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  1. Article: COVID-19 and De Novo Movement Disorders: Lessons Learned So Far.

    Ganguly, Jacky / Kumar, Hrishikesh

    Annals of Indian Academy of Neurology

    2023  Volume 26, Issue 5, Page(s) 621–622

    Language English
    Publishing date 2023-10-18
    Publishing country India
    Document type Editorial
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.aian_824_23
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  2. Article ; Online: Teaching Video NeuroImage: Pendular Vertical Oscillations in a Young Adult With a Pontine Hemorrhage.

    Ganguly, Jacky / Mukherjee, Soumava / Singh, Nilam / Kumar, Hrishikesh

    Neurology

    2023  Volume 101, Issue 11, Page(s) e1184–e1185

    MeSH term(s) Humans ; Young Adult ; Nystagmus, Pathologic ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207477
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  3. Article ; Online: Pattern Specific Dysgraphia-Beyond Letter Specificity.

    Ganguly, Jacky / Choudhury, Supriyo / Kumar, Hrishikesh

    Movement disorders clinical practice

    2023  Volume 10, Issue 5, Page(s) 856–857

    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13721
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  4. Article: Intravenous Immunoglobulin may Reverse Multisystem Inflammation in COVID-19 Pneumonitis and Guillain-Barré Syndrome.

    Chakraborty, Nilanchal / Kumar, Hrishikesh

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2021  Volume 24, Issue 12, Page(s) 1264–1268

    Abstract: Introduction: The novel coronavirus disease 2019 (COVID-19) poses an unprecedented crisis for public health, although several potential therapies have been provisionally applied but a unified consensus is yet to be achieved.: Case description: A 75- ... ...

    Abstract Introduction: The novel coronavirus disease 2019 (COVID-19) poses an unprecedented crisis for public health, although several potential therapies have been provisionally applied but a unified consensus is yet to be achieved.
    Case description: A 75-year-old man, COVID-19 reverse transcription-polymerase chain reaction (RT-PCR) positive on admission, presented with acute onset progressively ascending weakness of all four limbs. Nerve conduction velocity (NCV) study suggested acute demyelinating and axonal type of motor polyradiculoneuropathy. Hence, Guillain-Barré syndrome (GBS) related to COVID-19 infection was considered. His respiratory status worsened to severe acute respiratory distress syndrome (ARDS) on the second week of illness. He was started on intravenous immunoglobulin (IVIg) dosed over 5 days. His ventilator support started to improve after the 10th day of admission. His inflammatory markers started to improve, ventilator supports were weaned down and he was extubated on the 17th day of illness. Intravenous immunoglobulin is rich in viral immunoglobulin G (IgG), competitively binds Fcy receptor, preventing SARS-CoV-2 spike protein from attaching to the angiotensin-converting enzyme 2 (ACE 2) receptor, inhibiting viral entry into the cell.
    Clinical significance: Intravenous immunoglobulin can inhibit the production of inflammatory factors and decrease inflammatory injury, multisystem inflammation (MSI) in SARS-CoV-2.
    Conclusion: While the use of hyperimmune globulin requires a tedious job of collection from convalescent patients with verified and adequate titers, the use of IVIg could be an easier option to modulate the immune storm and faster recovery in SARS-CoV-2.
    How to cite this article: Chakraborty N, Kumar H. Intravenous Immunoglobulin may Reverse Multisystem Inflammation in COVID-19 Pneumonitis and Guillain-Barré Syndrome. Indian J Crit Care Med 2020;24(12):1264-1268.
    Language English
    Publishing date 2021-01-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23688
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  5. Article ; Online: Integration of multi-sensor remote sensing, geological and geochemical data for delineation of Pb–Zn bearing carbonates of Middle Aravalli group in Zawar–Dungarpur Belt, NW India

    Jain, Ronak / Bhu, Harsh / Kumar, Hrishikesh / Purohit, Ritesh

    Geocarto International. 2022 Dec. 13, v. 37, no. 27 p.17165-17199

    2022  

    Abstract: The rocks of the Aravalli Protocontinent of NW India are enriched in lead–zinc bearing deposits amongst which the Zawar mineralized belt is one of the famous for base metal deposits and was mined since ancient times. In the present study, an attempt has ... ...

