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  1. Article ; Online: Addition-Fragmentation Ring-Opening Polymerization of Bio-Based Thiocarbonyl l-Lactide for Dual Degradable Vinyl Copolymers.

    Kamiki, Ryoya / Kubo, Tomohiro / Satoh, Kotaro

    Macromolecular rapid communications

    2022  Volume 44, Issue 2, Page(s) e2200537

    Abstract: This study is designed to synthesize novel degradable polymers by radical addition-fragmentation ring-opening copolymerization of bio-based thiocarbonyl compounds with various vinyl monomers. Thiocarbonyl l-lactide is capable of radical copolymerization ... ...

    Abstract This study is designed to synthesize novel degradable polymers by radical addition-fragmentation ring-opening copolymerization of bio-based thiocarbonyl compounds with various vinyl monomers. Thiocarbonyl l-lactide is capable of radical copolymerization with acrylates and styrene via radical addition to the carbon-sulfur double bonds followed by ring-opening as well as controlled copolymerization in conjunction with the reversible addition-fragmentation chain transfer (RAFT) process. The obtained polymers possess ring-opened thioester and ring-retained thioacetal functionalities in the backbone, both of which could be cleaved under appropriate conditions with different chemical stimuli.
    MeSH term(s) Polymerization ; Dioxanes ; Polymers/chemistry ; Acrylates
    Chemical Substances dilactide (95-96-5) ; Dioxanes ; Polymers ; Acrylates
    Language English
    Publishing date 2022-09-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475027-2
    ISSN 1521-3927 ; 1022-1336
    ISSN (online) 1521-3927
    ISSN 1022-1336
    DOI 10.1002/marc.202200537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hydrophilic bio-based polymers by radical copolymerization of cyclic vinyl ethers derived from glycerol.

    Kashima, Riko / Kajita, Akito / Kubo, Tomohiro / Kamigaito, Masami / Satoh, Kotaro

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 63, Page(s) 8766–8769

    Abstract: In this study, novel functional polymers were obtained by using glycerol as a bio-based precursor, which is abundant and inexpensive renewable feedstock with a polyol skeleton. Cyclic vinyl ethers with acetal linkage were derived from glycerol to yield ... ...

    Abstract In this study, novel functional polymers were obtained by using glycerol as a bio-based precursor, which is abundant and inexpensive renewable feedstock with a polyol skeleton. Cyclic vinyl ethers with acetal linkage were derived from glycerol to yield well-defined copolymers by reversible addition-fragmentation chain transfer (RAFT) radical copolymerization with common vinyl monomers. The resulting acetal-containing copolymers could be hydrolyzed under acidic conditions to afford water-soluble functional polymers with pendent diols.
    MeSH term(s) Acetals ; Ethers, Cyclic ; Glycerol ; Polymerization ; Polymers
    Chemical Substances Acetals ; Ethers, Cyclic ; Polymers ; Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc02651a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pulmonary Metastasectomy after Radiofrequency Ablation of Hepatocellular Carcinoma.

    Osuga, Takahiro / Tanaka, Shingo / Kubo, Tomohiro / Hamaguchi, Kota / Ito, Ryo / Sakurada, Akira / Ishikawa, Keidai / Miyanishi, Koji

    Case reports in oncology

    2024  Volume 17, Issue 1, Page(s) 407–416

    Abstract: Introduction: Single distant metastases after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) are rare. There are no guidelines for treating patients without liver tumors after resecting lung metastases.: Case presentation: Here, we ... ...

