendations to prevent POI do not target this. This review aims to summarise evidence for the use of acetylcholinesterase inhibitors, neostigmine and pyridostigmine, to reduce the time to return of gastrointestinal function (GI) following abdominal surgery.
    Methods: A systematic search of various databases was performed from 1946 to May 2023. Randomised controlled trials (RCTs) on acetylcholinesterase inhibitors in intra-abdominal surgery were included. Data on time to flatus and/or stool and side effects were extracted.
    Results: Among 776 screened manuscripts, 8 RCTs (703 patients) investigating acetylcholinesterase inhibitors in intra-abdominal surgery were analysed. Five studies showed a significant reduction in time to flatus and/or stool by 17-47.6 h. Methodological variations, differing procedure types, and potential bias were observed. Limited studies reported side effects or length of stay.
    Conclusion: Acetylcholinesterase inhibitors may reduce the time for GI to return. However, current evidence is limited and biased. Further studies incorporating acetylcholinesterase inhibitors in an enhanced recovery protocol are required to address this question, especially for patients undergoing colorectal surgery.
    MeSH term(s) Humans ; Cholinesterase Inhibitors/therapeutic use ; Recovery of Function ; Flatulence ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Postoperative Complications/drug therapy ; Ileus
    Chemical Substances Cholinesterase Inhibitors
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 605888-7
    ISSN 1421-9883 ; 0253-4886
    ISSN (online) 1421-9883
    ISSN 0253-4886
    DOI 10.1159/000535753
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    Zs.A 2004: Show issues Location:
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  5. Article ; Online: ASO Author Reflections: Limited Surgery Plus Radiotherapy for Melanoma Patients with Cervical Node Metastases.

    Thompson, John F / Kroon, Hidde M

    Annals of surgical oncology

    2018  Volume 25, Issue Suppl 3, Page(s) 912–913

    MeSH term(s) Carcinoma ; Humans ; Lymph Nodes ; Melanoma ; Radiotherapy, Adjuvant
    Language English
    Publishing date 2018-10-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-018-6959-7
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    Zs.A 4042: Show issues Location:
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  6. Article ; Online: Isolated Limb Infusion and Isolated Limb Perfusion for Melanoma: Can the Outcomes of these Procedures be Compared?

    Kroon, Hidde M / Thompson, John F

    Annals of surgical oncology

    2018  Volume 26, Issue 1, Page(s) 8–9

    MeSH term(s) Chemotherapy, Cancer, Regional Perfusion/methods ; Chemotherapy, Cancer, Regional Perfusion/mortality ; Extremities ; Humans ; Infusions, Intravenous ; Melanoma/drug therapy ; Melanoma/mortality ; Melphalan/administration & dosage
    Chemical Substances Melphalan (Q41OR9510P)
    Language English
    Publishing date 2018-11-21
    Publishing country United States
    Document type Comparative Study ; Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-018-7067-4
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  7. Article ; Online: Letter re: Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma: A multicenter experience.

    Kroon, Hidde M / Thompson, John F

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2018  Volume 45, Issue 6, Page(s) 1121

    MeSH term(s) Carcinoma, Merkel Cell ; Chemotherapy, Cancer, Regional Perfusion ; Humans ; Melphalan ; Skin Neoplasms
    Chemical Substances Melphalan (Q41OR9510P)
    Language English
    Publishing date 2018-11-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2018.10.544
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    Zs.A 1149: Show issues Location:
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    Zs.MO 549: Show issues

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  8. Article ; Online: ASO Author Reflections: Return to Isolated Limb Infusion for In-Transit Melanoma.

    Carr, Michael J / Kroon, Hidde M / Zager, Jonathan S

    Annals of surgical oncology

    2020  Volume 27, Issue 13, Page(s) 5119–5120

    MeSH term(s) Chemotherapy, Cancer, Regional Perfusion ; Extracorporeal Circulation ; Extremities ; Humans ; Melanoma/drug therapy ; Skin Neoplasms/drug therapy
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09113-1
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  9. Article ; Online: ASO Author Reflection: Isolated Limb Infusion for Locally Advanced Melanoma in the Extremely Old Patient is Safe and Effective.

    Teras, Jüri / Kroon, Hidde M / Zager, Jonathan S

    Annals of surgical oncology

    2020  Volume 27, Issue 5, Page(s) 1430–1431

    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Chemotherapy, Cancer, Regional Perfusion ; Extremities/blood supply ; Humans ; Infusions, Intralesional ; Melanoma/drug therapy ; Melanoma/pathology
    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08314-y
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  10. Article: Molecular Aspects of the Isolated Limb Infusion Procedure.

    Teras, Jüri / Carr, Michael J / Zager, Jonathan S / Kroon, Hidde M

    Biomedicines

    2021  Volume 9, Issue 2

    Abstract: For decades, isolated limb infusion (ILI) and hyperthermic isolated limb perfusion (HILP) have been used to treat melanoma in-transit metastases and unresectable sarcoma confined to the limb utilizing the effect of loco-regional high-dose chemotherapy to ...

    Abstract For decades, isolated limb infusion (ILI) and hyperthermic isolated limb perfusion (HILP) have been used to treat melanoma in-transit metastases and unresectable sarcoma confined to the limb utilizing the effect of loco-regional high-dose chemotherapy to the isolated limb. Both procedures are able to provide high response rates in patients with numerous or bulky lesions in whom other loco-regional treatments are becoming ineffective. In comparison to systemic therapies, on the other hand, ILI and HILP have the advantage of not being associated with systemic side-effects. Although in principle ILI and HILP are similar procedures, ILI is technically simpler to perform and differs from HILP in that it takes advantage of the hypoxic and acidotic environment that develops in the isolated limb, potentiating anti-tumour activity of the cytotoxic agents melphalan +/- actinomycin-D. Due to its simplicity, ILI can be used in both preclinical and clinical studies to test new cytotoxic regimens and combinations with the aim to overcome tumour resistance. In the future, administration of cytotoxic agents by ILI, in combination with systemic treatments such as BRAF/MEK/KIT inhibitors, immunotherapy (CTLA-4 blockade), and/or programmed death (PD-1) pathway inhibitors, has the potential to improve responses further by inducing increased tumour cell death while limiting the ability of the tumour to suppress the immune response.
    Language English
    Publishing date 2021-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9020163
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