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  1. Article: THE REGULATION OF AIRWAY SMOOTH MUSCLE CONTRACTION.

    Kudo, Makoto

    Arerugi = [Allergy

    2017  Volume 66, Issue 6, Page(s) 798–803

    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.66.798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 245: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Potential Inhibition of COVID-19-driven Pneumonia by Immunosuppressive Therapy and anti-TNFα Antibodies: A Case Report.

    Kunisaki, Reiko / Tsukiji, Jun / Kudo, Makoto

    Journal of Crohn's & colitis

    2020  Volume 14, Issue 12, Page(s) 1786–1787

    MeSH term(s) COVID-19/complications ; COVID-19/immunology ; COVID-19/physiopathology ; COVID-19/prevention & control ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Infliximab/therapeutic use ; Male ; Middle Aged ; Patient Acuity ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances Immunosuppressive Agents ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU)
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjaa105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6634: Show issues Location:
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  3. Article: A functionally improved case of obstructive impairment caused by systemic lupus erythematosus.

    Kamimaki, Chisato / Yamamoto, Masaki / Sawazumi, Tomoe / Kudo, Makoto / Kaneko, Takeshi

    Breathe (Sheffield, England)

    2021  Volume 17, Issue 2, Page(s) 200288

    Abstract: Pulmonary lymphoproliferative diseases are often associated with collagen diseases. In addition to treatment of the primary disease, additional treatments may be considered depending on the pathology presented in the case. ...

    Abstract Pulmonary lymphoproliferative diseases are often associated with collagen diseases. In addition to treatment of the primary disease, additional treatments may be considered depending on the pathology presented in the case.
    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0288-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Factors Related to Continuation of Health Behaviours among Stroke Survivors.

    Yuki, Toshiya / Kudo, Makoto

    Journal of the Japanese Physical Therapy Association = Rigaku ryoho

    2015  Volume 14, Issue 1, Page(s) 1–11

    Abstract: Purpose: This study investigated stroke survivors' perspectives of health behaviours after stroke. We aimed to explore the actual process by which stroke survivors changed their health behaviours.: Method: Semi-structured interviews were conducted ... ...

    Abstract Purpose: This study investigated stroke survivors' perspectives of health behaviours after stroke. We aimed to explore the actual process by which stroke survivors changed their health behaviours.
    Method: Semi-structured interviews were conducted with 40 people in a 1-year prospective study in the regional city of Chiba, Japan. Interviews covered views of health behaviours in order to explore why patients change their risk factors. Data were analysed using the principles of modified grounded theory.
    Results: Six categories related to practising health behaviours were identified: cause of stroke, antithetic thinking, awareness of the body, fear of disease progression, view of health, and psychological meaning of practise. Stroke survivors constructed a meaning of practise for each health behaviour. The recognition of previous lifestyle as cause of stroke, hope for recovery, and fear of future progression influenced health behaviours.
    Conclusions: The key finding of this study is that when cognitive behavioural therapy principles are enforced, an important aspect is that stroke survivors recognize the possibility that previous lifestyle was a cause of stroke and appreciate the necessity of preventing a new stroke.
    Language English
    Publishing date 2015-01-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2044149-6
    ISSN 0289-3770 ; 1344-1272
    ISSN (online) 0289-3770
    ISSN 1344-1272
    DOI 10.1298/jjpta.Vol14_001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Heme oxygenase-1 as an important predictor of the severity of COVID-19.

    Hara, Yu / Tsukiji, Jun / Yabe, Aya / Onishi, Yoshika / Hirose, Haruka / Yamamoto, Masaki / Kudo, Makoto / Kaneko, Takeshi / Ebina, Toshiaki

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0273500

    Abstract: Background and objective: A cytokine storm is caused by inflammatory cells, including pro-inflammatory macrophage phenotype (M1), and play a critical role in the pathogenesis of COVID-19, in which diffuse alveolar damage occurs in the lungs due to ... ...

