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  1. Article ; Online: In perspective: CSL112 (apolipoprotein A-I) infusions and cardiovascular outcomes in patients with acute myocardial infarction: the ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II) trial.

    Verbrugge, Frederik H / Krychtiuk, Konstantin A

    European heart journal. Acute cardiovascular care

    2024  Volume 13, Issue 4, Page(s) 362–364

    MeSH term(s) Humans ; Myocardial Infarction ; Apolipoprotein A-I/administration & dosage ; Infusions, Intravenous ; Treatment Outcome
    Chemical Substances Apolipoprotein A-I
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuae046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Initial haemodynamic assessment of cardiogenic shock: back to basics?

    Krychtiuk, Konstantin A / Speidl, Walter S

    European heart journal. Acute cardiovascular care

    2023  Volume 12, Issue 10, Page(s) 661–662

    MeSH term(s) Humans ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Myocardial Infarction ; Hemodynamics
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuad103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-Sensitivity Cardiac Troponin Assays: Ready for Prime Time!

    Krychtiuk, Konstantin A / Newby, L Kristin

    Annual review of medicine

    2023  Volume 75, Page(s) 459–474

    Abstract: Rapid and accurate triage of patients presenting with chest pain to an emergency department (ED) is critical to prevent ED overcrowding and unnecessary resource use in individuals at low risk of acute myocardial infarction (AMI) and to efficiently and ... ...

    Abstract Rapid and accurate triage of patients presenting with chest pain to an emergency department (ED) is critical to prevent ED overcrowding and unnecessary resource use in individuals at low risk of acute myocardial infarction (AMI) and to efficiently and effectively guide patients at high risk to definite therapy. The use of biomarkers for rule-out or rule-in of suspected AMI has evolved substantially over the last several decades. Previously well-established biomarkers have been replaced by cardiac troponin (cTn). High-sensitivity cTn (hs-cTn) assays represent the newest generation of cTn assays and offer tremendous advantages, including improved sensitivity and precision. Still, implementation of these assays in the United States lags behind several other areas of the world. Within this educational review, we discuss the evolution of biomarker testing for detection of myocardial injury, address the specifics of hs-cTn assays and their recommended use within triage algorithms, and highlight potential challenges in their use. Ultimately, we focus on implementation strategies for hs-cTn assays, as they are now clearly ready for prime time.
    MeSH term(s) Humans ; Myocardial Infarction/diagnosis ; Biomarkers ; Chest Pain/diagnosis ; Algorithms ; Troponin
    Chemical Substances Biomarkers ; Troponin
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-051022-113931
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    Ua VI Zs.321: Show issues Location:
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  4. Article ; Online: In older persons at risk for dementia, a multidomain approach reduced stroke and transient ischemic attack.

    Krychtiuk, Konstantin A / Granger, Christopher B

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) JC55

    Abstract: Source citation: Lehtisalo J, Rusanen M, Solomon A, et al. ...

    Abstract Source citation: Lehtisalo J, Rusanen M, Solomon A, et al.
    MeSH term(s) Aged ; Aged, 80 and over ; Dementia ; Humans ; Ischemic Attack, Transient/prevention & control ; Life Style ; Stroke/prevention & control
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0030
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    Ua VI Zs.178/2: Show issues Location:
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  5. Article ; Online: In older men, an invitation for comprehensive CV screening did not reduce death at 5.6 y.

    Krychtiuk, Konstantin A / Granger, Christopher B

    Annals of internal medicine

    2022  Volume 175, Issue 12, Page(s) JC140

    Abstract: Source citation: Lindholt JS, Søgaard R, Rasmussen LM, et al. ...

    Abstract Source citation: Lindholt JS, Søgaard R, Rasmussen LM, et al.
    Language English
    Publishing date 2022-12-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0098
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  6. Article ; Online: Moderna COVID-19 vaccine was linked to myocarditis or myopericarditis at 28 d (4.2 events/100 000 persons).

    Krychtiuk, Konstantin A / Newby, L Kristin

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) JC58

    Abstract: Source citation: Husby A, Hansen JV, Fosbøl E, et al. ...

    Abstract Source citation: Husby A, Hansen JV, Fosbøl E, et al.
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273/adverse effects ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cohort Studies ; Humans ; Myocarditis/chemically induced ; Myocarditis/epidemiology ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0021
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    Ua VI Zs.178/2: Show issues Location:
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  7. Article: Mechanical Circulatory Support Systems in Fulminant Myocarditis: Recent Advances and Outlook.

    Lenz, Max / Krychtiuk, Konstantin A / Zilberszac, Robert / Heinz, Gottfried / Riebandt, Julia / Speidl, Walter S

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051197
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  8. Article ; Online: Repeated occurrence of severe hypotension associated with azithromycin infusion in a patient with fulminant myocarditis: a case report.

    Lenz, Max / Krychtiuk, Konstantin A / Zilberszac, Robert / Speidl, Walter S / Heinz, Gottfried

    European heart journal. Case reports

    2024  Volume 8, Issue 4, Page(s) ytae208

    Abstract: Background: Intravenous administration of azithromycin has been linked to severe hypotension in some case reports in the past. We report a further case of profound shock requiring excessive use of vasopressors and extracorporeal membrane oxygenation ( ... ...

    Abstract Background: Intravenous administration of azithromycin has been linked to severe hypotension in some case reports in the past. We report a further case of profound shock requiring excessive use of vasopressors and extracorporeal membrane oxygenation (ECMO).
    Case summary: An 18-year-old Caucasian male was admitted due to fulminant myocarditis and signs of cardiogenic shock. He had to be put on venoarterial ECMO only hours after admission. Due to the occurrence of disseminated intravascular coagulation and heparin-induced thrombocytopenia, haemodynamic support was discontinued on Day 8. On Day 11 of his stay, the patient started to exhibit signs of severe infection and a single 1500 mg dose of azithromycin was prescribed. Immediately after starting the infusion, the patient developed profound hypotension and signs of cardiogenic shock. Consecutively, venoarterial ECMO had to be re-established, and the azithromycin infusion was stopped in the process. It took the restart of the compound to recognize the connection between the administration of the therapy and the occurrence of cardiogenic shock. After discontinuing azithromycin, no further sudden hypotensive episodes were recorded, and the patient received left ventricular assist device implantation as a bridge to recovery or transplant.
    Discussion: Rapid-onset hypotension appears to be a very rare but important adverse drug reaction associated with intravenous administration of azithromycin. Factors such as preceding infection and reduced biventricular function may facilitate the described occurrence.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae208
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  9. Article ; Online: In-hospital initiation of PCSK9 inhibitors in ACS: pros and cons.

    Krychtiuk, Konstantin A / Claeys, Marc J / Gencer, Baris / Mach, François

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2023  Volume 19, Issue 4, Page(s) e283–e285

    MeSH term(s) Humans ; PCSK9 Inhibitors ; Proprotein Convertase 9 ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cognition
    Chemical Substances PCSK9 Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-07-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-E-23-00014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6680: Show issues Location:
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  10. Article ; Online: Patient advocacy in #EHJACVC: tackling acute cardiovascular care together.

    Krychtiuk, Konstantin A / Aleksic, Milica / Galbraith, Mary

    European heart journal. Acute cardiovascular care

    2022  Volume 11, Issue 9, Page(s) 669–671

    MeSH term(s) Critical Care ; Humans ; Patient Advocacy ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuac097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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