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Article ; Online: An unexpected adverse event of endoscopic ultrasonography: acute aortic dissection.

Kubota, Dai / Tsuji, Yosuke / Mizutani, Hiroya / Nagao, Sayaka / Fujishiro, Mitsuhiro

2022 Volume 96, Issue 5, Page(s) 866–867

MeSH term(s)	Humans ; Endosonography/adverse effects ; Aneurysm, Dissecting/diagnostic imaging ; Ultrasonography ; Acute Disease ; Aortic Aneurysm, Thoracic
Language	English
Publishing date	2022-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2022.07.021
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article ; Online: Subtotal esophageal endoscopic submucosal dissection for long-segment Barrett's esophagus and adenocarcinoma.

Kubota, Dai / Sakaguchi, Yoshiki / Nagao, Sayaka / Tsuji, Yosuke / Fujishiro, Mitsuhiro

Endoscopy

2021 Volume 54, Issue 10, Page(s) E583–E584

MeSH term(s)	Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Barrett Esophagus/pathology ; Barrett Esophagus/surgery ; Endoscopic Mucosal Resection ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagoscopy ; Humans
Language	English
Publishing date	2021-12-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1704-7548
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article: Verification of the increase in concomitant dysplasia and cancer with the size of sessile serrated lesions.

Ohki, Daisuke / Tsuji, Yosuke / Hisada, Hiroyuki / Nakagawa, Hideki / Mizutani, Satoru / Oshio, Kaori / Sato, Junichi / Kubota, Dai / Cho, Rina / Miura, Yuko / Mizutani, Hiroya / Sakaguchi, Yoshiki / Takahashi, Yu / Yakabi, Seiichi / Kakushima, Naomi / Yamamichi, Nobutake / Ushiku, Tetsuo / Fujishiro, Mitsuhiro

Endoscopy international open

2024 Volume 12, Issue 3, Page(s) E448–E455

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-2246-0820
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Article: Subtotal esophageal endoscopic submucosal dissection for long-segment Barrett’s esophagus and adenocarcinoma

Kubota, Dai / Sakaguchi, Yoshiki / Nagao, Sayaka / Tsuji, Yosuke / Fujishiro, Mitsuhiro

Endoscopy

2021 Volume 54, Issue 10, Page(s) E583–E584

Language	English
Publishing date	2021-12-21
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1704-7548
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Risk factors for incomplete resection with pharyngeal endoscopic submucosal dissection and long-term prognosis after resection.

Sakaguchi, Yoshiki / Saito, Yuki / Ando, Mizuo / Yoshida, Masafumi / Fukuoka, Osamu / Kobayashi, Kenya / Kubota, Dai / Ohki, Daisuke / Mizutani, Hiroya / Niimi, Keiko / Tsuji, Yosuke / Fujishiro, Mitsuhiro / Yamasoba, Tatsuya

Surgical endoscopy

2023 Volume 37, Issue 5, Page(s) 3593–3601

Abstract: Background: Advances in endoscopic imaging technology have led to an increase in detection of superficial pharyngeal squamous carcinoma. Endoscopic submucosal dissection (ESD) has been reported to be effective for the treatment of these lesions, however ...