    Abstract Background and objective: A cytokine storm is caused by inflammatory cells, including pro-inflammatory macrophage phenotype (M1), and play a critical role in the pathogenesis of COVID-19, in which diffuse alveolar damage occurs in the lungs due to oxidative stress exposure. Heme oxygenase (HO)-1 is a stress-induced protein produced by the anti-inflammatory / anti-oxidative macrophage phenotype (M2), which also produces soluble CD163 (sCD163). In our study, we investigated and determined that serum HO-1 can be a predictive biomarker for assessing both the severity and the outcome of COVID-19 patients.
    Method: The serum concentrations of HO-1 and sCD163 of COVID-19 patients were measured on admission. The relationship between these biomarkers and other clinical parameters and outcomes were evaluated.
    Results: Sixty-four COVID-19 patients (11 mild, 38 moderate, and 15 severe cases) were assessed. The serum HO-1 tended to increase (11.0 ng/mL vs. 24.3 ng/mL vs. 59.6 ng/mL with severity). Serum HO-1 correlated with serum lactate dehydrogenase (R = 0.422), C-reactive protein (R = 0.463), and the ground glass opacity (GGO) and consolidation score (R = 0.625) of chest computed tomography. The serum HO-1 showed a better area under the curve (AUC) for predicting ICU admission than the serum sCD163 (HO-1; 0.816 and sCD163; 0.743). In addition, composite parameters including serum HO-1 and the GGO and consolidation score showed a higher AUC for predicting ICU admission than the AUC of a single parameter.
    Conclusion: Clinically, serum HO-1, reflecting the activation of M2, could be a very useful marker for evaluating disease severity and predicting prognoses for COVID-19 patients. In addition, controlling activated M2 might be a preventative COVID-19 therapeutic target.
    MeSH term(s) Biomarkers ; COVID-19 ; Heme Oxygenase-1/metabolism ; Humans ; Macrophages/metabolism ; Prognosis
    Chemical Substances Biomarkers ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Potential inhibition of COVID-19-driven pneumonia by immunosuppressive therapy and anti-TNFα antibodies: a case report

    Kunisaki, Reiko / Tsukiji, Jun / Kudo, Makoto

    J. crohns. colitis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32473011
    Database COVID19

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  7. Article ; Online: Potential Inhibition of COVID-19-driven Pneumonia by Immunosuppressive Therapy and anti-TNFα Antibodies

    Kunisaki, Reiko / Tsukiji, Jun / Kudo, Makoto

    Journal of Crohn's and Colitis ; ISSN 1873-9946 1876-4479

    A Case Report

    2020  

    Keywords Gastroenterology ; General Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/ecco-jcc/jjaa105
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Low-temperature adaptive conductive hydrogel based on ice structuring proteins/CaCl2 anti-freeze system as wearable strain and temperature sensor

    Lu, Chunyin / Qiu, Jianhui / Zhao, Wei / Sakai, Eiichi / Zhang, Guohong / Nobe, Rie / Kudo, Makoto / Komiyama, Takao

    International journal of biological macromolecules. 2021 Oct. 01, v. 188

    2021  

    Abstract: Conductive hydrogels as wearable devices meet the basic demands of mechanical flexibility and smart sensing. However, achieving anti-freeze property in conductive hydrogels is still challengeable. Here, a novel anti-freezing system based on ice ... ...

    Abstract Conductive hydrogels as wearable devices meet the basic demands of mechanical flexibility and smart sensing. However, achieving anti-freeze property in conductive hydrogels is still challengeable. Here, a novel anti-freezing system based on ice structuring proteins and CaCl₂ was introduced to enable a conductive hydrogel with low-temperature adaptability. Both formation of ice nuclei and ice growth of the hydrogel at sub-zero temperature could be inhibited. Supported by the anti-freeze system, the hydrogel revealed good flexibility (890% at −20 °C), recovery and conductivity (0.50 S/m at −20 °C) at both room temperature and sub-zero temperature. The low-temperature adaptability enabled the hydrogel to be used as strain and temperature sensors at both room temperature and sub-zero temperature. The anti-freeze system in this work is expected to open up a new avenue to promote the conductive hydrogel with low-temperature adaptability.
    Keywords ambient temperature ; hydrogels ; ice
    Language English
    Dates of publication 2021-1001
    Size p. 534-541.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.08.060
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article ; Online: The clinical impact of comorbidities among patients with idiopathic pulmonary fibrosis undergoing anti-fibrotic treatment: A multicenter retrospective observational study.

    Aoki, Ayako / Hara, Yu / Fujii, Hiroaki / Murohashi, Kota / Nagasawa, Ryo / Tagami, Yoichi / Enomoto, Tatsuji / Matsumoto, Yutaka / Masuda, Makoto / Watanabe, Keisuke / Horita, Nobuyuki / Kobayashi, Nobuaki / Kudo, Makoto / Ogura, Takashi / Kaneko, Takeshi

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0291489

    Abstract: Background: Among patients with idiopathic pulmonary fibrosis (IPF), few studies have investigated the clinical impact of anti-fibrotic treatment (AFT) with and without comorbidities. The aim of the study was to determine whether Charlson Comorbidity ... ...

