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  1. Article ; Online: Genetic Testing for Cardiomyopathy in Japan 2022: Current Status and Issues of Precision Medicine.

    Kubo, Toru / Kitaoka, Hiroaki

    Journal of cardiac failure

    2023  Volume 29, Issue 5, Page(s) 805–814

    Abstract: Although many causative genes for primary cardiomyopathy have been identified, the use of genetic testing in routine practice is limited in Japan presently. Genetic diagnosis has been reported to be useful for early diagnosis through cascade genetic ... ...

    Abstract Although many causative genes for primary cardiomyopathy have been identified, the use of genetic testing in routine practice is limited in Japan presently. Genetic diagnosis has been reported to be useful for early diagnosis through cascade genetic screening in the family, differentiating secondary cardiomyopathies, and predicting prognosis in some patients; nonetheless, the acquisition of genetic information for cardiomyopathy is stagnating in actual clinical practice. There seem to be a number of reasons for this phenomenon, and although the use of next-generation sequencers has resolved some of the past issues, the importance of pathogenicity studies of variants that are identified is growing. To ensure that patients with cardiomyopathy and their relatives can receive precision medicine, the results of genetic analysis linked to clinical information need to be collected, and a database of variants in Japanese people needs to be established.
    MeSH term(s) Humans ; Precision Medicine ; Japan/epidemiology ; Heart Failure/genetics ; Cardiomyopathies/diagnosis ; Cardiomyopathies/genetics ; Genetic Testing
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2022.11.017
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  2. Article ; Online: Mitral valve repair with papillary muscle repositioning for functional mitral regurgitation (Type IIIb) with metal allergies: a case report.

    Mitsuishi, Atsuyuki / Miura, Yujiro / Kubo, Toru

    European heart journal. Case reports

    2023  Volume 7, Issue 7, Page(s) ytad283

    Abstract: Background: Prosthetic heart valves, rings, and clips commonly used in heart surgery may contain metals, such as nickel and cobalt, that can cause severe hypersensitivity reactions in allergic patients. These reactions can cause paravalvular leakage and ...

    Abstract Background: Prosthetic heart valves, rings, and clips commonly used in heart surgery may contain metals, such as nickel and cobalt, that can cause severe hypersensitivity reactions in allergic patients. These reactions can cause paravalvular leakage and valve dysfunction. Similarly, stainless steel sternal wires can cause contact dermatitis. We should select rings, valves, and wires that do not contain any metals known to cause allergies in patients undergoing cardiac surgery.
    Case summary: We report the case of a 79-year-old man with severe functional mitral regurgitation (Type IIIb) and a history of nickel and cobalt allergies. We safely performed mitral valve repair with papillary muscle repositioning with nickel- and cobalt-free rings in this patient. He was discharged from the hospital on the 26th postoperative day without dialysis intervention. Two years after surgery, mitral and tricuspid regurgitation had not worsened.
    Discussion: According to the 2020 American Heart Association guidelines, surgery for severe functional mitral valve insufficiency (Type IIIb) is considered class IIb. Meanwhile, transcatheter edge-to-edge repair is class IIa. Long-term regurgitation is difficult to control with valve replacement and annuloplasty alone; recurrence has been observed. Therefore, additional techniques were considered. Papillary muscle repositioning has been reported and shown good results. The method used in the present case made intervening in the subvalvular tissue easy and demonstrated technical feasibility, safety, and effectiveness.
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad283
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  3. Article: Fabry disease and its cardiac involvement.

    Kubo, Toru

    Journal of general and family medicine

    2017  Volume 18, Issue 5, Page(s) 225–229

    Abstract: Fabry disease (FD) is an X-linked lysosomal storage disorder that results from a deficiency of α-galactosidase A activity. This enzymatic defect leads to the progressive accumulation of glycosphingolipids throughout the body and causes multisystemic ... ...

    Abstract Fabry disease (FD) is an X-linked lysosomal storage disorder that results from a deficiency of α-galactosidase A activity. This enzymatic defect leads to the progressive accumulation of glycosphingolipids throughout the body and causes multisystemic problems including neurological, ocular, skin, renal, and cardiac manifestations in classical type of FD. The majority of patients with this disease have cardiac involvement that is mainly manifested as left ventricular hypertrophy (LVH). A cardiac variant of FD with late-onset isolated cardiac manifestation has also been recognized. Recent studies have revealed that the prevalence of FD in patients with unexplained LVH is about 1%. Cardiac involvement of FD is associated with significant morbidity and early death due to heart failure or ventricular arrhythmias. As disease-specific enzyme replacement therapy is now available for FD, correct diagnosis is important.
    Language English
    Publishing date 2017-05-08
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2189-6577
    ISSN 2189-6577
    DOI 10.1002/jgf2.76
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  4. Article ; Online: The Dawn of Precision Medicine in Cardiomyopathies　- Advance Preparations of Ethnicity-Specific Database.

