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Article: Non-familial paediatric oral myofibroma - A masquerade. Case report with a brief literature review.

Kulkarni, Spoorti / Kudva, Adarsh / Gadicherla, Srikanth / Carnelio, Sunitha

Journal of oral and maxillofacial pathology : JOMFP

2023 Volume 27, Issue Suppl 1, Page(s) S1–S5

Abstract: Myofibromas are fibrous tumours that could be of familial or non-familial origin, belonging to the fibroblastic and myofibroblastic subset with a wide spectrum of clinical behaviour. Oral myofibromas present with a broad range of differential diagnoses, ... ...

Abstract	Myofibromas are fibrous tumours that could be of familial or non-familial origin, belonging to the fibroblastic and myofibroblastic subset with a wide spectrum of clinical behaviour. Oral myofibromas present with a broad range of differential diagnoses, including benign and malignant lesions. Histopathologically, these lesions may imitate many other soft tissue tumours of the oral cavity, such as spindle cell tumours of nerve, smooth muscle cell origin, and other myofibroblastic lesions, thus leading to misdiagnosis and mistreatment. In the present paper, we report a soft tissue lesion, which presented as a growth on the gingivobuccal sulcus in a 7-year-old child. We also emphasise the various differential diagnoses that need to be eliminated and the importance of immunohistochemistry to know the nature of tumour cells in establishing the accurate diagnosis.
Language	English
Publishing date	2023-02-04
Publishing country	India
Document type	Case Reports
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.jomfp_141_22
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Article: "Giant cell fibroma of buccal mucosa -an unusual lesion of unusual size": A case report.

Shetty, Nisha / Kudva, Adarsh / Carnelio, Sunitha / Kudva, Ranjini

Journal of oral and maxillofacial pathology : JOMFP

2023 Volume 27, Issue 4, Page(s) 772–775

Abstract: Giant cell fibroma is a benign oral fibrous tumour. The clinical appearance of majority of non-neoplastic fibrous growths is similar, but unique histopathological features of giant cell fibroma aid in its final diagnosis. It usually manifests as an ... ...

Abstract	Giant cell fibroma is a benign oral fibrous tumour. The clinical appearance of majority of non-neoplastic fibrous growths is similar, but unique histopathological features of giant cell fibroma aid in its final diagnosis. It usually manifests as an asymptomatic, sessile or pedunculated mass usually less than 1 cm in diameter. In this case report, we highlight a case of giant cell fibroma in a 58-year-old male patient, which had an unusual size with associated pain. Although giant cell fibromas are benign lesions, it is important for dentists to be aware of this lesion based on its frequency of occurrence and need for its accurate diagnosis.
Language	English
Publishing date	2023-12-20
Publishing country	India
Document type	Case Reports
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.jomfp_218_23
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Article ; Online: An unsolved dilemma in the reliability of virtual planning in mandibular reconstruction surgery: Short communication.

Kudva, Adarsh / Chichra, Muskaan / Unadkat, Asmita / Singh, Anupam

Oral oncology

2023 Volume 138, Page(s) 106334

MeSH term(s)	Humans ; Mandibular Reconstruction ; Reproducibility of Results ; Mandible/surgery ; Plastic Surgery Procedures ; Surgery, Computer-Assisted ; Free Tissue Flaps/surgery
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Letter
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2023.106334
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Simultaneous Reconstruction of Mandibular and Maxillary Defects Using the Single Free Fibular Osseocutaneous Flap: Case Series and Review of the Literature.

Lin, Chih-Hung / Kudva, Adarsh

Annals of plastic surgery

2021 Volume 86, Issue 4, Page(s) 428–433

Abstract: Background: The facial profile requires adequate maxillary and mandibular projection. Although oral cancer tumor ablation might create ipsilateral maxillary and mandibular defect, fibular flap is popular in mandibular defect reconstruction. However, the ...

