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  1. Book ; Online ; E-Book: Environmental toxicology and ecosystem

    Kumar, Ashutosh

    2023  

    Abstract: This book covers varied aspects of environmental contaminants and their effect on the living organisms. It addresses the basics of ecotoxicity assessment, interaction of the abiotic or biotic factors with the novel chemical entities, and the fate of the ...

    Author's details edited by Ashutosh Kumar
    Abstract "This book covers varied aspects of environmental contaminants and their effect on the living organisms. It addresses the basics of ecotoxicity assessment, interaction of the abiotic or biotic factors with the novel chemical entities, and the fate of the natural organic matter upon interaction with new chemical entities. It further includes models for ecotoxicity studies and high-throughput approaches including OMICS. It provides an overview of the ecological risk assessment, regulatory toxicology guidelines, and possible roadmaps for protection of environmental health. Features: Discusses environmental toxicology facets and their effects on the ecosystem. Provides an introduction of environmental toxicology keeping in view the paradigm shift on entry of novel materials in the environment. Includes bioavailability, bioconcentration, and biomagnification of trophic transfer of pollutants. Covers high-throughput approaches for ecotoxicity assessment. Explores roadmaps for environmental protection and sustainable development. This book is geared toward graduate students and researchers in Environmental Sciences and Engineering, Toxicology, and Ecology."--Provided by publisher.
    Keywords Ecosystem health ; Environmental toxicology
    Subject code 577
    Language English
    Size 1 online resource (xiii, 290 pages) :, illustrations (chiefly colour), colour portrait
    Edition First edition.
    Publisher CRC Press
    Publishing place Boca Raton, Florida ; London ; New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-324434-3 ; 1-000-81149-2 ; 1-003-24434-3 ; 1-000-81152-2 ; 9781032154947 ; 978-1-00-324434-9 ; 978-1-000-81149-0 ; 978-1-003-24434-9 ; 978-1-000-81152-0 ; 1032154942
    DOI 10.1201/9781003244349
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Bacterial survival in the hostile environment

    Kumar, Ashutosh / Tenguria, Shivendra

    (Developments in applied microbiology and biotechnology)

    2023  

    Author's details edited by Ashutosh Kumar and Shivendra Tenguria
    Series title Developments in applied microbiology and biotechnology
    Keywords Bacterial diseases ; Host-bacteria relationships
    Subject code 616.92
    Language English
    Size 1 online resource (xviii, 256 pages) :, colour illustrations.
    Publisher Elsevier
    Publishing place London, England ; San Diego, California
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-97220-9 ; 9780323918060 ; 978-0-323-97220-8 ; 0323918069
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: PubExN: An Automated PubMed Bulk Article Extractor with Affiliation Normalization Package.

    Kumar, Ashutosh / Sharaff, Aakanksha

    SN computer science

    2023  Volume 4, Issue 4, Page(s) 353

    Abstract: Biomedical article extraction is the preliminary step for every biomedical application. These applications are helpful in finding the gene, disease, chemical, drugs, protein entities. Finding entities relation such as gene-gene entities, drug-disease ... ...

    Abstract Biomedical article extraction is the preliminary step for every biomedical application. These applications are helpful in finding the gene, disease, chemical, drugs, protein entities. Finding entities relation such as gene-gene entities, drug-disease interaction, and chemical protein relation the PubExN can be helpful for these types of biomedical applications. In most cases, domain experts do this extraction process on their own. Human interference makes this process time-consuming and there is a high probability, that documents can be missed during the extraction process. To get rid of these complicated processes a python package is introduced to automate the process of bulk extraction from the PubMed database. The extraction process covers all the citation information with the associated abstract. The batch approach is used to extract the bulk extraction. The motivation for the development of PubExN was to provide flexibility for the extraction process of biomedical article's text data from NCBI's PubMed database. Basically, NCBI's PubMed database article contains the article id or can say PubMed-id (PMID), the title of the article, abstract, authors information, etc. This package will benefit many biomedical texts mining research including biomedical named entity recognition, biomedical relation extraction, literature discovery, knowledgebase creation, and various biomedical Natural Language Processing (NLP) tasks. In addition, it could be used in the author name disambiguation problems and new drug discoveries. This package will help save time and extra effort for the extraction and normalization process of PubMed articles.
    Language English
    Publishing date 2023-04-26
    Publishing country Singapore
    Document type Journal Article
    ISSN 2661-8907
    ISSN (online) 2661-8907
    DOI 10.1007/s42979-023-01687-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of seasonal and spatial distribution of particulate matters and gaseous pollutants around an open cast coal mining area of Odisha, India.