    Abstract Background: Among patients with idiopathic pulmonary fibrosis (IPF), few studies have investigated the clinical impact of anti-fibrotic treatment (AFT) with and without comorbidities. The aim of the study was to determine whether Charlson Comorbidity Index score (CCIS) can predict the efficacy of AFT in patients with IPF.
    Methods: We retrospectively assessed data extracted from the medical records of IPF patients who received anti-fibrotic agents between 2009 and 2019. The collected data included age, sex, CCIS, pulmonary function test, high-resolution computed tomography (HRCT) pattern, gender/age/physiology (GAP) score, and 3-year IPF-related events defined as the first acute exacerbation or death within 3 years after starting AFT.
    Results: We assessed 130 patients (median age, 74 years) who received nintedanib (n = 70) or pirfenidone (n = 60). Median duration of AFT was 425 days. Patients were categorized into high (≥ 3 points) and low (≤ 2 points) CCIS groups. There was no significant difference between the groups in terms of age, sex, duration of AFT, GAP score, or incidence of usual interstitial pneumonia pattern on HRCT except percentage predicted diffusion capacity of lung for carbon monoxide. Also, significant difference was not seen between the groups for 3-year IPF-related events (P = 0.75). Especially, in the low CCIS group but not the high CCIS group, the longer duration of AFT had better disease outcome.
    Conclusion: In the present study, we could not show any relation between CCIS and IPF disease outcomes in patients undergoing AFT, though the longer duration of AFT might be beneficial for IPF outcomes among patients with low CCIS.
    MeSH term(s) Aged ; Humans ; Antifibrotic Agents ; Comorbidity ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/epidemiology ; Retrospective Studies
    Chemical Substances Antifibrotic Agents
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: X-ray irradiation negatively affects immune responses in the lymphatic network.

    Kanabuchi, Sawa / Kitamura, Narufumi / Takano-Kasuya, Mayumi / Inose, Tomoya / Nishidate, Chihiro / Yamanashi, Mizuki / Kudo, Makoto / Ito, Tatsuki / Ito, Naho / Okamoto, Hiroshi / Taniyama, Yusuke / Kobayashi, Yoshio / Kamei, Takashi / Gonda, Kohsuke

    Microvascular research

    2023  Volume 148, Page(s) 104511

    Abstract: Immune checkpoint inhibitor therapy has been attracting attention as a new cancer treatment and is likely to be widely used in combination with radiotherapy. Therefore, examination of the effects of X-ray irradiation on sentinel lymph nodes and lymphatic ...

    Abstract Immune checkpoint inhibitor therapy has been attracting attention as a new cancer treatment and is likely to be widely used in combination with radiotherapy. Therefore, examination of the effects of X-ray irradiation on sentinel lymph nodes and lymphatic vessels, which are involved in antigen presentation, is important for therapy. The hindlimbs of mice were irradiated with X-rays (total radiation doses: 2, 10, and 30 Gy), and X-ray computed tomography (CT) imaging was performed using 15-nm or 2-nm gold nanoparticles (AuNPs) as contrast agents on days 7, 14, and 28 after irradiation to evaluate the diameter of the collecting lymph vessels and lymph flow within the irradiated area. X-ray CT imaging data using 15-nm AuNPs on day 28 after irradiation showed that the diameter of the collecting lymph vessels was significantly larger in all irradiated groups compared to the control group (p ≤ 0.01). CT imaging with 2-nm AuNPs showed that lymphatic drainage was significantly reduced in the lymph nodes irradiated with 10 Gy and 30 Gy compared to the lymph nodes irradiated with 2 Gy (p ≤ 0.05). Additionally, immunohistochemical analyses were conducted to evaluate the area density and morphology of high endothelial venules (HEVs) in the lymph nodes, which are important vessels for naive T cells to enter the lymph nodes. The expression level of MECA-79, which specifically localized to HEVs, was significantly decreased in the 10 Gy and 30 Gy irradiation groups compared to the control group (p ≤ 0.05). There was a significant decrease in normal HEV morphology (p ≤ 0.05) and a significant increase in abnormal HEV morphology (p ≤ 0.05) in all irradiated groups. These results also showed that X-ray irradiation induced a time- and radiation dose-dependent increase in the diameter of the collecting lymph vessels, stagnation of intralymphatic lymph flow, and a reduction in the area density of HEVs and their abnormal morphology, demonstrating that X-ray irradiation affected the immune responses. Therefore, these findings suggest that X-ray irradiation to lymph nodes may impair the opportunity for antigen presentation in the lymph nodes, which is the key to cancer immunity, and that for this reason, it is important to carefully plan irradiation of sentinel lymph nodes and develop treatment strategies according to future treatment options.
    MeSH term(s) Animals ; Mice ; X-Rays ; Gold ; Lymphatic Metastasis/pathology ; Metal Nanoparticles ; Lymph Nodes/pathology ; Lymph Nodes/radiation effects ; Lymphatic Vessels/diagnostic imaging ; Immunity
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2023.104511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 746: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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