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Article ; Online: Evaluation of the correlation between the access SARS-CoV-2 IgM and IgG II antibody tests with the SARS-CoV-2 surrogate virus neutralization test.

Kitagawa, Yutaro / Imai, Kazuo / Matsuoka, Masaru / Fukada, Ai / Kubota, Katsumi / Sato, Momoko / Takada, Tomohito / Noguchi, Sakiko / Tarumoto, Norihito / Maesaki, Shigefumi / Takeuchi, Shinichi / Maeda, Takuya

Journal of medical virology

2021 Volume 94, Issue 1, Page(s) 335–341

Abstract: Fully automated immunoassays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies that are strongly correlated with neutralization antibodies (nAbs) are clinically important because they enable the assessment of humoral ... ...

Abstract	Fully automated immunoassays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies that are strongly correlated with neutralization antibodies (nAbs) are clinically important because they enable the assessment of humoral immunity after infection and vaccination. Access SARS-CoV-2 immunoglobulin M (IgM) and immunoglobulin G (IgG) II antibody tests are semi-quantitative, fully automated immunoassays that detect anti-receptor-binding domain (RBD) antibodies and might reflect nAb levels in coronavirus disease 2019 (COVID-19). However, no studies have investigated the clinical utility of these tests in association with nAbs to date. To evaluate the clinical utility of Access SARS-CoV-2 IgM and IgG II antibody tests and their correlation with the SARS-CoV-2 surrogate virus neutralization test (sVNT) that measures nAbs in patients with COVID-19, we analyzed 54 convalescent serum samples from COVID-19 patients and 89 serum samples from non-COVID-19 patients. The presence of anti-RBD antibodies was detected using Access SARS-CoV-2 IgM and IgG II antibody tests, while nAbs were measured by sVNT. The sensitivity and specificity of sVNT were 94.4% and 98.9%, respectively. There were strong positive correlations between the inhibition values of sVNT and the results of the Access SARS-CoV-2 IgM (R = 0.95, R
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19/diagnosis ; Female ; Humans ; Immunoassay/methods ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Middle Aged ; Neutralization Tests/methods ; SARS-CoV-2/immunology ; Sensitivity and Specificity
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27338
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Article ; Online: Cross-reactive humoral immune responses against seasonal human coronaviruses in COVID-19 patients with different disease severities.

Imai, Kazuo / Matsuoka, Masaru / Tabata, Sakiko / Kitagawa, Yutaro / Nagura-Ikeda, Mayu / Kubota, Katsumi / Fukada, Ai / Takada, Tomohito / Sato, Momoko / Noguchi, Sakiko / Takeuchi, Shinichi / Arakawa, Noriaki / Miyoshi, Kazuyasu / Saito, Yoshiro / Maeda, Takuya

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 111, Page(s) 68–75

Abstract: Background: The cross-reactive antibody response against seasonal human coronaviruses (HCoVs) was evaluated according to disease severity in patients with COVID-19 in Japan.: Methods: In total, 194 paired serum samples collected from 97 patients with ...

Abstract	Background: The cross-reactive antibody response against seasonal human coronaviruses (HCoVs) was evaluated according to disease severity in patients with COVID-19 in Japan. Methods: In total, 194 paired serum samples collected from 97 patients with COVID-19 (mild, 35; severe, 62) were analyzed on admission and during convalescence. IgG antibodies against the nucleocapsid (N) and spike (S) proteins of SARS-CoV-2 and four seasonal HCoVs (HCoV-NL63, -229E, -OC43, and -HKU1) were detected by enzyme-linked immunosorbent assays. Results: There was no difference in optical density (OD) values for seasonal HCoVs on admission between the severe and mild cases. In addition, a specific pattern of disease severity-associated OD values for HCoVs was not identified. Significant increases in OD values from admission to convalescence for HCoV-HKU1and -OC43 IgG-S, and for HCoV-NL63 and -229E IgG-N were observed in the severe cases. Significant differences were observed between the mild and severe cases for HCoV-HKU1 and -OC43 IgG-S OD values during convalescence. Correlations were found between the fold changes for HCoV-OC43 IgG-S OD values, and for SARS-CoV-2 IgG-S OD values, and C-reactive protein, lactate dehydrogenase, and lymphocyte levels. Conclusion: There was no association between the antibody titer for seasonal HCoVs in the early phase of COVID-19 and disease severity.
MeSH term(s)	COVID-19 ; Humans ; Immunity, Humoral ; SARS-CoV-2 ; Seasons ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus
Chemical Substances	Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-08-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.08.026
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Article ; Online: Clinical characteristics and antibody response to SARS-CoV-2 spike 1 protein using VITROS Anti-SARS-CoV-2 antibody tests in COVID-19 patients in Japan.