    Abstract Introduction: Single distant metastases after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) are rare. There are no guidelines for treating patients without liver tumors after resecting lung metastases.
    Case presentation: Here, we report a patient with HCC recurring as a single lung metastasis 14 months after RFA. A 76-year-old woman with primary biliary cholangitis without hepatitis B virus or hepatitis C virus infection had been treated by RFA for a single 16-mm-sized HCC lesion in liver S8. Fourteen months thereafter, despite lack of intrahepatic recurrence, a single new 26-mm-sized mass was found in S10 of the right lung. The patient underwent right lower lobectomy. The histopathological diagnosis was HCC metastasis. Because no residual disease could be found, she was followed up without any additional treatment after surgery. She remains alive with no signs of recurrence 3 years later.
    Conclusion: HCC patients who relapse with lung metastases but without intrahepatic recurrence after RFA are extremely rare, especially when RFA is used to treat HCC lesions <30 mm. However, it should be noted that, although rare, HCC may recur in the form of extrahepatic metastases after RFA. Furthermore, it is suggested that, as in the presently-described case, at least some patients without intrahepatic recurrence whose lung metastases are completely resected have a good prognosis even without additional treatment for HCC.
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000536498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Advancements in minimal residual disease detection: a practical approach using single-cell droplet PCR for comprehensive monitoring in hematological malignancy.

    Uchiyama, Satoshi / Fukushima, Kentaro / Katagiri, Seiichiro / Tsuchiya, Junichi / Kubo, Tomohiro / Chi, SungGi / Minami, Yosuke

    Therapeutic advances in hematology

    2024  Volume 15, Page(s) 20406207241245510

    Abstract: The identification of chromosomal abnormalities accompanied by copy number alterations is important for understanding tumor characteristics. Testing methodologies for copy number abnormality have limited sensitivity, resulting in their use only for the ... ...

    Abstract The identification of chromosomal abnormalities accompanied by copy number alterations is important for understanding tumor characteristics. Testing methodologies for copy number abnormality have limited sensitivity, resulting in their use only for the sample provided at the time of diagnosis or recurrence of malignancy, but not for the monitoring of minimal residual disease (MRD) during and after therapy. We developped the "DimShift" technology which enable to measure the copy number of target gene/chromosome in each cell, which is given by the single cell droplet PCR. Qualitative result of DimShift given by peripheral blood was perfectly concordant with that of bone marrow. These findings and performances are promising to be the new methodology for MRD detection in malignant diseases utilizing bone marrow as well as peripheral blood.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2585183-4
    ISSN 2040-6215 ; 2040-6207
    ISSN (online) 2040-6215
    ISSN 2040-6207
    DOI 10.1177/20406207241245510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of Oligomers Derived from Biodegradable Polyesters on Eco- and Neurotoxicity.

    Yoshinaga, Naoto / Tateishi, Ayaka / Kobayashi, Yasuaki / Kubo, Tomohiro / Miyakawa, Hitoshi / Satoh, Kotaro / Numata, Keiji

    Biomacromolecules

    2023  Volume 24, Issue 6, Page(s) 2721–2729

    Abstract: Biodegradable polymers are eco-friendly materials and have attracted attention for use in a sustainable society because they are not accumulated in the environment. Although the characteristics of biodegradable polymers have been assessed well, the ... ...

    Abstract Biodegradable polymers are eco-friendly materials and have attracted attention for use in a sustainable society because they are not accumulated in the environment. Although the characteristics of biodegradable polymers have been assessed well, the effects of their degradation products have not. Herein, we comprehensively evaluated the chemical toxicities of biodegradable polyester, polycaprolactone (PCL), and synthetic oligocaprolactones (OCLs) with different degrees of polymerization. While the PCL did not show any adverse effects on various organisms, high levels of shorter OCLs and the monomer (1 μg/mL for freshwater microorganisms and 1 mg/mL for marine algae and mammalian cells) damaged the tested organisms, including freshwater microorganisms, marine algae, and mammalian cells, which indicated the toxicities of the degradation products under unnaturally high concentrations. These results highlight the need for a further understanding of the effects of the degradation products resulting from biodegradable polyesters to ensure a genuinely sustainable society.
    MeSH term(s) Animals ; Polyesters/chemistry ; Polymers/chemistry ; Mammals/metabolism
    Chemical Substances Polyesters ; Polymers
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: α- and β-tubulin C-terminal tails with distinct modifications are crucial for ciliary motility and assembly.

