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Article ; Online: Magnetic Field Sensing Using Tapered Small-Core Optical Fibre Surrounded by Different Concentrations of Magnetic Fluid.

Kumar, Rahul

2022 Volume 22, Issue 21

Abstract: In this paper, a high-sensitivity magnetic field sensor based on a single-mode-tapered small-core-single-mode (STSCS) optical fibre structure is investigated. The tapered small-core section of STSCS is surrounded by magnetic fluid (MF) containing ... ...

Abstract	In this paper, a high-sensitivity magnetic field sensor based on a single-mode-tapered small-core-single-mode (STSCS) optical fibre structure is investigated. The tapered small-core section of STSCS is surrounded by magnetic fluid (MF) containing ferromagnetic particles (FMPs) of different concentrations. The FMPs align themselves along the magnetic field, depending on the strength of the magnetic field. This alignment of FMPs changes the refractive index around the tapered small-core section, which in turn changes the output spectral response of the STSCS optical fibre structure. The change in spectral response is then calibrated for sensing the magnetic field strength. This paper also investigates the effect of both the taper waist diameter of the STSCS optical fibre structure and the concentration of MF surrounding it on the magnetic field sensitivity. The maximum sensitivity demonstrated in this paper is 0.46 nm/mT for a taper waist diameter of 10 μm surrounded by 1.22% FMPs in the MF. The magnetic sensor demonstrates reversible results, and its effects on the orientation of the magnetic field along the X-Y, X-Z and Y-Z axes are also investigated, which suggest that the sensor is capable of vector magnetic field measurement.
Language	English
Publishing date	2022-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22218536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High Throughput Screening Assessment of Reactive Oxygen Species (ROS) Generation using Dihydroethidium (DHE) Fluorescence Dye.

Kumar, Rahul / Gullapalli, Rama R

Journal of visualized experiments : JoVE

2024 , Issue 203

Abstract: Reactive oxygen species (ROS) play a key role in the regulation of cellular metabolism in physiological and pathological processes. Physiological ROS production plays a central role in the spatial and temporal modulation of normal cellular functions such ...

Abstract	Reactive oxygen species (ROS) play a key role in the regulation of cellular metabolism in physiological and pathological processes. Physiological ROS production plays a central role in the spatial and temporal modulation of normal cellular functions such as proliferation, signaling, apoptosis, and senescence. In contrast, chronic ROS overproduction is responsible for a wide spectrum of diseases, such as cancer, cardiovascular disease, and diabetes, among others. Quantifying ROS levels in an accurate and reproducible manner is thus essential to understanding normal cellular functionality. Fluorescence imaging-based methods to characterize intra-cellular ROS species is a common approach. Many of the imaging ROS protocols in the literature use 2'-7'-dichlorodihydrofluorescein diacetate (DCFH-DA) dye. However, this dye suffers from significant limitations in its usage and interpretability. The current protocol demonstrates the use of a dihydroethidium (DHE) fluorescent probe as an alternative method to quantify total ROS production in a high-throughput setting. The high throughput imaging platform, CX7 Cellomics, was used to measure and quantify the ROS production. This study was conducted in three hepatocellular cancer cell lines - HepG2, JHH4, and HUH-7. This protocol provides an in-depth description of the various procedures involved in the assessment of ROS within the cells, including - preparation of DHE solution, incubation of cells with DHE solution, and measurement of DHE intensity necessary to characterize the ROS production. This protocol demonstrates that DHE fluorescent dye is a robust and reproducible choice to characterize intracellular ROS production in a high-throughput manner. High throughput approaches to measure ROS production are likely to be helpful in a variety of studies, such as toxicology, drug screening, and cancer biology.
MeSH term(s)	Fluorescent Dyes ; Reactive Oxygen Species/metabolism ; High-Throughput Screening Assays ; Ethidium
Chemical Substances	Fluorescent Dyes ; dihydroethidium (104821-25-2) ; Reactive Oxygen Species ; Ethidium (EN464416SI)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/66238
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effective-diode-based analysis of industrial solar photovoltaic panel by utilizing novel three-diode solar cell model against conventional single and double solar cell.

