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  1. Article: 'Snapshot' of an annual data from a large South Indian Renal Biopsy Registry.

    Jayaprakash, V / Kumar, T Dinesh / Gopalakrishnan, N / Kurien, Anila Abraham

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2022  Volume 32, Issue 2, Page(s) 522–529

    Abstract: Results from biopsy registries are important to know about the prevalence of renal diseases. In large studies done over several years, significant interobserver variability could have existed. Single-year biopsy registry data are analyzed in this study. ... ...

    Abstract Results from biopsy registries are important to know about the prevalence of renal diseases. In large studies done over several years, significant interobserver variability could have existed. Single-year biopsy registry data are analyzed in this study. The study included 481 renal biopsy specimens including 65 from allografts. Primary glomerulonephritis constituted 37.74% and secondary glomerular diseases constituted 32.21% of native kidney biopsies. Minimal change disease was the most common primary glomerular disease, followed by membranous nephropathy (MN). Lupus nephritis was the most common secondary glomerular disease. This study included specimens from 34 geriatric patients and MN was the most common lesion in that age group. Acute cellular rejection was the most common diagnosis in renal allograft biopsies.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Biopsy/statistics & numerical data ; Female ; Glomerulonephritis/epidemiology ; Glomerulonephritis/pathology ; Glomerulonephritis, IGA/epidemiology ; Glomerulonephritis, IGA/pathology ; Glomerulonephritis, Membranous/epidemiology ; Glomerulonephritis, Membranous/pathology ; Humans ; Kidney/pathology ; Kidney Diseases/epidemiology ; Kidney Diseases/pathology ; Kidney Transplantation ; Lupus Nephritis/epidemiology ; Lupus Nephritis/pathology ; Male ; Registries ; Retrospective Studies ; Sex Distribution
    Language English
    Publishing date 2022-01-08
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    DOI 10.4103/1319-2442.335465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4735: Show issues Location:
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  2. Article: Assessment of Quality of Platelet-Rich Plasma Produced With Desktop Centrifuge and Comparison With Standardized Commercially Available Platelet-rich plasma.

    Srinivasan, V Ramesh / Rekha, M / Edsor, Effie / Raja, S Pradheep / Kumar, T Dinesh / Kalaiselvan, S

    Journal of pharmacy & bioallied sciences

    2020  Volume 12, Issue Suppl 1, Page(s) S607–S612

    Abstract: Aims: The aim of this study was to assess the quality of platelet-rich plasma (PRP) produced by in-house desktop centrifuge method and compare it with that of standardized commercial PRP.: Materials and methods: REMI desktop centrifuge was used to ... ...

    Abstract Aims: The aim of this study was to assess the quality of platelet-rich plasma (PRP) produced by in-house desktop centrifuge method and compare it with that of standardized commercial PRP.
    Materials and methods: REMI desktop centrifuge was used to prepare PRP and to compare with standardized commercial PRP by calculating the quantity of platelets using Beckman Coulter cell counter in 10 PRP samples and assessing the morphological quality of platelets using JEOL JEM transmission electron microscope (TEM).
    Statistical analysis used: The
    Results: The platelet count was lesser than that of standardized commercial PRP. When viewed under JEOL JEM transmission electron microscope, the α granules in platelets were intact and the morphological quality of the PRP was good.
    Conclusions: With this study, we have determined that the morphological quality of PRP produced by the in-house desktop centrifuge method is comparable to that of standardized commercial PRP. Though the quantity of platelets was less than 1 million cells/μL, the clinical results were good with desired bone formation, thereby providing good avenue for further research.
    Language English
    Publishing date 2020-08-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.JPBS_163_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinicopathological profile and outcome of adult infection-related glomerulonephritis: A prospective follow-up study.

    Arivazhagan, S / Rajasekar, D / Gopalakrishnan, N / Sakthirajan, R / Dhanapriya, J / Kumar, T Dinesh / Balasubramanian, T / Malathy, N

    The National medical journal of India

    2021  Volume 33, Issue 5, Page(s) 260–264

    Abstract: Background: . Infection-related glomerulonephritis (IRGN) in adults is witnessing a dramatic shift in its epidemiology and outcome. Adult IRGN studies are all retrospective in nature, and Indian studies are scarce.: Methods: . We did this prospective ...

