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  1. Article: Neurosarcoidosis Presenting as Normal Pressure Hydrocephalus in a Patient with Pulmonary Sarcoidosis.

    Prabhu, Sushmita / Kumar, Pramukh Arun / Kumar, Sumukh Arun / Dasari, Mahati / Mishra, Ajay K / Donaghy, Justin

    Journal of community hospital internal medicine perspectives

    2023  Volume 13, Issue 1, Page(s) 33–36

    Abstract: A gentleman in his early 50's with past medical history significant for biopsy confirmed pulmonary sarcoidosis presented with acute onset confusion, gait disturbance and bowel/urinary incontinence. Brain imaging was consistent with normal pressure ... ...

    Abstract A gentleman in his early 50's with past medical history significant for biopsy confirmed pulmonary sarcoidosis presented with acute onset confusion, gait disturbance and bowel/urinary incontinence. Brain imaging was consistent with normal pressure hydrocephalus and CSF studies supported the suspicion of neurosarcoidosis. He received treatment with a prolonged course of steroids with good effect. We discuss a rare case of normal pressure hydrocephalus as a presenting feature of neurosarcoidosis and the rationale of starting empiric treatment for probable diagnosis of the same.
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Catheter ablation versus medical therapy in atrial fibrillation: an umbrella review of meta-analyses of randomized clinical trials.

    Titus, Anoop / Syeed, Sakil / Baburaj, Abiram / Bhanushali, Karan / Gaikwad, Pramod / Sooraj, Mannil / Saji, Anu Mariam / Mir, Wasey Ali Yadullahi / Kumar, Pramukh Arun / Dasari, Mahati / Ahmed, Mubashir Ayaz / Khan, Mohammed Omer / Titus, Aishwarya / Gaur, Janamjey / Annappah, Dilanthy / Raj, Arjun / Noreen, Nabeela / Hasdianda, Adrian / Sattar, Yasar /
    Narasimhan, Bharat / Mehta, Nishaki / Desimone, Christopher V / Deshmukh, Abhishek / Ganatra, Sarju / Nasir, Khurram / Dani, Sourbha

    BMC cardiovascular disorders

    2024  Volume 24, Issue 1, Page(s) 131

    Abstract: This umbrella review synthesizes data from 17 meta-analyses investigating the comparative outcomes of catheter ablation (CA) and medical treatment (MT) for atrial fibrillation (AF). Outcomes assessed were mortality, risk of hospitalization, AF recurrence, ...

    Abstract This umbrella review synthesizes data from 17 meta-analyses investigating the comparative outcomes of catheter ablation (CA) and medical treatment (MT) for atrial fibrillation (AF). Outcomes assessed were mortality, risk of hospitalization, AF recurrence, cardiovascular events, pulmonary vein stenosis, major bleeding, and changes in left ventricular ejection fraction (LVEF) and MLHFQ score. The findings indicate that CA significantly reduces overall mortality and cardiovascular hospitalization with high strength of evidence. The risk of AF recurrence was notably lower with CA, with moderate strength of evidence. Two associations reported an increased risk of pulmonary vein stenosis and major bleeding with CA, supported by high strength of evidence. Improved LVEF and a positive change in MLHFQ were also associated with CA. Among patients with AF and heart failure, CA appears superior to MT for reducing mortality, improving LVEF, and reducing cardiovascular rehospitalizations. In nonspecific populations, CA reduced mortality and improved LVEF but had higher complication rates. Our findings suggest that CA might offer significant benefits in managing AF, particularly in patients with heart failure. However, the risk of complications, including pulmonary vein stenosis and major bleeding, is notable. Further research in understudied populations may help refine these conclusions.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Catheter Ablation/adverse effects ; Heart Failure/diagnosis ; Heart Failure/therapy ; Hemorrhage/chemically induced ; Randomized Controlled Trials as Topic ; Stenosis, Pulmonary Vein/etiology ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left ; Meta-Analysis as Topic
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03670-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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