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Article ; Online: Three-dimensional Analysis of Maxillary Morphology in Infants with Unilateral Cleft Lip and Palate.

Zheng, Jie / Kuang, Wenying / Yuan, Shiyu / He, Hong / Yuan, Wenjun

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2024 , Page(s) 10556656241228903

Abstract: Objective: To three-dimensionally (3D) analyze the maxillary morphology of infants with unilateral cleft lip and palate (UCLP) and preliminarily classify the alveolar arch to assist in personalization of sequence therapy.: Design: Retrospective study. ...

Abstract	Objective: To three-dimensionally (3D) analyze the maxillary morphology of infants with unilateral cleft lip and palate (UCLP) and preliminarily classify the alveolar arch to assist in personalization of sequence therapy. Design: Retrospective study. Setting: Patients with UCLP referred to outpatients' clinic. Participants: 84 nonsyndromic infants with complete UCLP were recruited (58 boys, 26 girls, mean age 29.48 days). Main outcome measure: Morphometric analysis was conducted on 3D maxillary models. Principal component analysis (PCA) and cluster analysis were combined to classify maxillary phenotypes preliminarily. The Wilcoxon Signed Rank test and the Kruskal-Wallis test were used to compare differences between variables. A Results: The maxilla was divided into three types: narrow, homogenous and broad, accounting for 9.52%, 23.81% and 66.67% respectively. The alveolar cleft site (median value) was located in 61% of the total length of the alveolar arch. In the comparison of anterior and total alveolar lengths, the non-cleft side had longer alveolar bone than the affected side, a difference of approximately 2 mm. Pairwise comparisons of variables describing alveolar symmetry revealed significant differences in all subjects; whereas type C had poorer arch symmetry than types A and B, mainly in terms of anterior and overall symmetry. Conclusions: In infants with UCLP, the maxillary alveolar arch was inherently asymmetrical with partially bone missing (about 2 mm). Significant differences in alveolar bone morphology and symmetry exist between different types of infants, with individuals with broad clefts (type C, the largest proportion) having the worst maxillary development.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656241228903
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Article ; Online: Novel Three-Dimensional Coordinate System to Analyze Alveolar Molding Effects of Pre-Surgical Nasoalveolar Molding on Infants With Non-Syndromic Unilateral Cleft Lip and Palate.

Zheng, Jie / He, Hong / Kuang, Wenying / Yuan, Wenjun

The Journal of craniofacial surgery

2020 Volume 31, Issue 3, Page(s) 653–657

Abstract: The aim of this study is to establish a stable 3-dimensional (3D) coordinate system for investigating the alveolar molding effects of pre-surgical nasoalveolar molding (PNAM) on non-syndromic unilateral cleft lip and palate (UCLP) patients, basing on the ...

Abstract	The aim of this study is to establish a stable 3-dimensional (3D) coordinate system for investigating the alveolar molding effects of pre-surgical nasoalveolar molding (PNAM) on non-syndromic unilateral cleft lip and palate (UCLP) patients, basing on the Frankfort Horizontal (FH) plane.Twenty-one non-syndromic UCLP neonates who sought medical advice in the department of Orthodontics, from 2016.5 to 2017.10 were enrolled in the present study. All neonates were subjected to PNAM before the cleft lip repair. The treatment duration was 75.76 days. Silicone rubber models were obtained and scanned using a 3D laser scanner pre- and post-PNAM treatment. A 3D coordinate system based on the FH reference plane was built utilizing Rhino3D software to record the landmark 3D coordinates, to measure the distance, angle, and length variables. The Paired Student's t test and the Pearson correlation coefficient were used to calculate reproducibility and reliability of the landmark localization for repeated measurements. Changes of the measurement variables were analyzed by the Paired Student's t test.This study revealed a high reproducibility and reliability for most of the landmarks. By the end of PNAM treatment, the cleft gap was reduced with the malformation of alveolar segments aligned normally and the anterior points of both alveolar segments were rotated to the cleft side.Utilizing the FH plane to set up a rigorous and stable 3D system is meaningful. PNAM therapy is effective in reducing the severity of the maxillary deformity not only on the non-cleft side, but also on the cleft side.
MeSH term(s)	Cleft Lip/diagnostic imaging ; Cleft Lip/surgery ; Cleft Palate/diagnostic imaging ; Cleft Palate/surgery ; Duration of Therapy ; Female ; Humans ; Imaging, Three-Dimensional ; Infant ; Infant, Newborn ; Lasers ; Lip ; Male ; Preoperative Care/methods ; Reproducibility of Results ; Silicone Elastomers
Chemical Substances	Silicone Elastomers
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000006148
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Article ; Online: Reliability and Validity of the CLEFT-Q in a Chinese Context.

