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Article ; Online: Failure of placentation and pregnancy complications: The role of feto-maternal immune balance.

Milosevic Stevanovic, Jelena / Krstic, Miljan / Vukomanovic, Predrag / Kutlesic, Ranko / Trajkovic, Sonja Pop / Simic, Dusan

European journal of obstetrics, gynecology, and reproductive biology

2024 Volume 295, Page(s) 126–135

MeSH term(s)	Pregnancy ; Female ; Humans ; Placentation ; Placenta ; Pregnancy Complications/etiology
Language	English
Publishing date	2024-02-12
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2024.02.024
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Article: EBV Negative Angioimmunoblastic T-Cell Lymphoma with Sequential Development of Diffuse Large B-Cell Lymphoma in Course of Progression.

Petković, Ivan / Stojnev, Slavica / Popović, Aleksandar / Krstić, Miljan / Pejčić, Ivica

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

2021 Volume 37, Issue 4, Page(s) 694–696

Language	English
Publishing date	2021-03-25
Publishing country	India
Document type	Journal Article
ZDB-ID	2422370-0
ISSN	0974-0449 ; 0971-4502
ISSN (online)	0974-0449
ISSN	0971-4502
DOI	10.1007/s12288-021-01425-w
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Article ; Online: A case of mycotic keratitis due to Fusarium sp. with an undesirable outcome.

Trenkić, Marija / Babić, Gordana Stanković / Randelović, Marina / Krstić, Miljan / Radenković, Marija / Tasić-Otašević, Suzana

Journal of infection in developing countries

2022 Volume 16, Issue 4, Page(s) 729–732

Abstract: Fungal keratitis, an infective disease of the cornea, represents a serious diagnostic and therapeutic problem that, if not recognized on time, could lead to irreversible eye damage. Herein we report a case of fungal keratitis due to Fusarium spp. ... ...

Abstract	Fungal keratitis, an infective disease of the cornea, represents a serious diagnostic and therapeutic problem that, if not recognized on time, could lead to irreversible eye damage. Herein we report a case of fungal keratitis due to Fusarium spp. infection. The 60-year-old man was admitted to our clinic due to an atraumatic acute onset of the disease, with a decrease in the visual acuity, photophobia, redness, and severe pain in the right eye. Clinical observation revealed an ulcer that affected 1/3 of the cornea and a hypopion in the anterior chamber. After the first results of microbiological analyzes, local and systemic antifungal therapy was applied. Due to the fact that the patient voluntarily left the treatment, there was a drastic worsening of the local findings as a full thickness total corneal infiltrate with more intense anterior chamber reaction. Finally, evisceration was performed. Given the fact that fungal keratitis is more prevalent in developing countries, official protocols and available effective antifungals are crucial for adequate treatment and a favorable outcome of this infection.
MeSH term(s)	Antifungal Agents/therapeutic use ; Corneal Ulcer/diagnosis ; Corneal Ulcer/drug therapy ; Corneal Ulcer/microbiology ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/drug therapy ; Fusariosis/diagnosis ; Fusariosis/drug therapy ; Fusariosis/microbiology ; Fusarium ; Humans ; Keratitis/diagnosis ; Keratitis/drug therapy ; Keratitis/microbiology ; Male ; Middle Aged
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2022-04-30
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.15824
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Article: New cases of human dirofilariosis on the Balkan Peninsula – “Masked intruders” uncovered by a surgeon

Momčilović, Stefan / Gabrielli, Simona / Đenić, Nebojša / Živković, Nataša / Stevanović, Goran / Krstić, Miljan / Ranđelović, Marina / Tasić-Otašević, Suzana

Parasitology international. 2022 Feb., v. 86

2022

Abstract: Dirofilaria spp. nematodes are accidental parasites of humans causing mild to serious, superficial or visceral infections. Superficial dirofilariosis is rather common in Europe and is typically manifested as subcutaneous form. Herein we report 46 new ... ...

