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  1. Article ; Online: Reduced Risk of Transfusion-Transmitted Babesiosis With Blood Donor Testing.

    Eder, Anne F / O'Callaghan, Sharon / Kumar, Sanjai

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  Volume 78, Issue 1, Page(s) 228–230

    MeSH term(s) Humans ; Babesiosis/diagnosis ; Blood Donors ; Blood Transfusion
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Research Support, U.S. Gov't, Non-P.H.S. ; Letter
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad536
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Highly Efficient Cell-Penetrating Probes of Protein Arginine Deiminases for Functional Proteomics.

    Kumar, Sanjai

    Chembiochem : a European journal of chemical biology

    2018  Volume 19, Issue 17, Page(s) 1806–1809

    Abstract: Protein arginine deiminases (PADs) have recently emerged at the forefront of drug-discovery programs for several human disorders. Despite this, a precise understanding of their functional roles in human biology remains to be fully elucidated. This report ...

    Abstract Protein arginine deiminases (PADs) have recently emerged at the forefront of drug-discovery programs for several human disorders. Despite this, a precise understanding of their functional roles in human biology remains to be fully elucidated. This report highlights a recent development of next-generation activity-based PAD probes that are highly efficient, cell active, and metabolically stable. This discovery should rapidly expedite functional assignments of PAD biology in both normal and diseased cells, thereby leading to the development of PAD-targeted therapeutics in the near future.
    MeSH term(s) Catalytic Domain ; Click Chemistry ; Humans ; Molecular Probes/chemistry ; Protein-Arginine Deiminases/chemistry ; Protein-Arginine Deiminases/metabolism ; Proteomics/methods
    Chemical Substances Molecular Probes ; Protein-Arginine Deiminases (EC 3.5.3.15)
    Language English
    Publishing date 2018-07-23
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.201800257
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  3. Article ; Online: Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG).

    Kostka, Julia / Maharjan, Anu S / Kumar, Sanjai / Hackenyos, Douglas / Krause, Peter J / Dieckhaus, Kevin

    PLoS neglected tropical diseases

    2024  Volume 18, Issue 3, Page(s) e0012035

    Abstract: Background: Babesiosis is a worldwide emerging protozoan infection that is associated with a spectrum of disease severity from asymptomatic infection to severe organ damage and death. While effective treatment strategies are available, some ... ...

    Abstract Background: Babesiosis is a worldwide emerging protozoan infection that is associated with a spectrum of disease severity from asymptomatic infection to severe organ damage and death. While effective treatment strategies are available, some immunocompromised patients experience severe acute and prolonged/relapsing illness due in part to an impaired host antibody response. Intravenous immunoglobulin (IVIG) has been used as an adjunctive therapy in some immunocompromised babesiosis patients, but its therapeutic effect is uncertain. We evaluated the presence of Babesia microti antibodies in commercial samples of IVIG.
    Methods/principle findings: The presence of B. microti antibodies in commercial samples of IVIG were tested using an immunofluorescence assay. A subset of samples was then tested for B. microti antibodies using an enzyme linked immunosorbent assay. Out of 57 commercial IVIG samples tested using IFA, and 52 samples tested using ELISA, none were positive for B. microti antibodies.
    Conclusions: Commercially available IVIG may not be of therapeutic benefit for babesiosis patients. Additional sampling of IVIG for B. microti antibody and a clinical trial of babesiosis patients given IVIG compared with controls would provide further insight into the use of IVIG for the treatment of babesiosis.
    MeSH term(s) Humans ; Immunoglobulins, Intravenous/therapeutic use ; Babesiosis/drug therapy ; Babesia microti ; Antibodies, Protozoan ; Enzyme-Linked Immunosorbent Assay
    Chemical Substances Immunoglobulins, Intravenous ; Antibodies, Protozoan
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0012035
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  4. Article: Technologies for Detection of Babesia microti: Advances and Challenges

    Meredith, Scott / Oakley, Miranda / Kumar, Sanjai

    Pathogens. 2021 Nov. 30, v. 10, no. 12

    2021  

    Abstract: The biology of intraerythrocytic Babesia parasites presents unique challenges for the diagnosis of human babesiosis. Antibody-based assays are highly sensitive but fail to detect early stage Babesia infections prior to seroconversion (window period) and ... ...

