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Article ; Online: Effect of the Radial Velocity Distribution on the Loss Generation of a Contra-Rotating Fan in a Ventilation System

Xingyu Jia / Xi Zhang / Kui Guo / Xuehui Li

Entropy, Vol 25, Iss 433, p

2023 Volume 433

Abstract: Quantification of the loss generation of ducted contra-rotating fan (CRF) blades is difficult to achieve, since there are no guide vanes between rotors. A blade design program was established to investigate the relationship between radial velocity ... ...

Abstract	Quantification of the loss generation of ducted contra-rotating fan (CRF) blades is difficult to achieve, since there are no guide vanes between rotors. A blade design program was established to investigate the relationship between radial velocity distribution and incurred loss. Numerical and experimental techniques were used to confirm the optimal configuration’s overall performance. The relationship between loss and velocity distribution under the impact of spanwise load distribution was confirmed by the entropy contour from various perspectives. The appropriate radial velocity distribution can improve the operating efficiency of a CRF by reducing the entropy around the annulus under design and near-stall conditions. This regularity could provide some strategies in the design of contra-rotating blades.
Keywords	radial velocity distribution ; contra-rotating fan ; entropy production ; numerical simulation ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Subject code	532
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: 内蒙古草原区植被覆盖度时空演变及其驱动力.

Kui, Guo-Xian / Shi, Chang-Qing / Yang, Jian-Ying / Li, Rui-Peng / Wei, Guang-Kuo / Liu, Jia-Qi

Ying yong sheng tai xue bao = The journal of applied ecology

2023 Volume 34, Issue 10, Page(s) 2713–2722

Abstract: Inner Mongolia grassland is rich in natural vegetation and mineral resources. Based on Landsat5/7/8 NDVI data, we used pixel binary model to invert vegetation coverage of Inner Mongolia grassland area, investigated the stability, spatial distribution, ... ...

Title translation	Spatial-temporal variations of vegetation coverage and its driving force in Inner Mongolia grassland, China.
Abstract	Inner Mongolia grassland is rich in natural vegetation and mineral resources. Based on Landsat5/7/8 NDVI data, we used pixel binary model to invert vegetation coverage of Inner Mongolia grassland area, investigated the stability, spatial distribution, and future evolution trend of vegetation coverage by using Sen+MK and Hurst index, and analyzed the driving factors of the spatial differentiation of vegetation coverage by the optimal parameters-based geographical detector. The results showed that vegetation coverage of Inner Mongolia grassland showed an increasing trend from 2006 to 2020, and the overall spatial pattern was high in the east and low in the west, mainly with great fluctuation. The regions with slight or obvious improvement characteristics (64.8%) were much more than those with slight or severe degradation characteristics (23.2%). Compared with that in the past 15 years, the proportion of degraded vegetation in the future is expected to increase to 36.6%. The central part of Xilin Gol League and Wulanqab in the central grassland area, the western part of Hulunbuir and Erdos in the eastern grassland area, and Wuhai in the western grassland area were at the risk of degradation, which should be paid more attention. Precipitation was the dominant factor of spatial differentiation in Inner Mongolia grassland, while soil type, land use, and air temperature had the most significant synergistic effect.
MeSH term(s)	Grassland ; Temperature ; China ; Forecasting ; Soil ; Ecosystem
Chemical Substances	Soil
Language	Chinese
Publishing date	2023-10-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202310.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Purification and fermentation characteristics of exopolysaccharide from Fomitopsis castaneus Imaz

Wen-kui, Guo / Chi Yu-Jie

International journal of biological macromolecules. 2017,

2017

Abstract: Short-chain fatty acids (SCFAs), which are the end products of carbohydrate fermentation in the gut, mainly contribute to energy metabolism in mammals. The amount of SCFAs produced during fermentation is an important parameter that characterizes the ... ...

