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  1. Article ; Online: Genetic and Epigenetic Basis of Drug-Induced Liver Injury.

    Singh, Snigdha / Kumar, P V S N Kiran / Kumar, J Pradeep / Tomo, Sojit / Yadav, Dharamveer / Sharma, Praveen / Rao, Mahadev / Banerjee, Mithu

    Seminars in liver disease

    2023  Volume 43, Issue 2, Page(s) 163–175

    Abstract: Drug-induced liver injury (DILI) is a rare but severe adverse drug reaction seen in pharmacotherapy and a major cause of postmarketing drug withdrawals. Advances in genome-wide studies indicate that genetic and epigenetic diversity can lead to inter- ... ...

    Abstract Drug-induced liver injury (DILI) is a rare but severe adverse drug reaction seen in pharmacotherapy and a major cause of postmarketing drug withdrawals. Advances in genome-wide studies indicate that genetic and epigenetic diversity can lead to inter-individual differences in drug response and toxicity. It is necessary to identify how the genetic variations, in the presence of environmental factors, can contribute to development and progression of DILI. Studies on microRNA, histone modification, DNA methylation, and single nucleotide polymorphisms related to DILI were retrieved from databases and were analyzed for the current research and updated to develop this narrative review. We have compiled some of the major genetic, epigenetic, and pharmacogenetic factors leading to DILI. Many validated genetic risk factors of DILI, such as variants of drug-metabolizing enzymes, HLA alleles, and some transporters were identified. In conclusion, these studies provide useful information in risk alleles identification and on implementation of personalized medicine.
    MeSH term(s) Humans ; Chemical and Drug Induced Liver Injury/genetics ; Alleles ; Polymorphism, Single Nucleotide ; Epigenesis, Genetic ; Risk Factors
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/a-2097-0531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Genetic and Epigenetic Basis of Drug-Induced Liver Injury

    Singh, Snigdha / Kumar, P.V.S.N. Kiran / Kumar, J. Pradeep / Tomo, Sojit / Yadav, Dharamveer / Sharma, Praveen / Rao, Mahadev / Banerjee, Mithu

    Seminars in Liver Disease

    2023  Volume 43, Issue 02, Page(s) 163–175

    Abstract: Drug-induced liver injury (DILI) is a rare but severe adverse drug reaction seen in pharmacotherapy and a major cause of postmarketing drug withdrawals. Advances in genome-wide studies indicate that genetic and epigenetic diversity can lead to inter- ... ...

    Abstract Drug-induced liver injury (DILI) is a rare but severe adverse drug reaction seen in pharmacotherapy and a major cause of postmarketing drug withdrawals. Advances in genome-wide studies indicate that genetic and epigenetic diversity can lead to inter-individual differences in drug response and toxicity. It is necessary to identify how the genetic variations, in the presence of environmental factors, can contribute to development and progression of DILI. Studies on microRNA, histone modification, DNA methylation, and single nucleotide polymorphisms related to DILI were retrieved from databases and were analyzed for the current research and updated to develop this narrative review. We have compiled some of the major genetic, epigenetic, and pharmacogenetic factors leading to DILI. Many validated genetic risk factors of DILI, such as variants of drug-metabolizing enzymes, HLA alleles, and some transporters were identified. In conclusion, these studies provide useful information in risk alleles identification and on implementation of personalized medicine.
    Keywords drug-induced liver injury (DILI) ; miRNA ; DNA methylation ; histone modifications ; single nucleotide polymorphisms
    Language English
    Publishing date 2023-05-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/a-2097-0531
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: FeF3-catalyzed MCR in PEG-400: ultrasound assisted synthesis of N-substituted 2-aminopyridines

    Kumar Reddy, Dinne Naresh / Chandrasekhar, Kothapalli Bannoth / Siva Ganesh, Yaddanapudi Sesha / Reddy, G. Rajeshwar / Kumar, J. Pradeep / Kapavarapu, Ravi Kumar / Pal, Manojit

    RSC advances. 2016 July 14, v. 6, no. 71

    2016  

    Abstract: FeF3 catalyzed four component reaction under ultrasound irradiation was explored for the first time to prepare N-substituted 2-aminopyridines in good yields. The methodology involved the use of readily available starting materials and PEG-400 under mild ... ...

    Abstract FeF3 catalyzed four component reaction under ultrasound irradiation was explored for the first time to prepare N-substituted 2-aminopyridines in good yields. The methodology involved the use of readily available starting materials and PEG-400 under mild reaction conditions in the presence of air. The one-pot methodology afforded a range of compounds of pharmacological interest indicating its potential in generating a diversity based library of small molecules useful for medicinal chemistry and drug discovery.
    Keywords air ; drugs ; ultrasonic treatment
    Language English
    Dates of publication 2016-0714
    Size p. 67212-67217.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c6ra14228a
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Synthesis and characterization of diopside particles and their suitability along with chitosan matrix for bone tissue engineering in vitro and in vivo.

    Kumar, J Pradeep / Lakshmi, L / Jyothsna, V / Balaji, D R Prashanth / Saravanan, S / Moorthi, A / Selvamurugan, N

    Journal of biomedical nanotechnology

    2014  Volume 10, Issue 6, Page(s) 970–981

    Abstract: The scaffolds for bone tissue engineering should be porous to harbor the growth of new tissue ingrowths, biodegradable with no toxic end products, and biocompatible with no cytotoxicity. In this study we report that Diopside (CaMgSi2O6) (Dp) particles ... ...

    Abstract The scaffolds for bone tissue engineering should be porous to harbor the growth of new tissue ingrowths, biodegradable with no toxic end products, and biocompatible with no cytotoxicity. In this study we report that Diopside (CaMgSi2O6) (Dp) particles can be synthesized at a more economical route using the agricultural waste rice straw. Along with chitosan (CS) matrix, the CS/Dp scaffolds were synthesized and evaluated for their physico-chemical properties by SEM, EDS, XRD, FT-IR studies. Addition of Dp particles to chitosan matrix decreased water retention capacity but there was no change in their degradation properties. Dp particles in CS/Dp scaffolds exhibited good affinity for protein adsorption. Apatite forming ability of the CS/Dp scaffolds depicted their bioactivity. These scaffolds were found to be compatible with human osteoblastic cells (MG-63) and the cells were able to attach and proliferate with extended morphology on the CS/Dp membranes. The CS/Dp scaffolds supported up regulation of mRNA expression of osteoblast differentiation marker genes such alkaline phosphatase (ALP), type I collagen (COL-I) in the presence of osteogenic environment suggesting their osteo-conductive nature. In vivo rat model system identified that the CS/Dp scaffolds are biocompatible and may have the property of recruiting cells due to deposition of collagen. Hence, these studies suggest that the prepared CS/Dp scaffolds have potential applications towards bone tissue engineering.
    MeSH term(s) Animals ; Bone Substitutes/chemical synthesis ; Chitosan/adverse effects ; Chitosan/chemistry ; Elastic Modulus ; Equipment Design ; Equipment Failure Analysis ; Male ; Materials Testing ; Nanoparticles/adverse effects ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Particle Size ; Rats ; Rats, Wistar ; Silicic Acid/adverse effects ; Silicic Acid/chemistry ; Tensile Strength ; Tissue Engineering/instrumentation ; Tissue Scaffolds
    Chemical Substances Bone Substitutes ; Silicic Acid (1343-98-2) ; diopside (14483-19-3) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2014-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1550-7033
    ISSN 1550-7033
    DOI 10.1166/jbn.2014.1808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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