    Abstract The biology of intraerythrocytic Babesia parasites presents unique challenges for the diagnosis of human babesiosis. Antibody-based assays are highly sensitive but fail to detect early stage Babesia infections prior to seroconversion (window period) and cannot distinguish between an active infection and a previously resolved infection. On the other hand, nucleic acid-based tests (NAT) may lack the sensitivity to detect window cases when parasite burden is below detection limits and asymptomatic low-grade infections. Recent technological advances have improved the sensitivity, specificity and high throughput of NAT and the antibody-based detection of Babesia. Some of these advances include genomics approaches for the identification of novel high-copy-number targets for NAT and immunodominant antigens for superior antigen and antibody-based assays for Babesia. Future advances would also rely on next generation sequencing and CRISPR technology to improve Babesia detection. This review article will discuss the historical perspective and current status of technologies for the detection of Babesia microti, the most common Babesia species causing human babesiosis in the United States, and their implications for early diagnosis of acute babesiosis, blood safety and surveillance studies to monitor areas of expansion and emergence and spread of Babesia species and their genetic variants in the United States and globally.
    Keywords Babesia microti ; babesiosis ; blood ; early diagnosis ; genomics ; humans ; monitoring ; parasites ; seroconversion
    Language English
    Dates of publication 2021-1130
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10121563
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Technologies for Detection of

    Meredith, Scott / Oakley, Miranda / Kumar, Sanjai

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: The biology of ... ...

    Abstract The biology of intraerythrocytic
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10121563
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  6. Article: A Vaccine for Human Babesiosis: Prospects and Feasibility

    Al-Nazal, Hanan / Low, Leanne / Kumar, Sanjai / Good, Michael F. / Stanisic, Danielle I.

    Trends in parasitology. 2022,

    2022  

    Abstract: Babesiosis is a tick-borne disease, caused by intraerythrocytic Babesia parasites. It is a well-known illness in companion animals and livestock, resulting in substantial economic losses in the cattle industry. Babesiosis is also recognised as an ... ...

    Abstract Babesiosis is a tick-borne disease, caused by intraerythrocytic Babesia parasites. It is a well-known illness in companion animals and livestock, resulting in substantial economic losses in the cattle industry. Babesiosis is also recognised as an emerging zoonosis of humans in many countries worldwide. There is no vaccine against human babesiosis. Currently, preventive measures are focused on vector avoidance. Although not always effective, treatment includes anti-microbial therapy and exchange transfusion. In this review we discuss the host’s immune response to the parasite, vaccines being used to prevent babesiosis in animals and lessons from malaria vaccine development efforts to inform the development of a human babesiosis vaccine. An effective human vaccine would be a significant advance towards curtailing this rapidly emerging disease.
    Keywords Babesia ; babesiosis ; cattle industry ; drug therapy ; humans ; immune response ; livestock ; malaria vaccines ; parasites ; parasitology ; vaccine development ; zoonoses
    Language English
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.07.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
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  7. Article ; Online: A vaccine for human babesiosis: prospects and feasibility.

    Al-Nazal, Hanan / Low, Leanne M / Kumar, Sanjai / Good, Michael F / Stanisic, Danielle I

    Trends in parasitology

    2022  Volume 38, Issue 10, Page(s) 904–918

    Abstract: Babesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-known illness in companion animals and livestock, resulting in substantial economic losses in the cattle industry. Babesiosis is also recognized as an emerging ...

