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Article ; Online: Quantum error channels in high energetic photonic systems.

Hiesmayr, B C / Krzemień, W / Bała, M

2024 Volume 14, Issue 1, Page(s) 9672

Abstract: In medical applications-such as positron emission tomography (PET)-511 keV photons that experience Compton scattering are studied. We present a consistent framework based on quantum error-correction channels-intensively studied in quantum computing-to ... ...

Abstract	In medical applications-such as positron emission tomography (PET)-511 keV photons that experience Compton scattering are studied. We present a consistent framework based on quantum error-correction channels-intensively studied in quantum computing-to fully describe the quantum information-theoretic content of high energetic photons undergoing Compton scattering, characterized by the Klein-Nishina formula in unoriented matter. In this way, we can predict the expected spatial distribution of two or more, pure or mixed, polarization entangled or separable photons. This framework allows us to characterize the accessible and inaccessible information for different parameter ranges. It also answers the question of how to describe successive multi-photon scattering. In addition our formalism provides a complete framework for dealing with single and all multi-partite errors that can occur in the propagation, providing the basis for modeling future dedicated experiments that will then have applications in medicine, such as reducing errors in PET imaging or exploring possibilities for quantum-based diagnostic indicators.
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60472-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tuning Photodynamic Properties of BODIPY Dyes, Porphyrins' Little Sisters.

Krzemien, Wojciech / Rohlickova, Monika / Machacek, Miloslav / Novakova, Veronika / Piskorz, Jaroslaw / Zimcik, Petr

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 14

Abstract: The photodynamic properties of a series of non-halogenated, dibrominated and diiodinated BODIPYs with a phthalimido or amino end modification on the phenoxypentyl and phenoxyoctyl linker in ... ...

Abstract	The photodynamic properties of a series of non-halogenated, dibrominated and diiodinated BODIPYs with a phthalimido or amino end modification on the phenoxypentyl and phenoxyoctyl linker in the
Language	English
Publishing date	2021-07-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26144194
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Book ; Online: Search for eta-mesic 4He with the WASA-at-COSY detector

Krzemien, Wojciech

2012

Abstract: We performed a search for the 4He-eta bound state via exclusive measurement of the excitation function for the dd->3Heppi- reaction, where the outgoing p-pi- pair originates from the conversion of the eta meson on a neutron inside the 4He nucleus. The ... ...

Abstract	We performed a search for the 4He-eta bound state via exclusive measurement of the excitation function for the dd->3Heppi- reaction, where the outgoing p-pi- pair originates from the conversion of the eta meson on a neutron inside the 4He nucleus. The measurements were performed at the Cooler Synchrotron COSY-Juelich with the WASA-at-COSY detection system.The internal deuteron beam of COSY was scattered on a pellet-type deuteron target. The data were taken during a slow acceleration of the beam from 2.185 GeV/c to 2.400 GeV/c crossing the kinematical threshold for the eta production in the dd->4He-eta reaction at 2.336 GeV/c. The corresponding excess energy in the 4He-eta system varied from -51.4 MeV to 22 MeV. Events corresponding to decays of the eta-mesic 4He were selected using cuts on the 3He momentum, p and pi- kinetic energies and the relative p-pi- angle in the center of mass system. The range of the applied cuts was inferred from simulations of decay of the 4He-eta bound state proceeding via excitation the N* resonance. The integrated luminosity in the experiment was determined using the dd->3He-n reaction and the relative normalization of the points of the dd->3Heppi- excitation function was based on the quasi-elastic proton-proton scattering. No signal of the 4He-eta bound state was observed in the excitation function. An upper limit for the cross-section for the bound state formation and decay in the process dd->(4He-eta)_bound->3Heppi- determined for the bound state width of 10, 20 and 30 MeV equals to 28, 32 and 41 nb, respectively. The measured angular and momentum distributions of the reaction products are close to those simulated under the assumption of uniform phase-space distribution. Comment: Ph.D. Thesis (Advisor:Prof. Jerzy Smyrski), 2011, 122 pages
Keywords	Nuclear Experiment
Subject code	551
Publishing date	2012-02-26
Publishing country	us
Document type	Book ; Online
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Article ; Online: JWH-133, a Selective Cannabinoid CB₂ Receptor Agonist, Exerts Toxic Effects on Neuroblastoma SH-SY5Y Cells.

Wojcieszak, Jakub / Krzemień, Wojciech / Zawilska, Jolanta B

Journal of molecular neuroscience : MN

2016 Volume 58, Issue 4, Page(s) 441–445

Abstract: Endocannabinoid system plays an important role in the regulation of diverse physiological functions. Although cannabinoid type 2 receptors (CB2) are involved in the modulation of immune system in peripheral tissues, recent findings demonstrated that they ...

