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Article: Identification of potential biomarkers for bone metastasis using human cancer metastasis database.

Bhardwaj, Mahima / Sri, Thanvi / Krupanidhi, Srirama / Singh, Sachidanand

International journal of health sciences

2024 Volume 18, Issue 3, Page(s) 6–14

Abstract: Objective: Information theory has been successfully employed to identify optimal pathway networks, mutual information (MI), and entropy as a dynamic response in statistical methods and estimate input and output information in systems biology. This ... ...

Abstract	Objective: Information theory has been successfully employed to identify optimal pathway networks, mutual information (MI), and entropy as a dynamic response in statistical methods and estimate input and output information in systems biology. This research aims to investigate potentially integrated gene signatures for bone metastasis using graph-based information theory from the dynamic interaction interphase. Methods: The expression dataset with the series ID GSE26964 for bone metastasis from prostate cancer was retrieved. The dataset was segregated for differentially expressed genes (DEGs) using the Human Cancer Metastasis Database. MI was considered to capture non-linear connections to classify the key DEGs from the collected dataset using gene-gene statistical analysis and then a protein-protein interaction network (PPIN). The PPIN was used to calculate centrality metrics, bottlenecks, and functional annotations. Results: A total of 531 DEGs were identified. Thirteen genes were classified as highly correlated based on their gene expression data matrix. The extended PPIN of the 13 genes comprised 53 nodes and 372 edges. A total of four DEGs were identified as hubs. One novel gene was identified with strong network connectivity. Conclusion: The novel biomarkers for metastasis may provide information on cancer metastasis to the bone by implying MI and information theory.
Language	English
Publishing date	2024-05-08
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2603595-9
ISSN	1658-3639
ISSN	1658-3639
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: IMMUNOLOGICAL IMPLICATIONS IN MAMMALIAN SEMI-ALLOGENEIC PREGNANCY.

Krupanidhi, Srirama

Roumanian archives of microbiology and immunology

2015 Volume 74, Issue 3-4, Page(s) 99–104

Abstract: The mammalian conceptus is a semi-allograft. The maternal tolerance towards semi-allograft is primed by a battery of cytokines and resident decidual cells. Invasion of embryonic trophoblast, decidual vascular remodeling and unresponsive incipient 'Triple- ...

Abstract	The mammalian conceptus is a semi-allograft. The maternal tolerance towards semi-allograft is primed by a battery of cytokines and resident decidual cells. Invasion of embryonic trophoblast, decidual vascular remodeling and unresponsive incipient 'Triple-negative' (CD3-, CD4- and CD8-) T-cells of foetus promote normal pregnancy. On the other hand, the maternal cytokine profile shift towards Th1 response is shown to enhance the risk during pregnancy. The periodical examination of maternal serum levels of Th1 and Th2 response mediated cytokines constitutes prognostic biomarkers to initiate therapeutic regimens.
MeSH term(s)	Animals ; Cytokines/genetics ; Cytokines/immunology ; Decidua/growth & development ; Decidua/immunology ; Female ; Humans ; Pregnancy/immunology ; Trophoblasts/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2015-07
Publishing country	Romania
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1101928-1
ISSN	1222-3891
ISSN	1222-3891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In Vitro

Indira, Mikkili / Peele, Karlapudi Abraham / Krupanidhi, Srirama / Prabhakar, Kodali Vidya / Vimala, K B S / Kavya, P Satya / Sravya, I / Venkateswarulu, T C

Tropical life sciences research

2023 Volume 34, Issue 3, Page(s) 197–215

Abstract: ... Citrus ... ...

Abstract	Citrus medica
Language	English
Publishing date	2023-09-30
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	2607038-8
ISSN	2180-4249 ; 1985-3718
ISSN (online)	2180-4249
ISSN	1985-3718
DOI	10.21315/tlsr2023.34.3.11
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characterization of bacteriocin ABC transporter ATP-binding protein produced by a newly isolated Enterococcus casseliflavus MI001 strain

Indira Mikkili / Venkateswarulu TC / Abraham Peele Karlapudi / Vidya Prabhakar Kodali / Krupanidhi Srirama

Beni-Suef University Journal of Basic and Applied Sciences, Vol 8, Iss 1, Pp 1-

2019 Volume 7

Abstract: Abstract Background ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes. Results In the present study, bacteriocin isolated from the Enterococcus casseliflavus ...