    Kubo, Tomohiro / Tani, Yuma / Yanagisawa, Haru-Aki / Kikkawa, Masahide / Oda, Toshiyuki

    Journal of cell science

    2023  Volume 136, Issue 16

    Abstract: α- and β-tubulin have an unstructured glutamate-rich region at their C-terminal tails (CTTs). The function of this region in cilia and flagella is still unclear, except that glutamates in CTTs act as the sites for post-translational modifications that ... ...

    Abstract α- and β-tubulin have an unstructured glutamate-rich region at their C-terminal tails (CTTs). The function of this region in cilia and flagella is still unclear, except that glutamates in CTTs act as the sites for post-translational modifications that affect ciliary motility. The unicellular alga Chlamydomonas possesses only two α-tubulin and two β-tubulin genes, each pair encoding an identical protein. This simple gene organization might enable a complete replacement of the wild-type tubulin with its mutated version. Here, using CRISPR/Cas9, we generated mutant strains expressing tubulins with modified CTTs. We found that the mutant strain in which four glutamate residues in the α-tubulin CTT had been replaced by alanine almost completely lacked polyglutamylated tubulin and displayed paralyzed cilia. In contrast, the mutant strain lacking the glutamate-rich region of the β-tubulin CTT assembled short cilia without the central apparatus. This phenotype is similar to mutant strains harboring a mutation in a subunit of katanin, the function of which has been shown to depend on the β-tubulin CTT. Therefore, our study reveals distinct and important roles of α- and β-tubulin CTTs in the formation and function of cilia.
    MeSH term(s) Tubulin/metabolism ; Glutamic Acid/metabolism ; Cilia/metabolism ; Flagella/metabolism ; Protein Processing, Post-Translational ; Microtubules/metabolism
    Chemical Substances Tubulin ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.261070
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 14: Show issues

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  7. Article: Hydrophilic bio-based polymers by radical copolymerization of cyclic vinyl ethers derived from glycerol

    Kashima, Riko / Kajita, Akito / Kubo, Tomohiro / Kamigaito, Masami / Satoh, Kotaro

    Chemical communications. 2022 Aug. 4, v. 58, no. 63

    2022  

    Abstract: In this study, novel functional polymers were obtained by using glycerol as a bio-based precursor, which is abundant and inexpensive renewable feedstock with a polyol skeleton. Cyclic vinyl ethers with acetal linkage were derived from glycerol to yield ... ...

    Abstract In this study, novel functional polymers were obtained by using glycerol as a bio-based precursor, which is abundant and inexpensive renewable feedstock with a polyol skeleton. Cyclic vinyl ethers with acetal linkage were derived from glycerol to yield well-defined copolymers by reversible addition-fragmentation chain transfer (RAFT) radical copolymerization with common vinyl monomers. The resulting acetal-containing copolymers could be hydrolyzed under acidic conditions to afford water-soluble functional polymers with pendent diols.
    Keywords composite polymers ; copolymerization ; feedstocks ; glycerol ; glycols ; hydrophilicity ; skeleton ; water solubility
    Language English
    Dates of publication 2022-0804
    Size p. 8766-8769.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc02651a
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  8. Article ; Online: Chlamydomonas as a tool to study tubulin polyglutamylation.

    Kubo, Tomohiro / Oda, Toshiyuki

    Microscopy (Oxford, England)

    2018  Volume 68, Issue 1, Page(s) 80–91

    Abstract: The diversity of α- and β-tubulin is facilitated by various post-translational modifications (PTMs), such as acetylation, tyrosination, glycylation, glutamylation, phosphorylation and methylation. These PTMs affect the stability and structure of ... ...