Ding, Yuzhe / Kuang, Wenying / Zhang, Xinyu / Zhang, Wenjuan / Xu, Jingyi / Yan, Jianan / Guo, Yanyu / Zheng, Jie / Yuan, Wenjun

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2023 , Page(s) 10556656231184966

Abstract: Objective: To develop an appropriate Chinese version of the CLEFT-Q through translation and cultural adaptation and to evaluate its reliability and validity.: Design: The English CLEFT-Q was translated into Chinese following the International Society ...

Abstract	Objective: To develop an appropriate Chinese version of the CLEFT-Q through translation and cultural adaptation and to evaluate its reliability and validity. Design: The English CLEFT-Q was translated into Chinese following the International Society for Pharmacoeconomics and Outcomes Research guidelines, including cognitive debriefing interviews, and its reliability and validity were assessed. Participants: Patients (N = 246) were mostly in active orthodontic treatment, had a mean age of 14.7 ± 4.4 years, 29% were female, and were born with isolated cleft lip ± alveolus (12%), cleft palate (1%), or cleft lip and palate (87%). Main outcome measures: The Chinese CLEFT-Q, including 13 subscales covering Appearance, Health-Related Quality of Life (HRQOL), and Facial Function. Criterion validity instruments included the Negative Physical Self, Satisfaction with Life Scale, and Scale of Positive and Negative Experience. Results: The wording of 67 items was adapted in the final translation. The internal consistency of the Chinese version of the CLEFT-Q was high based on Cronbach's alphas of 0.85 to 0.98 and split-half reliability of 0.85 to 0.92. Exploratory and confirmatory factor analyses yielded three factors, which demonstrated construct validity by broadly matching the structure of the original CLEFT-Q. The Appearance and HRQOL dimensions had weak to moderate correlations (r = -0.35 to 0.67) with the corresponding instruments for criterion validity. Conclusions: The Chinese version of the CLEFT-Q is a patient-reported outcome measure that can reflect the quality of life of Chinese patients with cleft lip and/or palate with good reliability and validity.
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656231184966
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Article ; Online: Presurgical nasoalveolar molding with 3D printing for a patient with unilateral cleft lip, alveolus, and palate.

Zheng, Jie / He, Hong / Kuang, Wenying / Yuan, Wenjun

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2019 Volume 156, Issue 3, Page(s) 412–419

Abstract: An 8-day-old male infant with unilateral cleft lip, alveolus, and palate had a wide alveolar defect, soft tissue deformity, and a markedly sunken nasal wing at the cleft side. The patient was treated with a series of 3D-printed molding plates and ... ...

Abstract	An 8-day-old male infant with unilateral cleft lip, alveolus, and palate had a wide alveolar defect, soft tissue deformity, and a markedly sunken nasal wing at the cleft side. The patient was treated with a series of 3D-printed molding plates and synchronously with a nasal hook. The cleft edges moved closer by 9 mm at the alveolar ridge and the nasal wing was lifted considerably. Split-type 3D printing of presurgical nasoalveolar molding helped to reduce the cleft gap, improve the arch form, approximate lip segments, and distinctly improve the morphology of the nose by correcting the flattened nasal wings.
MeSH term(s)	Alveolar Process/surgery ; Cleft Lip/diagnostic imaging ; Cleft Lip/surgery ; Cleft Palate/diagnostic imaging ; Cleft Palate/surgery ; Computer-Aided Design ; Dental Impression Technique ; Dental Models ; Humans ; Infant, Newborn ; Male ; Nose/surgery ; Orthognathic Surgical Procedures/methods ; Palate/surgery ; Printing, Three-Dimensional ; Reconstructive Surgical Procedures/methods ; Treatment Outcome
Language	English
Publishing date	2019-08-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2018.04.031
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Article ; Online: Skeletal Maturation in Patients With Cleft Lip and/or Palate: A Systematic Review.

