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Article ; Online: Resilience of aerobic sludge biomass under chlorpyrifos stress and its recovery potential.

Kumar, Rajneesh / Saini, Gurvinder Kaur / Jawed, Mohammad

2024 Volume 352, Page(s) 141324

Abstract: Non-agricultural sources of pesticides in urban areas are responsible for their presence in domestic wastewater. Therefore, pesticides are typically found in sewage treatment plants in developed and developing countries as micro-pollutant. The presence ... ...

Abstract	Non-agricultural sources of pesticides in urban areas are responsible for their presence in domestic wastewater. Therefore, pesticides are typically found in sewage treatment plants in developed and developing countries as micro-pollutant. The presence of pesticides in the wastewater can impart stress on the aerobic sludge biomass and disrupt the functioning of the plant. However, there exists a knowledge gap regarding the resilience of aerobic sludge biomass towards stress due to the presence of pesticides in the wastewater. This study investigated the impact of chlorpyrifos (CPS) - a widely used pesticide, on sludge biomass and explored its recovery capability when CPS is discontinued in the influent. Four duplicate reactors were operated with different CPS concentrations ranging from 50 to 200 mg/L. Chemical oxygen demand (COD) removal for reactors has ranged within 18-73 % at the steady state of the stressed phase, whereas COD removal for the control reactor was 91 %. CPS stress slightly inhibited filamentous biomass growth. Biomass activity and cell viability have decreased significantly, whereas biochemical contents have varied slightly under CPS stress. The activities of the enzymes dehydrogenase and urease were significantly inhibited when compared to catalase and protease. Amplified ribosomal DNA restriction analysis reflected changes in the microbial community. The discontinuation of CPS has allowed aerobic sludge biomass to recover in its organic degradation capability (COD removal of more than 88 % at steady-state conditions of recovery phase operation), biomass growth, and cell viability. In addition, enzyme activities have retrieved to their original levels, and 78-93 % similarity of microbial community structure has been displayed between CPS-exposed and control reactor biomasses. Overall, the present study has indicated the orderly changes in the quality of aerobic sludge biomass under CPS stress through physico-chemical and biological characteristics. The study also has highlighted the self-recovery of sludge biomass characteristics stressed with different concentrations of CPS.
MeSH term(s)	Sewage/chemistry ; Wastewater ; Waste Disposal, Fluid ; Biomass ; Chlorpyrifos ; Resilience, Psychological ; Bioreactors ; Pesticides/analysis ; Biological Oxygen Demand Analysis
Chemical Substances	Sewage ; Wastewater ; Chlorpyrifos (JCS58I644W) ; Pesticides
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141324
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Article: Unconventional solar air heater with triangular flow-passage: A CFD based comparative performance assessment of different cross-sectional rib-roughnesses

Kumar, Rajneesh / Goel, Varun

Renewable energy. 2021 July, v. 172

2021

Abstract: Roughness is one of the effective and promising method to improve heat transfer through the solar air heater. The cross-sectional shape of roughness provided on the absorber plate shows a strong influence on solar air heater performance. In this work, ... ...

Abstract	Roughness is one of the effective and promising method to improve heat transfer through the solar air heater. The cross-sectional shape of roughness provided on the absorber plate shows a strong influence on solar air heater performance. In this work, the influence of various roughness-elements (such as semi-circular, circular, triangular, square, rectangular) has been investigated on flow dynamics as well as thermal characteristics of solar air heater and these geometries were investigated in triangular passage solar air heater. Commercial software is used for simulating heat and flow dynamics of roughened solar air under steady-state conditions. At Reynolds number of 18.7 × 10³, the best thermohydraulic performance parameter (TPP) obtained is 2.75 for forward-chamfered rectangular rib (with e/w = 2). The maximum value of TPP obtained for various roughness geometries decrease in the order of 2.68, 2.57, 2.45, 2.06, 1.79, and 1.60 for backward-chamfered rectangular rib (with e/w = 2), rectangular rib (with e/w = 2), rectangular rib (with e/w = 0.67), square rib, semi-circular rib, and circular ribs, respectively.
Keywords	Reynolds number ; air ; computer software ; heat transfer ; hydrodynamics ; roughness ; solar heaters
Language	English
Dates of publication	2021-07
Size	p. 1267-1278.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2021.03.068
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Article ; Online: Recovery potential of aerobic sludge biomass from Co (II) stress in sequencing batch reactors