    Sharma, Rajat / Kumar, Ashutosh

    Environmental science and pollution research international

    2023  Volume 30, Issue 14, Page(s) 39842–39856

    Abstract: Open cast mining - a predominant method of coal production in India (94.46% of total coal production) - has been found to be a major factor which is responsible for the emission of dust particles and gaseous pollutants, leading to the deterioration of ... ...

    Abstract Open cast mining - a predominant method of coal production in India (94.46% of total coal production) - has been found to be a major factor which is responsible for the emission of dust particles and gaseous pollutants, leading to the deterioration of air quality in the coal mining area. Considering the health concerns and environmental impacts of these pollutants, the inhabited villages of Ib valley coalfield area of Orisha, India, were selected for this study. In this regard, various researchers have performed the analysis of air quality data and modeling for the dispersion of pollutants. However, a long-term study on spatial and seasonal variations of air pollutants and their relationship with meteorological parameters were missing in the literature. Accordingly, the spatial and seasonal variations of air pollutants in the area were assessed for a period of six years (2014 - 2020), and concentrations of PM
    MeSH term(s) Particulate Matter/analysis ; Coal Mining ; Seasons ; Environmental Pollutants/analysis ; Environmental Monitoring/methods ; Air Pollutants/analysis ; Air Pollution/analysis ; Sulfur Dioxide/analysis ; India ; Coal/analysis
    Chemical Substances Particulate Matter ; Environmental Pollutants ; Air Pollutants ; Sulfur Dioxide (0UZA3422Q4) ; Coal
    Language English
    Publishing date 2023-01-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-25034-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Determinants of quantification of tourism waste in the hilly terrain of Himalayas: A spatial approach.

    Sharma, Rajat / Kumar, Ashutosh

    Waste management (New York, N.Y.)

    2023  Volume 166, Page(s) 46–57

    Abstract: The rapid economic development in environmentally sensitive zone of Himalayas resulted in the increased generation of tourism waste. However, the accounting methodology for accumulation of tourism waste in the hilly terrain was found to be missing. ... ...

    Abstract The rapid economic development in environmentally sensitive zone of Himalayas resulted in the increased generation of tourism waste. However, the accounting methodology for accumulation of tourism waste in the hilly terrain was found to be missing. Accordingly, the socio-economic factors influencing the tourism waste generation were identified, and their correlation analysis was performed. The tourism waste generated within and outside an urban local body was quantified over a period of 12 years (2008-2019) using a novel methodology, considering the socioeconomic factors, such as economic significance, geographical terrain, location of tourist destinations and tourism-related activities. The spatial dependency of tourism waste accumulation in the Himalayan state of Himachal Pradesh, India was analyzed using the geographically weighted regression. Furthermore, the air pollutants' emission (PM
    MeSH term(s) Tourism ; Air Pollutants/analysis ; Socioeconomic Factors ; Economic Development ; India
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2001471-5
    ISSN 1879-2456 ; 0956-053X
    ISSN (online) 1879-2456
    ISSN 0956-053X
    DOI 10.1016/j.wasman.2023.04.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is Expectant Management Noninferior to Early Ibuprofen for Patent Ductus Arteriosus?: Evidence-based Medicine Viewpoint.

    Kumar, Ashutosh / Dutta, Sourabh

    Indian pediatrics

    2023  Volume 60, Issue 6, Page(s) 488–489

    MeSH term(s) Infant, Newborn ; Humans ; Ibuprofen/therapeutic use ; Ductus Arteriosus, Patent/drug therapy ; Watchful Waiting ; Infant, Premature ; Persistent Fetal Circulation Syndrome ; Evidence-Based Medicine
    Chemical Substances Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2023-06-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Artificial Intelligence Technologies used for the Assessment of Pharmaceutical Excipients.

    Kumar, Ashutosh / Gupta, Ghanshyam Das / Raikwar, Sarjana

    Current pharmaceutical design

    2024  

    Language English
    Publishing date 2024-01-29
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128285827240119095013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Rare Tumor at an Unusual Site with a Rare Association.