Abstract	Dirofilaria spp. nematodes are accidental parasites of humans causing mild to serious, superficial or visceral infections. Superficial dirofilariosis is rather common in Europe and is typically manifested as subcutaneous form. Herein we report 46 new cases of human dirofilariosis (19 patients with subcutaneous, 18 patients with ocular, 4 patients wih genital, 2 patients with submucosal, 2 patients with pulmonary and 1 patient with intramuscular form of infection) that were recorded from the beginning of 2015 to May 2021 on the Balkan Peninsula with a goal to update the prevalence of this parasitosis and point out potential problems in diagnosis and treatment. Besides, given the high possibility of misinterpretation as tumor, our second aim was to encourage the inclusion of this pathogen in the differential diagnosis of subcutaneous nodules. Although quite common forms, subcutaneous and ocular dirofilariosis can be very often misdiagnosed in clinical practice due to the absence of specific clinical manifestations. Therefore, raising awareness of clinicians about this zoonosis is needed as well as closer collaboration between physicians and veterinarians.
Keywords	Dirofilaria ; dirofilariasis ; humans ; neoplasms ; parasitology ; pathogens ; patients ; zoonoses ; Europe
Language	English
Dates of publication	2022-02
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1363151-2
ISSN	1383-5769
ISSN	1383-5769
DOI	10.1016/j.parint.2021.102482
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Traumatic Intrahepatic Biloma – A Rare Entity Mimicking Neoplasm of the Liver

Radovanović Aleksandra / Krstić Miljan / Gligorijević Jasmina / Veličkov Aleksandra / Stojanović Marko

Acta Facultatis Medicae Naissensis, Vol 36, Iss 1, Pp 79-

A Case Report

2019 Volume 85

Abstract: Bilomas represent large collections of bile, produced due to a rupture of bile ducts. Most frequently, they are located in the perihepatic tissues, rarely intrahepatic ones. Usually, bile ducts rupture is caused by trauma, spontaneous or iatrogenic, or ... ...

Abstract	Bilomas represent large collections of bile, produced due to a rupture of bile ducts. Most frequently, they are located in the perihepatic tissues, rarely intrahepatic ones. Usually, bile ducts rupture is caused by trauma, spontaneous or iatrogenic, or some underlying disease. The majority of bilomas cases are treated by means of drainage procedures. In spite of advanced diagnostic techniques, sometimes they can be misinterpreted as neoplasm. We report a case of biloma that was surgically removed due to suspicion of malignancy, which was histologically examined.
Keywords	biloma ; trauma ; liver ; histopathologic confirmation ; Medicine ; R
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Clinical and pathological significance of proliferation index and p53 expression in gastric adenocarcinoma.

Zindovic, Miljan / Vuletic, Milena / Milenkovic, Sanja / Jancic, Snezana / Krstic, Miljan / Zindovic, Dunja / Milosevic, Velimir

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2021 Volume 26, Issue 4, Page(s) 1466–1478

Abstract: Purpose: The purpose of our work was to investigate the association between proliferative index [proIDX] and expression index p53 (p53IDX) with the clinical and pathological characteristics of gastric adenocarcinoma.: Methods: The biopsy material of ... ...

Abstract	Purpose: The purpose of our work was to investigate the association between proliferative index [proIDX] and expression index p53 (p53IDX) with the clinical and pathological characteristics of gastric adenocarcinoma. Methods: The biopsy material of 90 patients operated on for gastric cancer was routinely processed in paraffin and archived. After the histopathological report was made, two study groups were formed, the first group (n=45) comprised biopsies with intestinal carcinoma and the second (n=45) biopsies of diffuse gastric cancer. In both cases, the control group consisted of biopsies of surrounding non-tumor tissue The routine Hematoxylin-Eosin and immunohistochemical ABC method with anti-Ki67 and anti-p53 antibodies was applied at sections 3-5 μm thick. The expression of Ki67 and p53 was quantified stereometrically. For statistical analysis SPSS (19.0) was used. Results: Significantly higher Ki67 expression was found in both types of adenocarcinoma compared to the control group, as well as significant association of proIDX with most of testing parameters. Expression of p53 was significantly higher in the intestinal type compared to the diffuse type and the control group and was significantly associated with age and histological grade. Diffuse type particulary showed, significant association of p53IDX with most of the histological parameters tested. Conclusion: Our results point a highly significant correlation of the Ki67 and p53 expression with indicators of gastric adenocarcinoma progression, which may help to identify patients with an aggressive gastric adenocarcinoma phenotype.
MeSH term(s)	Adenocarcinoma/chemistry ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Female ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/chemistry ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Tumor Suppressor Protein p53/analysis ; Tumor Suppressor Protein p53/biosynthesis
Chemical Substances	Tumor Suppressor Protein p53
Language	English
Publishing date	2021-10-22
Publishing country	Cyprus
Document type	Journal Article
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article ; Online: The association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients.