    Abstract The diversity of α- and β-tubulin is facilitated by various post-translational modifications (PTMs), such as acetylation, tyrosination, glycylation, glutamylation, phosphorylation and methylation. These PTMs affect the stability and structure of microtubules as well as the interaction between microtubules and microtubule-associated proteins, including molecular motors. Therefore, it is extremely important to investigate the roles of tubulin PTMs for understanding the cell cycle, cell motility and intracellular trafficking. Tubulin PTMs were first studied in the 1980s, and considerable progress has been made since then; it is likely that additional mechanisms remain yet to be elucidated. Here, we discuss one such modification, tubulin glutamylation, and introduce our research on the eukaryotic flagellum of the unicellular green alga Chlamydomonas reinhardtii.
    MeSH term(s) Chlamydomonas reinhardtii/metabolism ; Cilia/metabolism ; Flagella/metabolism ; Glutamic Acid/chemistry ; Microtubules/metabolism ; Peptide Synthases/metabolism ; Protein Processing, Post-Translational/physiology ; Tubulin/metabolism
    Chemical Substances Tubulin ; Glutamic Acid (3KX376GY7L) ; Peptide Synthases (EC 6.3.2.-) ; tubulin polyglutamylase (EC 6.3.2.-)
    Language English
    Publishing date 2018-09-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2707496-1
    ISSN 2050-5701 ; 2050-5698
    ISSN (online) 2050-5701
    ISSN 2050-5698
    DOI 10.1093/jmicro/dfy044
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    Zs.B 1211: Show issues Location:
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  9. Article: Two cases of resected gallbladder carcinosarcoma with a contrasting course.

    Kato, Toru / Kimura, Yasutoshi / Kubo, Tomohiro / Murota, Ayako / Hasegawa, Tadashi / Takemasa, Ichiro

    International journal of surgery case reports

    2022  Volume 92, Page(s) 106915

    Abstract: Introduction: Carcinosarcoma of the gallbladder is a rare tumor with both carcinoma and sarcoma components.: Case presentation: In this paper, we report two cases. The first case is of a man in his 60s who was preoperatively diagnosed with ... ...

    Abstract Introduction: Carcinosarcoma of the gallbladder is a rare tumor with both carcinoma and sarcoma components.
    Case presentation: In this paper, we report two cases. The first case is of a man in his 60s who was preoperatively diagnosed with gallbladder carcinosarcoma and has achieved 6 years and 6 months survival through aggressive surgical treatment. The second case is of a woman in her 70s who was diagnosed with locally advanced gallbladder cancer; she underwent multidisciplinary treatment for the same, but died 8 months after the surgery. While the primary disorder was the same in both cases, the clinical courses contrasted sharply.
    Discussion: There is no established chemotherapy or radiation therapy for gallbladder carcinosarcoma, and the only curative treatment is surgery. However, it has a very poor prognosis.
    Conclusion: Carcinosarcoma of the gallbladder may progress very rapidly, and the treatment management should be carefully decided.
    Language English
    Publishing date 2022-03-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.106915
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  10. Article ; Online: Pemphigus vulgaris as an immune-related adverse event in recurrent metastatic esophageal squamous cell carcinoma treated with ipilimumab plus nivolumab: a case report and literature review.

    Nakamura, Hajime / Shionoya, Aika / Arihara, Yohei / Hayasaka, Naotaka / Kubo, Tomohiro / Usami, Makoto / Sugita, Shintaro / Uhara, Hisashi / Takada, Kohichi

    Frontiers in immunology

    2023  Volume 14, Page(s) 1259071

    Abstract: Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall ... ...

    Abstract Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall survival in patients with advanced ESCC, this increases the incidence of immune-related adverse events (irAEs). Here, we describe an ESCC case that developed pemphigus vulgaris (PV), an extremely rare cutaneous irAE, during ipilimumab plus nivolumab treatment. The patient achieved a partial response to treatment. The PV was successfully managed after the cessation of ipilimumab and the use of a topical steroid. We should thus re-treat ESCC with nivolumab monotherapy. In the era of ICIs as standard cancer therapeutics, diagnostic criteria for blistering diseases need to be established to properly manage patients with cutaneous irAEs.
    MeSH term(s) Humans ; Esophageal Squamous Cell Carcinoma/diagnosis ; Esophageal Squamous Cell Carcinoma/drug therapy ; Pemphigus/diagnosis ; Pemphigus/drug therapy ; Ipilimumab/adverse effects ; Nivolumab/adverse effects ; Esophageal Neoplasms/drug therapy
    Chemical Substances Ipilimumab ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Review ; Case Reports
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1259071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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