    Abstract Background: . Infection-related glomerulonephritis (IRGN) in adults is witnessing a dramatic shift in its epidemiology and outcome. Adult IRGN studies are all retrospective in nature, and Indian studies are scarce.
    Methods: . We did this prospective study (September 2016-April 2018) on all patients with biopsy-proven IRGN and age ≥18 years satisfying three of five diagnostic criteria. Patients with persistent hypocomplementaemia (>3 months) were excluded. We did electron microscopy in those without a minimum of three diagnostic criteria and did an extensive search for any occult infection in every patient.
    Results: . Forty-five patients were studied with a mean (SD) follow-up of 45.7 (20) weeks. Their mean age was 41.5 years (18-70 years), with a female preponderance (1:1.25). At presentation, the majority had oedema (100%), oliguria (84.4%), hypertension (80%) and haematuria (77.8%). Of them, 86.7% had renal insufficiency and 35.6% required dialysis. Only 53.3% of them had evidence of antecedent/ current infection, with skin/subcutaneous focus being the most common site. Hypocomplementaemia was present in 82.2% of patients. Salient pathological features were endocapillary proliferation (93.3%), neutrophilic infiltration (88.9%), presence of crescents (17.8%), interstitial infiltration (24.4%), moderate-to-severe interstitial fibrosis with tubular atrophy (IFTA; 15.5%) and underlying diabetic glomerulosclerosis (8.9%). Only 66.7% of patients made complete renal recovery. By logistic regression analysis, the predictors of poor outcome were a requirement for dialysis at presentation (p=0.04) and presence of IFTA (p = 0.03).
    Conclusion: . A proportion of adult IRGN patients progress to chronic kidney disease.
    MeSH term(s) Adolescent ; Adult ; Female ; Follow-Up Studies ; Glomerulonephritis/complications ; Glomerulonephritis/epidemiology ; Humans ; Kidney ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2021-07-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.4103/0970-258X.317465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2493: Show issues Location:
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  4. Article: Lymphomatous Infiltration of Kidneys.

    Dhanapriya, J / Kumar, T Dinesh / Gopalakrishnan, N / Balasubramaniyan, T

    The Journal of the Association of Physicians of India

    2015  Volume 63, Issue 5, Page(s) 74–76

    Abstract: Renal involvement in lymphoma usually occurs late in the course of the disease and is clinically silent. Acute kidney injury (AKI) is rare, with the reported incidence of 0.5% in the literature. We describe here a 20 years old female patient who ... ...

    Abstract Renal involvement in lymphoma usually occurs late in the course of the disease and is clinically silent. Acute kidney injury (AKI) is rare, with the reported incidence of 0.5% in the literature. We describe here a 20 years old female patient who presented with non-dialysis requiring AKI and renal biopsy showed lymphomatous infiltration of kidneys. Though renal function improved, patient died due to central nervous system involvement.
    MeSH term(s) Acute Kidney Injury/etiology ; Female ; Humans ; Kidney Neoplasms/complications ; Kidney Neoplasms/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Young Adult
    Language English
    Publishing date 2015-05
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 313: Show issues Location:
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  5. Article: Familial Lecithin Cholesterol Acyl Transferase Deficiency with Chronic Kidney Disease.

    Gopalakrishnan, N / Arul, R / Dhanapriya, J / Kumar, T Dinesh / Sakthirajan, R / Balasubramaniyan, T

    The Journal of the Association of Physicians of India

    2016  Volume 64, Issue 10, Page(s) 90–91

    Abstract: Familial lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare autosomal recessive (AR) disease caused by mutation in the LCAT gene. LCAT enzyme esterifies cholesterol molecules in high-density lipoprotein(HDL) and low density-lipoprotein (LDL) ...

    Abstract Familial lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare autosomal recessive (AR) disease caused by mutation in the LCAT gene. LCAT enzyme esterifies cholesterol molecules in high-density lipoprotein(HDL) and low density-lipoprotein (LDL) particles. This enzyme deficiency is characterised by progressive corneal opacification, glomerulopathy, mild - moderate haemolytic anaemia and very low plasma levels of HDL. We here report a 34 year-old lady who presented with hypertension, nephrotic proteinuria, renal failure, corneal ring opacities, anemia and dyslipidemia. The diagnosis of familial LCAT deficiency was confirmed by clinical examination, characteristic dyslipidemia, undetectable LCAT levels in plasma and positive family history.
    MeSH term(s) Adult ; Female ; Humans ; Lecithin Cholesterol Acyltransferase Deficiency/complications ; Lecithin Cholesterol Acyltransferase Deficiency/genetics ; Renal Insufficiency, Chronic/complications
    Language English
    Publishing date 2016-10-17
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 313: Show issues Location:
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