    Abstract The rocks of the Aravalli Protocontinent of NW India are enriched in lead–zinc bearing deposits amongst which the Zawar mineralized belt is one of the famous for base metal deposits and was mined since ancient times. In the present study, an attempt has been made to identify and map the extension of the mineralized belt and base metal prognostic zones using the integration of multi-sensor remote sensing, geological and geochemical data. Remote Sensing studies were carried out using ASTER, AVIRIS-NG, and ASAR datasets to understand the extension and associated structural features of host rocks (dolomite in the present case) of lead–zinc mineralization from the Middle Aravalli Group. Relative band depth (B6 + B9/B8) was used to delineate the dolomite of the region using the ASTER imagery. Mineral map was derived using the AVIRIS-NG dataset with the help of the MTMF algorithm. Multifrequency and multipolarization ASAR datasets demarcated the structural features in the complexly deformed rocks of the extended belt. The obtained results from remote sensing were validated with the help of geological and geochemical studies. Geological studies (field surveys and petrographic studies) confirmed the presence of dolomites and associative mafics. Mineralogical, major oxides and trace elements data further substantiated the presence of dolomite, associated sulfides such as galena, sphalerite, pyrite, and chalcopyrite, and lead, zinc and copper in the Zawar–Dungarpur Belt. Presence of chromium and nickel were observed through the trace element studies of dolomite belt. The trace elements interpolated maps were superimposed by traced structural maps using ASAR datasets. The densely populated E-W lineaments are considered the suitable zones for base metal accumulation. These lineaments carried the base metal bearing fluid along with a low concentration of Chromium and Nickel. Under the finding of this study, the northern head of Hati Magra and near Keekawat are the suitable zones for Pb–Zn sulfide mineralization.
    Keywords Advanced Spaceborne Thermal Emission and Reflection Radiometer ; algorithms ; chromium ; copper ; data collection ; dolomite ; head ; lead ; mineralization ; nickel ; pyrite ; zinc ; India ; Multi-sensor remote sensing ; lead–zinc mineralization ; carbonates ; Zawar
    Language English
    Dates of publication 2022-1213
    Size p. 17165-17199.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1752-0762
    DOI 10.1080/10106049.2022.2123958
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  6. Article: Botulinum Toxin Injection in Truncal Dystonia: Time to Take Note.

    Choudhury, Supriyo / Kumar, Hrishikesh

    Annals of Indian Academy of Neurology

    2020  Volume 23, Issue 5, Page(s) 579

    Language English
    Publishing date 2020-12-08
    Publishing country India
    Document type Editorial
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_822_20
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  7. Article: Aqueous alteration mapping in Rishabdev ultramafic complex using imaging spectroscopy

    Kumar, Hrishikesh / Rajawat, A.S.

    International journal of applied earth observation and geoinformation. 2020 June, v. 88

    2020  

    Abstract: Hyperspectral remote sensing/imaging spectroscopy has enabled precise identification and mapping of hydrothermal alteration mineral assemblages based on diagnostic absorption features of minerals. In the present study, we use Airborne Visible InfraRed ... ...

    Abstract Hyperspectral remote sensing/imaging spectroscopy has enabled precise identification and mapping of hydrothermal alteration mineral assemblages based on diagnostic absorption features of minerals. In the present study, we use Airborne Visible InfraRed Imaging Spectrometer-Next Generation (AVIRIS-NG) datasets acquired over Rishabdev ultramafic suite to derive surficial mineral map using least square based spectral shape matching in wavelength range of diagnostic absorption features of minerals. Resulting mineral map revealed presence of hydrothermally altered serpentine group of minerals and associated alteration products (talc and dolomite) along with clays and phyllosilicates. Mineral maps are validated using field spectral measurements and published geological map. Involvement of low temperature (<350 °C) hydrothermal fluid in serpentinization of ultramafic rocks in the region is inferred from analysis of deepest absorption features of muscovites at 2.20 μm, spectral abundance of lizardite and absence of prenhite-pumpyllite facies mineral assemblages. Talc was found to be the most common alteration product of serpentines followed by dolomites. Intense alteration of serpentines to talc along the fracture zone is attributed to the circulation of carbon dioxide rich hydrothermal fluids along these conduits. Kaolinite and halloysite are primarily associated with granites and are the result of hydrothermal alteration of plagioclase feldspar in granites while muscovite and illites are generally associated with phyllites and quartzites . The study demonstrates the potential of imaging spectroscopy for mapping hydrothermal alteration mineral assemblages in ultramafic complex.
    Keywords absorption ; carbon dioxide ; cartography ; data collection ; dolomite ; halloysite ; kaolinite ; muscovite ; plagioclase ; quartzite ; serpentine ; spatial data ; spectroscopy ; talc ; temperature ; wavelengths
    Language English
    Dates of publication 2020-06
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1569-8432
    DOI 10.1016/j.jag.2020.102084
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  8. Article: Relevance of Subtype Classification of PSP.

    Chatterjee, Koustav / Choudhury, Supriyo / Kumar, Hrishikesh

    Annals of Indian Academy of Neurology

    2021  Volume 24, Issue 1, Page(s) 7

    Language English
    Publishing date 2021-02-05
    Publishing country India
    Document type Editorial
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_1039_20
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  9. Article ; Online: Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India.

    Sarkar, Swagata / Biswas, Arindam / Ansari, Sabbir / Choudhury, Supriyo / Banerjee, Rebecca / Chatterjee, Suparna / Dey, Sanjit / Kumar, Hrishikesh

    Neuroscience letters

    2024  Volume 825, Page(s) 137706

    Abstract: Introduction: Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson's disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key ... ...

