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  1. Article: Presence of the blaTEM Gene in Commensal Neisseria spp.: A Possible Cause for the Acquired Drug Resistance Among Pathogenic Respiratory Bacteria.

    Sunil, Anisha / Kumar, Kennedy / Sridharan, Kopula S

    Cureus

    2023  Volume 15, Issue 11, Page(s) e49389

    Abstract: Background The oral microbiome consists of various bacterial genera, ... ...

    Abstract Background The oral microbiome consists of various bacterial genera, with
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Retrospective Study on Antinuclear Antibody Patterns in Systemic Lupus Erythematosus Patients and Its Correlation With Serological Markers.

    Ramachandran, Aishwarya / Kumar, Kennedy / Sankaralingam, Rajeswari / Chinnadurai, Saranya / Chilukuri, Balaji

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50049

    Abstract: Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Detection of antinuclear antibodies (ANAs) aids in the diagnosis of SLE. The indirect immunofluorescence (IIF) assay is often used a routine screening test for the ... ...

    Abstract Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Detection of antinuclear antibodies (ANAs) aids in the diagnosis of SLE. The indirect immunofluorescence (IIF) assay is often used a routine screening test for the detection of ANA. The pathogenic role and significance of various patterns produced in IIF is yet to be explored.
    Aim: This study aimed to detect ANA patterns generated by IIF and correlate these patterns with specific antibodies detected by line immunoassay. We also investigated the significance of each ANA pattern and its association with specific serological SLE markers, such as complement molecules, anti-dsDNA, antiphospholipid antibody, and C-reactive protein (CRP), along with associations with direct Coombs test (DCT).
    Materials and methods: We conducted a retrospective study that included 204 patients newly diagnosed with SLE according to the European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) criteria. The detection and pattern determination of ANA was performed by IIF using HEp-20-10. Furthermore, line immunoassay was performed, and the antibody profile of each sample was obtained. Other immunodiagnostic markers were analyzed, including C3, C4, anti-dsDNA, antiphospholipid antibodies (anti-cardiolipin antibodies, anti-beta-2-glycoprotein I, and lupus anticoagulant), CRP, and DCT.
    Results: Of the 204 samples, the most frequent ANA pattern observed was nucleus speckled (52.9%), followed by nucleus homogenous (27.5%), mixed (13.7%), and cytoplasm speckled (5.9%). The nucleus homogenous pattern showed the most pathogenic immune profile due to its close association with markers of disease activity, namely, high anti-dsDNA titer, low C3 level, and DCT positivity.  Conclusion: This study showed that the most common pattern associated with SLE is nucleus speckled, followed by the nucleus homogenous pattern. Based on associations with specific serological markers, the nucleus homogenous pattern may be linked to a high disease activity in SLE.
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparison of Streptococcus mutans Adhesion on New and Recycled Metal Brackets: An In Vitro Study.

    Thiruvengadam, Vasumathi / Chitharanjan, Arun B / Kumar, Kennedy / Singaram, Venkatesan

    Cureus

    2022  Volume 14, Issue 3, Page(s) e23574

    Abstract: Background: Evaluation of adhesion of : Results: Comparing all the three groups and recycling methods, Group II brackets showed significantly more adhesion, Group I brackets showed lesser adhesion, and Group III brackets showed intermediate adhesion. ...

    Abstract Background: Evaluation of adhesion of
    Results: Comparing all the three groups and recycling methods, Group II brackets showed significantly more adhesion, Group I brackets showed lesser adhesion, and Group III brackets showed intermediate adhesion. When comparing recycling methods, all the three methods of recycling with all the three groups showed more bacterial adhesion than the control brackets, which was statistically insignificant (P > 0.05).
    Conclusion: Recycled brackets showed more bacterial adhesion and electropolishing resulted in reduced bacterial adhesion.
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimicrobial efficacy of zinc oxide nanoparticle-coated aligners on Streptococcus mutans and Candidaalbicans.

    Anita, Prathima / Sathyanarayana, Haritha Pottipalli / Kumar, Kennedy / Ramanathan, Krishnapriya / Kailasam, Vignesh

    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

    2022  Volume 163, Issue 3, Page(s) 338–346

    Abstract: Introduction: This study aimed to assess the antimicrobial effect of zinc oxide (ZnO) nanocoating on aligners.: Methods: Twenty-six samples of aligners were sputter-coated with ZnO nanoparticles and compared with 26 uncoated samples. The ... ...