Abstract	Short-chain fatty acids (SCFAs), which are the end products of carbohydrate fermentation in the gut, mainly contribute to energy metabolism in mammals. The amount of SCFAs produced during fermentation is an important parameter that characterizes the fermentation capacity of a system. This paper reports on the fermentation characteristics of exopolysaccharides (EPS) isolated from Fomitopsis castaneus Imaz, a wood-rot fungal species. We isolated and purified the main EPS fraction by freeze drying and DEAE-Sepharose fast flow chromatography. We then analyzed the monosaccharide composition of EPS. The isolated EPS was mainly composed of glucose, galactose, rhamnose, mannose, and arabinose. The characteristic absorption peaks of sugar esters were also detected. Fresh fecal extracts from healthy adults and children were used as fermentation substrate to simulate the human intestinal environment (anaerobic conditions at 37Â°C) and study the fermentation characteristics of the purified EPS. Adding the isolated EPS to the fermentation system of the simulated intestinal environment increased the SCFAs content in the fecal extract of adults and children. However, the yield of SCFAs, particularly butyric acid, in the fermentation system of fecal extract in children was higher than that in adults. Furthermore, adding exogenous lactic acid bacteria, such as Enterococcus fecalis and Enterococcus fecium, to the fermentation system effectively increased the SCFAs concentration in the model intestinal system of the children. By contrast, adding E. fecalis, Lactobacillus rhamnosus, and E. fecium increased the content of the produced SCFAs in the system of adults. Those results indicate that EPS isolated from F. castaneus Imaz was effectively fermented in the simulated intestinal environments, and the fermentation capability was enhanced by adding microbial flora.
Keywords	Enterococcus faecium ; Fomitopsis ; Lactobacillus rhamnosus ; absorption ; adults ; anaerobic conditions ; arabinose ; butyric acid ; children ; chromatography ; digestive system ; exopolysaccharides ; feces ; fermentation ; freeze drying ; fungi ; galactose ; glucose ; humans ; lactic acid bacteria ; mannose ; models ; rhamnose
Language	English
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2017.06.128
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China

Yongzhang Zhu / Li Shi / Yige Zeng / Dongri Piao / Yingbo Xie / Juan Du / Meng Gao / Wei Gao / Junli Tian / Jun Yue / Min Li / XiaoKui Guo / Yufeng Yao / YaoXia Kang

Infectious Diseases of Poverty, Vol 11, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Background Brucellosis poses a serious threat to human and animal health, particularly in developing countries such as China. The Inner Mongolia Autonomous Region is one of the most severely brucellosis-endemic provinces in China. Currently, the ...

Abstract	Abstract Background Brucellosis poses a serious threat to human and animal health, particularly in developing countries such as China. The Inner Mongolia Autonomous Region is one of the most severely brucellosis-endemic provinces in China. Currently, the host immune responses functioning to control Brucella infection and development remain poorly understood. The aim of this study is to further clarify the key immunity characteristics of diverse stages of brucellosis in Inner Mongolia. Methods We collected a total of 733 blood samples from acute (n = 137), chronic (n = 316), inapparent (n = 35), recovery (n = 99), and healthy (n = 146) groups from the rural community of Inner Mongolia between 2014 and 2015. The proportions of CD4+, CD8+, Th1, Th2, and Th17 T cells in peripheral blood and the expression of TLR2 and TLR4 in lymphocytes, monocytes and granulocytes were examined using flow cytometry analysis. The differences among the five groups were compared using one-way ANOVA and the Kruskal–Wallis method, respectively. Results Our results revealed that the proportions of CD4+ and CD8+ T cells were significantly different among the acute, chronic, recovery, and healthy control groups (P < 0.05), with lower proportions of CD4+ T cells and a higher proportion of CD8+ T cells in the acute, chronic, and recovery groups. The proportion of Th1 cells in the acute, chronic, and inapparent groups was higher than that in the healthy and recovery groups; however, there was no significant difference between patients and healthy individuals (P > 0.05). The proportion of Th2 lymphocytes was significantly higher in the acute and healthy groups than in the inapparent group (P < 0.05). The proportion of Th17 cells in the acute group was significantly higher than that in the healthy control, chronic, and inapparent groups (P < 0.05). Finally, the highest expression of TLR4 in lymphocytes, monocytes and granulocytes was observed in the recovery group, and this was followed by the acute, chronic, healthy control, and ...
Keywords	Human brucellosis ; CD4+ T cells ; CD8+ T cells ; Th cells ; TLR2 ; TLR4 ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework

