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Article: Microsurgical replantation after forehead avulsion - success or failure? A case report.

Kubík, M / Molitor, M / Zálešák, B

2024 Volume 66, Issue 1, Page(s) 16–21

Abstract: In this article we would like to present, to our best knowledge, the very first published replantation of a forehead/part of a forehead as a single unit. The patient is a 57-year-old male smoker who sustained an avulsion forehead injury after a dog bite. ...

Title translation	Microsurgical replantation after forehead avulsion – success or failure? A case report.
Abstract	In this article we would like to present, to our best knowledge, the very first published replantation of a forehead/part of a forehead as a single unit. The patient is a 57-year-old male smoker who sustained an avulsion forehead injury after a dog bite. Replantation was performed using microanastomosis of the supratrochlear vessels with restoration of good blood circulation after the procedure. Unfortunately, 5 days after the surgery, ischemia of the flap occurred followed by successful acute revision surgery. Nevertheless, the day after the ischemia reoccurred due to the time that passed, circumstances and unfavorable conditions affecting the sutured vessels, no further revision surgery was indicated. Observation continued and eventual wound necrosis after demarcation was left to be treated with skin grafting or per secundam intentionem. Only partial necrosis of the flap occurred, approximately 50%, which was subsequently treated with a full-thickness skin graft with very good results leading to the satisfaction of the patient.
MeSH term(s)	Humans ; Male ; Middle Aged ; Replantation/methods ; Microsurgery/methods ; Forehead/surgery ; Bites and Stings/surgery ; Animals ; Dogs
Language	English
Publishing date	2024-02-09
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	428718-6
ISSN	1805-4404 ; 0001-5423 ; 0323-0414
ISSN (online)	1805-4404
ISSN	0001-5423 ; 0323-0414
DOI	10.48095/ccachp202416
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Article: Brown tumor mimicking metastases-the late manifestation of hyperparathyroidism.

Tram, Louise / Kubik, Magdalena / Kvist Jensen, Kristina / Almasi, Charlotte E

Acta radiologica open

2022 Volume 11, Issue 9, Page(s) 20584601221128415

Abstract: Brown tumors are uncommon manifestations of hyperparathyroidism (HPT) that without awareness are easily misdiagnosed as metastases. This short report highlights the importance of clinical context and clear communication between medical specialties when ... ...

Abstract	Brown tumors are uncommon manifestations of hyperparathyroidism (HPT) that without awareness are easily misdiagnosed as metastases. This short report highlights the importance of clinical context and clear communication between medical specialties when interpreting complex radiologic findings.
Language	English
Publishing date	2022-09-17
Publishing country	England
Document type	Case Reports
ZDB-ID	2818429-4
ISSN	2058-4601
ISSN	2058-4601
DOI	10.1177/20584601221128415
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Article ; Online: Odontogenic Carcinosarcoma: Clinicopathologic and Molecular Features of Three Cases, a Literature Review and Nomenclature Proposal.

Cole, Grayson / Chi, Angela / Cook, Daniel R / Kubik, Mark / Bilodeau, Elizabeth A / Seethala, Raja R

Head and neck pathology

2023 Volume 17, Issue 3, Page(s) 751–767

Abstract: Background: Odontogenic carcinosarcoma (OCS) is a rare odontogenic malignancy with limited characterization and unexplored molecular features. We report clinicopathologic and molecular findings in 3 additional OCS and review the literature.: Methods: ...