Abstract	Endocannabinoid system plays an important role in the regulation of diverse physiological functions. Although cannabinoid type 2 receptors (CB2) are involved in the modulation of immune system in peripheral tissues, recent findings demonstrated that they are also expressed in the central nervous system and could constitute a new target for the treatment of neurodegenerative disorders. At present, very little is known about the potential effects of CB2-mimetic drugs on neuronal cells. This study aimed to examine whether JWH-133, a selective CB2 receptor agonist, affects the survival of SH-SY5Y neuroblastoma cell line, a widely used experimental in vitro model to study mechanisms of toxicity and protection in nigral dopaminergic neurons. Cell viability was assessed using two complementary methods: MTT test measuring mitochondrial activity and LDHe test indicating disruption of cell membrane integrity. In addition, cell proliferation was measured using BrdU incorporation assay. JWH-133 (10-40 μM) induced a concentration-dependent decrease of SH-SY5Y cell viability and proliferation rate. Using AM-630, a reverse agonist of CB2 receptors, as well as Z-VAD-FMK, a pan-caspase inhibitor, we demonstrated that the cytotoxic effect of JWH-133 presumably was not mediated by activation of CB2 receptors or by caspase pathway. Results of this work suggest that agonists of CB2 receptors when administered in multiple/high doses may induce neuronal damage.
MeSH term(s)	Cannabinoid Receptor Agonists/toxicity ; Cannabinoids/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Dopaminergic Neurons/drug effects ; Humans ; Receptor, Cannabinoid, CB2/agonists
Chemical Substances	Cannabinoid Receptor Agonists ; Cannabinoids ; Receptor, Cannabinoid, CB2 ; 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC (TDG8048RDA)
Language	English
Publishing date	2016-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-016-0726-7
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Book ; Online: J-PET Framework

Krzemien, Wojciech / Gajos, Aleksander / Kacprzak, Krzysztof / Rakoczy, Kamil / Korcyl, Grzegorz

Software platform for PET tomography data reconstruction and analysis

2020

Abstract: J-PET Framework is an open-source software platform for data analysis, written in C++ and based on the ROOT package. It provides a common environment for implementation of reconstruction, calibration and filtering procedures, as well as for user-level ... ...

Abstract	J-PET Framework is an open-source software platform for data analysis, written in C++ and based on the ROOT package. It provides a common environment for implementation of reconstruction, calibration and filtering procedures, as well as for user-level analyses of Positron Emission Tomography data. The library contains a set of building blocks that can be combined by users with even little programming experience, into chains of processing tasks through a convenient, simple and well-documented API. The generic input-output interface allows processing the data from various sources: low-level data from the tomography acquisition system or from diagnostic setups such as digital oscilloscopes, as well as high-level tomography structures e.g. sinograms or a list of lines-of-response. Moreover, the environment can be interfaced with Monte Carlo simulation packages such as GEANT and GATE, which are commonly used in the medical scientific community. Comment: 12 pages, 4 figures
Keywords	Physics - Instrumentation and Detectors ; Computer Science - Software Engineering ; Physics - Medical Physics
Subject code	004
Publishing date	2020-02-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Search for the 4He-η bound state in dd → (4He-η)bound → 3Henπ 0 and dd → (4He-η)bound → 3Hepπ− reactions with the WASA-at-COSY facility

Skurzok M. / Krzemien W. / Moskal P.

EPJ Web of Conferences, Vol 81, p

2014 Volume 02020

Abstract: In November 2010, the search for the 4He-η bound state was performed with high statistics and high acceptance with the WASA-at-COSY facility using a ramped beam technique. The signature of η - mesic nuclei is searched for in the measured excitation ... ...

Abstract	In November 2010, the search for the 4He-η bound state was performed with high statistics and high acceptance with the WASA-at-COSY facility using a ramped beam technique. The signature of η - mesic nuclei is searched for in the measured excitation functions for the two reaction channels: dd → 3Henπ0 and dd → 3Hepπ− near the η production threshold. This report includes the description of the experimental method and the status of the data analysis.
Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Search for the 4He-η bound state in dd → (4He-η)bound → 3Henπ 0 and dd → (4He-η)bound → 3Hepπ− reactions with the WASA-at-COSY facility

Skurzok M. / Krzemien W. / Moskal P.

EPJ Web of Conferences, Vol 81, p

2014 Volume 02020

Abstract	In November 2010, the search for the 4He-η bound state was performed with high statistics and high acceptance with the WASA-at-COSY facility using a ramped beam technique. The signature of η - mesic nuclei is searched for in the measured excitation functions for the two reaction channels: dd → 3Henπ0 and dd → 3Hepπ− near the η production threshold. This report includes the description of the experimental method and the status of the data analysis.
Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Search for the η-mesic 4He with WASA-at-COSY

Krzemien W. / Moskal P. / Smyrski J. / Skurzok M.