Ristic Petrovic, Ana / Stokanović, Dragana / Stojnev, Slavica / Potić Floranović, Milena / Krstić, Miljan / Djordjević, Ivana / Skakić, Aleksandar / Janković Veličković, Ljubinka

Bosnian journal of basic medical sciences

2022 Volume 22, Issue 4, Page(s) 523–530

Abstract: Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis. ... ...

Abstract	Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis. The aim was to analyze the association of NOTCH3 expression with histopathological and clinical parameters, and to determine its predictive impact on the clinical outcome in UBC patients. The present research included 614 UBC samples incorporated in paraffin tissue microarrays, evaluated by immunohistochemistry for NOTCH3 expression. The accrual period was four years, while the follow-up period was two years. The membranous expression was semi-quantified (0-3), and the mean degree was 1.81±0.94. Criteria for semi-quantification the NOTCH3 expression were the intensity of the staining and the percentage of positive cells. The samples with negative (0) and weak (1) NOTCH3 immunohistochemical (IHC) score were considered negative, while the samples that showed moderate (2) and strong (3) expression were considered positive. Higher degree of positivity was associated with higher risk of cancer-specific mortality (p<0.001). Independent predictors for cancer-specific mortality were NOTCH3 expression and high stage (p<0.001). NOTCH3 expression was not a statistically significant predictor of recurrence-free survival (p=0.816). This study indicated that NOTCH3 is a predictor of poor outcome, suggesting that the NOTCH3 could be potentially reliable IHC marker for selecting the UBC patients that would require more intensive follow-up, especially if they diagnosed in higher stage, with divergent differentiation in pathological report, and without recurrences which would lead them to more frequent medical assessments.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Carcinoma, Transitional Cell/metabolism ; Carcinoma, Transitional Cell/pathology ; Humans ; Immunohistochemistry ; Receptor, Notch3/metabolism ; Receptors, Notch ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; NOTCH3 protein, human ; Receptor, Notch3 ; Receptors, Notch
Language	English
Publishing date	2022-07-29
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ZDB-ID	2240029-1
ISSN	1840-4812 ; 1512-8601
ISSN (online)	1840-4812
ISSN	1512-8601
DOI	10.17305/bjbms.2021.6767
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Article ; Online: Bevacizumab with Chemotherapy as a First-Line Treatment for Advanced Ovarian Cancer in a Serbian Cohort.

Conic, Irena / Nedovic, Bojan / Stojnev, Slavica / Todorovska, Ilinka / Dimitrijevic, Aleksandra / Krstic, Miljan / Djordjevic, Ivana / Djordjevic, Biljana

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 5

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab/therapeutic use ; Carboplatin/therapeutic use ; Female ; Humans ; Ovarian Neoplasms/drug therapy ; Paclitaxel/therapeutic use ; Serbia
Chemical Substances	Antibodies, Monoclonal, Humanized ; Bevacizumab (2S9ZZM9Q9V) ; Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58050607
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Article ; Online: Developmental Characteristics of the Glomerular and Tubular Portion of the Nephron in the Human Foetal Kidney Cortex: Morphometrical and Immunohistochemical Analysis.

Antic, Milorad / Dakovic Bjelakovic, Marija / Petrovic, Aleksandar / Bjelakovic, Marko / Radenkovic, Goran / Zivkovic, Nikola / Krstic, Miljan / Antic, Vladimir

Cells, tissues, organs

2022 Volume 212, Issue 3, Page(s) 203–214

Abstract: This study aimed to morphometrically examine the development of glomeruli and tubules in the kidney cortex of human foetuses at different gestational ages (GAs). We also investigated the expression of the proliferation marker Ki-67 and apoptosis-related ... ...