Abstract	Background: Odontogenic carcinosarcoma (OCS) is a rare odontogenic malignancy with limited characterization and unexplored molecular features. We report clinicopathologic and molecular findings in 3 additional OCS and review the literature. Methods: 3 OCS (5.1%) were identified among 59 malignant odontogenic tumors (in our archives from 1992 to 2022). Clinical, radiologic, histopathologic, immunophenotypic, and molecular findings were reviewed. Data from prior case reports and systematic or non-systematic reviews were extracted for analysis. Results: Three mandibular OCS (age range: 66 to 72 years; 1 male, 2 females) were identified. Case 1 had novel clear-cell morphology, multiple recurrences, and a lethal outcome 28 months after resection. EWSR1 rearrangements were negative, but the tumor showed focal nuclear β-catenin and strong LEF-1 immunoreactivity. Case 2 demonstrated ameloblastic and sclerosing features and encased the inferior alveolar nerve; the patient was disease-free 22 months after resection with adjuvant chemoradiation therapy. LEF-1 was again strongly positive, and next-generation sequencing demonstrated 9p region-(CDKN2A, CDKN2B) copy number loss, and 12q region-(MDM2, CDK4) copy number gain. Case 3 showed clear-cell and markedly sclerosing features; no follow-up information was available. Literature review along with the current cases yielded 20 cases. OCS showed a male predilection (1.5:1), mandibular predominance (80%, typically posterior), and a bimodal age distribution (modes: 27.7 years, 62.7 years). OCS presented as masses (100%), often with pain (55%), and paresthesia (45%). Tumors were typically radiolucent (88.9%), with bone destruction (61.1%), and/or tooth effacement (27.8%). Preoperative biopsy was sensitive for malignancy (85.7%). At least 45% show evidence for a precursor lesion. 3-year DSS and DFS were 58% and 35%, respectively. Regional and distant (usually lung) metastatic rates were 25% and 31.3%, respectively. Increased mitotic rates and presence of tumor necrosis trended toward worse DSS and DFS. Conclusion: OCS is a rare but aggressive malignancy, often arising from precursor tumors and may represent a terminal phenotype rather than a distinct entity. We describe novel clear-cell and sclerosing morphologies. Wnt pathway alterations appear important. Mitotic rates and necrosis may be adverse prognosticators. In keeping with nomenclature trends in other sites, OCS may be more appropriately designated as "biphasic sarcomatoid odontogenic carcinomas."
MeSH term(s)	Female ; Humans ; Male ; Aged ; Adult ; Odontogenic Tumors/pathology ; Mouth Neoplasms ; Carcinosarcoma/genetics ; Carcinosarcoma/pathology ; Carcinoma ; Biopsy
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-023-01569-3
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Article: Neurologic sequelae associated with delayed identification of iatrogenic skull base injury during endoscopic sinus surgery (ESS).

Kubik, M / Lee, S / Snyderman, C / Wang, E

Rhinology

2017 Volume 55, Issue 1, Page(s) 53–58

Abstract: Background: Skull base injury is an infrequent complication during endoscopic sinus surgery (ESS). We hypothesize that late recognition and repair of CSF leaks during ESS is associated with increased neurologic morbidity.: Methodology: A ... ...

Abstract	Background: Skull base injury is an infrequent complication during endoscopic sinus surgery (ESS). We hypothesize that late recognition and repair of CSF leaks during ESS is associated with increased neurologic morbidity. Methodology: A retrospective review was performed of patients with skull base injury during ESS at a tertiary center from 1999-2015. The study population was separated into early (less than 72 hrs) and late (more than 72 hrs) intervention groups. Study parameters included time to diagnosis, imaging, site of injury, type of repair, neurologic complications, and clinical outcomes. Results: Seventeen patients were studied. The primary surgical interventions included ESS and balloon sinuplasty. Mean latency from primary surgery to presentation to our facility was 11 days. The most common injury site was the cribriform plate and the mean defect size 4.5 mm. Late diagnosis was associated with increased total neurologic complications and increased rates of postoperative meningitis. No neurologic complications occurred in patients diagnosed intraoperatively. All patients underwent successful endoscopic repair. Conclusion: Skull base injury is a rare but major complication following both balloon sinuplasty and traditional primary ESS. Early diagnosis and endoscopic repair may prevent neurologic morbidity in these patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cerebrospinal Fluid Rhinorrhea/complications ; Cerebrospinal Fluid Rhinorrhea/diagnosis ; Cerebrospinal Fluid Rhinorrhea/etiology ; Cerebrospinal Fluid Rhinorrhea/surgery ; Chronic Disease ; Delayed Diagnosis/adverse effects ; Endoscopy/adverse effects ; Female ; Humans ; Iatrogenic Disease ; Male ; Middle Aged ; Paranasal Sinuses ; Postoperative Complications/diagnosis ; Postoperative Complications/surgery ; Retrospective Studies ; Rhinitis/surgery ; Sinusitis/surgery ; Skull Base/injuries ; Skull Base/surgery ; Young Adult
Language	English
Publishing date	2017-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin16.169
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Book: Minimal dowland