    Abstract Introduction: Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson's disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key role of dopamine type 3 (D3) receptor polymorphism (Ser9Gly; rs6280) in LID. Its contribution to development of LID among Indian PD patients has remained relatively unexplored and merits further investigation.
    Methods and materials: 200 well-characterised PD patients (100 without LID and 100 with LID) and 100 age-matched healthy controls were recruited from the outpatient department of Institute of Neurosciences Kolkata. MDS-UPDRS (Unified Parkinson's Disease Rating Scale from International Movement Disorder Society) Part III and AIMS (abnormal involuntary movement scale) were performed for estimation of severity of motor features and LID respectively in the ON state of the disease. Participants were analysed for the presence of Ser9Gly single nucleotide variant (SNV) (rs6280) by polymerase chain reaction followed by restriction fragment length polymorphism techniques.
    Results: The frequency of AA genotype (serine type) was more frequently present in PD patients with LID compared to PD patients without LID (50 % vs 28 %; P = 0.002; OR = 2.57, 95 % CI: 1.43 - 4.62). The abnormal involuntary movement scale score was significantly higher in PD patients with AA genotype compared to carriers of glycine allele (AG + GG) (4.08 ± 3.35; P = 0.002).
    Conclusion: We observed a significant association of serine type SNV (rs6280) in D3 receptor gene in a cohort of PD patients with LID from India. More severe motor severity was found in patients with glycine substitution of the same SNV. The current study emphasised the role of D3 receptor in the pathogenesis of LID.
    MeSH term(s) Animals ; Humans ; Antiparkinson Agents/therapeutic use ; Dyskinesia, Drug-Induced/genetics ; Dyskinesia, Drug-Induced/drug therapy ; Glycine ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Parkinson Disease/genetics ; Polymorphism, Single Nucleotide ; Receptors, Dopamine D3/genetics ; Serine/genetics
    Chemical Substances Antiparkinson Agents ; Glycine (TE7660XO1C) ; Levodopa (46627O600J) ; Receptors, Dopamine D3 ; Serine (452VLY9402) ; DRD3 protein, human
    Language English
    Publishing date 2024-02-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2024.137706
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  10. Article ; Online: Characterizing gait and exploring neuro-morphometry in patients with PSP-Richardson's syndrome and vascular parkinsonism.

    Chatterjee, Koustav / Paul, Subhadip / Banerjee, Rebecca / Choudhury, Supriyo / Tiwari, Mona / Basu, Purba / Kumar, Hrishikesh

    Parkinsonism & related disorders

    2023  Volume 113, Page(s) 105483

    Abstract: Gait differentiation in progressive supranuclear palsy (PSP) and vascular parkinsonism (VaP) is sometimes difficult to detect with the naked eye. Here, we compared specific gait parameters, neuro-morphometric indices, and their associations between ... ...

    Abstract Gait differentiation in progressive supranuclear palsy (PSP) and vascular parkinsonism (VaP) is sometimes difficult to detect with the naked eye. Here, we compared specific gait parameters, neuro-morphometric indices, and their associations between patients with PSP Richardson's syndrome (PSP-RS) and VaP. A total of 18 PSP-RS and 13 VaP patients were recruited. Spatio-temporal gait parameters (GAITRite®) and neuroanatomical morphometry (FreeSurfer pipeline) were assessed. The groups were compared using unpaired t-tests involving 10000 random permutations after statistically controlling for total UPDRS-III and H&Y scores. Statistically significant differences between the groups were decided at < 5% Benjamini-Hochberg False Discovery Rate (FDR) for multiple-comparison related corrections. Spearman's correlations were performed to assess the significant associations (p < 0.05) between the gait parameters and morphometry indices. Among all the spatio-temporal gait parameters, PSP-RS patients displayed greater stride time, step time, swing time, and stance time variabilities compared to VaP. Morphometric analyses showed that thalamus, and caudate volumes were significantly lower, but cerebellar cortex, hippocampus, amygdala, accumbens, and putamen volumes were higher in PSP-RS than VaP. Moreover, the bilateral insula was significantly thinner in VaP than in PSP-RS. Correlation analyses support the involvement of limbic structures besides cerebellum in postural control during self-paced walking of PSP-RS patients. Our findings underline the importance of examining individual brain regions to understand the association of cortical and subcortical morphometric estimates and gait variability parameters in PSP-RS and VaP. This study suggests the involvement of the limbic system in addition to the classical neural structures for motor control and gait.
    MeSH term(s) Humans ; Supranuclear Palsy, Progressive/diagnosis ; Parkinsonian Disorders/diagnosis ; Brain/diagnostic imaging ; Parkinson Disease, Secondary/complications ; Gait
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2023.105483
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