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  1. Article: Cold Agglutinin Disease and COVID-19: A Scoping Review of Treatments and Outcomes.

    Musuuza, Jackson S / Kumar, Silpa / Posa, Dheeraj Kumar / Hans, Aakash / Nayyar, Sankett / Christensen, Leslie / Kamoga, Gilbert-Roy

    Journal of clinical medicine research

    2024  Volume 16, Issue 1, Page(s) 8–14

    Abstract: Background: Reports suggest that patients with both acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and cold agglutinin disease (CAD) may experience poorer survival when treated with rituximab. We conducted a scoping review to evaluate ... ...

    Abstract Background: Reports suggest that patients with both acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and cold agglutinin disease (CAD) may experience poorer survival when treated with rituximab. We conducted a scoping review to evaluate severe outcomes, including intensive care unit (ICU) admission and mortality, in coronavirus disease 2019 (COVID-19) patients with CAD on various treatments, including rituximab.
    Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). Four literature databases were searched on December 19, 2023, for studies reporting lab-confirmed SARS-CoV-2 and CAD, excluding rheumatological conditions.
    Results: Of the 741 screened articles, 19 were included. Studies, predominantly case reports (17/19) or case series (2/19), were mainly from the USA (8/19) and India (3/19), with others across Europe and Asia. Among 23 patients (61% female, median age 61 years), 21/23 had a new CAD diagnosis; only two had pre-existing CAD. Overall, 74% recovered, 21% died, and outcomes for one were unreported. Nine (39%) were ICU-admitted. Of rituximab-treated patients (n = 4), 25% were ICU-admitted, none died. Non-rituximab treatments (n = 19) saw 42% ICU admissions and 26% mortality.
    Conclusions: This review found no increased risk of severe outcomes in CAD and COVID-19 patients treated with rituximab.
    Language English
    Publishing date 2024-01-31
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr5102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Beam Focal Spot Offset Determination for Linear Accelerators: A Phantom less Method.

    AjayKumar, Silpa / C, Arathi / B, Resmi K / A, Suja C / Jose, Lisha / V, Vinin N / Muttath, Geetha / Musthafa, M M

    The Gulf journal of oncology

    2023  Volume 1, Issue 43, Page(s) 46–50

    Abstract: The effectiveness of radiotherapy treatment is influenced by the position of beam focal spot; therefore, it is important to verify the beam focal spot periodically. In this study the beam focal spot offset is measured using an electronic portal imaging ( ... ...

    Abstract The effectiveness of radiotherapy treatment is influenced by the position of beam focal spot; therefore, it is important to verify the beam focal spot periodically. In this study the beam focal spot offset is measured using an electronic portal imaging (EPID) based technique and co- rotational penumbra modulation technique(CPM).
    Materials and methods: This method utilizes one set of jaws and the multileaf collimator (MLC) to form a symmetric field and then a 180o collimator rotation was utilized to determine the radiation isocenter defined by the jaws and the MLC, respectively. The difference between these two isocentres is then directly correlated with the beam focal spot offset of the linear accelerator. In the current study, the method has been used for Varian ClinaciX and Elekta Versa HD linear accelerators. Since an Elektalinac with the Agility® head does not have two set of jaws, a modified method that making use of one set of diaphragms, the MLC and a full 360o collimator rotation is implemented.
    Result: The method is validated against CPM and found to be in agreement within 0.00923± 0.009360 mm ( SD) also the method has been found to be reproducible to within 0.0365 mm (SD).
    Conclusion: The method could be used for routine quality assurance (QA) to ensure that the beam focal spot offset is in tolerance.
    MeSH term(s) Humans ; Phantoms, Imaging ; Radiotherapy ; Particle Accelerators
    Language English
    Publishing date 2023-09-21
    Publishing country Kuwait
    Document type Journal Article
    ISSN 2078-2101
    ISSN 2078-2101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular and clinical epidemiology of carbapenem resistant

    Baleivanualala, Sakiusa C / Isaia, Lupeoletalalelei / Devi, Swastika V / Howden, Benjamin / Gorrie, Claire L / Matanitobua, Silivia / Sharma, Sajnel / Wilson, Donald / Kumar, Silpa / Maharaj, Komal / Beatson, Scott / Boseiwaqa, Lusiana V / Dyet, Kristin / Crump, John A / Hill, Philip C / Ussher, James E

    The Lancet regional health. Western Pacific

    2023  Volume 40, Page(s) 100896

    Abstract: Background: Carbapenem resistant : Methods: In this multicountry cohort study, we analysed clinical isolates of CR: Findings: Of CR: Interpretation: We identified unrecognised outbreaks of CR: Funding: This project was funded by an Otago ... ...

    Abstract Background: Carbapenem resistant
    Methods: In this multicountry cohort study, we analysed clinical isolates of CR
    Findings: Of CR
    Interpretation: We identified unrecognised outbreaks of CR
    Funding: This project was funded by an Otago Global Health Institute seed grant and Maurice Wilkins Centre of Research Excellence (CoREs) grant (SC0000169653, RO0000002300).
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2023.100896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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