Abstract	This study aimed to morphometrically examine the development of glomeruli and tubules in the kidney cortex of human foetuses at different gestational ages (GAs). We also investigated the expression of the proliferation marker Ki-67 and apoptosis-related markers Bcl-2 and Bax during nephrogenesis using immunohistochemistry. Kidney samples from 38 human foetuses of both sexes with GA ranging from 13 to 40 weeks were analysed. The samples were divided into 7 groups based on GA, each corresponding to 1 lunar month. Foetal kidneys showed a spatiotemporal gradient of nephron differentiation with the transient stages of nephron anlage located in the nephrogenic zone and immature nephrons located in the subjacent maturation zone. In the inner cortex, nephrons establish the morphological characteristics of definitive nephrons. The average area, perimeter, and Feret's diameter of the glomeruli formed within the kidney cortex gradually decreased up to a period of 29-32 weeks of gestation and subsequently increased until a period of 37-40 weeks. There was a weak negative correlation with GA. In contrast, the areal density of glomeruli increased up to a period of 21-24 weeks and then gradually decreased until a period of 37-40 weeks, showing a moderate negative correlation with GA. The average area of renal tubules slightly decreased until a period of 21-24 weeks of gestation and then gradually increased until a period of 36-40 weeks, showing a moderate positive correlation with GA. The average areal density of renal tubules increased significantly until a period of 21-24 weeks of gestation, remained relatively constant until a period of 33-36 weeks, and then increased significantly at 36-40 weeks. There was a strong positive correlation with GA. Our results showed that Ki-67 was expressed in numerous cells of the metanephric mesenchyme, pretubular aggregates, renal vesicles, comma-shaped bodies, and early S-shaped bodies. During subsequent development and the spatial expansion of nephrons towards the mature zone, the expression of Ki-67 was markedly reduced. Similarly, Bcl-2 was strongly expressed in induced nephrogenic progenitor cells, pretubular aggregates, renal vesicles, and comma-shaped bodies. As vascularisation and maturation of the nephron proceeded, Bcl-2 staining became less intense and limited to the parietal layer of the Bowman's capsule and renal tubules. Weak Bax expression was observed in individual scattered cells within segments of the nephrons at all developmental stages. In the mature zone, more intense Bax staining was observed in the renal tubules.
MeSH term(s)	Male ; Female ; Humans ; bcl-2-Associated X Protein/metabolism ; Ki-67 Antigen/metabolism ; Kidney ; Nephrons ; Kidney Glomerulus ; Kidney Diseases/metabolism ; Fetus ; Proto-Oncogene Proteins c-bcl-2/metabolism
Chemical Substances	bcl-2-Associated X Protein ; Ki-67 Antigen ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2022-05-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1468141-9
ISSN	1422-6421 ; 1422-6405
ISSN (online)	1422-6421
ISSN	1422-6405
DOI	10.1159/000525185
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Article ; Online: Eruptive Nevi on the Palms and Soles with no Association with an Underlying Disease or Medications.

Tiodorović, Danica / Cekić, Sladjana / Krstić, Miljan / Vidović, Nataša / Zalaudek, Iris

Acta dermatovenerologica Croatica : ADC

2019 Volume 27, Issue 3, Page(s) 180–183

Abstract: Eruptive melanocytic nevi are an unusual phenomenon characterized by sudden onset of multiple melanocytic nevi on previously unaffected skin. The majority of case reports have linked this condition with blistering skin disease or immunosuppression. There ...

Abstract	Eruptive melanocytic nevi are an unusual phenomenon characterized by sudden onset of multiple melanocytic nevi on previously unaffected skin. The majority of case reports have linked this condition with blistering skin disease or immunosuppression. There are only three reports of eruptive nevi developing on the palms and /or soles in healthy individuals. Herein we present the clinical and dermoscopic features of two cases of eruptive acral nevi that developed in healthy individuals in the absence of any recognizable underlying disease and review the current literature of eruptive nevi.
MeSH term(s)	Adult ; Dermoscopy ; Female ; Foot Dermatoses/diagnosis ; Foot Dermatoses/etiology ; Humans ; Male ; Middle Aged ; Nevus, Pigmented/diagnosis ; Nevus, Pigmented/etiology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/etiology
Language	English
Publishing date	2019-09-18
Publishing country	Croatia
Document type	Case Reports ; Journal Article
ZDB-ID	1180727-1
ISSN	1847-6538 ; 1330-027X
ISSN (online)	1847-6538
ISSN	1330-027X
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