Duofang Chen / Jimin Liang / Kui Guo

Computational and Mathematical Methods in Medicine, Vol

2015 Volume 2015

Abstract: By recording a time series of tomographic images, dynamic fluorescence molecular tomography (FMT) allows exploring perfusion, biodistribution, and pharmacokinetics of labeled substances in vivo. Usually, dynamic tomographic images are first reconstructed ...

Abstract	By recording a time series of tomographic images, dynamic fluorescence molecular tomography (FMT) allows exploring perfusion, biodistribution, and pharmacokinetics of labeled substances in vivo. Usually, dynamic tomographic images are first reconstructed frame by frame, and then unmixing based on principle component analysis (PCA) or independent component analysis (ICA) is performed to detect and visualize functional structures with different kinetic patterns. PCA and ICA assume sources are statistically uncorrelated or independent and don’t perform well when correlated sources are present. In this paper, we deduce the relationship between the measured imaging data and the kinetic patterns and present a temporal unmixing approach, which is based on nonnegative blind source separation (BSS) method with a convex analysis framework to separate the measured data. The presented method requires no assumption on source independence or zero correlations. Several numerical simulations and phantom experiments are conducted to investigate the performance of the proposed temporal unmixing method. The results indicate that it is feasible to unmix the measured data before the tomographic reconstruction and the BSS based method provides better unmixing quality compared with PCA and ICA.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	006
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reducing Liver Fat by Low Carbohydrate Caloric Restriction Targets Hepatic Glucose Production in Non-Diabetic Obese Adults with Non-Alcoholic Fatty Liver Disease

Haoyong Yu / Weiping Jia / ZengKui Guo

Journal of Clinical Medicine, Vol 3, Iss 3, Pp 1050-

2014 Volume 1063

Abstract: Non-alcoholic fatty liver disease (NAFLD) impairs liver functions, the organ responsible for the regulation of endogenous glucose production and thus plays a key role in glycemic homeostasis. Therefore, interventions designed to normalize liver fat ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) impairs liver functions, the organ responsible for the regulation of endogenous glucose production and thus plays a key role in glycemic homeostasis. Therefore, interventions designed to normalize liver fat content are needed to improve glucose metabolism in patients affected by NAFLD such as obesity. Objective: this investigation is designed to determine the effects of caloric restriction on hepatic and peripheral glucose metabolism in obese humans with NAFLD. Methods: eight non-diabetic obese adults were restricted for daily energy intake (800 kcal) and low carbohydrate (<10%) for 8 weeks. Body compositions, liver fat and hepatic glucose production (HGP) and peripheral glucose disposal before and after the intervention were determined. Results: the caloric restriction reduced liver fat content by 2/3 (p = 0.004). Abdominal subcutaneous and visceral fat, body weight, BMI, waist circumference and fasting plasma triglyceride and free fatty acid concentrations all significantly decreased (p < 0.05). The suppression of post-load HGP was improved by 22% (p = 0.002) whereas glucose disposal was not affected (p = 0.3). Fasting glucose remained unchanged and the changes in the 2-hour plasma glucose and insulin concentration were modest and statistically insignificant (p > 0.05). Liver fat is the only independent variable highly correlated to HGP after the removal of confounders. Conclusion: NAFLD impairs HGP but not peripheral glucose disposal; low carbohydrate caloric restriction effectively lowers liver fat which appears to directly correct the HGP impairment.
Keywords	obesity ; caloric restriction ; liver fat ; hepatic glucose production ; glucose disposal ; Medicine ; R
Subject code	670 ; 610
Language	English
Publishing date	2014-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PRL2 serves as a negative regulator in cell adaptation to oxidative stress

Xinyue Du / Yang Zhang / Xiao Li / Qi Li / Chenyun Wu / Guangjie Chen / XiaoKui Guo / Yongqiang Weng / Zhaojun Wang

Cell & Bioscience, Vol 9, Iss 1, Pp 1-

2019 Volume 11

Abstract: Abstract High levels of ROS cause oxidative stress, which plays a critical role in cell death. As a ROS effector protein, PRL2 senses ROS and controls phagocyte bactericidal activity during infection. Here we report PRL2 regulates oxidative stress ... ...

