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  1. Article ; Online: Distinct dynamics of antigen-specific induction and differentiation of different CD11c

    Steuten, Juulke / Bos, Amélie V / Kuijper, Lisan H / Claireaux, Mathieu / Olijhoek, Wouter / Elias, George / Duurland, Mariel C / Jorritsma, Tineke / Marsman, Casper / Paul, Alberta G A / Garcia Vallejo, Juan J / van Gils, Marit J / Wieske, Luuk / Kuijpers, Taco W / Eftimov, Filip / van Ham, S Marieke / Ten Brinke, Anja

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 3, Page(s) 689–699.e6

    Abstract: Background: CD11c: Objectives: We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-specific development and differentiation properties of 3 separate CD11c: Methods: Dynamics of the response of the 3 CD11c: ... ...

    Abstract Background: CD11c
    Objectives: We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-specific development and differentiation properties of 3 separate CD11c
    Methods: Dynamics of the response of the 3 CD11c
    Results: In contrast to a durable expansion of antigen-specific CD11c
    Conclusion: Overall, CD11c
    MeSH term(s) Humans ; B-Lymphocyte Subsets ; COVID-19 Vaccines ; COVID-19 ; SARS-CoV-2 ; Cell Differentiation
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.92: Show issues Location:
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  2. Article ; Online: T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination.

    Verstegen, Niels J M / Hagen, Ruth R / Kreher, Christine / Kuijper, Lisan H / Dijssel, Jet van den / Ashhurst, Thomas / Kummer, Laura Y L / Palomares Cabeza, Virginia / Steenhuis, Maurice / Duurland, Mariël C / Jongh, Rivka de / Schoot, C Ellen van der / Konijn, Veronique A L / Mul, Erik / Kedzierska, Katherine / van Dam, Koos P J / Stalman, Eileen W / Boekel, Laura / Wolbink, Gertjan /
    Tas, Sander W / Killestein, Joep / Rispens, Theo / Wieske, Luuk / Kuijpers, Taco W / Eftimov, Filip / van Kempen, Zoé L E / van Ham, S Marieke / Ten Brinke, Anja / van de Sandt, Carolien E

    Journal of neurology, neurosurgery, and psychiatry

    2024  

    Abstract: Background: Messenger RNA (mRNA) vaccines provide robust protection against SARS-CoV-2 in healthy individuals. However, immunity after vaccination of patients with multiple sclerosis (MS) treated with ocrelizumab (OCR), a B cell-depleting anti-CD20 ... ...

    Abstract Background: Messenger RNA (mRNA) vaccines provide robust protection against SARS-CoV-2 in healthy individuals. However, immunity after vaccination of patients with multiple sclerosis (MS) treated with ocrelizumab (OCR), a B cell-depleting anti-CD20 monoclonal antibody, is not yet fully understood.
    Methods: In this study, deep immune profiling techniques were employed to investigate the immune response induced by SARS-CoV-2 mRNA vaccines in untreated patients with MS (n=21), OCR-treated patients with MS (n=57) and healthy individuals (n=30).
    Results: Among OCR-treated patients with MS, 63% did not produce detectable levels of antibodies (non-seroconverted), and those who did have lower spike receptor-binding domain-specific IgG responses compared with healthy individuals and untreated patients with MS. Before vaccination, no discernible immunological differences were observed between non-seroconverted and seroconverted OCR-treated patients with MS. However, non-seroconverted patients received overall more OCR infusions, had shorter intervals since their last OCR infusion and displayed higher OCR serum concentrations at the time of their initial vaccination. Following two vaccinations, non-seroconverted patients displayed smaller B cell compartments but instead exhibited more robust activation of general CD4
    Conclusion: These findings highlight the importance of optimising treatment regimens when scheduling SARS-CoV-2 vaccination for OCR-treated patients with MS to maximise their humoral and cellular immune responses. This study provides valuable insights for optimising vaccination strategies in OCR-treated patients with MS, including the identification of CD38 and HLA-DR as potential markers to explore vaccine efficacy in non-seroconverting OCR-treated patients with MS.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2023-332224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.93: Show issues Location:
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  3. Article ; Online: mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8

    van den Dijssel, Jet / Duurland, Mariël C / Konijn, Veronique Al / Kummer, Laura Yl / Hagen, Ruth R / Kuijper, Lisan H / Wieske, Luuk / van Dam, Koos Pj / Stalman, Eileen W / Steenhuis, Maurice / Geerdes, Dionne M / Mok, Juk Yee / Kragten, Angela Hm / Menage, Charlotte / Koets, Lianne / Veldhuisen, Barbera / Verstegen, Niels Jm / van der Schoot, C Ellen / van Esch, Wim Je /
    D'Haens, Geert Ram / Löwenberg, Mark / Volkers, Adriaan G / Rispens, Theo / Kuijpers, Taco W / Eftimov, Filip / van Gisbergen, Klaas Pjm / van Ham, S Marieke / Ten Brinke, Anja / van de Sandt, Carolien E

    Journal of autoimmunity

    2024  Volume 144, Page(s) 103175

    Abstract: SARS-CoV-2-specific ... ...

