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  1. AU="Kumar, Terrence"
  2. AU="Rkha, Samia"
  3. AU="Stein, Jamal M"

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  1. Article ; Online: Malignant phyllodes tumour of the breast with early recurrence in a young patient.

    Klooz, Andrea / Kumar, Terrence / Maxwell, Jessica

    BMJ case reports

    2024  Volume 17, Issue 3

    Abstract: A young woman in her 20s was found to have a left breast malignant phyllodes tumour by ultrasound-guided core needle biopsy, after identifying a palpable lump. She then underwent lumpectomy excision with >1 cm gross margins; however, final pathology ... ...

    Abstract A young woman in her 20s was found to have a left breast malignant phyllodes tumour by ultrasound-guided core needle biopsy, after identifying a palpable lump. She then underwent lumpectomy excision with >1 cm gross margins; however, final pathology demonstrated <1 cm margins at the superior margin. She then underwent re-excision of superior and medial margins to ensure at least a 1 cm margin. Biopsy tract was not excised at initial or re-excision surgery. Approximately 6 weeks after completion lumpectomy, the patient noted a new palpable mass near the previous biopsy site and underwent punch biopsy. Final pathology of this new mass was concordant with early recurrence. The patient then underwent lumpectomy of the new mass along with excision of the overlying skin and biopsy tract with >1 cm margins.
    MeSH term(s) Female ; Humans ; Phyllodes Tumor/surgery ; Phyllodes Tumor/pathology ; Breast/pathology ; Mastectomy, Segmental ; Image-Guided Biopsy ; Retrospective Studies ; Chronic Disease ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Neoplasm Recurrence, Local/surgery ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-258352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Quantifying Human Monocyte Chemotaxis In Vitro and Murine Lymphocyte Trafficking In Vivo.

    Prangley, Eliza / Kumar, Terrence / Ponda, Manish P

    Journal of visualized experiments : JoVE

    2017  , Issue 128

    Abstract: Chemotaxis is migration along a specific chemical ... ...

    Abstract Chemotaxis is migration along a specific chemical gradient
    MeSH term(s) Animals ; Chemotaxis, Leukocyte/physiology ; Flow Cytometry/methods ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Lymphocytes/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology
    Language English
    Publishing date 2017-10-30
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/56218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characteristics of pathologic complete response for locally advanced rectal cancer.

    Cloos, Adam J / Schissel, Makayla / Batra, Rishi / Donahue, Steven R / Wenos, Chelsea D / Kumar, Terrence / Leinicke, Jennifer A / Thompson, Jon S / Langenfeld, Sean J

    American journal of surgery

    2023  Volume 226, Issue 6, Page(s) 873–877

    Abstract: Background: Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR).: Methods: The ... ...

    Abstract Background: Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR).
    Methods: The National Surgical Quality Improvement Program proctectomy-targeted database was utilized to identify all patients from 2016 to 2020 who underwent NACRT followed by proctectomy with curative intent for T3-4N0-2 rectal cancers.
    Results: A total of 1891 patients were included, of which 253 (13.4%) demonstrated a pCR. Pretreatment N0 staging was associated with a higher rate of pCR (18.9%) when compared to N1 (6.7%) and N2 (6.7%) (p < 0.0001). Patients clinically staged at T3N0 had the highest rate of pCR (19.5%). Gender, age, race, weight, smoking status, and tumor height were not associated with pCR.
    Conclusions: Patients with cN0 disease were more likely to experience a pCR compared to cN1-2 patients. Tumor height relative to anal verge or patient demographics were not associated with pCR.
    MeSH term(s) Humans ; Neoplasm Staging ; Rectum/surgery ; Rectum/pathology ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Neoadjuvant Therapy ; Proctectomy ; Retrospective Studies ; Chemoradiotherapy ; Treatment Outcome
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2023.07.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Quantifying human monocyte chemotaxis In Vitro and murine lymphocyte trafficking In Vivo

    Prangley, Eliza / Kumar, Terrence / Ponda, Manish P

    Journal of visualized experiments. 2017 Oct. 30, , no. 128

    2017  

    Abstract: Chemotaxis is migration along a specific chemical gradient1. Chemokines are chemotactic cytokines that promote cellular trafficking with anatomic and temporal specificity2. Chemotaxis is a critical function of lymphocytes and other immune cells that can ... ...

    Abstract Chemotaxis is migration along a specific chemical gradient1. Chemokines are chemotactic cytokines that promote cellular trafficking with anatomic and temporal specificity2. Chemotaxis is a critical function of lymphocytes and other immune cells that can be quantitatively assessed in vitro. This manuscript describes methods that permit the evaluation of chemotaxis, both in vitro and in vivo, for diverse cell types including cell lines and native cells. The in vitro, plate-based format permits the comparison of several conditions simultaneously in real-time, and can be completed within 1-4 h. In vitro assay conditions can be manipulated to introduce agonists and antagonists, as well as differentiate chemotaxis from chemokinesis, which is random movement. For in vivo trafficking assessments, immune cells can be labeled with multiple fluorescent dyes and used for adoptive transfer. The differential labeling of cells allows for mixed cell populations to be introduced into the same animal, thereby decreasing variance and reducing the number of animals required for an adequately powered experiment. Migration into lymphoid tissue occurs in as little as 1 h, and multiple tissue compartments can be sampled. Flow cytometry following tissue harvest allows for a rapid and quantitative analysis of the migratory patterns of multiple cell types.
    Keywords agonists ; animal use reduction ; antagonists ; cell lines ; chemokines ; chemotaxis ; flow cytometry ; fluorescent dyes ; humans ; in vitro studies ; lymphocytes ; mice ; migratory behavior ; monocytes ; quantitative analysis ; variance
    Language English
    Dates of publication 2017-1030
    Size p. e56218.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/56218
    Database NAL-Catalogue (AGRICOLA)

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