Nagura-Ikeda, Mayu / Imai, Kazuo / Kubota, Katsumi / Noguchi, Sakiko / Kitagawa, Yutaro / Matsuoka, Masaru / Tabata, Sakiko / Miyoshi, Kazuyasu / Ito, Toshimitsu / Tamura, Kaku / Maeda, Takuya

Journal of medical microbiology

2021 Volume 70, Issue 4

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19 Serological Testing/methods ; Diagnostic Tests, Routine ; Female ; Hospitalization ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Japan ; Kinetics ; Male ; Middle Aged ; Prognosis ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/immunology ; Young Adult
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-04-16
Publishing country	England
Document type	Evaluation Study ; Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001291
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Article ; Online: Clinical evaluation of the antibody response in patients with COVID-19 using automated high-throughput immunoassays.

Kubota, Katsumi / Kitagawa, Yutaro / Matsuoka, Masaru / Imai, Kazuo / Orihara, Yuta / Kawamura, Rieko / Sakai, Jun / Ishibashi, Noriomi / Tarumoto, Norihito / Takeuchi, Shinichi / Maesaki, Shigefumi / Maeda, Takuya

Diagnostic microbiology and infectious disease

2021 Volume 100, Issue 3, Page(s) 115370

Abstract: Several automated high-throughput immunoassays for detecting anti-SARS-CoV-2 antibodies by a semi-quantitative approach have been commercialized. In this study, we describe the timeline of the antibody response in patients with RT-PCR-confirmed COVID-19. ...

Abstract	Several automated high-throughput immunoassays for detecting anti-SARS-CoV-2 antibodies by a semi-quantitative approach have been commercialized. In this study, we describe the timeline of the antibody response in patients with RT-PCR-confirmed COVID-19. A total of 292 sequential serum samples from 33 Japanese patients were retrospectively analyzed using four test kits for SARS-CoV-2: the Abbott SARS-CoV-2 IgG assay (Abbott), Elecsys® Anti-SARS-CoV-2 assay (Roche Diagnostic), and VITROS® Anti-SARS-CoV-2 Total and IgG assays (Ortho Clinical Diagnostics). All automated immunoassays could equivalently identify positive sera collected within 2 weeks after symptom onset (99.3%-100%). In addition, the S protein-based automated immunoassay, the VITROS® Anti-SARS-CoV-2 Total assay, may play a complementary role in evaluating passive antibody therapies or vaccines against SARS-CoV-2, although further research is required.
MeSH term(s)	Adult ; Aged ; Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19 Serological Testing/methods ; Female ; High-Throughput Screening Assays ; Humans ; Immunoassay ; Kinetics ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Comparative Study ; Evaluation Study ; Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2021.115370
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Zs.A 1845: Show issues

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Article ; Online: Antibody response patterns in COVID-19 patients with different levels of disease severity in Japan.

Imai, Kazuo / Kitagawa, Yutaro / Tabata, Sakiko / Kubota, Katsumi / Nagura-Ikeda, Mayu / Matsuoka, Masaru / Miyoshi, Kazuyasu / Sakai, Jun / Ishibashi, Noriomi / Tarumoto, Norihito / Takeuchi, Shinichi / Ito, Toshimitsu / Maesaki, Shigefumi / Tamura, Kaku / Maeda, Takuya

Journal of medical virology

2021 Volume 93, Issue 5, Page(s) 3211–3218

Abstract: We analyzed antibody response patterns according to the level of disease severity in patients with novel coronavirus disease 2019 (COVID-19) in Japan. We analyzed 611 serum specimens from 231 patients with COVID-19 (mild, 170; severe, 31; critical, 30). ... ...

Abstract	We analyzed antibody response patterns according to the level of disease severity in patients with novel coronavirus disease 2019 (COVID-19) in Japan. We analyzed 611 serum specimens from 231 patients with COVID-19 (mild, 170; severe, 31; critical, 30). Immunoglobulin M (IgM) and IgG antibodies against nucleocapsid protein (N) and spike 1 protein (S1) were detected by enzyme-linked immunosorbent assays. The peaks of fitting curves for the optical density (OD) values of IgM and IgG antibodies against N appeared simultaneously, while those against S1 were delayed compared with N. The OD values of IgM against N and IgG against both N and S1 were significantly higher in the severe and critical cases than in the mild cases at 11 days after symptom onset. The seroconversion rates of IgG were higher than those of IgM against both N and S1 during the clinical course based on the optimal cut-off values defined in this study. The seroconversion rates of IgG and IgM against N and S1 were higher in the severe and critical cases than in the mild cases. Our findings show that a stronger antibody response occurred in COVID-19 patients with greater disease severity and there were low seroconversion rates of antibodies against N and S1 in the mild cases.
MeSH term(s)	Antibodies, Viral/blood ; Antibodies, Viral/classification ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/pathology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/classification ; Immunoglobulin M/blood ; Immunoglobulin M/classification ; Japan/epidemiology ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26899
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Article: A highly practical and enantioselective reagent for the allylation of aldehydes.