    Goyal, Pratika / Meena, Dilip / Kumar, Ashutosh

    Indian dermatology online journal

    2024  Volume 15, Issue 2, Page(s) 363–365

    Language English
    Publishing date 2024-02-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2585814-2
    ISSN 2249-5673 ; 2229-5178
    ISSN (online) 2249-5673
    ISSN 2229-5178
    DOI 10.4103/idoj.idoj_466_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Idiopathic membranous nephropathy and synchronous mononeuritis multiplex secondary to idiopathic small vessel vasculitis.

    Jayanatha, Kalpa / Kumar, Ashutosh / Sapsford, Mark / Simpson, Mark

    BMJ case reports

    2024  Volume 17, Issue 2

    Abstract: Membranous nephropathy has been associated with demyelinating polyneuropathies and antiglomerular membrane disease; however, an association with vasculitic neuropathy has not been described. This case describes a patient with biopsy-proven idiopathic ... ...

    Abstract Membranous nephropathy has been associated with demyelinating polyneuropathies and antiglomerular membrane disease; however, an association with vasculitic neuropathy has not been described. This case describes a patient with biopsy-proven idiopathic membranous nephropathy and synchronous mononeuritis multiplex secondary to idiopathic small vessel vasculitis, who presented with lower limb microvascular ischaemia, peripheral neuropathy and active urinary sediment. Her extensive non-invasive screening for immunological disease and radiological investigations for occult malignancy were unremarkable. The patient received intravenous methylprednisolone and intravenous rituximab induction therapy resulting in complete remission of both the idiopathic membranous nephropathy and small vessel vasculitis at 7 months post treatment.
    MeSH term(s) Female ; Humans ; Glomerulonephritis, Membranous/complications ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Vasculitis/complications ; Vasculitis/diagnosis ; Vasculitis/drug therapy ; Mononeuropathies/diagnosis ; Mononeuropathies/drug therapy ; Mononeuropathies/etiology ; Neoplasms, Unknown Primary ; Administration, Intravenous ; Peripheral Vascular Diseases
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-257762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bortezomib-loaded immunoliposomes against CD44 expressing macrophages: an interplay for inflammation resolution.

    Nasra, Simran / Shukla, Haly / Patel, Milonee / Kumar, Ashutosh

    Nanoscale

    2024  Volume 16, Issue 10, Page(s) 5280–5293

    Abstract: Macrophage-driven inflammation is the central player in a range of pathological conditions, comprising autoimmune disorders, various cancers, as well as chronic inflammatory states like rheumatoid arthritis. Therapeutic strategies tailored to ... ...

    Abstract Macrophage-driven inflammation is the central player in a range of pathological conditions, comprising autoimmune disorders, various cancers, as well as chronic inflammatory states like rheumatoid arthritis. Therapeutic strategies tailored to specifically target macrophage behavior have acquired substantial interest for their potential to alleviate chronic inflammation effectively. In this study, we introduce a pioneering therapeutic approach utilizing specialized CD44-targeted immunoliposomes carrying bortezomib to address inflammation at the cellular level and the significance of this strategy lies in its precision nature. Bortezomib's inhibition of the proteasome interferes with the finely-tuned mechanism that controls NFκB activation, ultimately leading to a downregulation of the inflammatory response. After performing computational docking demonstrating its strong binding affinity to the proteasome molecule, the resulting nano-construct displayed a hydrodynamic size of 144.26 ± 74.4 nm and a quasi-spherical morphology. Moreover, the nano-construct ensured a minimum shelf-life of 30 days, aiming for targeted delivery with practical longevity. Upon internalization of immunoliposomes, the interaction with CD44 receptors exhibited downstream signaling events. This included the activation of Jun amino-terminal kinases 1/2 (JNK1/2) and the extracellular-signal-regulated kinases (ERK) pathway. JNK1/2 activation may lead to the release of mitochondrial pro-apoptotic factors, triggering the intrinsic apoptotic pathway and activation of caspases, which was confirmed from the level of apoptotic gene and protein expression. The precise targeting and anti-inflammatory action of this therapy against macrophages hold promise for therapeutic interventions in a wide range of inflammatory conditions, offering a novel avenue for precision medicine in the battle against excessive inflammation.
    MeSH term(s) Humans ; Bortezomib/pharmacology ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Endopeptidase Complex/pharmacology ; Inflammation/drug therapy ; Inflammation/metabolism ; Liposomes/metabolism ; Macrophages/metabolism ; Hyaluronan Receptors/metabolism
    Chemical Substances Bortezomib (69G8BD63PP) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Liposomes ; CD44 protein, human ; Hyaluronan Receptors
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d4nr00137k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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