Abstract	Background: Advances in endoscopic imaging technology have led to an increase in detection of superficial pharyngeal squamous carcinoma. Endoscopic submucosal dissection (ESD) has been reported to be effective for the treatment of these lesions, however there is still insufficient evidence on the long-term results of pharyngeal ESD. Methods: This is a single-center retrospective study of all cases of superficial pharyngeal cancer that underwent ESD as primary treatment between January 2010 and May 2022. A total of 83 lesions in 63 patients were analyzed. Results: The en bloc resection rate was 100%, and R0 resection rate was 59.0%, with an adverse event rate of 6.0%. During a mean observation period of 1134 days, there were 0 cases of disease-specific metastasis or death. However, the 5-year cumulative incidence of metachronous head and neck cancer after resection was 27.1% and the 5-year overall survival and 10-year overall survival after pharyngeal ESD were 87.0% and 69.6%, respectively. Of the 34 cases with non-R0 resection, local recurrence occurred in 8.8%. Location of lesion (p = 0.011), disparity between demarcation of the lesion with NBI and iodine staining (p = 0.026), and non-effective laryngeal elevation (p = 0.080) were risk factors for non-R0 resection. Conclusion: Pharyngeal ESD is effective and safe. Further studies are needed to improve and standardize indications and strategies for pharyngeal ESD.
MeSH term(s)	Humans ; Retrospective Studies ; Endoscopic Mucosal Resection/methods ; Prognosis ; Endoscopy/adverse effects ; Treatment Outcome ; Pharyngeal Neoplasms/surgery ; Pharyngeal Neoplasms/pathology ; Risk Factors ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2023-01-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-022-09820-8
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Article ; Online: Repeated steroid injection and polyglycolic acid shielding for prevention of refractory esophageal stricture.

Sakaguchi, Yoshiki / Tsuji, Yosuke / Sato, Junichi / Kubota, Dai / Obata, Miho / Cho, Rina / Nagao, Sayaka / Miura, Yuko / Ohki, Daisuke / Mizutani, Hiroya / Yakabi, Seiichi / Kakushima, Naomi / Niimi, Keiko / Fujishiro, Mitsuhiro

Surgical endoscopy

2023 Volume 37, Issue 8, Page(s) 6267–6277

Abstract: Background: Postoperative stricture and refractory stricture are severe adverse events which occur after expansive esophageal endoscopic submucosal dissection (ESD). The aim of this study was to assess the efficacy of steroid injection, polyglycolic ... ...

Abstract	Background: Postoperative stricture and refractory stricture are severe adverse events which occur after expansive esophageal endoscopic submucosal dissection (ESD). The aim of this study was to assess the efficacy of steroid injection, polyglycolic acid (PGA) shielding, and of additional steroid injection thereafter for the prevention of refractory esophageal stricture. Methods: This is a retrospective cohort study of 816 consecutive cases of esophageal ESD performed between 2002 and 2021 at the University of Tokyo Hospital. After 2013, all patients with a diagnosis of superficial esophageal carcinoma covering over 1/2 the esophageal circumference underwent preventive treatment immediately after ESD with either "PGA shielding", "steroid injection", or "steroid injection + PGA shielding". Additional steroid injection was performed for high-risk patients after 2019. Results: The risk of refractory stricture was especially high in the cervical esophagus (OR 24.77, p = 0.002) and after total circumferential resection (OR 894.04, p < 0.001). "Steroid injection + PGA shielding" was the only method significantly effective in preventing stricture occurrence (OR 0.36; 95% CI 0.15-0.83, p = 0.012). This method also decreased the risk of refractory stricture (OR 0.38; 95% CI 0.10-1.28, p = 0.096), but additional steroid injection was the only significantly effective method for prevention of refractory stricture (OR 0.42; 95% CI 0.14-0.98, p = 0.029). Conclusion: Combining steroid injection and PGA shielding is effective for preventing post-ESD stricture and refractory stricture. Additional steroid injection is a viable option for patients at high-risk for refractory stricture.
MeSH term(s)	Humans ; Esophageal Stenosis/etiology ; Esophageal Stenosis/prevention & control ; Constriction, Pathologic/etiology ; Retrospective Studies ; Esophageal Neoplasms/pathology ; Steroids ; Polyglycolic Acid/therapeutic use ; Endoscopic Mucosal Resection/adverse effects ; Endoscopic Mucosal Resection/methods
Chemical Substances	Steroids ; Polyglycolic Acid (26009-03-0)
Language	English
Publishing date	2023-05-16
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-10111-z
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Article: Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility.

