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  1. Article ; Online: Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling.

    Vakhitova, Yulia V / Kalinina, Tatiana S / Zainullina, Liana F / Lusta, Anastasiya Yu / Volkova, Anna V / Kudryashov, Nikita V / Gudasheva, Tatiana A / Shimshirt, Alexander A / Kadnikov, Ilya A / Voronin, Mikhail V / Seredenin, Sergei B

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in the ...

    Abstract Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in the mouse Porsolt test, tail suspension test, Nomura water wheel test, in the chronic social defeat stress model and in the inflammation-induced model of depression. In the present study, we evaluated the effect of chronic per os administration of GSB-106 to Balb/c mice under unpredictable chronic mild stress (UCMS). It was observed for the first time that long term GSB-106 treatment (1 mg/kg, 26 days) during ongoing UCMS procedure ameliorated the depressive-like behaviors in mice as indicated by the Porsolt test. In addition, chronic per os administration of GSB-106 resulted in an increase in BDNF levels, which were found to be decreased in the prefrontal cortex and hippocampus of mice after UCMS. Furthermore, prolonged GSB-106 treatment was accompanied by an increase in the content of pTrkB
    MeSH term(s) Animals ; Antidepressive Agents/pharmacology ; Brain/metabolism ; Brain-Derived Neurotrophic Factor/drug effects ; Brain-Derived Neurotrophic Factor/metabolism ; Dipeptides/metabolism ; Dipeptides/pharmacology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Membrane Glycoproteins/drug effects ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred BALB C ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Protein-Tyrosine Kinases/drug effects ; Protein-Tyrosine Kinases/metabolism ; Signal Transduction/drug effects ; Stress, Psychological
    Chemical Substances Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Dipeptides ; Membrane Glycoproteins ; bis-(N-monosuccinyl-l-seryl-l-lysine)hexamethylenediamide ; Ntrk2 protein, mouse (EC 2.7.10.1) ; Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pharmacological Aspects of Neuro-Immune Interactions.

    Tarasov, Vadim V / Kudryashov, Nikita V / Chubarev, Vladimir N / Kalinina, Tatiana S / Barreto, George E / Ashraf, Ghulam Md / Aliev, Gjumrakch

    Current pharmaceutical design

    2017  Volume 24, Issue 1, Page(s) 15–21

    Abstract: The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and ... ...

    Abstract The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published data on pharmacological effects of psychotropic drugs possessing immunomodulatory and/or antiviral properties have shown a correlation between central effects of examined drugs associated with the impact on the processes of neurogenesis of adult brain and survival of neurons, and their ability to alter levels of key proinflammatory cytokines. The changes that occur as a result of the influence of pharmacological agents at one of the systems should inevitably lead to the functional reorganization at another. Integrative mechanisms underlying the neuro-immune interactions may explain the "pleiotropic" pharmacological effects of some antiviral and immunomodulatory drugs. Amantadine, which was originally considered as an antiviral agent, was approved as anti-parkinsonic drug after its wide medical use. The prolonged administration of interferon alpha caused depression in 30-45% of patients, thus limiting its clinical use. The antiviral drug "Oseltamivir" may provoke the development of central side effects, including abnormal behavior, delirium, impaired perception and suicides. Anti-herpethetical drug "Panavir" shows pronounced neuroprotective properties. The purpose of this review is to analyze the experimental and clinical data related to central effects of drugs with antiviral or/and immunotropic activity, and to discover the relationship of these effects with changes in reactivity of immune system and proinflammatory response.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Humans ; Immune System/drug effects ; Immune System/immunology ; Immunomodulation/drug effects ; Immunomodulation/immunology ; Nervous System/drug effects ; Nervous System/immunology ; Oseltamivir/pharmacology ; Probucol/pharmacology
    Chemical Substances Antiviral Agents ; Oseltamivir (20O93L6F9H) ; Probucol (P3CTH044XJ)
    Language English
    Publishing date 2017-09-04
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612823666170829135115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice.