    Abstract SARS-CoV-2-specific CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; SARS-CoV-2 ; 2019-nCoV Vaccine mRNA-1273 ; Tumor Necrosis Factor Inhibitors ; COVID-19 ; Vaccination ; Antibodies ; Inflammatory Bowel Diseases/drug therapy ; Antibodies, Viral
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; Tumor Necrosis Factor Inhibitors ; Antibodies ; Antibodies, Viral
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2024.103175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273.

    Verstegen, Niels J M / Hagen, Ruth R / van den Dijssel, Jet / Kuijper, Lisan H / Kreher, Christine / Ashhurst, Thomas / Kummer, Laura Y L / Steenhuis, Maurice / Duurland, Mariel / de Jongh, Rivka / de Jong, Nina / van der Schoot, C Ellen / Bos, Amélie V / Mul, Erik / Kedzierska, Katherine / van Dam, Koos P J / Stalman, Eileen W / Boekel, Laura / Wolbink, Gertjan /
    Tas, Sander W / Killestein, Joep / van Kempen, Zoé L E / Wieske, Luuk / Kuijpers, Taco W / Eftimov, Filip / Rispens, Theo / van Ham, S Marieke / Ten Brinke, Anja / van de Sandt, Carolien E

    eLife

    2022  Volume 11

    Abstract: Background: Patients affected by different types of autoimmune diseases, including common conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated with immunosuppressants to suppress disease activity. It is not fully ... ...

    Abstract Background: Patients affected by different types of autoimmune diseases, including common conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated with immunosuppressants to suppress disease activity. It is not fully understood how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific humoral and cellular immunity induced by infection and/or upon vaccination is affected by immunosuppressants.
    Methods: The dynamics of cellular immune reactivation upon vaccination of SARS-CoV-2 experienced MS patients treated with the humanized anti-CD20 monoclonal antibody ocrelizumab (OCR) and RA patients treated with methotrexate (MTX) monotherapy were analyzed at great depth via high-dimensional flow cytometry of whole blood samples upon vaccination with the SARS-CoV-2 mRNA-1273 (Moderna) vaccine. Longitudinal B and T cell immune responses were compared to SARS-CoV-2 experienced healthy controls (HCs) before and 7 days after the first and second vaccination.
    Results: OCR-treated MS patients exhibit a preserved recall response of CD8
    Conclusions: Together, these findings indicate that SARS-CoV-2 experienced MS-OCR patients may still benefit from vaccination by inducing a broad CD8
    Funding: This research project was supported by ZonMw (The Netherlands Organization for Health Research and Development, #10430072010007), the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement (#792532 and #860003), the European Commission (SUPPORT-E, #101015756) and by PPOC (#20_21 L2506), the NHMRC Leadership Investigator Grant (#1173871).
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; Antibodies, Viral ; Arthritis, Rheumatoid/drug therapy ; CD8-Positive T-Lymphocytes ; COVID-19/prevention & control ; Humans ; Immunosuppressive Agents/therapeutic use ; Multiple Sclerosis/drug therapy ; SARS-CoV-2 ; Vaccination ; Viral Vaccines/genetics
    Chemical Substances Antibodies, Viral ; Immunosuppressive Agents ; Viral Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.77969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Glioblastomas exploit truncated O

    Dusoswa, Sophie A / Verhoeff, Jan / Abels, Erik / Méndez-Huergo, Santiago P / Croci, Diego O / Kuijper, Lisan H / de Miguel, Elena / Wouters, Valerie M C J / Best, Myron G / Rodriguez, Ernesto / Cornelissen, Lenneke A M / van Vliet, Sandra J / Wesseling, Pieter / Breakefield, Xandra O / Noske, David P / Würdinger, Thomas / Broekman, Marike L D / Rabinovich, Gabriel A / van Kooyk, Yvette /
    Garcia-Vallejo, Juan J

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 7, Page(s) 3693–3703

    Abstract: Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of immune ...

    Abstract Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of immune suppression and resistance to immunotherapy. We and others demonstrated aberrant expression of glycans in different cancer types. These tumor-associated glycans trigger inhibitory signaling in TAMs through glycan-binding receptors. We investigated the glioblastoma glycocalyx as a tumor-intrinsic immune suppressor. We detected increased expression of both tumor-associated truncated O-linked glycans and their receptor, macrophage galactose-type lectin (MGL), on CD163
    MeSH term(s) Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/immunology ; Asialoglycoproteins/chemistry ; Asialoglycoproteins/genetics ; Asialoglycoproteins/immunology ; Glioblastoma/genetics ; Glioblastoma/immunology ; Humans ; Lectins, C-Type/chemistry ; Lectins, C-Type/genetics ; Lectins, C-Type/immunology ; Macrophages/immunology ; Male ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Mice ; Mice, Inbred C57BL ; Microglia/immunology ; Polysaccharides/chemistry ; Polysaccharides/immunology ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/immunology
    Chemical Substances Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Asialoglycoproteins ; CD163 antigen ; Clec10a protein, mouse ; Lectins, C-Type ; Membrane Proteins ; Polysaccharides ; Receptors, Cell Surface
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1907921117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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