EPJ Web of Conferences, Vol 66, p

2014 Volume 09009

Abstract: We conduct a search for the He − η bound state with the WASA-at-COSY facility measuring the excitation functions for the reaction channels: dd → 3Hepπ− and dd → 3Henπ0, where the outgoing N − π pairs originate from the conversion of the η meson on a ... ...

Abstract	We conduct a search for the He − η bound state with the WASA-at-COSY facility measuring the excitation functions for the reaction channels: dd → 3Hepπ− and dd → 3Henπ0, where the outgoing N − π pairs originate from the conversion of the η meson on a nucleon inside the He nucleus. Two dedicated experiments were performed at the Cooler Synchrotron COSY-Jülich with the WASA detector. The analysis of the 2008 data shows no signal of the 4He − η bound state. An upper limit for the cross-section for the bound state formation and decay in the process dd → (4He − η)bound → 3Hepπ−, was determined at the 90 % confidence level. In November 2010 a new data set was collected.
Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Search for the eta-mesic helium by means of WASA detector at COSY

Moskal, P. / Krzemien, W. / Skurzok, M.

2014

Abstract: The eta-mesic nuclei in which the eta meson is bound with nucleus via strong interaction was postulated about 25 years ago, however till now no experiment confirmed empirically its existence. The discovery of this new kind of an exotic nuclear matter ... ...

Abstract	The eta-mesic nuclei in which the eta meson is bound with nucleus via strong interaction was postulated about 25 years ago, however till now no experiment confirmed empirically its existence. The discovery of this new kind of an exotic nuclear matter would be very important for better understanding of the eta meson structure and its interaction with nucleons. The search for eta-mesic helium is carried out with high statistic and high acceptance with the WASA-at-COSY detection setup and the Cooler Synchrotron COSY. The search is conducted via the measurement of the excitation function for the chosen decay channels of the 4He-eta system. Until now two reactions dd -> (4He-eta)bound ->3Heppi- and dd -> (4He-eta)bound ->3Henpi0 have been measured with the beam momentum varied continuously around the eta meson production threshold. This contribution includes description of recently published results of the WASA-at-COSY experiment as well as brief presentation of preliminary results from the analysis of new data sample with 20 times larger statistics. Comment: Presented at HADRON-2013: the XV International Conference on Hadron Spectroscopy, Nara, Japan, November 2013
Keywords	Nuclear Experiment
Subject code	551
Publishing date	2014-02-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficiency determination of J-PET: first plastic scintillators-based PET scanner.

Sharma, S / Baran, J / Chug, N / Curceanu, C / Czerwiński, E / Dadgar, M / Dulski, K / Eliyan, K / Gajos, A / Gupta-Sharma, N / Hiesmayr, B C / Kacprzak, K / Kapłon, Ł / Klimaszewski, K / Konieczka, P / Korcyl, G / Kozik, T / Krzemień, W / Kumar, D /

Niedźwiecki, Sz / Panek, D / Parzych, S / Del Rio, E Perez / Raczyński, L / Choudhary, Shivani / Shopa, R Y / Skurzok, M / Stępień, E Ł / Tayefi, F / Tayefi, K / Wiślicki, W / Moskal, P

EJNMMI physics

2023 Volume 10, Issue 1, Page(s) 28

Abstract: Background: The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic ... ...

Abstract	Background: The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic scintillators are several times cheaper and could be considered as a more economical alternative to crystal scintillators in future PETs. JPET is also a first multi-photon PET prototype. For the development of multi-photon detection, with photon characterized by the continuous energy spectrum, it is important to estimate the efficiency of J-PET as a function of energy deposition. The aim of this work is to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. In this study, 3-hit events are investigated, where 2-hits are caused by 511 keV photons emitted in [Formula: see text] annihilations, while the third hit is caused by one of the scattered photons. The scattered photon is used to accurately measure the scattering angle and thus the energy deposition. Two hits by a primary and a scattered photon are sufficient to calculate the scattering angle of a photon, while the third hit ensures the precise labeling of the 511 keV photons. Results: By comparing experimental and simulated energy distribution spectra, the registration efficiency of the J-PET scanner was determined in the energy deposition range of 70-270 keV, where it varies between 20 and 100[Formula: see text]. In addition, the intrinsic efficiency of the J-PET was also determined as a function of the energy of the incident photons. Conclusion: A method for determining registration efficiency as a function of energy deposition and intrinsic efficiency as a function of incident photon energy of the J-PET scanner was demonstrated. This study is crucial for evaluating the performance of the scanner based on plastic scintillators and its applications as a standard and multi-photon PET systems. The method may be also used in the calibration of Compton-cameras developed for the ion-beam therapy monitoring and simultaneous multi-radionuclide imaging in nuclear medicine.
Language	English
Publishing date	2023-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00546-7
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