Wu, Xiaoyi / Kuang, Wenying / Zheng, Jie / Yang, Zhengkun / Ren, Meiqing / Yang, Ruicong / Yuan, Wenjun

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2021 Volume 59, Issue 3, Page(s) 307–319

Abstract: Objective: The objective of this systematic review was to evaluate the evidence regarding skeletal maturation in patients with cleft lip and/or palate (CL/P) and to investigate whether the skeletal maturation is delayed in these patients.: Design: ... ...

Abstract	Objective: The objective of this systematic review was to evaluate the evidence regarding skeletal maturation in patients with cleft lip and/or palate (CL/P) and to investigate whether the skeletal maturation is delayed in these patients. Design: Systematic review. Methods: Electronic and manual searches of scientific literature were conducted in 4 databases (MEDLINE, Embase, Cochrane Library, and Web of Science). Cohort studies that compared the skeletal maturation of patients with CL/P with that of children without CL/P were eligible for inclusion. The quality of included cohort studies was assessed using the Newcastle-Ottawa Scale. Patients and participants: Patients of any sex and ethnicity with CL/P and children without CL/P were included in this systematic review. Main outcome measures: Difference in skeletal maturation between patients with CL/P and patients without CL/P. Results: Thirteen retrospective cohort studies were included in this systematic review. Ten studies were considered of high quality and 3 were considered of general quality. The results of the included studies comparing skeletal maturation of patients with CL/P and children without CL/P were heterogeneous. Conclusion: Heterogeneity of skeletal maturation assessment methods, chronological age, sex, cleft type, and race may influence the final results of clinical studies on skeletal maturation in patients with CL/P. Overall, there is limited evidence to determine whether the skeletal maturation level of patients with CL/P is delayed compared to that of normal children. Further studies are needed to determine the skeletal maturation patterns in patients with CL/P.
MeSH term(s)	Child ; Cleft Lip ; Cleft Palate ; Humans ; Retrospective Studies
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656211007680
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Article ; Online: Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.

Kuang, Wenying / Aarts, Miranda / Kuijpers-Jagtman, Anne Marie / He, Hong / Ongkosuwito, Edwin M

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2021 Volume 59, Issue 11, Page(s) 1377–1390

Abstract: Objectives: To assess treatment outcome (transversal and sagittal dental arch relationships) and its determinants in complete bilateral cleft lip and palate (BCLP) evaluated with the modified Huddart-Bodenham scoring system and the BCLP Yardstick.: ... ...

Abstract	Objectives: To assess treatment outcome (transversal and sagittal dental arch relationships) and its determinants in complete bilateral cleft lip and palate (BCLP) evaluated with the modified Huddart-Bodenham scoring system and the BCLP Yardstick. Materials and methods: Multiple electronic databases were searched without time limitation. Randomized clinical trials, cohort and case control studies using BCLP Yardstick and/or modified Huddart-Bodenham system to judge treatment outcome of patients with BCLP were included. The Risk of Bias in Nonrandomized Studies of Interventions tool and Grading of Recommendations, Assessment, Development, and Evaluation was used. Results: Of the 528 studies identified by the electronic search, only eight retrospective studies met the inclusion criteria and were included. A total of 12 cleft centers were represented. All treatment protocols differed and background information was underreported. The results for the BCLP yardstick showed that all except the centers in New Zealand had a mean score lower than 3, indicating good treatment results. However, these studies had a moderate to high risk of bias. The modified Huddart-Bodenham scores were negative in all studies. No further meta-analysis was done due to heterogeneity and high risk of bias. The quality of evidence was graded as very low. Conclusion: Results for the dental arch relationship of studies in complete BCLP and possible determinants were not synthesized due to very low quality of evidence. Clinical research for patients with BCLP should focus on sound methodological designs to enable evidence-based decision making to improve treatment for patients with BCLP and thereby hopefully their quality of life.
MeSH term(s)	Cleft Lip/surgery ; Cleft Palate/surgery ; Dental Arch ; Humans ; Models, Dental ; Quality of Life ; Reproducibility of Results ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-10-18
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656211041883
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Article ; Online: Three-Dimensional Analysis of the Pharyngeal Airway Volume and Craniofacial Morphology in Patients With Bilateral Cleft Lip and Palate.