Kubota, Katsumi / Leighton, James L

Angewandte Chemie (International ed. in English)

2003 Volume 42, Issue 8, Page(s) 946–948

Language	English
Publishing date	2003-02-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.200390252
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Article ; Online: Clinical characteristics and antibody response to SARS-CoV-2 spike 1 protein using the VITROS Anti-SARS-CoV-2 antibody tests in COVID-19 patients in Japan

Nagura-Ikeda, Mayu / Imai, Kazuo / Kubota, Katsumi / Noguchi, Sakiko / Kitagawa, Yutaro / Matsuoka, Masaru / Tabata, Sakiko / Miyoshi, Kazuyasu / Ito, Toshimitsu / Tamura, Kaku / Maeda, Takuya

Abstract: Abstract Background: We evaluated clinical characteristics and the clinical utility of VITROS SARS-CoV-2 antibody tests according to COVID-19 severity in patients in Japan. Methods: We analyzed 255 serum specimens from 130 COVID-19 patients and examined ... ...

Abstract	Abstract Background: We evaluated clinical characteristics and the clinical utility of VITROS SARS-CoV-2 antibody tests according to COVID-19 severity in patients in Japan. Methods: We analyzed 255 serum specimens from 130 COVID-19 patients and examined clinical records and laboratory data. Presence of total (IgA, IgM, and IgG) and specific IgG antibody for the spike 1 antigen of SARS-CoV2 was determined using VITROS Anti-SARS-CoV-2 antibody tests. Findings: Overall, 98 (75.4%) and 32 (24.6%) patients had mild and severe COVID-19, respectively. On admission, 76 (58.5%) and 45 (34.6%) patients were positive for total and IgG antibody assays. Among 91 patients at discharge, 90 (98.9%) and 81 (89.0%) patients were positive for total and IgG antibody, respectively. Clinical background and laboratory findings on admission, but not the prevalence or concentration of total or IgG antibody, were associated with disease prognosis. Total and IgG antibody intensity were significantly higher in severe cases than in mild cases in serum collected after 11 days from onset, but not within 10 days. Conclusion: VITROS Anti-SARS-CoV-2 Total and IgG assays will be useful as supporting diagnostic and surveillance tools and for evaluation of humoral immune response to COVID-19. Clinical background and laboratory findings are preferable predictors of disease prognosis.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
Note	WHO #Covidence: #20166256
DOI	10.1101/2020.08.02.20166256
Database	COVID19

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Article ; Online: Clinical characteristics and antibody response to SARS-CoV-2 spike 1 protein using the VITROS Anti-SARS-CoV-2 antibody tests in COVID-19 patients in Japan

Nagura-Ikeda, Mayu / Imai, Kazuo / Kubota, Katsumi / Noguchi, Sakiko / Kitagawa, Yutaro / Matsuoka, Masaru / Tabata, Sakiko / Miyoshi, Kazuyasu / Ito, Toshimitsu / Tamura, Kaku / Maeda, Takuya

medRxiv

Abstract	Abstract Background: We evaluated clinical characteristics and the clinical utility of VITROS SARS-CoV-2 antibody tests according to COVID-19 severity in patients in Japan. Methods: We analyzed 255 serum specimens from 130 COVID-19 patients and examined clinical records and laboratory data. Presence of total (IgA, IgM, and IgG) and specific IgG antibody for the spike 1 antigen of SARS-CoV2 was determined using VITROS Anti-SARS-CoV-2 antibody tests. Findings: Overall, 98 (75.4%) and 32 (24.6%) patients had mild and severe COVID-19, respectively. On admission, 76 (58.5%) and 45 (34.6%) patients were positive for total and IgG antibody assays. Among 91 patients at discharge, 90 (98.9%) and 81 (89.0%) patients were positive for total and IgG antibody, respectively. Clinical background and laboratory findings on admission, but not the prevalence or concentration of total or IgG antibody, were associated with disease prognosis. Total and IgG antibody intensity were significantly higher in severe cases than in mild cases in serum collected after 11 days from onset, but not within 10 days. Conclusion: VITROS Anti-SARS-CoV-2 Total and IgG assays will be useful as supporting diagnostic and surveillance tools and for evaluation of humoral immune response to COVID-19. Clinical background and laboratory findings are preferable predictors of disease prognosis.
Keywords	covid19
Language	English
Publishing date	2020-08-04
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.08.02.20166256
Database	COVID19