Abstract	Background: The facial profile requires adequate maxillary and mandibular projection. Although oral cancer tumor ablation might create ipsilateral maxillary and mandibular defect, fibular flap is popular in mandibular defect reconstruction. However, the maxillary defect results in sunken cheek or oral contracture. A single fibular flap can provide several struts to rebuild 2 jaws with adequate 3-dimensional spatial placement. Materials and methods: In total, 7 cases of secondary oral contracture and 2 cases of primary oncologic tumor ablation underwent single fibular flap for 2 jaws. Using multiple osteotomies, the distal fibular struts were used for the upper jaw, the second struts were discarded (3-4 cm), and proximal struts were used for mandible defect reconstruction. There were 5 accompanying free flaps for facial lining (2) and contralateral oral contracture release (3). Results: All flaps survived without distal strut avascular necrosis, but 2 patients died from tumor metastasis. These patients presented adequate middle and lower facial profile. One patient underwent mandibular fibula strut distraction osteogenesis followed by integrated teeth on both jaws. Conclusions: Single fibular transfer can accomplish 2 jaw bony defects and facial profile reconstruction. It can release oral contracture functionally and correct sunken cheek aesthetically. The reconstructed fibula can allow secondary teeth implantation rehabilitation.
MeSH term(s)	Bone Transplantation ; Fibula/surgery ; Free Tissue Flaps ; Humans ; Mandible/surgery ; Mandibular Reconstruction ; Plastic Surgery Procedures
Language	English
Publishing date	2021-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000002436
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Zs.A 1419: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis.

Shetty, Smitha Sammith / Sharma, Mohit / Padam, Kanaka Sai Ram / Kudva, Adarsh / Patel, Pratik / Radhakrishnan, Raghu

Journal of oral biology and craniofacial research

2024 Volume 14, Issue 1, Page(s) 63–71

Abstract: Background: Oral submucous fibrosis (OSF) is a persistent oral mucosal condition that carries an elevated risk of undergoing malignant transformation. Our objective was to elucidate the involvement of epithelial-to-mesenchymal transition (EMT) in OSF ... ...

Abstract	Background: Oral submucous fibrosis (OSF) is a persistent oral mucosal condition that carries an elevated risk of undergoing malignant transformation. Our objective was to elucidate the involvement of epithelial-to-mesenchymal transition (EMT) in OSF and its progression to malignancy by studying a panel of EMT markers, thereby understanding the molecular mechanisms. Methods: An immunohistochemical analysis was done to detect the presence of E-cadherin, N-cadherin, pan-cytokeratin (PanCK), vimentin, α-SMA (alpha-smooth muscle actin), and CD44 in a total of 100 tissue samples. These samples comprised 40 cases of OSF, 20 cases of oral squamous cell carcinoma associated with OSF (OSFSCC), and 40 cases of oral squamous cell carcinoma (OSCC). A whole transcriptomic analysis was performed on a group of seven matched samples encompassing NOM, OSF, OSFSCC, and OSCC. Results: We observed significantly decreased expression of E-cadherin and PanCK, while N-cadherin, vimentin, α-SMA, and CD44 showed significantly higher expression in OSFSCC and OSCC as compared to OSF, both at protein and RNA levels. CD44 expression was noticeably higher in OSFSCC (p < 0.001) than in OSCC. Conclusion: Downregulation of epithelial markers with concomitant upregulation of mesenchymal and stem cell markers suggests the potential role of EMT and stemness in accelerating the pathogenesis and malignant transformation of OSF. The high levels of CD44 expression seen in OSFSCC indicate a high propensity for aggressiveness and acquisition of stem-like characteristics by the cells undergoing EMT.
Language	English
Publishing date	2024-01-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2212-4268
ISSN	2212-4268
DOI	10.1016/j.jobcr.2023.12.006
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Article ; Online: Profile of Patients with Maxillofacial Space Infections and Associated Risk Factors.

Gadicherla, Srikanth / Manglani, Kirti / Pentapati, Kalyana C / Kudva, Adarsh / Aramanadka, Chithra / Chandravel, Rajaji

TheScientificWorldJournal

2024 Volume 2024, Page(s) 9304671

Abstract: Objective: To evaluate the profile of patients operated for maxillofacial space infections and associated risk factors for the length of hospital stay.: Materials and methods: We conducted a retrospective study among patients operated for ... ...