Negi, Rajhans / Kumar, Rajneesh / Jawed, Mohammad

Environ Sci Pollut Res. 2022 Sept., v. 29, no. 41 p.61954-61966

2022

Abstract: Heavy metals in higher concentrations are often encountered in domestic sewage of developing and under-developed countries. High metallic concentrations can stress reactor sludge biomass morphology impeding its performance in organics reduction. However, ...

Abstract	Heavy metals in higher concentrations are often encountered in domestic sewage of developing and under-developed countries. High metallic concentrations can stress reactor sludge biomass morphology impeding its performance in organics reduction. However, the extent of damage and ability of sludge biomass to recover from the metallic stress is not fully understood. Also, there is no protocol to identify and prevent the sludge biomass from metallic stress in fully functional sewage treatment plants (STPs). This study investigates performance, metabolic activity, morphology, and settling characteristics of the sludge biomass under different Co(II) stress conditions. The extent of recovery in biomass, when the supply of Co(II) metal ion was discontinued in the inlet stream, was explored. The study also proposed a protocol based on simple settling characteristics of sludge biomass to get an early indication of metal infiltration to prevent potential damage to the biomass morphology. Four sequencing batch reactors (SBRs) with Co(II) ion concentrations of 0 (designated as RCo0), 5 (RCo5), 25 (RCo25), and 75 mg/L (RCo75) in the feed were operated with a cycle time of 12 h. Reactors were operated for 35 days with Co(II) in the feed (termed as stressed phase operation) followed by 24 days of operation without Co(II) in the feed (termed as recovery phase operation). Results show that COD removal in reactor RCo75 reduced to 48% on the 10th day of stressed phase operation, showing a lag in COD removal due to metallic stress. The activity of biomass in reactors RCo5, RCo25, and RCo75 was reduced by 39%, 45%, and 49%, respectively, in the stressed phase compared to the biomass in control reactor. Recovery in COD removal efficiency and specific biomass activity were observed in all the reactors after the removal of metallic stress. The settleability of sludge biomass in reactors RCo25 and RCo75 was significantly affected. Transformation in the shape of flocs in reactor RCo25 and RCo75 biomasses revealed the prolonged effect of metallic stress, which was observed to be irreversible even during the recovery phase operation.
Keywords	biochemical pathways ; biomass ; chemical oxygen demand ; sewage ; sewage treatment ; sludge
Language	English
Dates of publication	2022-09
Size	p. 61954-61966.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-19965-7
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Article: Simultaneous biodegradation of pyridine, indole, and ammonium along with phenol and thiocyanate by aerobic granular sludge

Tomar, Sachin Kumar / Kumar, Rajneesh / Chakraborty, Saswati

Journal of hazardous materials. 2022 Jan. 15, v. 422

2022

Abstract: Aerobic granular sludge potential for concurrent biodegradation of two nitrogenous heterocyclic compounds (NHCs), i.e., pyridine and indole, and ammonia nitrogen along with phenol and thiocyanate was investigated in three sequencing batch reactors (SBRs) ...