Mizutani, Satoru / Takahashi, Yu / Shimamoto, Takeshi / Nakagawa, Hideki / Hisada, Hiroyuki / Oshio, Kaori / Kubota, Dai / Mizutani, Hiroya / Ohki, Daisuke / Sakaguchi, Yoshiki / Yakabi, Seiichi / Niimi, Keiko / Kakushima, Naomi / Tsuji, Yosuke / Wada, Ryoichi / Yamamichi, Nobutake / Fujishiro, Mitsuhiro

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: The ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual's lifetime remains unclear. Therefore, this study aimed to ...

Abstract	The ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual's lifetime remains unclear. Therefore, this study aimed to analyze whether performing ABC screening twice in a lifetime is useful. We retrospectively analyzed the data of individuals who participated in health checkups in 2010 and 2015. We collected data on patient characteristics, pepsinogen levels, anti-
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13071284
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Article ; Online: Risk factors for gastric cancer in Japan in the 2010s: a large, long-term observational study.

Takahashi, Yu / Yamamichi, Nobutake / Kubota, Dai / Shimamoto, Takeshi / Nagao, Sayaka / Sakuma, Nobuyuki / Sakaguchi, Yoshiki / Yakabi, Seiichi / Tsuji, Yosuke / Wada, Ryoichi / Mitsushima, Toru / Ichinose, Masao / Fujishiro, Mitsuhiro

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

2022 Volume 25, Issue 3, Page(s) 481–489

Abstract: Background: The numbers of Helicobacter pylori (HP)-infected individuals and deaths due to gastric cancer are decreasing in Japan. We aimed to determine whether the serological test for chronic gastritis (the ABC method) is still useful for gastric ... ...

Abstract	Background: The numbers of Helicobacter pylori (HP)-infected individuals and deaths due to gastric cancer are decreasing in Japan. We aimed to determine whether the serological test for chronic gastritis (the ABC method) is still useful for gastric cancer risk stratification in the 2010s and to analyze risk factors for developing gastric cancer in Japan. Methods: In this prospective study, we monitored 20773 individuals for the incidence of gastric cancer from 2010 to 2019. The relationships between blood sampling results, physical examination, and lifestyle in 2010 and the cumulative incidence of gastric cancer were analyzed. Results: A total of 19343 participants who met the study criteria were analyzed. Overall, 0.08% of participants in group A (9/11717), 0.63% in group B (28/4452), 2.05% in group C (43/2098), 1.52% in group D (1/66), and 0.30% in group E (3/1010) developed gastric cancer. Cox hazard analysis showed that age ≥ 50 years; groups B, C, and D according to the ABC method; and current smoking habits were independent risk factors for gastric cancer. The hazard ratios (HRs) of the incidence of gastric cancer were 6.7 in group B and 21.7 in groups C and D, while the HRs of group E was 2.8, which was not significantly different from that of group A. The incidence of gastric cancer was not statistically significantly different between those with and without successful HP eradication in groups B, C, and D during follow-up. Conclusions: The ABC method was still useful for gastric cancer risk stratification in the 2010s.
MeSH term(s)	Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Japan/epidemiology ; Middle Aged ; Pepsinogen A ; Prospective Studies ; Risk Factors ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/etiology
Chemical Substances	Pepsinogen A (9001-10-9)
Language	English
Publishing date	2022-01-24
Publishing country	Japan
Document type	Journal Article ; Observational Study
ZDB-ID	1463526-4
ISSN	1436-3305 ; 1436-3291
ISSN (online)	1436-3305
ISSN	1436-3291
DOI	10.1007/s10120-021-01273-7
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Zs.A 5290: Show issues

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Article: Verification of the increase in concomitant dysplasia and cancer with the size of sessile serrated lesions

Endoscopy International Open

2024 Volume 12, Issue 03, Page(s) E448–E455

Abstract: Background and study aims: This study aimed to evaluate the relationship between sessile serrated lesion (SSL) size and the comorbidity rate of SSL with dysplasia (SSLD) and cancer in SSL (SSL-cancer).: Patients and methods: This retrospective, ... ...