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Article ; Online: Antibody response patterns in COVID-19 patients with different levels of disease severity-Japan

Imai, Kazuo / Kitagawa, Yutaro / Tabata, Sakiko / Kubota, Katsumi / Ikeda, Mayu / Matuoka, Masaru / Miyoshi, Kazuyasu / Sakai, Jun / Ishibashi, Noriomi / Tarumoto, Norihito / Takeuchi, Shinichi / Ito, Toshimitsu / Maesaki, Shigefumi / Tamura, Kaku / Maeda, Takuya

medRxiv

Abstract: Background: We analyzed antibody response patterns according to level of disease severity in patients with novel coronavirus disease 2019 (COVID-19) in Japan. Methods: We analyzed 611 serum specimens from 231 patients with COVID-19 (mild, 170; severe, 31; ...

Abstract	Background: We analyzed antibody response patterns according to level of disease severity in patients with novel coronavirus disease 2019 (COVID-19) in Japan. Methods: We analyzed 611 serum specimens from 231 patients with COVID-19 (mild, 170; severe, 31; critical, 30). IgM and IgG antibodies against nucleocapsid protein (N) and spike 1 protein (S1) were detected by enzyme-linked immunosorbent assays. Findings: The peaks of fitting curves for the OD values of IgM and IgG antibodies against N appeared simultaneously, while those against S1 were delayed compared with N. The OD values of IgM against N and IgG against both N and S1 were significantly higher in the severe and critical cases than in the mild cases at 11 days after symptom onset. The seroconversion rates of IgG were higher than those of IgM against both N and S1 during the clinical course based on the optimal cut-off values defined in this study. The seroconversion rates of IgG and IgM against N and S1 were higher in the severe and critical cases than in the mild cases. Conclusion: Our findings show that a stronger antibody response occurred in COVID-19 patients with greater disease severity and there were low seroconversion rates of antibodies against N and S1 in the mild cases. The antibody response patterns in our population suggest a second infection pattern, leading us to hypothesize that cross-reactivity occurs between SARS-CoV-2 and past infection with other human coronaviruses.
Keywords	covid19
Language	English
Publishing date	2020-11-23
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.11.20.20231696
Database	COVID19

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Article: Synthesis and structure–activity relationship of tricyclic carboxylic acids as novel anti-histamines

Kubota, Katsumi / Kurebayashi, Hirotaka / Miyachi, Hirotaka / Tobe, Masanori / Onishi, Masako / Isobe, Yoshiaki

Bioorganic & medicinal chemistry. 2011 May 1, v. 19, no. 9

2011

Abstract: A series of tricyclic carboxylic acids having 6-amino-pyrimidine-2,4(1H,3H)-dione with piperazino or homopiperazino moiety linked by propylene, were synthesized and evaluated for their affinity toward human histamine H₁ receptor and Caco-2 cell ... ...

Abstract	A series of tricyclic carboxylic acids having 6-amino-pyrimidine-2,4(1H,3H)-dione with piperazino or homopiperazino moiety linked by propylene, were synthesized and evaluated for their affinity toward human histamine H₁ receptor and Caco-2 cell permeability. Selected compounds were further evaluated for their oral anti-histaminic activity in mice, bioavailability in rats, and their anti-inflammatory activity in mice OVA-induced biphasic cutaneous reaction model. Among the compounds tested, dibenzoxazepine carboxylic acid 13b showed both histamine H₁ receptor antagonistic activity and anti-inflammatory activity in vivo. In addition, 13b exhibited low affinity toward α₁ receptor and low occupancy of H₁ receptor in the brain. It is therefore, believed that 13b is a potential candidate for development as 3rd generation anti-histamine.
Keywords	anti-inflammatory activity ; bioavailability ; brain ; carboxylic acids ; histamine ; human cell lines ; humans ; mice ; models ; permeability ; propylene ; rats ; structure-activity relationships
Language	English
Dates of publication	2011-0501
Size	p. 3005-3021.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2011.03.003
Database	NAL-Catalogue (AGRICOLA)

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