Abstract	Objective: To evaluate the profile of patients operated for maxillofacial space infections and associated risk factors for the length of hospital stay. Materials and methods: We conducted a retrospective study among patients operated for maxillofacial infections at our center from 2010 to 2020. Information collected from the records were age, sex, type and number of spaces involved, clinical signs and symptoms (pain, swelling, toothache, sore throat, otalgia, hoarseness, headache, cough, neck swelling, rancid breath, sialorrhea, gingival swelling, muffled voice, trismus, fever, dysphagia, odynophagia, malaise, lymphadenopathy, dyspnoea, pus discharge), treatment modality, total leukocyte count, evidence of bacterial growth, comorbidities, complications if any and length of hospital stay. Results: A total of 128 medical records were examined, out of which 59 were female. The mean age was 38.59 ± 19.7 and the length of hospital stay was 7.56 ± 3.8 days. The most commonly involved space was submandibular space (46.1%) and the common symptoms reported were swelling (99.2%), pain (86.7%), and trismus (68%). Four patients had complications like necrotizing fasciitis (1.6%), pneumonia (0.8%), and death in one patient (0.8%). Logistic regression showed that patients more than 36 years of age, male sex, evidence of bacterial growth, and diabetics had higher odds of increased hospital stay (>6 days). Multiple logistic regression analysis showed that age ( Conclusion: Our study showed that the age of the patient and evidence of bacterial culture were potential predictors of prolonged hospital stay among patients operated for maxillofacial space infections.
MeSH term(s)	Humans ; Male ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Infant, Newborn ; Trismus ; Retrospective Studies ; Risk Factors ; Headache ; Pain
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075968-X
ISSN	1537-744X ; 1537-744X
ISSN (online)	1537-744X
ISSN	1537-744X
DOI	10.1155/2024/9304671
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Article ; Online: Nintedanib-induced osteomyelitis of the jaw against the background of COVID-19 infection.

Kudva, Adarsh / Saha, Mehul / G, Srikanth / S, Arun / Sharma, Swati

Journal of stomatology, oral and maxillofacial surgery

2023 Volume 125, Issue 2, Page(s) 101651

Abstract: Purpose: Various medications are administered to treat Coronavirus Disease 2019 (COVID-19) infection and prevent its complications. Some medicines have complications and long-term effects, which may mimic other conditions, making precise diagnosis ... ...

Abstract	Purpose: Various medications are administered to treat Coronavirus Disease 2019 (COVID-19) infection and prevent its complications. Some medicines have complications and long-term effects, which may mimic other conditions, making precise diagnosis difficult. This report aims to bring to light one such complication, medication-related osteonecrosis of the jaw (MRONJ), secondary to a commonly prescribed medication for preventing lung fibrosis post-COVID-19 infection. Method: A 33-year-old male reported to our department with the typical clinical and radiological features of Mucormycosis of the upper jaw post-COVID-19 infection. However, on detailed evaluation of his history (controlled diabetic and short duration of steroid therapy) and review of the mycology staining, bacteriology, culture, and histopathological reports, we came to a negative diagnosis for Mucormycosis. The patient was, however, on treatment for the prevention of lung fibrosis with Nintedanib (tyrosine kinase inhibitor) 150 mg twice a day for one month. Result: In the absence of predisposing factors and negative laboratory findings for mucormycosis, we arrived at a diagnosis of MRONJ, attributable to Nintedanib therapy given to prevent lung fibrosis post-COVID-19 infection. Conclusion: The use of Nintedanib has recently increased due to the high incidence of lung fibrosis post-COVID-19 infection. However, Nintedanib should be considered a causative agent for osteonecrosis of the jaw in the absence of other obvious predisposing factors. Therefore, Nintedanib must be administered after a thorough consideration of risk factors.
MeSH term(s)	Male ; Humans ; Adult ; Pulmonary Fibrosis ; Mucormycosis ; COVID-19/complications ; Osteonecrosis ; Osteomyelitis/chemically induced ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy ; Indoles
Chemical Substances	nintedanib (G6HRD2P839) ; Indoles
Language	English
Publishing date	2023-09-29
Publishing country	France
Document type	Case Reports
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2023.101651
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Article: Use of the Smith's Spreader as a Self-Retaining Retractor in the Direct Approach to Clival Tumours - A Technical Note.

Kudva, Adarsh / Suryanarayan, Ramya K / Menon, Girish / Varshney, Surbhi

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 1, Page(s) 1476–1477

Abstract: The traditional Le Fort level 1 osteotomy has proven to be an effective in approaching central skull base lesions. The challenge being - stabilization of the down-fractured maxilla in an amenable position for tumour resection. The authors describe a ... ...