Abstract	Abstract Background ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes. Results In the present study, bacteriocin isolated from the Enterococcus casseliflavus MI001 strain was identified as an ABC transporter ATP-binding protein. The optimal conditions for the production of bacteriocin were found to be at 35 °C, a pH 5.5, and an incubation time of 24 h. Purification was performed using ammonium sulphate precipitation, gel filtration, and DEAE ion exchange chromatography. The bacteriocin was purified with an eightfold purification scheme resulting with a specific activity of 15,000 AU/mg. The NMR spectrum of purified bacteriocin revealed the presence of amino acids, namely lysine, methionine, cysteine, proline, threonine, tryptophan, and histidine. Further, the bacteriocin ABC transporter showed antimicrobial activity against food spoilage microorganisms. Conclusions The ABC transporter ATP-binding protein could be used as a potential alternative for food preservation, and it may be considered as a bio-preservative agent in food processing industries.
Keywords	Bacteriocin ; Enterococcus casseliflavus MI001 strain ; ABC transporter ; Three-step purification ; NMR spectrum ; Medicine (General) ; R5-920 ; Science ; Q
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of anti-cancer, anti-microbial and anti-biofilm potential of biosurfactant extracted from an Acinetobacter M6 strain

Abraham Peele Karlapudi / Venkateswarulu T.C. / Krupanidhi Srirama / Rohini Krishna Kota / Indira Mikkili / Vidya Prabhakar Kodali

Journal of King Saud University: Science, Vol 32, Iss 1, Pp 223-

2020 Volume 227

Abstract: Biosurfactants are amphiphilic compounds produced by bacteria either extracellularly or as a part of the cell membrane. Biosurfactants have had a profound impact on medical and pharmaceutical biotechnology. In our previous work, we isolated a new ... ...

Abstract	Biosurfactants are amphiphilic compounds produced by bacteria either extracellularly or as a part of the cell membrane. Biosurfactants have had a profound impact on medical and pharmaceutical biotechnology. In our previous work, we isolated a new biosurfactant produced by Acinetobacter indicus M6 which reduces the surface tension of water from 72.0 to 39.8 mN/m and which showed thermophilic, halophytic and acidophilic stability. The chemical nature was found to be a class of glycolipoprotein. Here, our research presents the extracted biosurfactant’s anti-proliferative activity against lung cancer cells (A549), and anti-microbial and anti-biofilm activity against MRSA. The anti-tumour activity of biosurfactant against lung cancer cells was evaluated in terms of cell viability at different concentrations. The results showed a decrease in the percentage of lung cancer viable cells with increasing biosurfactant concentrations and incubation time, with a significant decrease being observed at 200 µg/ml concentration leading to cell proliferation inhibition at G1 phase. Treatment of biofilms for seven days at 500 µg/ml resulted in up to 82.5% biofilm disruption. Keywords: Biosurfactant, Acinetobacter indicus M6, Cell viability, Anti-proliferative activity, Anti-biofilm activity
Keywords	Science (General) ; Q1-390
Subject code	500
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In silico sgRNA tool design for CRISPR control of quorum sensing in Acinetobacter species

Abraham Peele Karlapudi / Venkateswarulu T.C / Jahnavi Tammineedi / Krupanidhi Srirama / Lohit Kanumuri / Vidya Prabhakar Kodali

Genes and Diseases, Vol 5, Iss 2, Pp 123-

2018 Volume 129

Abstract: CRISPR genome editing utilizes Cas9 nuclease and single guide RNA (sgRNA), which directs the nuclease to a specific site in the genome and makes a double-stranded break (DSB). Design of sgRNA for CRISPR-Cas targeting, and to promote CRISPR adaptation, ... ...

Abstract	CRISPR genome editing utilizes Cas9 nuclease and single guide RNA (sgRNA), which directs the nuclease to a specific site in the genome and makes a double-stranded break (DSB). Design of sgRNA for CRISPR-Cas targeting, and to promote CRISPR adaptation, uses a regulatory mechanism that ensures maximum CRISPR-Cas9 system functions when a bacterial population is at highest risk of phage infection. Acinetobacter baumannii is the most regularly identified gram-negative bacterium infecting patients. Recent reports have demonstrated that the extent of diseases caused by A. baumannii is expanding and, in a few cases, now surpasses the quantity of infections caused by P. aeruginosa. Most Acinetobacter strains possess biofilm-forming ability, which plays a major role in virulence and drug resistance. Biofilm bacteria use quorum sensing, a cell-to-cell communication process, to activate gene expression. Many genes are involved in biofilm formation and the mechanism to disrupt the biofilm network is still not clearly understood. In this study, we performed in silico gene editing to exploit the AbaI gene, responsible for biofilm formation. The study explored different tools available for genome editing to create gene knockouts, selecting the A. baumannii AbaI gene as a target. Keywords: AbaI, Acinetobacter baumannii, CHOPCHOP, Crispr-cas9, sgRNA
Keywords	Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	572
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Screening of

Venkateswarulu, Thirupati Chinna / Eswaraiah, Gaddam / Krupanidhi, Srirama / Peele, Karlapudi Abraham / Mikkili, Indira / Narayana, Alugunulla Venkata / Ravuru, Bharath Kumar / Dulla, John Babu / Ambati, Ranga Rao

Food technology and biotechnology

2020 Volume 58, Issue 1, Page(s) 71–75

Abstract: Mangroves contain a wide range of bioactive compounds with pharmacological activities. In the present study, we analysed the separation and detection of phytoconstituents with the methanol extract ... ...