Kumar, Rahul / Kumar, Amitesh

Environmental science and pollution research international

2024 Volume 31, Issue 17, Page(s) 25356–25372

Abstract: Currently, the majority of the country has moved to renewable energy sources for electricity generation, and power companies are concentrating their efforts on renewable resources. Solar, wind, hydropower, and biomass are examples of renewable resources; ...

Abstract	Currently, the majority of the country has moved to renewable energy sources for electricity generation, and power companies are concentrating their efforts on renewable resources. Solar, wind, hydropower, and biomass are examples of renewable resources; of these, due to a lack of non-renewable resources, the solar industry is expanding. All year long, solar electricity is available, and it creates a calm, quiet atmosphere. The majority of large and small companies, as well as individual consumers, have shifted to PV solar cells for electricity generation. A trustworthy and precise simulation design of a photovoltaic system prior to installation is required to predict a photovoltaic system's performance. The current research aims to build models for solar PV systems with one, two, and three diodes and determine which model is most appropriate for each environmental circumstance to forecast performance accurately. By contrasting the experimental data of solar panel with simulated results of single-, double-, and triple-diode models, this study examines the accuracy of each model. These models' comparative performance study has been done using the MATLAB/Simulink, taking into account the influence of changing model parameters and the performance of the models under varying climatic circumstances. These models, despite their simplicity, are quite sensitive and react to even a little change in temperature and irradiance. Under conditions of low solar irradiance or shading conditions, three-diode photovoltaic models are shown to be more accurate. We can forecast the power output of solar photovoltaic systems under changeable input circumstances by understanding the I-V curves with the help of the performance assessment of the models used in this work.
MeSH term(s)	Sunlight ; Computer Simulation ; Wind ; Temperature ; Electricity ; Solar Energy
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32474-z
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Article ; Online: Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease.

Susmitha, Gudimetla / Kumar, Rahul

Neuropharmacology

2023 Volume 229, Page(s) 109478

Abstract: Alzheimer's disease (AD) is the leading cause of dementia in the elderly and detected during the advanced stages where the chances of reversal are minimum. The gut-brain axis mediates a bidirectional communication between the gut and brain, which is ... ...

Abstract	Alzheimer's disease (AD) is the leading cause of dementia in the elderly and detected during the advanced stages where the chances of reversal are minimum. The gut-brain axis mediates a bidirectional communication between the gut and brain, which is dependent on bacterial products such as short chain fatty acids (SCFA) and neurotransmitters. Accumulating lines of evidence suggests that AD is associated with significant alteration in the composition of gut microbiota. Furthermore, transfer of gut microbiota from healthy individuals to patients can reshape the gut microbiota structure and thus holds the potential to be exploited for the treatment of various neurodegenerative disease. Moreover, AD-associated gut dysbiosis can be partially reversed by using probiotics, prebiotics, natural compounds and dietary modifications, but need further validations. Reversal of AD associated gut dysbiosis alleviate AD-associated pathological feature and therefore can be explored as a therapeutic approach in the future. The current review article will describe various studies suggesting that AD dysbiosis occurs with AD and highlights the causal role by focussing on the interventions that hold the potential to reverse the gut dysbiosis partially.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease ; Neurodegenerative Diseases ; Dysbiosis/complications ; Brain ; Probiotics/therapeutic use
Language	English
Publishing date	2023-03-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2023.109478
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Article ; Online: Support Vector Machine-Based Prediction Models for Drug Repurposing and Designing Novel Drugs for Colorectal Cancer.

