Artikel ; Online: What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity.
2019 Band 10, Seite(n) 1222
Abstract: Dendritic cells (DCs) are professional antigen presenting cells (APCs) that originate in the bone marrow and are continuously replenished from hematopoietic progenitor cells. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are distinguished by ... ...
| Abstract | Dendritic cells (DCs) are professional antigen presenting cells (APCs) that originate in the bone marrow and are continuously replenished from hematopoietic progenitor cells. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are distinguished by morphology and function, and can be easily discriminated by surface marker expression, both in mouse and man. Classification of DCs based on their ontology takes into account their origin as well as their requirements for transcription factor (TF) expression. cDCs and pDCs of myeloid origin differentiate from a common DC progenitor (CDP) through committed pre-DC stages. pDCs have also been shown to originate from a lymphoid progenitor derived IL-7R |
|---|---|
| Mesh-Begriff(e) | Animals ; Cell Differentiation/immunology ; Cell Plasticity/immunology ; Computational Biology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Humans ; Lymphoid Progenitor Cells/cytology ; Lymphoid Progenitor Cells/metabolism ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Lymphoid Tissue/metabolism ; Myeloid Progenitor Cells/cytology ; Myeloid Progenitor Cells/metabolism ; Signal Transduction |
| Sprache | Englisch |
| Erscheinungsdatum | 2019-05-29 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2019.01222 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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