Kuang, Wenying / Zheng, Jie / Li, Shaolin / Yuan, Shiyu / He, Hong / Yuan, Wenjun

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2020 Volume 58, Issue 3, Page(s) 332–339

Abstract: Objective: This study aimed to determine the correlations between the craniofacial morphology and pharyngeal airway volume in patients with complete bilateral cleft lip and palate (BCLP).: Design: Retrospective study.: Setting: Tertiary hospital.!# ...

Abstract	Objective: This study aimed to determine the correlations between the craniofacial morphology and pharyngeal airway volume in patients with complete bilateral cleft lip and palate (BCLP). Design: Retrospective study. Setting: Tertiary hospital. Participants: Twenty-seven patients with complete BCLP and 27 class I control patients, aged 10 to 14 years. Main outcome measure: The pharyngeal airway volume and craniofacial morphology were evaluated using cone-beam computed tomography. Measurements were compared between groups and any correlations were identified. Results: A significantly smaller total pharyngeal airway volume (TPV), oropharyngeal airway volume, and upper (UOPV) and lower (LOPV) oropharyngeal airway volume were found in patients with BCLP than in class I control patients, with no difference in the nasopharyngeal volume between groups. Furthermore, the craniofacial morphology measurements of N-Me, S-Go, Or-C, Ptm-C, Me-C, Co-Go, Go-Me, Ptm-Or, N-S-Ar, and Ar-Go-Me significantly differed between the BCLP and control groups (all Conclusions: Total pharyngeal airway volume, TPV, OPV, UOPV, and LOPV were significantly smaller in patients with BCLP than in class I controls. In patients with BCLP, the maxilla showed inhibited sagittal development and a retrograde position; moreover, the pharyngeal airway volume was weakly associated with the position of the maxilla and mandible relative to the coronal plane.
MeSH term(s)	Adolescent ; Cephalometry ; Child ; Cleft Lip/diagnostic imaging ; Cleft Palate/diagnostic imaging ; Cone-Beam Computed Tomography ; Humans ; Maxilla/diagnostic imaging ; Pharynx/diagnostic imaging ; Retrospective Studies
Language	English
Publishing date	2020-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/1055665620946982
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Article ; Online: A Three-Dimensional Study of the Nasolabial Soft Tissue Symmetry in Children With Unilateral Complete Cleft Lip and Palate Using Traditional and Split-Type Nasoalveolar Molding.

Cai, Donglin / Zheng, Jie / Kuang, Wenying / Li, Zhelun / Yuan, Shiyu / Xiong, Hui / Yuan, Wenjun

The Journal of craniofacial surgery

2020 Volume 31, Issue 6, Page(s) 1785–1789

Abstract: Background: Presurgical nasoalveolar molding (NAM) is the most common preoperative treatment for cleft lip and palate. However, NAM may have some limitations such as requiring high technical sensitivity and frequent visits. To simplify the device, some ... ...

Abstract	Background: Presurgical nasoalveolar molding (NAM) is the most common preoperative treatment for cleft lip and palate. However, NAM may have some limitations such as requiring high technical sensitivity and frequent visits. To simplify the device, some scholars have changed the traditional NAM into a split-NAM consisting of a alveolar molding plate and a nasal hook. This study compared the shaping effect of split NAM and traditional NAM on nasolabial soft tissue using three-dimensional (3D) measurement. Methods: A total of 39 patients with unilateral cleft lip and palate (UCLP) were enrolled and divided into 2 groups. 13 patients were treated with split-NAM while the other 26 patients were treated with traditional NAM. 3D images of all patients' craniofacial soft tissue before and after NAM treatment were recorded and measured by three-dimensional software. Statistical analysis of measurements in both groups was performed using SPSS software. Results: After treatment, nasal soft tissue symmetry in the split-NAM group was better improved than that in the NAM group in vertical and anterior-posterior direction, but was worse improved in transverse direction. There was no significant difference in labial soft tissue symmetry between two groups. Conclusions: The split NAM can better elevate the alar and nostrils of the cleft side, and have a better forward effect on alar outer edge, nasal base, and nostrils. However, the traditional NAM can better reduce the width of nasal base.
MeSH term(s)	Child ; Cleft Lip/surgery ; Cleft Palate/surgery ; Humans ; Imaging, Three-Dimensional ; Nasoalveolar Molding ; Nose/surgery ; Reconstructive Surgical Procedures ; Splints
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000006593
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Zs.MO 175: Show issues