    Abstract Introduction: This study aimed to assess the antimicrobial effect of zinc oxide (ZnO) nanocoating on aligners.
    Methods: Twenty-six samples of aligners were sputter-coated with ZnO nanoparticles and compared with 26 uncoated samples. The antimicrobial effect was assessed on Streptococcus mutans and Candida albicans. The thickness of the ZnO coating was standardized at 100 nm. The antimicrobial effect was evaluated for 7 days at the following time points: 6 hours, 12 hours, first day, second day, fourth day, and seventh day. Colony culture tests were performed for microbial evaluation.
    Results: ZnO-coated aligners showed significant antimicrobial efficacy against S mutans at all time points tested (P <0.001). The antimicrobial effect was observed up to 2 days after a decline. The activity against C albicans was minimal at all time points, and no statistical significance was observed (P >0.05).
    Conclusions: ZnO-nanocoated aligners were effective against S mutans, with the maximum antibacterial effect observed until 2 days and lasting for 7 days. The effect against C albicans was minimal. ZnO-coated aligners appears to be a promising technique to facilitate antimicrobial efficacy against S mutans.
    MeSH term(s) Humans ; Zinc Oxide/pharmacology ; Streptococcus mutans ; Anti-Infective Agents/pharmacology ; Nanoparticles ; Candida albicans
    Chemical Substances Zinc Oxide (SOI2LOH54Z) ; Anti-Infective Agents
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356699-7
    ISSN 1097-6752 ; 0889-5406 ; 0002-9416
    ISSN (online) 1097-6752
    ISSN 0889-5406 ; 0002-9416
    DOI 10.1016/j.ajodo.2021.11.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Atypical Pneumonia - Screening in a Tertiary Care Centre.

    Dorairaj, Aruna / Kopula, Sridharan Sathyamoorthy / Kumar, Kennedy

    Journal of clinical and diagnostic research : JCDR

    2015  Volume 9, Issue 11, Page(s) DC18–20

    Abstract: Introduction: Pneumonia is one of the leading infectious causes of mortality and morbidity worldwide. Atypical respiratory pathogens account for 30 - 40% of these infections. The three most important atypical pathogens are Mycoplasma pneumoniae, ... ...

    Abstract Introduction: Pneumonia is one of the leading infectious causes of mortality and morbidity worldwide. Atypical respiratory pathogens account for 30 - 40% of these infections. The three most important atypical pathogens are Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legionella pneumophila.
    Aim: To screen for atypical pathogens as cause for community acquired pneumonia.
    Materials and methods: A cross-sectional study was done with 107 patients who had clinical suspicion of atypical pneumonia. The presence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legionella pneumophila were screened from the patient's sample. Respiratory samples in the form of sputum, Broncheoalveolar lavage and Non- Broncheoalveolar lavage were used for cultivation of Mycoplasma pneumoniae and Legionella pneumophila. Urine specimen was used for the detection of Legionella antigen. Serum samples were used for the detection of Mycoplasma pneumoniae IgM and Chlamydophila pneumoniae IgM antibodies.
    Results: Among the 107 samples screened, 13(12.1%) were positive for antibodies against atypical pathogens. Out of which 7(6.5%) had IgM antibodies against Mycoplasma pneumoniae and the rest 6(5.6%) had Chlamydophila pneumoniae IgM antibodies. All the samples were culture negative for Mycoplasma pneumoniae and Legionella pneumophila. Urinary antigen detection for Legionella pneumophila was also negative in patients.
    Conclusion: Atypical pathogens should also be considered routinely as a cause of lower respiratory tract infections, especially Chlamydia pneumoniae and Mycoplasma pneumoniae in our country. Serological diagnosis by ELISA can be adopted for determining the infections by atypical pathogens as cultivation is difficult and also requires special media and prolonged incubation. This may not be feasible for many laboratories. Early diagnosis and treatment will reduce the complications.
    Language English
    Publishing date 2015-11-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2015/16499.6835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Evaluation of antimicrobial properties of bioactive glass used in regenerative periodontal therapy.

    Chandrasekar, Ram Sabarish / Lavu, Vamsi / Kumar, Kennedy / Rao, Suresh Ranga

    Journal of Indian Society of Periodontology

    2015  Volume 19, Issue 5, Page(s) 516–519

    Abstract: Context: Bone grafting materials which have an inherent anti-microbial property against initial colonizers of plaque bacteria would be useful in regenerative periodontal surgical procedures.: Aims: This study was performed to analyze the ... ...

    Abstract Context: Bone grafting materials which have an inherent anti-microbial property against initial colonizers of plaque bacteria would be useful in regenerative periodontal surgical procedures.
    Aims: This study was performed to analyze the antibacterial property of a Perioglas™ against a common oral commensal Streptococcus salivarius (early colonizer).
    Settings and design: In vitro observational study.
    Materials and methods: Perioglas™ (in various concentrations) was assessed for its antibacterial property against the ATCC 13419 strain of S. salivarius. The anti-microbial activity was analyzed in terms of reduction in colony-forming units in culture plates and smear following a 24 h incubation at 37°C.
    Statistical analysis used: Observational study - No statistical analysis applicable.
    Results: The bioactive glass (BAG) exerted an antibacterial effect against the S. salivarius in the suspending media and smear. The antibacterial activity of BAG increased in proportion with its concentration.
    Conclusions: Perioglas™ demonstrated a considerable antibacterial effect against S. salivarius at 50 mg/mL concentration.
    Language English
    Publishing date 2015-10-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2545458-4
    ISSN 0975-1580 ; 0972-124X
    ISSN (online) 0975-1580
    ISSN 0972-124X
    DOI 10.4103/0972-124X.167166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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