Sengupta, Avik / Singh, Saurabh Kumar / Kumar, Rahul

ACS omega

2024 Volume 9, Issue 16, Page(s) 18584–18592

Abstract: Colorectal cancer (CRC) has witnessed a concerning increase in incidence and poses a significant therapeutic challenge due to its poor prognosis. There is a pressing demand to identify novel drug therapies to combat CRC. In this study, we addressed this ... ...

Abstract	Colorectal cancer (CRC) has witnessed a concerning increase in incidence and poses a significant therapeutic challenge due to its poor prognosis. There is a pressing demand to identify novel drug therapies to combat CRC. In this study, we addressed this need by utilizing the pharmacological profiles of anticancer drugs from the Genomics of Drug Sensitivity in Cancer (GDSC) database and developed QSAR models using the Support Vector Machine (SVM) algorithm for prediction of alternative and promiscuous anticancer compounds for CRC treatment. Our QSAR models demonstrated their robustness by achieving a high correlation of determination (
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c01195
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the Potential of Curry Leaves for their Therapeutic Action

Kumar Rahul / Gupta Shifali / Kaur Paranjeet / Kumar Sahu Sanjeev

BIO Web of Conferences, Vol 86, p

2024 Volume 01037

Abstract: Curry leaves (Murryakoenigii), which are valued for their aromatic flavour, have been mainstay of Indian cuisine for ages. These leaves are becoming more well known for their potential to affect metabolic pathways in additional to their gastronomic value. ...

Abstract	Curry leaves (Murryakoenigii), which are valued for their aromatic flavour, have been mainstay of Indian cuisine for ages. These leaves are becoming more well known for their potential to affect metabolic pathways in additional to their gastronomic value. The molecular mechanistic potential of curry leaves in relation to metabolic control is examined in this abstract. Curry leaves contain a variety of bioactive substance, such as antioxidant, anti-inflammatory agent, and substance that modulate insulin sensitivity, which have potential to have an effect on crucial metabolic processes. Their contribution to the management of oxidative stress, inflammation, blood sugar, cholesterol, weight, gut health, liver function, thermogenesis, and appetite regulation is discussed in this work. Although encouraging, more study is necessary to complete clarify the mechanism of action and to determine the efficacy of curry leaves in metabolic disorder.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ESG Volatility Prediction Using GARCH and LSTM Models

Mishra Akshay Kumar / Kumar Rahul / Bal Debi Prasad

Financial Internet Quarterly, Vol 19, Iss 4, Pp 97-

2023 Volume 114

Abstract: This study aims to predict the ESG (environmental, social, and governance) return volatility based on ESG index data from 26 October 2017 and 31 March 2023 in the case of India. In this study, we utilized GARCH (Generalized Autoregressive Conditional ... ...

Abstract	This study aims to predict the ESG (environmental, social, and governance) return volatility based on ESG index data from 26 October 2017 and 31 March 2023 in the case of India. In this study, we utilized GARCH (Generalized Autoregressive Conditional Heteroskedasticity) and LSTM (Long Short-Term Memory) models for forecasting the return of ESG volatility and to evaluate the model’s suitability for prediction. The study’s findings demonstrate the GARCH effect inside the ESG return volatility data, indicating the occurrence of volatility in response to market fluctuations. This study provides insight concerning the suitability of models for volatility predictions. Moreover, based on the analysis of the return volatility of the ESG index, the GARCH model is more appropriate than the LSTM model.
Keywords	esg volatility ; garch ; lstm model ; c53 ; d53 ; g34 ; o13 ; Finance ; HG1-9999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spin-glass behavior in Li

Kumar, Rahul / Sundaresan, A

Journal of physics. Condensed matter : an Institute of Physics journal

2022 Volume 34, Issue 41

Abstract: We report a detailed experimental study on the structural and magnetic properties of ... ...

Abstract	We report a detailed experimental study on the structural and magnetic properties of Li
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ac86b2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Liver Transplantation in Chronic Liver Disease and Acute on Chronic Liver Failure- Indication, Timing and Practices.