Abstract	Abstract High levels of ROS cause oxidative stress, which plays a critical role in cell death. As a ROS effector protein, PRL2 senses ROS and controls phagocyte bactericidal activity during infection. Here we report PRL2 regulates oxidative stress induced cell death. PRL2 senses oxidative stress via highly reactive cysteine residues at 46 and 101. The oxidation of PRL2 causes protein degradation and supports pro-survival PDK1/AKT signal which in turn to protect cells against oxidative stress. As a result, PRL2 levels have a high correlation with oxidative stress induced cell death. In vivo experiments showed PRL2 deficient cells survive better in inflammatory oxidative environment and resist to ionizing radiation. Our finding suggests PRL2 serves as a negative regulator in cell adaptation to oxidative stress. Therefore, PRL2 could be targeted to modulate cell viability in inflammation or irradiation associated therapy.
Keywords	PRL2 ; Oxidative stress ; Cell death ; Inflammation ; Ionizing radiation ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: China's application of the One Health approach in addressing public health threats at the human-animal-environment interface

Jing-Shu Liu / Xin-Chen Li / Qi-Yu Zhang / Le-Fei Han / Shang Xia / Kokouvi Kassegne / Yong-Zhang Zhu / Kun Yin / Qin-Qin Hu / Le-Shan Xiu / Xiang-Cheng Wang / Odel Y. Li / Min Li / Zheng-Bin Zhou / Ke Dong / Lu He / Shu-Xun Wang / Xue-Chen Yang / Yan Zhang /

Xiao-Kui Guo / Shi-Zhu Li / Xiao-Nong Zhou / Xiao-Xi Zhang

One Health, Vol 17, Iss , Pp 100607- (2023)

Advances and challenges

2023

Abstract: Background: Due to emerging issues such as global climate change and zoonotic disease pandemics, the One Health approach has gained more attention since the turn of the 21st century. Although One Health thinking has deep roots and early applications in ... ...

Abstract	Background: Due to emerging issues such as global climate change and zoonotic disease pandemics, the One Health approach has gained more attention since the turn of the 21st century. Although One Health thinking has deep roots and early applications in Chinese history, significant gaps exist in China's real-world implementation at the complex interface of the human-animal-environment. Methods: We abstracted the data from the global One Health index study and analysed China's performance in selected fields based on Structure-Process-Outcome model. By comparing China to the Belt & Road and G20 countries, the advances and gaps in China's One Health performance were determined and analysed. Findings: For the selected scientific fields, China generally performs better in ensuring food security and controlling antimicrobial resistance and worse in addressing climate change. Based on the SPO model, the “structure” indicators have the highest proportion (80.00%) of high ranking and the “outcome” indicators have the highest proportion (20.00%) of low ranking. When compared with Belt and Road countries, China scores above the median in almost all indicators (16 out of 18) under the selected scientific fields. When compared with G20 countries, China ranks highest in food security (scores 72.56 and ranks 6th), and lowest in climate change (48.74, 11th). Conclusion: Our results indicate that while China has made significant efforts to enhance the application of the One Health approach in national policies, it still faces challenges in translating policies into practical measures. It is recommended that a holistic One Health action framework be established for China in accordance with diverse social and cultural contexts, with a particular emphasis on overcoming data barriers and mobilizing stakeholders both domestically and globally. Implementation mechanisms, with clarified stakeholder responsibilities and incentives, should be improved along with top-level design.
Keywords	One Health ; China ; Zoonotic diseases ; Food security ; Antimicrobial resistance ; Climate change ; Medicine (General) ; R5-920
Subject code	950
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effects of initial participation motivations on learning engagement in transition training for future general practitioners in rural China

