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  1. Artikel ; Online: Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

    Sherif Elsharkawy / Maisoon Al-Jawad / Maria F. Pantano / Esther Tejeda-Montes / Khushbu Mehta / Hasan Jamal / Shweta Agarwal / Kseniya Shuturminska / Alistair Rice / Nadezda V. Tarakina / Rory M. Wilson / Andy J. Bushby / Matilde Alonso / Jose C. Rodriguez-Cabello / Ettore Barbieri / Armando del Río Hernández / Molly M. Stevens / Nicola M. Pugno / Paul Anderson /
    Alvaro Mata

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 12

    Abstract: There is evidence that disordered proteins play a role in the mineralization process. Here, the authors report on the development of elastin-like recombinant protein membranes using disordered-ordered interplay to investigate and guide mineralization. ...

    Abstract There is evidence that disordered proteins play a role in the mineralization process. Here, the authors report on the development of elastin-like recombinant protein membranes using disordered-ordered interplay to investigate and guide mineralization.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

    Sherif Elsharkawy / Maisoon Al-Jawad / Maria F. Pantano / Esther Tejeda-Montes / Khushbu Mehta / Hasan Jamal / Shweta Agarwal / Kseniya Shuturminska / Alistair Rice / Nadezda V. Tarakina / Rory M. Wilson / Andy J. Bushby / Matilde Alonso / Jose C. Rodriguez-Cabello / Ettore Barbieri / Armando del Río Hernández / Molly M. Stevens / Nicola M. Pugno / Paul Anderson /
    Alvaro Mata

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 12

    Abstract: There is evidence that disordered proteins play a role in the mineralization process. Here, the authors report on the development of elastin-like recombinant protein membranes using disordered-ordered interplay to investigate and guide mineralization. ...

    Abstract There is evidence that disordered proteins play a role in the mineralization process. Here, the authors report on the development of elastin-like recombinant protein membranes using disordered-ordered interplay to investigate and guide mineralization.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Characterization of a novel intrinsically radiopaque Drug-eluting Bead for image-guided therapy: DC Bead LUMI™

    Ashrafi, Koorosh / Alessandro Radaelli / Andrew J. Bushby / Andrew L. Lewis / Andrew S. Mikhail / Ayele H. Negussie / Bradford J. Wood / David L. Woods / Delphine Blino / Elliot B. Levy / Hugh Britton / Kseniya Shuturminska / Mark den Hartog / Matthew R. Dreher / Orianne Domenge / Sean L. Willis / Venkatesh Krishnasamy / Yiqing Tang

    Journal of Controlled Release. 2017 Mar. 28, v. 250

    2017  

    Abstract: We have developed a straightforward and efficient method of introducing radiopacity into Polyvinyl alcohol (PVA)-2-Acrylamido-2-methylpropane sulfonic acid (AMPS) hydrogel beads (DC Bead™) that are currently used in the clinic to treat liver ... ...

    Abstract We have developed a straightforward and efficient method of introducing radiopacity into Polyvinyl alcohol (PVA)-2-Acrylamido-2-methylpropane sulfonic acid (AMPS) hydrogel beads (DC Bead™) that are currently used in the clinic to treat liver malignancies. Coupling of 2,3,5-triiodobenzaldehyde to the PVA backbone of pre-formed beads yields a uniformly distributed level of iodine attached throughout the bead structure (~150mg/mL) which is sufficient to be imaged under standard fluoroscopy and computed tomography (CT) imaging modalities used in treatment procedures (DC Bead LUMI™). Despite the chemical modification increasing the density of the beads to ~1.3g/cm3 and the compressive modulus by two orders of magnitude, they remain easily suspended, handled and administered through standard microcatheters. As the core chemistry of DC Bead LUMI™ is the same as DC Bead™, it interacts with drugs using ion-exchange between sulfonic acid groups on the polymer and the positively charged amine groups of the drugs. Both doxorubicin (Dox) and irinotecan (Iri) elution kinetics for all bead sizes evaluated were within the parameters already investigated within the clinic for DC Bead™. Drug loading did not affect the radiopacity and there was a direct relationship between bead attenuation and Dox concentration. The ability (Dox)-loaded DC Bead LUMI™ to be visualized in vivo was demonstrated by the administration of into hepatic arteries of a VX2 tumor-bearing rabbit under fluoroscopy, followed by subsequent CT imaging.
    Schlagwörter arteries ; computed tomography ; doxorubicin ; hydrocolloids ; image analysis ; iodine ; ion exchange ; liver ; polyvinyl alcohol ; rabbits ; sulfonic acid ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2017-0328
    Umfang p. 36-47.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2017.02.001
    Datenquelle NAL Katalog (AGRICOLA)

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