    Abstract Babesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-known illness in companion animals and livestock, resulting in substantial economic losses in the cattle industry. Babesiosis is also recognized as an emerging zoonosis of humans in many countries worldwide. There is no vaccine against human babesiosis. Currently, preventive measures are focused on vector avoidance. Although not always effective, treatment includes antimicrobial therapy and exchange transfusion. In this review, we discuss the host's immune response to the parasite, vaccines being used to prevent babesiosis in animals, and lessons from malaria vaccine development efforts to inform the development of a human babesiosis vaccine. An effective human vaccine would be a significant advance towards curtailing this rapidly emerging disease.
    MeSH term(s) Animals ; Babesia ; Babesiosis/parasitology ; Babesiosis/prevention & control ; Cattle ; Cattle Diseases/parasitology ; Cattle Diseases/prevention & control ; Feasibility Studies ; Humans ; Tick-Borne Diseases ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.07.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 251: Show issues

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  8. Article ; Online: Protective efficacy and correlates of immunity of immunodominant recombinant

    Meredith, Scott / Majam, Victoria / Zheng, Hong / Verma, Nitin / Puri, Ankit / Akue, Adovi / KuKuruga, Mark / Oakley, Miranda / Kumar, Sanjai

    Infection and immunity

    2023  Volume 91, Issue 10, Page(s) e0016223

    Abstract: Babesia microti, ...

    Abstract Babesia microti,
    MeSH term(s) Humans ; Mice ; Animals ; United States ; Babesia microti/physiology ; Babesiosis ; Immunodominant Epitopes ; Cytokines ; Immunization
    Chemical Substances Immunodominant Epitopes ; Cytokines
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00162-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
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  9. Article: Persistence of

    Bloch, Evan M / Kumar, Sanjai / Krause, Peter J

    Pathogens (Basel, Switzerland)

    2019  Volume 8, Issue 3

    Abstract: Persistent infection is a characteristic feature of babesiosis, a worldwide, emerging tick-borne disease caused by members of the ... ...

    Abstract Persistent infection is a characteristic feature of babesiosis, a worldwide, emerging tick-borne disease caused by members of the genus
    Language English
    Publishing date 2019-07-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens8030102
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  10. Article ; Online: Adverse neuropsychiatric effects of antimalarial drugs.

    Grabias, Bryan / Kumar, Sanjai

    Expert opinion on drug safety

    2016  Volume 15, Issue 7, Page(s) 903–910

    Abstract: Introduction: Antimalarial drugs are the primary weapon to treat parasite infection, save lives, and curtail further transmission. Accumulating data have indicated that at least some antimalarial drugs may contribute to severe neurological and/or ... ...

    Abstract Introduction: Antimalarial drugs are the primary weapon to treat parasite infection, save lives, and curtail further transmission. Accumulating data have indicated that at least some antimalarial drugs may contribute to severe neurological and/or psychiatric side effects which further complicates their use and limits the pool of available medications.
    Areas covered: In this review article, we summarize published scientific studies in search of evidence of the neuropsychiatric effects that may be attributed to the commonly used antimalarial drugs administered alone or in combination. Each individual drug was used as a search term in addition to keywords such as neuropsychiatric, adverse events, and neurotoxicity.
    Expert opinion: Accumulating data based on published reports over several decades have suggested that among the major commonly used antimalarial drugs, only mefloquine exhibited clear indications of serious neurological and/or psychiatric side effects. A more systematic approach to assess the neuropsychiatric adverse effects of new or repurposed antimalarial drugs on their safety, tolerability and efficacy phases of clinical studies and in post-marketing surveillance, is needed to ensure that these life-saving tools remain available and can be prescribed with appropriate caution and medical judgment.
    MeSH term(s) Antimalarials/adverse effects ; Antimalarials/therapeutic use ; Humans ; Malaria/drug therapy ; Mefloquine/adverse effects ; Mefloquine/therapeutic use ; Mental Disorders/chemically induced ; Neurotoxicity Syndromes/etiology
    Chemical Substances Antimalarials ; Mefloquine (TML814419R)
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2016.1175428
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    Zs.A 6096: Show issues Location:
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