Guan-yu Cui / Mei-lin Yao / Xia Zhang / Yan-kui Guo / Hui-min Li / Xiu-ping Yao

Medical Education Online, Vol 21, Iss 0, Pp 1-

perceived deterrents as mediator

2016 Volume 8

Abstract: Background: For the shortage of high-quality general practitioners (GPs) in China's rural areas, Chinese government has taken steps to encourage rural specialists to participate in transition training for future GPs. Specialists’ initial participation ... ...

Abstract	Background: For the shortage of high-quality general practitioners (GPs) in China's rural areas, Chinese government has taken steps to encourage rural specialists to participate in transition training for future GPs. Specialists’ initial participation motivations and their perceived deterrents during training may play important roles for their learning engagement in the transition training. This study aimed at revealing the relationships among the variables of initial participation motivations, perceived deterrents in training, and learning engagement. Methods: A questionnaire survey was used in this study. A total of 156 rural specialists who participated in transition training for future GPs filled out the questionnaire, which consisted of the measurements of initial participation motivations, perceived deterrents, and learning engagement in training. The data about specialists’ demographic variables were collected at the same time. Results: The variance of initial escape/stimulations motivation significantly predicted the variance of learning engagement through the full mediating role of perceived deterrents in training. In addition, initial educational preparation motivations predicted the variance of learning engagement directly. Conclusions: Specialists’ initial participation motivations and perceived deterrents in training played important roles for learning engagement in the transition training.
Keywords	transition training ; general practice ; initial participation motivations ; perceived deterrents in training ; learning engagement ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
Subject code	370
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals

Fei-Fei Gu / Ye Chen / De-Ping Dong / Zhen Song / Xiao-Kui Guo / Yu-Xing Ni / Li-Zhong Han

Chinese Medical Journal, Vol 129, Iss 19, Pp 2319-

2016 Volume 2324

Abstract: Background: Staphylococcus aureus is one of the predominant causes of skin and soft tissue infections (SSTIs), but limited data were available regarding the characterization of S. aureus from SSTIs patients in Jiangsu Province in China. We aimed to ... ...

Abstract	Background: Staphylococcus aureus is one of the predominant causes of skin and soft tissue infections (SSTIs), but limited data were available regarding the characterization of S. aureus from SSTIs patients in Jiangsu Province in China. We aimed to investigate the molecular epidemiology of S. aureus among SSTIs patients in two hospitals of Jiangsu Province. Methods: Sixty-two patients with SSTIs from two Chinese hospitals in Jiangsu Province were enrolled in this study, and 62 S. aureus isolates were collected from February 2014 to January 2015. S. aureus isolates were characterized by antimicrobial susceptibility testing, toxin gene detection, and molecular typing with sequence type, Staphylococcus protein A gene type, accessory gene regulator (agr) group, and Staphylococcal cassette chromosome mec t ype. Results: Sixteen (25.8%) methicillin-resistant S. aureus (MRSA) isolates were detected, and there was no isolate found resistant to vancomycin, teicoplanin, sulfamethoxazole-trimethoprim, and linezolid. The sei was the toxin gene most frequently found, and no lukS/F-PV-positive isolates were detected among the SSTIs' patients. Molecular analysis revealed that ST398 (10/62, 16.1%; 2 MRSA and 8 methicillin-susceptible S. aureus) to be the dominant clone, followed by ST5 (8/62, 12.9%) and ST7 (8/62, 12.9%). Conclusions: The livestock ST398 was the most common clone among patients with S. aureus SSTIs in Jiangsu Province, China. Surveillance and further studies on the important livestock ST398 clone in human infections are necessarily requested.
Keywords	Livestock ; Molecular Epidemiology ; Skin and Soft Tissue Infections ; ST398 ; Staphylococcus aureus ; Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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