Abstract	Aerobic granular sludge potential for concurrent biodegradation of two nitrogenous heterocyclic compounds (NHCs), i.e., pyridine and indole, and ammonia nitrogen along with phenol and thiocyanate was investigated in three sequencing batch reactors (SBRs) (R1, R2, and R3). Pyridine and indole were provided, respectively, in R1 and R2, whereas R3 was operated with a mixture of equimolar concentrations of pyridine and indole. Three concentrations of NHCs (1.0, 2.5, and 5.0 mM) were investigated to observe the impact on aerobic granules. Pyridine did not exhibit any adverse effect on the granular characteristics (volatile suspended solids of 6.00 ± 0.08 g L⁻¹ and sludge volume index of 37.98 ± 0.84 mL gTSS⁻¹) up to a concentration of 5.0 mM (402.93 ± 6.29 mg L⁻¹) (R1) with around 74% and >98% removal for pyridine and other pollutants (phenol, thiocyanate, and ammonia nitrogen), respectively. However, indole had a substantial adverse impact on the granular characteristics and other contaminants removal with a concentration of more than 1.0 mM (120.65 ± 4.84 mg L⁻¹) (R2). The current research work provides an experimental treatment methodology for the wastewater in which pyridine, indole, ammonium, phenol, and thiocyanate coexist.
Keywords	adverse effects ; ammonium ; ammonium nitrogen ; biodegradation ; indoles ; phenol ; pyridines ; sludge ; thiocyanates ; wastewater
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.126861
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Article: A Case of Inflammatory Pseudotumour Masquerading as Hepatocellular Carcinoma.

Rajamanickam Chandrasekaran, Kalki / Aftab, Syed / Al Jajeh, Issam / Kumar, Rajneesh

Cureus

2023 Volume 15, Issue 9, Page(s) e45897

Abstract: Inflammatory pseudotumors (IPTs) of the liver can mimic malignant lesions. As the name implies, they are usually associated with an inflammatory process and usually regress with the treatment of the underlying pathology. We report a case of a 67-year-old ...

Abstract	Inflammatory pseudotumors (IPTs) of the liver can mimic malignant lesions. As the name implies, they are usually associated with an inflammatory process and usually regress with the treatment of the underlying pathology. We report a case of a 67-year-old female who presented with right upper quadrant pain, deranged liver enzymes, elevated tumor markers [alpha-fetoprotein (AFP) and CA 19-9], and a large liver mass on imaging, suspected to be hepatocellular carcinoma (HCC). She was eventually diagnosed with IPT complicating the liver inflammation due to autoimmune hepatitis (AIH). She responded well to treatment with steroids and immunosuppressive therapy.
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45897
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Article: Echocardiographic and Angiographic Assessment of Right Ventricular Function and Right Coronary Artery Stenosis in Acute Inferior Wall Myocardial Infarction.

Kumar, Rajneesh / Kumar, Prakash / Srivastava, Prabin K / Kumar, Prashant

Cureus

2023 Volume 15, Issue 10, Page(s) e46403

Abstract: Background: Cardiovascular diseases (CVDs) are a global concern. CVD remains a primary cause of death despite reduced coronary heart disease death rates. Acute coronary syndrome (ACS) involves myocardial infarction (MI) and unstable angina, sharing ... ...