    Kudryashov, Nikita V / Kalinina, Tatiana S / Shimshirt, Alexander A / Korolev, Anton O / Volkova, Anna V / Voronina, Tatiana A

    Behavioural pharmacology

    2017  Volume 29, Issue 4, Page(s) 375–378

    Abstract: The antidepressant-like effect of fluoxetine (20 mg/kg i.p.) has been assessed using the forced swimming test (FST) in IRC (CD-1) mice exposed or not to a pretest session of different duration (5 or 20 min). The influence of the mitochondrial ... ...

    Abstract The antidepressant-like effect of fluoxetine (20 mg/kg i.p.) has been assessed using the forced swimming test (FST) in IRC (CD-1) mice exposed or not to a pretest session of different duration (5 or 20 min). The influence of the mitochondrial translocator protein (TSPO) activity on the antidepressant-like effect of fluoxetine (20 mg/kg i.p.) in the FST was also studied. The antidepressant-like effect of fluoxetine was observed only in mice subjected to a 5-min pretest session 24 h before the FST. The TSPO antagonist PK11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 1 or 3 mg/kg i.p.] inhibited the antidepressant activity of fluoxetine in the FST. In the present study, fluoxetine or PK11195 was administered for a short duration. We suppose that the functional activity of TSPO may depend on a pretest session and that using this procedure is necessary to detect antidepressant activity of fluoxetine-like drugs.
    MeSH term(s) Animals ; Antidepressive Agents/pharmacology ; Depression/drug therapy ; Depressive Disorder/drug therapy ; Disease Models, Animal ; Fluoxetine/metabolism ; Fluoxetine/pharmacology ; Isoquinolines/pharmacology ; Male ; Mice ; Mice, Inbred ICR ; Mitochondrial Trifunctional Protein/drug effects ; Mitochondrial Trifunctional Protein/metabolism ; Mitochondrial Trifunctional Protein/physiology ; Motor Activity/drug effects ; Serotonin Uptake Inhibitors/pharmacology ; Signal Transduction/drug effects ; Stress, Psychological/drug therapy ; Swimming
    Chemical Substances Antidepressive Agents ; Isoquinolines ; Serotonin Uptake Inhibitors ; Fluoxetine (01K63SUP8D) ; Mitochondrial Trifunctional Protein (EC 2.3.1.16) ; PK 11195 (YNF83VN1RL)
    Language English
    Publishing date 2017-09-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1027374-8
    ISSN 1473-5849 ; 0955-8810
    ISSN (online) 1473-5849
    ISSN 0955-8810
    DOI 10.1097/FBP.0000000000000359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2883: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Serotonin limits generation of chromaffin cells during adrenal organ development.

    Kameneva, Polina / Melnikova, Victoria I / Kastriti, Maria Eleni / Kurtova, Anastasia / Kryukov, Emil / Murtazina, Aliia / Faure, Louis / Poverennaya, Irina / Artemov, Artem V / Kalinina, Tatiana S / Kudryashov, Nikita V / Bader, Michael / Skoda, Jan / Chlapek, Petr / Curylova, Lucie / Sourada, Lukas / Neradil, Jakub / Tesarova, Marketa / Pasqualetti, Massimo /
    Gaspar, Patricia / Yakushov, Vasily D / Sheftel, Boris I / Zikmund, Tomas / Kaiser, Jozef / Fried, Kaj / Alenina, Natalia / Voronezhskaya, Elena E / Adameyko, Igor

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2901

    Abstract: Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that ... ...

    Abstract Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3A
    MeSH term(s) Adrenal Glands/metabolism ; Animals ; Catecholamines/metabolism ; Chromaffin Cells/metabolism ; Female ; Mice ; Neuroblastoma/metabolism ; Pregnancy ; Serotonin/metabolism
    Chemical Substances Catecholamines ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30438-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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