Choudhury, Ashok / Adali, Gupse / Kaewdech, Apichat / Giri, Suprabhat / Kumar, Rahul

Journal of clinical and experimental hepatology

2024 Volume 14, Issue 3, Page(s) 101347

Abstract: Liver transplantation (LT) is the second most common solid organ transplantation worldwide. LT is considered the best and most definitive therapeutic option for patients with decompensated chronic liver disease (CLD), hepatocellular carcinoma (HCC), ... ...

Abstract	Liver transplantation (LT) is the second most common solid organ transplantation worldwide. LT is considered the best and most definitive therapeutic option for patients with decompensated chronic liver disease (CLD), hepatocellular carcinoma (HCC), acute liver failure (ALF), and acute-on-chronic liver failure (ACLF). The etiology of CLD shows wide geographical variation, with viral hepatitis being the major etiology in the east and alcohol-related liver disease (ALD) in the west. Non-alcoholic fatty liver disease (NAFLD) is on an increasing trend and is expected to be the most common etiology on a global scale. Since the first successful LT, there have been radical changes in the indications for LT. In many circumstances, not just the liver disease itself but factors such as extra-hepatic organ dysfunction or failures necessitate LT. ACLF is a dynamic syndrome that has extremely high short-term mortality. Currently, there is no single approved therapy for ACLF, and LT seems to be the only feasible therapeutic option for selected patients at high risk of mortality. Early identification of ACLF, stratification of patients according to disease severity, aggressive organ support, and etiology-specific treatment approaches have a significant impact on post-transplant outcomes. This review briefly describes the indications, timing, and referral practices for LT in patients with CLD and ACLF.
Language	English
Publishing date	2024-01-26
Publishing country	India
Document type	Journal Article ; Review
ISSN	0973-6883
ISSN	0973-6883
DOI	10.1016/j.jceh.2024.101347
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Article ; Online: Time-domain heart rate dynamics in the prognosis of progressive atherosclerosis.

Kumar, Rahul / Aggarwal, Yogender / Nigam, Vinod Kumar / Sinha, Rakesh Kumar

Nutrition, metabolism, and cardiovascular diseases : NMCD

2024

Abstract: Background and aim: The regular uptake of a high-fat diet (HFD) with changing lifestyle causes atherosclerosis leading to cardiovascular diseases and autonomic dysfunction. Therefore, the current study aimed to investigate the correlation of autonomic ... ...

Abstract	Background and aim: The regular uptake of a high-fat diet (HFD) with changing lifestyle causes atherosclerosis leading to cardiovascular diseases and autonomic dysfunction. Therefore, the current study aimed to investigate the correlation of autonomic activity to lipid and atherosclerosis markers. Further, the study proposes a support vector machine (SVM) based model in the prediction of atherosclerosis severity. Methods and results: The Lead-II electrocardiogram and blood markers were measured from both the control and the experiment subjects each week for nine consecutive weeks. The time-domain heart rate variability (HRV) parameters were derived, and the significance level was tested using a one-way Analysis of Variance. The correlation analysis was performed to determine the relation between autonomic parameters and lipid and atherosclerosis markers. The statistically significant time-domain values were used as features of the SVM. The observed results demonstrated the reduced time domain HRV parameters with the increase in lipid and atherosclerosis index markers with the progressive atherosclerosis severity. The correlation analysis revealed a negative association between time-domain HRV parameters with lipid and atherosclerosis parameters. The percentage accuracy increases from 86.58% to 98.71% with the increase in atherosclerosis severity with regular consumption of HFD. Conclusions: Atherosclerosis causes autonomic dysfunction with reduced HRV. The negative correlation between autonomic parameters and lipid profile and atherosclerosis indexes marker revealed the potential role of vagal activity in the prognosis of atherosclerosis progression. The support vector machine presented a respectable accuracy in the prediction of atherosclerosis severity from the control group.
Language	English
Publishing date	2024-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2024.01.011
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