Abstract	Background: Cardiovascular diseases (CVDs) are a global concern. CVD remains a primary cause of death despite reduced coronary heart disease death rates. Acute coronary syndrome (ACS) involves myocardial infarction (MI) and unstable angina, sharing mechanisms such as plaque instability. Our study assesses the right ventricular (RV) function's predictive value in acute inferior wall MI (IWMI) to identify high-risk patients with an elevated likelihood of experiencing severe cardiac complications, hemodynamic instability, or a higher mortality risk following an acute IWMI. Methodology: The research was conducted in the Department of Cardiology at the Rajendra Institute of Medical Sciences (RIMS), Ranchi, from July 2021 to June 2022, following the necessary ethical approval. A cohort of 140 patients with IWMI, carefully chosen according to rigorous criteria, clearly understood the study's objectives before providing informed consent. The evaluations were conducted in the following order: clinical assessments, followed by blood testing, then echocardiography, and finally, coronary angiography. Furthermore, the study examined risk factors and utilized statistical methods to elucidate the associations between qualities and results. Results: The study included 140 participants, with 61% being male and 39% female. Among the participants, 14% were aged 30-45, 50% were aged 46-60, and 30% were over 60. Age shows significant proportions in different categories. Diabetes, dyslipidemia, hypertension, and smoking/tobacco addiction did not differ among stenosis groups. Proximal right coronary artery (RCA) stenosis patients had elevated jugular venous pressure (JVP). The echocardiograms were performed within 48 hours of post-percutaneous coronary intervention, and significant differences between groups were observed. Participants with proximal stenosis had lower tricuspid annular plane systolic excursion (TAPSE) and right ventricular fractional area change (RVFAC), which showed compromised RV systolic function. Proximal stenosis patients had reduced systolic motion velocity (Sm), indicating impaired myocardial contraction. Echocardiographic parameters such as early diastolic velocity (Em), atrial contraction velocity (Am), Em/Am ratio (a marker of diastolic function), isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) between groups were different, indicating distinct cardiac functions. Proximal stenosis increased the myocardial performance index (MPI), indicating cardiac impairment. The left ventricular ejection fraction (LVEF) was comparable in the two stenosis groups, indicating similar left ventricular performance. Conclusion: Echocardiography showed significant RV function differences in acute inferior wall ST-segment elevation myocardial infarction (STEMI) patients with proximal and distal RCA lesions. RV dysfunction is linked to right ventricle myocardial infarction (RVMI), and echocardiographic markers can provide valuable insights. Results emphasize that acute inferior wall STEMI is diagnosed by electrocardiogram (ECG) criteria, particularly ST-segment elevation. However, these markers emphasize the importance of RV assessment in RCA involvement assessment. These findings suggest that RV function can help diagnose acute inferior wall STEMI RCA involvement. In acute inferior STEMIs, RV function echocardiography is essential for RCA lesion location.
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46403
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Article ; Online: Fagopyrum tataricum (L.) Gaertn interacts with Gsk-3β/Nrf-2 signalling to protect neurotoxicity in a zebrafish model.

Rahmatkar, Shubham Nilkanth / Rana, Anil Kumar / Kumar, Rajneesh / Singh, Damanpreet

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 2, Page(s) 117187

Abstract: Ethnopharmacological relevance: Fagopyrum tataricum (L.) Gaertn is used as a folk medicine in many Asian countries due to its anti-inflammatory, antioxidant, and several other health-promoting properties. It is also prescribed to improve neurocognitive ... ...