Abstract	Background and study aims: This study aimed to evaluate the relationship between sessile serrated lesion (SSL) size and the comorbidity rate of SSL with dysplasia (SSLD) and cancer in SSL (SSL-cancer). Patients and methods: This retrospective, single-center analysis identified SSL cases that underwent endoscopic resection between January 2015 and December 2022. The prevalence of SSL, SSLD, and SSL-cancer and their annual trends were assessed. The tumor diameter was stratified as 0 to 5 mm, 6 to 9 mm, 10 to 19 mm, and ≥ 20 mm in size. Furthermore, the frequency of SSL-D/SSL-cancer was determined in each group. Results: The prevalence of SSL was 2.9% (1328/45799). This prevalence was 1.8% (112/6192) in 2015 and 4.2% (230/5500) in 2022, indicating an increasing trend over time. A total of 1825 lesions were assessed: 1751 (96.0%), 55 (3.0%), 14 (0.8%), and 5 (0.3%) of lesions were SSL, SSL with low-grade dysplasia, SSL with high-grade dysplasia and SSL-cancer, respectively. Stratifying the SSLs by size: 0 to 5 mm, 5 to 9 mm, 10 to 19 mm, and ≥ 20 mm, SSLD and SSL-cancer rates were 2.3% (10/429), 2.4% (16/674), 5.3% (31/584), and 11.8% (16/136), respectively. SSLD and SSL-cancer were observed in 2.4% (26/1103) of small SSLs < 10 mm. Conclusions: In cases of SSL, the rate of SSLD and SSL-cancer increased as the lesion diameter increased. A certain rate of SSLD and SSL-cancer was observed even in small SSLs less than 5mm.
Keywords	Endoscopy Upper GI Tract ; Endoscopic resection (ESD, EMRc, ...) ; Endoscopy Lower GI Tract ; Polyps / adenomas / ... ; Colorectal cancer
Language	English
Publishing date	2024-01-15
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722 ; 2196-9736
ISSN (online)	2196-9736
ISSN	2364-3722 ; 2196-9736
DOI	10.1055/a-2246-0820
Database	Thieme publisher's database

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Article ; Online: Endoscopic Treatment of Superficial Gastric Cancer: Present Status and Future.

Hisada, Hiroyuki / Sakaguchi, Yoshiki / Oshio, Kaori / Mizutani, Satoru / Nakagawa, Hideki / Sato, Junichi / Kubota, Dai / Obata, Miho / Cho, Rina / Nagao, Sayaka / Miura, Yuko / Mizutani, Hiroya / Ohki, Daisuke / Yakabi, Seiichi / Takahashi, Yu / Kakushima, Naomi / Tsuji, Yosuke / Yamamichi, Nobutake / Fujishiro, Mitsuhiro

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 7, Page(s) 4678–4688

Abstract: Although the mortality rates of gastric cancer (GC) are gradually declining, gastric cancer is still the fourth leading cause of cancer-related death worldwide. This may be due to the high rate of patients who are diagnosed with GC at advanced stages. ... ...

Abstract	Although the mortality rates of gastric cancer (GC) are gradually declining, gastric cancer is still the fourth leading cause of cancer-related death worldwide. This may be due to the high rate of patients who are diagnosed with GC at advanced stages. However, in countries such as Japan with endoscopic screening systems, more than half of GCs are discovered at an early stage, enabling endoscopic resection (ER). Especially after the introduction of endoscopic submucosal dissection (ESD) in Japan around 2000, a high en bloc resection rate allowing pathological assessment of margin and depth has become possible. While ER is a diagnostic method of treatment and may not always be curative, it is widely accepted as standard treatment because it is less invasive than surgery and can provide an accurate diagnosis for deciding whether additional surgery is necessary. The curability of ER is currently assessed by the completeness of primary tumor removal and the possibility of lymph node metastasis. This review introduces methods, indications, and curability criteria for ER of EGC. Despite recent advances, several problems remain unsolved. This review will also outline the latest evidence concerning future issues.
MeSH term(s)	Early Detection of Cancer ; Endoscopic Mucosal Resection ; Gastric Mucosa/pathology ; Gastric Mucosa/surgery ; Gastroscopy ; Humans ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29070371
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