    Kubo, Toru / Morita, Hiroyuki

    Circulation journal : official journal of the Japanese Circulation Society

    2021  Volume 85, Issue 9, Page(s) 1479–1480

    MeSH term(s) Cardiomyopathies/therapy ; Databases, Factual ; Ethnicity ; Humans ; Precision Medicine
    Language English
    Publishing date 2021-06-12
    Publishing country Japan
    Document type Journal Article ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-0424
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  5. Article: [Cardiomyopathy: progress in diagnosis and treatments. Topics: II. Secondary cardiomyopathy; 1. Cardiac Fabry disease].

    Kubo, Toru

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2014  Volume 103, Issue 2, Page(s) 293–298

    MeSH term(s) Biomarkers/analysis ; Biopsy ; Cardiomyopathies/diagnosis ; Cardiomyopathies/etiology ; Cardiomyopathies/physiopathology ; Cardiomyopathies/therapy ; Diagnostic Imaging/methods ; Fabry Disease/diagnosis ; Fabry Disease/etiology ; Fabry Disease/physiopathology ; Fabry Disease/therapy ; Humans ; Practice Guidelines as Topic
    Chemical Substances Biomarkers
    Language Japanese
    Publishing date 2014-03-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.103.293
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  6. Article ; Online: A Drifting Dislodged Leadless Pacemaker in the Bilateral Pulmonary Arteries.

    Sugiura, Kenta / Baba, Yuichi / Hirota, Takayoshi / Kubo, Toru / Kitaoka, Hiroaki

    JACC. Case reports

    2022  Volume 4, Issue 14, Page(s) 844–846

    Abstract: We report a rare phenomenon during implantation of a leadless pacemaker. The device was dislodged into the left pulmonary artery (PA) during the implantation procedure and then migrated the next day from the left PA to the right PA. ( ...

    Abstract We report a rare phenomenon during implantation of a leadless pacemaker. The device was dislodged into the left pulmonary artery (PA) during the implantation procedure and then migrated the next day from the left PA to the right PA. (
    Language English
    Publishing date 2022-07-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.03.034
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  7. Article ; Online: Estimating the prevalence, clinical characteristics, and treatment patterns of hypertrophic cardiomyopathy in Japan: A nationwide medical claims database study.

    Terasaka, Naoki / Spanopoulos, Dionysis / Miyagoshi, Hidetaka / Kubo, Toru / Kitaoka, Hiroaki

    Journal of cardiology

    2022  Volume 81, Issue 3, Page(s) 316–322

    Abstract: Background: Limited data are available regarding therapies for hypertrophic cardiomyopathy (HCM). This study assessed the prevalence, clinical characteristics, and treatment patterns of HCM in Japan.: Methods: This retrospective database study ... ...

    Abstract Background: Limited data are available regarding therapies for hypertrophic cardiomyopathy (HCM). This study assessed the prevalence, clinical characteristics, and treatment patterns of HCM in Japan.
    Methods: This retrospective database study analyzed data from 438 hospitals in the Japan Medical Data Vision database from 2016 to 2020. We identified 3913 patients (15 %) with obstructive HCM (oHCM) and 21,714 patients (85 %) with nonobstructive HCM (nHCM).
    Results: The estimated total number of patients with oHCM and nHCM in 2020 among Japanese hospitals was 8500 and 43,500, respectively. The prevalence of oHCM and nHCM steadily increased by 27 % and 12 %, respectively, from 2016 to 2020, with a 1:5.2 ratio of oHCM to nHCM in 2020. The mean age of the oHCM and nHCM populations was 72 and 70 years, respectively, and comorbidities included atrial fibrillation (AF) (oHCM, 33.8 %; nHCM, 32.2 %), other arrythmia (30.1 %; 27.6 %), and stroke (16.6 %; 16.4 %). Furthermore, 45.0 % of oHCM and 37.7 % of nHCM patients had undergone at least one hospitalization. A substantial number of HCM patients aged between 20 and 59 years reported AF (oHCM, 17-37 %; nHCM, 4-24 %) and stroke (oHCM, 0-12 %; nHCM, 3-10 %). β-blockers (oHCM, 64.0 %; nHCM, 42.1 %) were the most frequently prescribed treatment, followed by Na channel blockers (29.5 %; 5.7 %), calcium channel blockers (18.1 %; 8.8 %), direct oral anticoagulants (14.5 %; 15.2 %), and warfarin (11.0 %; 11.4 %).
    Conclusions: This study provides important information on the current epidemiological and clinical characteristics of HCM in Japan.
    MeSH term(s) Humans ; Young Adult ; Adult ; Middle Aged ; Retrospective Studies ; Prevalence ; Japan/epidemiology ; Cardiomyopathy, Hypertrophic/epidemiology ; Cardiomyopathy, Hypertrophic/therapy ; Stroke/epidemiology ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/therapy
    Language English
    Publishing date 2022-10-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2022.09.015
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    Zs.A 1794: Show issues Location:
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  8. Article ; Online: Prognostic impact of frailty based on a comprehensive frailty assessment in patients with heart failure.

