Article ; Online: Diagnostic Testing for Chronic Granulomatous Disease.
Methods in molecular biology (Clifton, N.J.)
2019 Volume 1982, Page(s) 543–571
Abstract: Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency associated with recurrent bacterial infections, granulomas, and increased mortality. It is characterized by the inability of phagocytes (neutrophils, monocytes, etc.) to generate ... ...
Abstract | Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency associated with recurrent bacterial infections, granulomas, and increased mortality. It is characterized by the inability of phagocytes (neutrophils, monocytes, etc.) to generate reactive oxygen species (ROS), a major component of the microbicidal repertoire of phagocytes. Diagnosis of patients with CGD is commonly based on the assessment of ROS production by neutrophils. Multiple assays to assess ROS production are described-a flow cytometric dihydrorhodamine assay and a histochemical nitroblue tetrazolium assay, both of which can be used to visualize ROS production in individual cells, and two quantitative assays-O |
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MeSH term(s) | Biological Assay ; Biomarkers ; Flow Cytometry ; Granulomatous Disease, Chronic/diagnosis ; Granulomatous Disease, Chronic/etiology ; Granulomatous Disease, Chronic/metabolism ; Humans ; Molecular Diagnostic Techniques ; NADPH Oxidases/chemistry ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Neutrophils/immunology ; Neutrophils/metabolism ; Phagocytes/immunology ; Phagocytes/metabolism ; Reactive Oxygen Species/metabolism |
Chemical Substances | Biomarkers ; Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-) |
Language | English |
Publishing date | 2019-06-06 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural |
ISSN | 1940-6029 |
ISSN (online) | 1940-6029 |
DOI | 10.1007/978-1-4939-9424-3_33 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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