Abstract	The traditional Le Fort level 1 osteotomy has proven to be an effective in approaching central skull base lesions. The challenge being - stabilization of the down-fractured maxilla in an amenable position for tumour resection. The authors describe a simple technique to overcome the task of stabilizing the down-fractured maxilla.
Language	English
Publishing date	2023-10-24
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04292-1
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Zs.A 5300: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: To Assess the Effect of Trauma on the Temporomandibular Joint in Postoperative Cases of Zygomaticomaxillary Complex Fractures.

Sankaran, Mridula / Aramanadka, Chithra / Kudva, Adarsh / Gadicherla, Srikanth

Journal of maxillofacial and oral surgery

2022 , Page(s) 1–6

Abstract: Aim and objectives: The study aims to assess the incidence and features of temporomandibular joint(TMJ) dysfunction in post-surgical treatment of unilateral zygomaticomaxillary complex(ZMC) fractures.The objectives are:To assess severity of TMJ ... ...

Abstract	Aim and objectives: The study aims to assess the incidence and features of temporomandibular joint(TMJ) dysfunction in post-surgical treatment of unilateral zygomaticomaxillary complex(ZMC) fractures.The objectives are:To assess severity of TMJ dysfunction in postoperative cases of ZMC fractures.To create awareness of the same among clinicians. Methods: Patients presenting with zygomaticomaxillary complex fractures were evaluated prospectively. Evaluation of TMJ dysfunction was done by different parameters via questionnaire, clinical and radiographic examination preoperatively and a follow-up period of 1 week, 3 months and 6 months. The parameters were, clicking of joint, pain on opening /closing, pain on biting, deviation of mandible, pain in the preauricular region, ringing sound and mouth opening. Statistical analysis was done by the Friedman test and Post Hoc analysis. Results: On presentation, 69.1% patients diagnosed with ZMC fractures presented with symptoms related to TMJ dysfunction. Post-surgery 1 week majority findings persisted, with 21 patients complained of pain on opening or closing and 2 patients with a persistent opening click. These symptoms, however, decreased over the 3 month and 6 month follow up period. 5 patients presented with decreased mouth opening which was attributed to lack of adequate physiotherapy. Conclusion: Patients presented with mild symptoms of TMJ dysfunction until 6 months post-surgery, however these symptoms weren't significant as the pain score assessed was found to decrease in the following post-operative periods. And the symptoms present were'nt exclusive to conclude a TMJ dysfunction. Early treatment and a close follow up are key to prevent progression of symptoms.
Language	English
Publishing date	2022-12-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-022-01826-y
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Article: Current Concepts for Reconstruction of Oral Tissues Following Ablative Surgery: A Comprehensive Approach.

Tsao, Chung-Kan / Kudva, Adarsh / Cheong, David Chon-Fok / Hung, Shao-Yu

Journal of maxillofacial and oral surgery

2022 Volume 21, Issue 2, Page(s) 358–368

Abstract: Appropriate concepts of reconstruction can eliminate contraindications, reduce the incidence of complications, increase the success rates, and promote the outcomes. Besides, appropriate concepts can also help economical use of expensive technology or ... ...

Abstract	Appropriate concepts of reconstruction can eliminate contraindications, reduce the incidence of complications, increase the success rates, and promote the outcomes. Besides, appropriate concepts can also help economical use of expensive technology or assistant tools on the patients who are necessary and beneficial. This paper provides a comprehensive approach to select reconstructive methods for oral defects following ablative surgery. A comprehensive approach should have a thorough understanding of the reconstructive goals, the patient's information, the surgeon's ability, and the hospital's support. To achieve a basic structural and functional restoration of oral cavity, "reconstruction ladder" could be skipped to free flap transfer. Goal-oriented thinking process with rethinking the feasibility assessment can help the surgeon to find the most appropriate method of reconstruction. Appropriate methods can mostly achieve the above-average results and rarely lead to inadequate results. Current concepts for reconstruction of oral tissue are the balance between maximal outcome and minimal complication, maximal accuracy and minimal cost, maximal efficacy and minimal investment. A comprehensive approach to select flap, a reliable method to harvest flap, and a customized flap design/inset are keystones to achieve a relatively better outcome. The awesome of limitations from the surgeon's ability, hospital's support, and the patient's condition can minimize the complications.
Language	English
Publishing date	2022-03-10
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-022-01704-7
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