    Hamada, Tomoyuki / Kubo, Toru / Kawai, Kazuya / Nakaoka, Yoko / Yabe, Toshikazu / Furuno, Takashi / Yamada, Eisuke / Kitaoka, Hiroaki

    ESC heart failure

    2024  

    Abstract: Aims: This study aimed to evaluate the impact of frailty and living function domains based on the Kihon Checklist (KCL), a questionnaire for a comprehensive frailty assessment, on prognosis in patients with acute heart failure (AHF).: Methods and ... ...

    Abstract Aims: This study aimed to evaluate the impact of frailty and living function domains based on the Kihon Checklist (KCL), a questionnaire for a comprehensive frailty assessment, on prognosis in patients with acute heart failure (AHF).
    Methods and results: The Kochi Registry of Subjects with Acute Decompensated Heart Failure (Kochi YOSACOI) study was a prospective multicentre cohort study enrolling 1061 patients hospitalized for AHF from May 2017 to December 2019 in Japan. We divided patients into three groups according to the severity of frailty using the KCL and compared clinical outcomes after discharge. The primary endpoint was all-cause death, and the secondary outcomes were cardiovascular death, heart failure (HF) rehospitalization, and the composite event of cardiovascular death and HF rehospitalization. Of 936 patients (median age, 81 years; 48.9% women) who could be assessed for frailty, we identified frailty in 501 patients (53.5%), prefrailty in 290 patients (31.0%), and non-frailty in 145 patients (15.5%). Compared with prefrail and non-frail patients, frail patients were older (83 vs. 79 and 72 years, P < 0.001), were more likely to be women (53.9% vs. 43.1% and 43.4%, P = 0.005), and were more likely to have a history of previous HF hospitalization (35.4% vs. 25.3% and 19.6%, P < 0.001) and multimorbidity (90.8% vs. 81.0% and 73.8%, P < 0.001). Frail patients had a lower rate of discharge to home (79.7% vs. 94.8% and 96.5%, P < 0.001). During the 2 year follow-up period, frail patients had a higher incidence rate of all-cause death, cardiovascular death, and HF rehospitalization (log-rank P < 0.001, P < 0.001, and P = 0.003, respectively). After adjusting for other prognostic factors, multivariate analysis showed that frailty was associated with all-cause death [adjusted hazard ratio (HR): 2.917, 95% confidence interval (CI): 1.326-6.417, P = 0.008] and cardiovascular death (adjusted HR: 7.026, 95% CI: 1.700-29.030, P = 0.007). Among all domains of the KCL, the cognitive function domain was associated with a higher risk of all-cause death (P = 0.004) and cardiovascular death (P < 0.001). The depression domain remained associated with a higher risk of HF rehospitalization (P = 0.045). The risk for all-cause death increased with an increase in total KCL score (adjusted HR: 1.819, 95% CI: 1.300-2.547, P < 0.001).
    Conclusions: The KCL is a useful tool for risk stratification of adverse outcomes in patients with AHF. Functional declines in psycho-emotional domains including cognitive function and depressed mood contribute to adverse outcomes.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14728
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  9. Article ; Online: The High Road or the Low Road? A Question Regarding Whether to Use Upper or Lower Pulmonary Veins in Measuring Pulmonary Vein Flow.

    Baba, Yuichi / Kubo, Toru / Kitaoka, Hiroaki

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2021  Volume 34, Issue 10, Page(s) 1116–1117

    MeSH term(s) Blood Flow Velocity ; Humans ; Pulmonary Veins/diagnostic imaging
    Language English
    Publishing date 2021-06-05
    Publishing country United States
    Document type Letter
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2021.05.018
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    Zs.MG 55: Show issues

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  10. Article ; Online: A Novel Disease Entity in Search of Its Own Identity　- Takotsubo Syndrome. Is It Really "Cardiomyopathy"?

    Doi, Yoshinori L / Kubo, Toru / Kitaoka, Hiroaki

    Circulation reports

    2020  Volume 2, Issue 8, Page(s) 446–448

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-07-15
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-20-0057
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