Kubik, Michael

für Mandoline und Gitarre

(Musik für Mandoline und Gitarre)

2014

Author's details	Michael Kubik
Series title	Musik für Mandoline und Gitarre
Size	14 S
Edition	[Partitur, Stimmen]
Publisher	Trekel
Publishing place	Hamburg
Document type	Book
Accompanying material	2 St
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Transient response of magnetorheological fluid on rapid change of magnetic field in shear mode.

Kubík, Michal / Válek, Josef / Žáček, Jiří / Jeniš, Filip / Borin, Dmitry / Strecker, Zbyněk / Mazůrek, Ivan

Scientific reports

2022 Volume 12, Issue 1, Page(s) 10612

Abstract: The transient behaviour of magnetorheological (MR) devices is an important parameter for modern semi-actively controlled suspension systems. A significant part of the MR device response time is the MR fluid response time itself. A significant factor is ... ...

Abstract	The transient behaviour of magnetorheological (MR) devices is an important parameter for modern semi-actively controlled suspension systems. A significant part of the MR device response time is the MR fluid response time itself. A significant factor is the so-called rheological response time. The rheological response time is connected with the structuring particle's time and the development of shear stress in MR fluid during the deformation. The main aim of this paper is to experimentally determine the rheological response time of MR fluid and evaluated the effect of shear rate, magnetic field level, and carrier fluid viscosity. The unique design of the rheometer, which allows the rapid change of a magnetic field, is presented. The rheological response time of MRF 132-DG and MRC-C1L is in the range of 0.8-1.4 ms, depending on the shear rate. The higher the shear rate, the shorter the response time. It can be stated that the higher the magnetization of the MR fluid, the lower the response time. The higher the viscosity, the higher the rheological response time. The measured data of rheological response time was generalized and one master curve was determined.
Language	English
Publishing date	2022-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-14718-5
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Article ; Online: Scrotal Paget's Disease Associated With Human Epidermal Growth Factor Receptor 2-Overexpressing Metastatic Apocrine Carcinoma With Complete Response to Paclitaxel, Trastuzumab, and Pertuzumab.

Nowicka-Matus, Kinga / Salkus, Giedrius / Sønderkær, Mads / Søkilde Pedersen, Inge / Ernst, Anja / Kubik, Magdalena / Takacs-Szabo, Zsuzsanna / Ladekarl, Morten

JCO precision oncology

2023 Volume 7, Page(s) e2300173

MeSH term(s)	Humans ; Female ; Trastuzumab/therapeutic use ; Paclitaxel/therapeutic use ; Breast Neoplasms ; Carcinoma
Chemical Substances	Trastuzumab (P188ANX8CK) ; ERBB2 protein, human (EC 2.7.10.1) ; pertuzumab (K16AIQ8CTM) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.23.00173
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Article ; Online: Discharge Disposition After Head and Neck Reconstruction: Effect on Adjuvant Therapy and Outcomes.

Dang, Sophia / Patel, Terral / Lao, Isabella / Sridharan, Shaum S / Solari, Mario G / Kim, Seungwon / Duvvuri, Umamaheswar / Ferris, Robert / Kubik, Mark

The Laryngoscope

2023 Volume 133, Issue 11, Page(s) 2977–2983

Abstract: Objectives: Head and neck cancer patients that require major reconstruction often have advanced-stage disease. Discharge disposition of patients can vary and impact time to adjuvant treatment. We sought to examine outcomes in patients discharged to ... ...