Abstract	Ethnopharmacological relevance: Fagopyrum tataricum (L.) Gaertn is used as a folk medicine in many Asian countries due to its anti-inflammatory, antioxidant, and several other health-promoting properties. It is also prescribed to improve neurocognitive functions and alleviate inflammatory conditions. Aim of the study: Oxidative stress and neuroinflammation plays a crucial role in neurodegenerative conditions. Hence, based on the ethnomedical claims and available literature, the present study investigated neuroprotective efficacy of a seed extract (ft-ext) of Fagopyrum tataricum against acrylamide (ACR)-induced neurotoxicity. Materials and methods: The phytochemical characterization of ft-ext was performed by a high-performance liquid chromatography method. Molecular interactions of the identified compounds of ft-ext were studied using an in-silico docking tool. An in-vitro protein denaturation assay was done to check anti-inflammatory activity. The 5 days' post-fertilized zebrafish larvae were exposed to 1 mM and 2.5 mM ACR with or without ft-ext for 72 h to study its neuroprotective efficacy. Real-time polymerase chain reaction and western blotting studies were performed to analyse the oxidative stress-related gene and protein expressions respectively. Results: The extract showed the presence of chlorogenic acid, rutin, caffeic acid, vitexin, syringic acid, quercetin, p-coumaric acid, kaempferol, and ferulic acid. In-vitro protein denaturation assay of ft-ext showed a potent anti-inflammatory effect. The ft-ext improved ACR-mediated locomotor deficit and reduced overall mortality in the larvae. The brain lipid peroxidation and protein carbonylation results revealed an elevated level of oxidative stress in the ACR-treated group, which was reduced in ft-ext-treated larvae. The extract treatment increased the expression of nrf2, gpx, and hmox1a, while simultaneously downregulated trxr2 levels in the brain of larvae exposed to ACR. The treatment also showed inactivation of Gsk-3β, thus maintaining a normal pool of Nrf2 and β-catenin. Molecular docking of identified compounds of ft-ext showed possible hydrogen and hydrophobic interactions with Gsk-3β. Conclusion: The ft-ext prevents ACR-mediated neurotoxicity by suppressing Gsk-3β mediated oxidative stress.
MeSH term(s)	Animals ; Zebrafish ; Glycogen Synthase Kinase 3 beta/metabolism ; Fagopyrum/chemistry ; NF-E2-Related Factor 2/metabolism ; Molecular Docking Simulation ; Oxidative Stress ; Plant Extracts/pharmacology ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; NF-E2-Related Factor 2 ; Plant Extracts ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-09-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117187
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Article ; Online: Buckwheat tartary regulates the Gsk-3β/β-catenin pathway to prevent neurobehavioral impairments in a rat model of surgical menopause.

Rana, Anil Kumar / Sharma, Supriya / Kumar, Rajneesh / Singh, Damanpreet

Metabolic brain disease

2023 Volume 38, Issue 6, Page(s) 1859–1875

Abstract: Menopause is a natural aging process characterized by decreased levels of sex hormones in females. Deprivation of estrogen following menopause results in alterations of dendritic arborization of the neuron that leads to neurobehavioral complications. ... ...

Abstract	Menopause is a natural aging process characterized by decreased levels of sex hormones in females. Deprivation of estrogen following menopause results in alterations of dendritic arborization of the neuron that leads to neurobehavioral complications. Hormone replacement therapy is in practice to manage postmenopausal conditions but is associated with a lot of adverse effects. In the present study, the efficacy of buckwheat tartary (Fagopyrum tataricum) whole seed extract was investigated against the neurobehavioral complication in middle-aged ovariectomized rats, which mimic the clinical postmenopausal condition. Hydroalcoholic extraction (80% ethanol) was done, and quantification of major marker compounds in the extract was performed using HPLC. Oral treatment of the extract following the critical window period rescued the reconsolidation process of spatial and recognition memory, as well as depression-like behavior. Gene expression analysis disclosed elevated oxidative stress and neuroinflammation that largely disturb the integrity of the blood-brain barrier in ovariectomized rats. Gfap and Pparγ expression also showed reactive astrogliosis in the rats subjected to ovariectomy. The extract treatment reverted the elevated oxidative stress, neuroinflammation and expression of the studied genes. Furthermore, protein expression analysis revealed that Gsk-3β was activated differentially in the brain, as suggested by β-catenin protein expression, which was normalized following the treatment with extract and rescued the altered neurobehavioral process. The results of the current study concluded that Fagopyrum tataricum seed extract is better option to overcome the neurobehavioral complications associated with the menopause.
MeSH term(s)	Female ; Rats ; Animals ; beta Catenin/metabolism ; Fagopyrum/genetics ; Fagopyrum/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Neuroinflammatory Diseases ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/metabolism ; Menopause
Chemical Substances	beta Catenin ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Plant Proteins ; Plant Extracts
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632824-6
ISSN	1573-7365 ; 0885-7490
ISSN (online)	1573-7365
ISSN	0885-7490
DOI	10.1007/s11011-023-01213-7
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Article ; Online: Application of triangular duct in solar-assisted air-heating system with surface roughness: a numerical investigation.

