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  1. Article: Einsatz von diätetischen Kombipräparaten als Basismaßnahme bei Herzrhythmusstörungen

    Kuhl, T.

    Herzmedizin

    2022  Volume 38, Issue 5, Page(s) 38

    Language German
    Document type Article
    ZDB-ID 561578-1
    ISSN 0171-9238
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2206: Show issues Location:
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  2. Article: Learning with self-generated drawings and the impact of learners' emotional states.

    Navratil, Sabrina D / Kühl, Tim

    Frontiers in psychology

    2023  Volume 14, Page(s) 1286022

    Abstract: Introduction: The present study examined the influence of emotional states when learning with self-generated drawings. It was assumed that learners in a positive emotional state would profit from learning with self-generated drawings, while learners in ... ...

    Abstract Introduction: The present study examined the influence of emotional states when learning with self-generated drawings. It was assumed that learners in a positive emotional state would profit from learning with self-generated drawings, while learners in a negative emotional state would not profit from this strategy to the same extent but would rather benefit through reading.
    Methods: University students (
    Results: Results showed that learning with self-generated drawings was more beneficial for a following transfer test than learning without drawings - irrespective of a learner's emotional state. The quality of self-generated drawings predicted the learning outcomes of the retention and pictorial test, but not for transfer.
    Discussion: Missing effects of emotional states and the missing interaction with self-generated drawings will be discussed.
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1286022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Edman Degradation Reveals Unequivocal Analysis of the Disulfide Connectivity in Peptides and Proteins.

    Elsayed, Yomnah Y / Kühl, Toni / Imhof, Diana

    Analytical chemistry

    2024  Volume 96, Issue 10, Page(s) 4057–4066

    Abstract: Disulfide bridges in peptides and proteins play an essential role in maintaining their conformation, structural integrity, and consequently function. Despite ongoing efforts, it is still not possible to detect disulfide bonds and the connectivity of ... ...

    Abstract Disulfide bridges in peptides and proteins play an essential role in maintaining their conformation, structural integrity, and consequently function. Despite ongoing efforts, it is still not possible to detect disulfide bonds and the connectivity of multiply bridged peptides directly through a simple and sufficiently validated protein sequencing or peptide mapping method. Partial or complete reduction and chemical cysteine modification are required as initial steps, followed by the application of a proper detection method. Edman degradation (ED) has been used for primary sequence determination but is largely neglected since the establishment of mass spectrometry (MS)-based protein sequencing. Here, we evaluated and thoroughly characterized the phenyl thiohydantoin (PTH) cysteine derivatives PTH-S-methyl cysteine and PTH-S-carbamidomethyl cysteine as bioanalytical standards for cysteine detection and quantification as well as for the elucidation of the disulfide connectivity in peptides by ED. Validation of the established derivatives was performed according to the guidelines of the International Committee of Harmonization on bioanalytical method validation, and their analytical properties were confirmed as reference standards. A series of model peptides was sequenced to test the usability of the PTH-Cys-derivatives as standards, whereas the native disulfide-bonded peptides CCAP-vil, μ-conotoxin KIIIA, and human insulin were used as case studies to determine their disulfide bond connectivity completely independent of MS analysis.
    MeSH term(s) Humans ; Cysteine/chemistry ; Disulfides/chemistry ; Peptides/chemistry ; Proteins ; Amino Acid Sequence
    Chemical Substances Cysteine (K848JZ4886) ; Disulfides ; Peptides ; Proteins
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Book ; Thesis: Kompetitive Sorption, Diffusionsprozesse und Transport von Kationen in Böden

    Kuhl, Thomas

    experimentelle Erfassung und Modellierung von binären Stoffsystemen

    (Bonner bodenkundliche Abhandlungen ; 43)

    2005  

    Author's details Thomas Kuhl. Institut für Bodenkunde, Bonn. [Rheinische Friedrich-Wilhelms-Universität, Bonn]
    Series title Bonner bodenkundliche Abhandlungen ; 43
    Collection
    Subject code 631.417
    Language German
    Size VI, 264 S., graph. Darst., 21 cm
    Publisher Inst. für Bodenkunde
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2005
    HBZ-ID HT014750432
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    068/565 available for loan (reading room) Freihandmagazin (U1)

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  5. Book ; Audio / Video ; Online: The Challenge of Integrating Multiple Pesticide Residues in Consumer Risk Assessments.

    Kuhl, T.

    2015  

    Keywords ddc:610 ; Pesticide--Analytic--methods--Residues
    Language English
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book ; Audio / Video ; Online: The Challenge of Integrating Multiple Pesticide Residues in Consumer Risk Assessments.

    Kuhl, T.

    2015  

    Keywords Text ; ddc:610 ; Pesticide -- Analytic -- methods -- Residues
    Language English
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Comparative studies of soluble and immobilized Fe(III) heme-peptide complexes as alternative heterogeneous biocatalysts.

    Lukas, Joey / Družeta, Ivona / Kühl, Toni

    Biological chemistry

    2022  Volume 403, Issue 11-12, Page(s) 1099–1105

    Abstract: Fe(III) heme is known to possess low catalytic activity when exposed to hydrogen peroxide and a reducing substrate. Efficient non-covalently linked Fe(III) heme-peptide complexes may represent suitable alternatives as a new group of green catalysts. Here, ...

    Abstract Fe(III) heme is known to possess low catalytic activity when exposed to hydrogen peroxide and a reducing substrate. Efficient non-covalently linked Fe(III) heme-peptide complexes may represent suitable alternatives as a new group of green catalysts. Here, we evaluated a set of heme-peptide complexes by determination of their peroxidase-like activity and the kinetics of the catalytic conversion in both, the soluble and the immobilized state. We show the impact of peptide length on binding of the peptides to Fe(III) heme and the catalytic activity. Immobilization of the peptide onto a polymer support maintains the catalytic performance of the Fe(III) heme-peptide complex. This study thus opens up a new perspective with regard to the development of heterogeneous biocatalysts with a peroxidase-like activity.
    MeSH term(s) Heme/chemistry ; Ferric Compounds/chemistry ; Catalysis ; Peptides ; Peroxidases/chemistry ; Peroxidases/metabolism
    Chemical Substances Heme (42VZT0U6YR) ; Ferric Compounds ; Peptides ; Peroxidases (EC 1.11.1.-)
    Language English
    Publishing date 2022-10-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2022-0199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.50: Show issues Location:
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  8. Article ; Online: Patientin mit Morbus Parkinson und unklarer Somnolenz.

    Kuhl, Thomas

    Deutsche medizinische Wochenschrift (1946)

    2015  Volume 140, Issue 9, Page(s) 643, 689

    Title translation Patient with Parkinson's disease und unclear somnolence.
    MeSH term(s) Aged ; Coma/diagnosis ; Coma/etiology ; Diagnosis, Differential ; Facies ; Female ; Hashimoto Disease/complications ; Hashimoto Disease/diagnosis ; Humans ; Myxedema/complications ; Myxedema/diagnosis ; Parkinson Disease/complications ; Parkinson Disease/diagnosis
    Language German
    Publishing date 2015-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-0041-101568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Thesis ; Online: The response of the Baltic Sea sponge Halichondria panicea upon challenge with Vibrio bacteria

    Kuhl, Theresa

    2017  

    Language English
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Audio / Video ; Online: Das TTC - Konzept in der Risikobewertung von Pflanzenschutzmittel-Wirkstoffen und ihren Metaboliten

    Kuhl, T.

    2012  

    Keywords Risk Assessment ; TTC
    Language German
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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