Abstract	Objectives: Head and neck cancer patients that require major reconstruction often have advanced-stage disease. Discharge disposition of patients can vary and impact time to adjuvant treatment. We sought to examine outcomes in patients discharged to skilled nursing facilities (SNF) compared to those discharged home, including the impact on adjuvant therapy initiation and treatment package time (TPT). Methods: Patients with head and neck squamous cell carcinoma treated with surgical resection and microvascular free flap reconstruction from 2019 to 2022 were included. Retrospective review was conducted to evaluate the impact of disposition on time to radiation (RT) and TPT. Results: 230 patients were included, with 165 (71.7%) discharged to home and 65 (28.3%) discharged to SNF. 79.1% of patients were recommended adjuvant therapy. Average time to RT was 59 days for patients discharged to home compared to 70.1 days for patients discharged to SNF. Disposition was an independent risk factor for delays to starting RT (p = 0.03). TPT was 101.7 days for patients discharged to home versus 112.3 days for those who discharged to SNF. Patients discharged to SNF had higher rates of readmission (p < 0.005) compared to patients discharged home in an adjusted multivariate logistic regression. Conclusions: Patients discharged to an SNF had significantly delayed time to initiation of adjuvant treatment and higher rates of readmission. Timeliness to adjuvant treatment has recently been established as a quality measure, thus identifying delays to adjuvant treatment initiation should be a priority. Level of evidence: 3 Laryngoscope, 133:2977-2983, 2023.
MeSH term(s)	Humans ; Patient Discharge ; Patient Readmission ; Retrospective Studies ; Risk Factors ; Head and Neck Neoplasms/surgery ; Skilled Nursing Facilities
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30648
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Article ; Online: Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.

Stoll, Anna C / Kemp, Christopher J / Patterson, Joseph R / Kubik, Michael / Kuhn, Nathan / Benskey, Matthew / Duffy, Megan F / Luk, Kelvin C / Sortwell, Caryl E

Journal of neuroinflammation

2024 Volume 21, Issue 1, Page(s) 108

Abstract: Background: Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostriatal dopamine ...

Abstract	Background: Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostriatal dopamine (DA) neurons. These pathological features can be recapitulated in vivo using the α-syn preformed fibril (PFF) model of synucleinopathy. We have previously determined that microglia proximal to PFF-induced nigral α-syn inclusions increase in soma size, upregulate major-histocompatibility complex-II (MHC-II) expression, and increase expression of a suite of inflammation-associated transcripts. This microglial response is observed months prior to degeneration, suggesting that microglia reacting to α-syn inclusion may contribute to neurodegeneration and could represent a potential target for novel therapeutics. The goal of this study was to determine whether colony stimulating factor-1 receptor (CSF1R)-mediated microglial depletion impacts the magnitude of α-syn aggregation, nigrostriatal degeneration, or the response of microglial in the context of the α-syn PFF model. Methods: Male Fischer 344 rats were injected intrastriatally with either α-syn PFFs or saline. Rats were continuously administered Pexidartinib (PLX3397B, 600 mg/kg), a CSF1R inhibitor, to deplete microglia for a period of either 2 or 6 months. Results: CSF1R inhibition resulted in significant depletion (~ 43%) of ionized calcium-binding adapter molecule 1 immunoreactive (Iba-1ir) microglia within the SNpc. However, CSF1R inhibition did not impact the increase in microglial number, soma size, number of MHC-II immunoreactive microglia or microglial expression of Cd74, Cxcl10, Rt-1a2, Grn, Csf1r, Tyrobp, and Fcer1g associated with phosphorylated α-syn (pSyn) nigral inclusions. Further, accumulation of pSyn and degeneration of nigral neurons was not impacted by CSF1R inhibition. Paradoxically, long term CSF1R inhibition resulted in increased soma size of remaining Iba-1ir microglia in both control and PFF rats, as well as expression of MHC-II in extranigral regions. Conclusions: Collectively, our results suggest that CSF1R inhibition does not impact the microglial response to nigral pSyn inclusions and that CSF1R inhibition is not a viable disease-modifying strategy for PD.
MeSH term(s)	Animals ; Microglia/metabolism ; Microglia/drug effects ; alpha-Synuclein/metabolism ; Rats ; Male ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Rats, Inbred F344 ; Pyrroles/pharmacology ; Aminopyridines/pharmacology ; Inclusion Bodies/metabolism ; Inclusion Bodies/pathology ; Substantia Nigra/metabolism ; Substantia Nigra/pathology ; Substantia Nigra/drug effects ; Disease Models, Animal
Chemical Substances	alpha-Synuclein ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; pexidartinib (6783M2LV5X) ; Pyrroles ; Aminopyridines
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-024-03108-5
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Article ; Online: Influence of observer-dependency on left ventricular hypertrabeculation mass measurement and its relationship with left ventricular volume and ejection fraction - comparison between manual and semiautomatic CMR image analysis methods.