Kumar, Rajneesh / Reddy, Palvai Srinivas / Kharub, Manjeet / Bharadwaj, Gaurav

Environmental science and pollution research international

2023

Abstract: The device called solar air heater (SAH) is used to collect and transfer solar-thermal energy to air that can further be used for space heating, drying, etc. The conventional air heater (solar-assisted) has poor performance, and with this work, an ... ...

Abstract	The device called solar air heater (SAH) is used to collect and transfer solar-thermal energy to air that can further be used for space heating, drying, etc. The conventional air heater (solar-assisted) has poor performance, and with this work, an attempt has been made to improve its performance by providing surface roughness over the heated surface. The roughness employed over the surface has an elliptical cavity, and its distribution over the heated surface is defined with the three parameters (dimensionless): relative flow-wise distance (ranging from 6 to 14), relative cavity depth (ranging from 0.016 to 0.038), and relative crosswise distance (ranging from 6 to 14). A CFD code has been developed and validated with experimentation to do the parametric study for understanding the effect of the proposed surface roughness on the performance of the air heater. It is concluded that the proposed surface roughness promotes the local turbulence, flow separation, and strong vortices in the flow field resulting in comparatively higher thermal performance in the proposed air heater. But this higher thermal performance is achieved at the expense of higher-pressure loss in the passage. A substantial change in heat augmentation by 2.57 times (with 2.3 times higher pressure loss) which results in 1.75 times higher thermo-hydraulic performance has been noticed over conventional designs at a relative flow-wise distance of 10, relative cavity depth 0.038, and relative crosswise distance of 10.
Language	English
Publishing date	2023-07-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-28794-1
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Article ; Online: Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model.

Rana, Anil Kumar / Kumar, Rajneesh / Shukla, Durgesh Nandan / Singh, Damanpreet

Free radical biology & medicine

2023 Volume 207, Page(s) 107–119

Abstract: Cerebral ischemic stroke is one of the leading causes of adult disability worldwide. Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we investigated the efficacy of rutin and lithium co-treatment in improving ... ...

Abstract	Cerebral ischemic stroke is one of the leading causes of adult disability worldwide. Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we investigated the efficacy of rutin and lithium co-treatment in improving post-stroke neurological outcomes in a transient global cerebral ischemia-reperfusion injury rat model. Middle-aged male rats were subjected to transient global cerebral ischemia-reperfusion. NORT and Y-maze were used to assess the cognitive processes. Lipid peroxidation, protein carbonylation, and nitric oxide assays were performed to study oxidative stress. The excitotoxicity index was calculated by HPLC. Real time-PCR and western blotting were performed to study gene and protein expressions. The co-administration of rutin and lithium improved the overall survival, recognition memory, spatial working memory, and neurological score following cerebral ischemia-reperfusion in rats. Further, a marked decrease in malonaldehyde, protein carbonyls, and nitric oxide levels was observed following combined treatment. The mRNA expression of antioxidant (Hmox1 and Nqo1) and pro-inflammatory (Il2, Il6, and Il1β) markers were significantly attenuated in the rutin and lithium co-administrated group. The treatment inhibited the Gsk-3β and maintained a normal pool of the downstream β-catenin and Nrf2 proteins. The results revealed that co-administration of rutin and lithium had a neuroprotective potential, suggesting it to be a viable treatment to overcome post-stroke deaths and neurological complications.
MeSH term(s)	Rats ; Male ; Animals ; Glycogen Synthase Kinase 3 beta/genetics ; Lithium/therapeutic use ; Rutin/pharmacology ; Rutin/therapeutic use ; Nitric Oxide/therapeutic use ; Stroke/drug therapy ; Brain Ischemia/genetics ; Reperfusion Injury/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use
Chemical Substances	Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Lithium (9FN79X2M3F) ; Rutin (5G06TVY3R7) ; Nitric Oxide (31C4KY9ESH) ; Neuroprotective Agents
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2023.07.004
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