Article ; Online: HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.
PloS one
2016 Volume 11, Issue 4, Page(s) e0150835
Abstract: The large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers ... ...
| Abstract | The large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers correlate with changes in disease severity. This study presents a cross-sectional/longitudinal study of HIV-1 single nucleotide polymorphisms (SNPs) contained within the viral promoter or long terminal repeat (LTR) in patients within the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort. HIV-1 LTR SNPs were found to associate with the classical clinical disease parameters CD4+ T-cell count and log viral load. They were found in both defined and undefined transcription factor binding sites of the LTR. A novel SNP identified at position 108 in a known COUP (chicken ovalbumin upstream promoter)/AP1 transcription factor binding site was significantly correlated with binding phenotypes that are potentially the underlying cause of the associated clinical outcome (increase in viral load and decrease in CD4+ T-cell count). |
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| MeSH term(s) | Binding Sites/genetics ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Cross-Sectional Studies ; Female ; Genetic Association Studies/methods ; HIV Infections/metabolism ; HIV Infections/pathology ; HIV Infections/virology ; HIV Long Terminal Repeat/genetics ; HIV-1/genetics ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Promoter Regions, Genetic/genetics ; Severity of Illness Index ; Transcription Factors/genetics ; Viral Load/genetics |
| Chemical Substances | Transcription Factors |
| Language | English |
| Publishing date | 2016-04-21 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ISSN | 1932-6203 |
| ISSN (online) | 1932-6203 |
| DOI | 10.1371/journal.pone.0150835 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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