Kubik, Marcin / Dąbrowska-Kugacka, Alicja / Dorniak, Karolina / Kutniewska-Kubik, Marta / Daniłowicz-Szymanowicz, Ludmiła / Lewicka, Ewa / Szurowska, Edyta / Raczak, Grzegorz

PloS one

2020 Volume 15, Issue 3, Page(s) e0230134

Abstract: Background: Recent studies concerning left ventricular noncompaction (LVNC) suggest that the extent of left ventricular (LV) hypertrabeculation has no impact on prognosis. The variety of methods of LV noncompacted myocardial mass (NCM) assessment may ... ...

Abstract	Background: Recent studies concerning left ventricular noncompaction (LVNC) suggest that the extent of left ventricular (LV) hypertrabeculation has no impact on prognosis. The variety of methods of LV noncompacted myocardial mass (NCM) assessment may influence the results. Hence, we compared two methods of NCM estimation: largely observer-independent Hautvast's(H) computed algorithm-based approach and commonly used Jacquier's(J) method, and their associations with LV end-diastolic volume (EDV) and ejection fraction (EF). Methods: Cardiac magnetic resonance images of 77 persons (45±17yo) - 42 LVNC, 15 non-ischemic dilative cardiomyopathy, 20 control group were analyzed. LVNC patients were divided into the subgroup with normal (LVNCN) and high EDV (LVNCDCM). NCM and total left ventricular mass (LVM) were estimated by Hautvast's [excluding intertrabecular blood (ITB) and including papillary muscles (PMs) into NCM] and Jacquier's approach (including ITB and PMs, if unclearly distinguished, into NCM). Results: The cut-off value of NCM for LVNC diagnosis was 22% (AUC 0.933) for NCMH/LVMH and 26% (AUC 0.883) for NCMJ/LVMJ. Inter- and intra-observer variability (estimated by coefficient of variation [CoV] and intraclass correlation coefficient [ICC]) of NCMH/LVMH appeared better than of NCMJ/LVMJ (CoV 4.3%, ICC 0.981 and CoV 4.9%, ICC 0.978; respectively for NCMH/LVMH, while for NCMJ/LVMJ: CoV 19.7%, ICC 0.15 and CoV 12.9%, ICC 0.504). In LVNCN subgroup, the correlation between EDV and NCMH was stronger than NCMJ (r = 0.677, p<0.001 vs. r = 0.480, p = 0.038; respectively). In LVNC the EDV correlated with NCMH/LVMH (r = 0.391, p<0.01), but not with NCMJ/LVMJ. In the overall group a relationship was present between EF and NCMH/LVMH (r = -0.449, p<0.001), but not NCMJ/LVMJ. Only NCMH/LVMH explained the variability of EDV (b 0.434, p<0.001). Conclusions: Choosing a method of NCM assessment that is less observer-dependent might increase the reliability of results. The impact of method selection on the LV parameters and cut-off values for hypertrabeculation should be further investigated.
MeSH term(s)	Adult ; Aged ; Female ; Heart Defects, Congenital/physiopathology ; Heart Ventricles/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging, Cine/methods ; Male ; Middle Aged ; Observer Variation ; Reproducibility of Results ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function/physiology ; Ventricular Function, Left/physiology
Language	English
Publishing date	2020-03-11
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0230134
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