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Article ; Online: Receptor activator of nuclear factor-kappa ligand, OPG, and IGF-I expression during orthodontically induced inflammatory root resorption in the recombinant human growth hormone-treated rats.

Hu, Yajun / Liu, Wentao / Liu, Zhijian / Kuang, Wenying / He, Hong

The Angle orthodontist

2014 Volume 85, Issue 4, Page(s) 562–569

Abstract: Objective: To investigate the effects of growth hormone (GH) on local receptor activator of nuclear factor-kappa ligand (RANKL), OPG, and IGF-I expression during orthodontically induced inflammatory root resorption in rats.: Materials and methods: ... ...

Abstract	Objective: To investigate the effects of growth hormone (GH) on local receptor activator of nuclear factor-kappa ligand (RANKL), OPG, and IGF-I expression during orthodontically induced inflammatory root resorption in rats. Materials and methods: Forty Wistar rats (gender: male; age: 7 weeks) were randomly divided into control and experimental groups. A force of 50 g was applied to move the right upper first molars mesially. The experimental and control groups received daily subcutaneous injections of recombinant human growth hormone (GH; 2 mg/kg) and equivalent volumes of saline, respectively. The rats were sacrificed on days 1, 3, 7, and 14. Micro-computed tomography-reconstructed images of the upper right first molars were used to survey root resorption and tooth movement. Horizontal sections of the maxillae were prepared for hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemical staining. Results: Resorption lacunae appeared on the compressed side of the distal buccal root of the right first molar on days 7 and 14. Compared with the control groups, GH-treated groups showed more RANKL-positive cells and osteoclasts on day 3 and more OPG- and IGF-I-positive cells and fewer odontoclasts on days 7 and 14. Indexes of root resorption were lower and tooth movement was faster in the GH-treated groups than in the control groups on days 7 and 14. Conclusions: The inhibitory effect of GH on root resorption by heavy force might be mediated by RANKL/OPG and IGF-I. Short-term GH administration may be a method with which to reduce root resorption and shorten treatment time, especially in patients who are susceptible to root resorption.
MeSH term(s)	Animals ; Cell Count ; Disease Models, Animal ; Human Growth Hormone/pharmacology ; Humans ; Image Processing, Computer-Assisted/methods ; Insulin-Like Growth Factor I/analysis ; Insulin-Like Growth Factor I/drug effects ; Male ; Molar/chemistry ; Osteoclasts/pathology ; Osteoprotegerin/analysis ; Osteoprotegerin/drug effects ; Periodontal Ligament/chemistry ; Periodontal Ligament/drug effects ; RANK Ligand/analysis ; RANK Ligand/drug effects ; Random Allocation ; Rats ; Rats, Wistar ; Recombinant Proteins ; Root Resorption/metabolism ; Tartrate-Resistant Acid Phosphatase/analysis ; Time Factors ; Tooth Movement Techniques/adverse effects ; X-Ray Microtomography/methods
Chemical Substances	Osteoprotegerin ; RANK Ligand ; Recombinant Proteins ; Tnfrsf11b protein, rat ; Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; Tartrate-Resistant Acid Phosphatase (EC 3.1.3.2)
Language	English
Publishing date	2014-09-03
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390289-4
ISSN	1945-7103 ; 0003-3219
ISSN (online)	1945-7103
ISSN	0003-3219
DOI	10.2319/052014-361.1
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