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  1. Article: Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Attenuate Ca

    Milenina, L S / Krutetskaya, Z I / Antonov, V G / Krutetskaya, N I

    Cell and tissue biology

    2022  Volume 16, Issue 3, Page(s) 233–244

    Abstract: Sigma-1 receptors are ubiquitous multifunctional ligand-regulated molecular chaperones in the endoplasmic reticulum membrane with a unique history, structure, and pharmacological profile. Sigma-1 receptors bind ligands of different chemical structure and ...

    Abstract Sigma-1 receptors are ubiquitous multifunctional ligand-regulated molecular chaperones in the endoplasmic reticulum membrane with a unique history, structure, and pharmacological profile. Sigma-1 receptors bind ligands of different chemical structure and pharmacological action and modulate a wide range of cellular processes in health and disease, including Ca
    Language English
    Publishing date 2022-05-27
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 2390107-X
    ISSN 1990-5203 ; 1990-519X
    ISSN (online) 1990-5203
    ISSN 1990-519X
    DOI 10.1134/S1990519X22030075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [THE EFFECT OF EPOXYGENASE INHIBITORS ON Ca(2+)-RESPONSES INDUCED BY GLUTOXIM AND MOLIXAN IN MACROPHAGES].

    Milenina, L S / Krutetskaya, Z I / Naumova, A A / Butov, S N / Krutetskaya, N I / Antonov, V G

    Tsitologiia

    2015  Volume 57, Issue 7, Page(s) 518–525

    Abstract: Using Fura-2AM microfluorimetry the possible involvement of epoxygenase pathway of arachidonic acid metabolism in the effect of glutoxim and molixan on intracellular Ca2+ concentration in rat peritoneal macrophages was investigated. It was shown for the ... ...

    Abstract Using Fura-2AM microfluorimetry the possible involvement of epoxygenase pathway of arachidonic acid metabolism in the effect of glutoxim and molixan on intracellular Ca2+ concentration in rat peritoneal macrophages was investigated. It was shown for the first time that preincubation of the macrophages with epoxygenase inhibitors, proadifen and econazole, significantly decreases the intracellular Ca2+ concentration increase induced by glutoxim and molixan. The addition of the epoxygenase inhibitors during the already developed store-dependent Ca(2+)-entry induced by glutoxim or molixan partially inhibits Ca(2+)-entry. The obtained data suggest the involvement of the products and/or enzymes of epoxygenase pathway of the arachidonic acid metabolism in the glutoxim and molixan effect on the Ca2+ signaling processes in macrophages.
    MeSH term(s) Animals ; Calcium Signaling/drug effects ; Econazole/pharmacology ; Enzyme Inhibitors/pharmacology ; Macrophages, Peritoneal/cytology ; Macrophages, Peritoneal/metabolism ; Male ; Oligopeptides/pharmacology ; Proadifen/pharmacology ; Rats ; Rats, Wistar
    Chemical Substances Enzyme Inhibitors ; Oligopeptides ; glutoxim ; Econazole (6Z1Y2V4A7M) ; Proadifen (A510CA4CBT)
    Language Russian
    Publishing date 2015
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 280565-0
    ISSN 0041-3771
    ISSN 0041-3771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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