Abstract	Mangroves contain a wide range of bioactive compounds with pharmacological activities. In the present study, we analysed the separation and detection of phytoconstituents with the methanol extract of
Language	English
Publishing date	2020-06-19
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1340467-2
ISSN	1330-9862
ISSN	1330-9862
DOI	10.17113/ftb.58.01.20.6351
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recombinant pharmaceutical protein production in plants: unraveling the therapeutic potential of molecular pharming

Dirisala, VijayaR / Rahul R. Nair / Krupanidhi Srirama / Prakash Narayana Reddy / K. R. S. Sambasiva Rao / N. Satya Sampath Kumar / Giridhar Parvatam

Acta physiologiae plantarum. 2017 Jan., v. 39, no. 1

2017

Abstract: There is an increasing demand for the generation of recombinant pharmaceutical proteins for a wide array of therapeutic applications. In comparison to bacterial, yeast and animal cells, the production of recombinant proteins in plants with economic and ... ...

Abstract	There is an increasing demand for the generation of recombinant pharmaceutical proteins for a wide array of therapeutic applications. In comparison to bacterial, yeast and animal cells, the production of recombinant proteins in plants with economic and therapeutic importance has only started recently. The most important prerequisite of any expression systems is that it should be simple and inexpensive. In this regard, plant-based expression has emerged an as accepted alternative to conventional expression platforms due to economic feasibility, rapid scalability, higher stability of recombinant proteins, safety due to lack of harmful substances (human, animal pathogens and pyrogens) and capability of producing proteins with desired secondary modifications. Heterologous expression using plants has played a pivotal role in the development of a myriad of recombinant proteins, including neutraceuticals and monoclonal antibodies being utilized in various therapeutic approaches. This paper presents an overview about the current status, various strategies and advantages of pharmaceutical protein production in plant expression systems. We also present a summary of expression of therapeutic monoclonal antibodies, vaccines, clinical trials and the regulatory aspects of plant-based expression. Furthermore, the challenges encountered in plant expression such as costs associated with existing purification strategies are discussed.
Keywords	animal pathogens ; biopharmaceuticals ; clinical trials ; economic feasibility ; heterologous gene expression ; humans ; molecular farming ; monoclonal antibodies ; plant proteins ; recombinant proteins ; vaccines ; yeasts
Language	English
Dates of publication	2017-01
Size	p. 18.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	783102-x
ISSN	1861-1664 ; 0137-5881
ISSN (online)	1861-1664
ISSN	0137-5881
DOI	10.1007/s11738-016-2315-3
Database	NAL-Catalogue (AGRICOLA)

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Article: Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA.

Doughman, Scott D / Krupanidhi, Srirama / Sanjeevi, Carani B

Current diabetes reviews

2008 Volume 3, Issue 3, Page(s) 198–203

Abstract: Long-chain EPA/DHA omega-3 fatty acid supplementation can be co-preventative and co-therapeutic. Current research suggests increasing accumulated long chain omega-3s for health benefits and as natural medicine in several major diseases. But many believe ... ...

Abstract	Long-chain EPA/DHA omega-3 fatty acid supplementation can be co-preventative and co-therapeutic. Current research suggests increasing accumulated long chain omega-3s for health benefits and as natural medicine in several major diseases. But many believe plant omega-3 sources are nutritionally and therapeutically equivalent to the EPA/DHA omega-3 in fish oil. Although healthy, precursor ALA bio-conversion to EPA is inefficient and production of DHA is nearly absent, limiting the protective value of ALA supplementation from flax-oil, for example. Along with pollutants certain fish acquire high levels of EPA/DHA as predatory species. However, the origin of EPA/DHA in aquatic ecosystems is algae. Certain microalgae produce high levels of EPA or DHA. Now, organically produced DHA-rich microalgae oil is available. Clinical trials with DHA-rich oil indicate comparable efficacies to fish oil for protection from cardiovascular risk factors by lowering plasma triglycerides and oxidative stress. This review discusses 1) omega-3 fatty acids in nutrition and medicine; 2) omega-3s in physiology and gene regulation; 3) possible protective mechanisms of EPA/DHA in major diseases such as coronary heart disease, atherosclerosis, cancer and type 2 diabetes; 4) EPA and DHA requirements considering fish oil safety; and 5) microalgae EPA and DHA-rich oils and recent clinical results.
MeSH term(s)	Animals ; Diet, Vegetarian/adverse effects ; Dietary Fats, Unsaturated/adverse effects ; Dietary Fats, Unsaturated/pharmacology ; Docosahexaenoic Acids/chemistry ; Docosahexaenoic Acids/supply & distribution ; Eicosapentaenoic Acid/chemistry ; Eicosapentaenoic Acid/supply & distribution ; Eukaryota/chemistry ; Fatty Acids, Omega-3/chemistry ; Fatty Acids, Omega-3/metabolism ; Fatty Acids, Omega-3/pharmacology ; Fatty Acids, Omega-3/therapeutic use ; Gene Expression Regulation/drug effects ; Humans ; Models, Biological ; Nutritional Physiological Phenomena ; Preventive Medicine/methods
Chemical Substances	Dietary Fats, Unsaturated ; Fatty Acids, Omega-3 ; Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2008-01-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1573-3998
ISSN	1573-3998
DOI	10.2174/157339907781368968
Database	MEDical Literature Analysis and Retrieval System OnLINE

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