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Article ; Online: The low loading of metal in metal-organic framework-derived NiN

Vyas, Ved / Kumar, Vishesh / Indra, Arindam

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 18, Page(s) 2544–2547

Abstract: The pyrolysis of Ni-substituted zeolitic imidazolate framework-8 produces ... ...

Abstract	The pyrolysis of Ni-substituted zeolitic imidazolate framework-8 produces NiN
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc06002k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Learning Continuous 2D Diffusion Maps from Particle Trajectories without Data Binning.

Kumar, Vishesh / Shepard Bryan, J / Rojewski, Alex / Manzo, Carlo / Pressé, Steve

bioRxiv : the preprint server for biology

2024

Abstract: Diffusion coefficients often vary across regions, such as cellular membranes, and quantifying their variation can provide valuable insight into local membrane properties such as composition and stiffness. Toward quantifying diffusion coefficient spatial ... ...

Abstract	Diffusion coefficients often vary across regions, such as cellular membranes, and quantifying their variation can provide valuable insight into local membrane properties such as composition and stiffness. Toward quantifying diffusion coefficient spatial maps and uncertainties from particle tracks, we use a Bayesian method and place Gaussian Process (GP) Priors on the maps. For the sake of computational efficiency, we leverage inducing point methods on GPs arising from the mathematical structure of the data giving rise to non-conjugate likelihood-prior pairs. We analyze both synthetic data, where ground truth is known, as well as data drawn from live-cell single-molecule imaging of membrane proteins. The resulting tool provides an unsupervised method to rigorously map diffusion coefficients continuously across membranes without data binning.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.27.582378
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Book ; Online: AI Audit

Ali, Safinah / Kumar, Vishesh / Breazeal, Cynthia

A Card Game to Reflect on Everyday AI Systems

2023

Abstract: An essential element of K-12 AI literacy is educating learners about the ethical and societal implications of AI systems. Previous work in AI ethics literacy have developed curriculum and classroom activities that engage learners in reflecting on the ... ...

Abstract	An essential element of K-12 AI literacy is educating learners about the ethical and societal implications of AI systems. Previous work in AI ethics literacy have developed curriculum and classroom activities that engage learners in reflecting on the ethical implications of AI systems and developing responsible AI. There is little work in using game-based learning methods in AI literacy. Games are known to be compelling media to teach children about complex STEM concepts. In this work, we developed a competitive card game for middle and high school students called "AI Audit" where they play as AI start-up founders building novel AI-powered technology. Players can challenge other players with potential harms of their technology or defend their own businesses by features that mitigate these harms. The game mechanics reward systems that are ethically developed or that take steps to mitigate potential harms. In this paper, we present the game design, teacher resources for classroom deployment and early playtesting results. We discuss our reflections about using games as teaching tools for AI literacy in K-12 classrooms.
Keywords	Computer Science - Computers and Society ; Computer Science - Artificial Intelligence ; Computer Science - Human-Computer Interaction
Subject code	170
Publishing date	2023-05-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Axillary transvalvular microaxial pump as extended bridge to transcatheter aortic valve replacement in cardiogenic shock with severe aortic stenosis.

Abraham, Jacob / Wang, Lian / Kumar, Vishesh / Kirker, Eric B / Spinelli, Kateri J

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2022 Volume 41, Issue 4, Page(s) 434–437

Abstract: Cardiogenic shock in the setting of severe aortic stenosis is associated with poor outcomes. We describe 5 patients with cardiogenic shock and severe aortic stenosis who received an axillary microaxial pump (Impella) as an extended bridge to ... ...

Abstract	Cardiogenic shock in the setting of severe aortic stenosis is associated with poor outcomes. We describe 5 patients with cardiogenic shock and severe aortic stenosis who received an axillary microaxial pump (Impella) as an extended bridge to transcatheter aortic valve replacement. The median (range) age was 65 (61-87) years old, 80% were male, and 80% presented with stage D or E cardiogenic shock. In most cases, balloon aortic valvuloplasty was performed prior to pump insertion. Stabilization by Impella allowed for heart team evaluation and additional interventions, including percutaneous coronary intervention, MitraClip, and cardioversion. After a median (range) of 7 (5-14) days of Impella support, semi-elective transcatheter aortic valve replacement was successfully performed. All patients survived to discharge. Four patients (80%) were alive beyond 1 year. In these high-risk patients, prolonged support with a microaxial pump allowed for stabilization, ancillary interventions, and multi-disciplinary heart team evaluation prior to transcatheter aortic valve replacement.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/surgery ; Heart-Assist Devices ; Humans ; Male ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/surgery ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2021.12.010
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Article: Genome-Wide Identification and Characterisation of Cytokinin-O-Glucosyltransferase (CGT) Genes of Rice Specific to Potential Pathogens.

Dauda, Wadzani Palnam / Shanmugam, Veerubommu / Tyagi, Aditya / Solanke, Amolkumar U / Kumar, Vishesh / Krishnan, Subbaiyan Gopala / Bashyal, Bishnu Maya / Aggarwal, Rashmi

Plants (Basel, Switzerland)

2022 Volume 11, Issue 7

Abstract: Cytokinin glucosyltransferases (CGTs) are key enzymes of plants for regulating the level and function of cytokinins. In a genomic identification of rice CGTs, 41 genes with the plant secondary product glycosyltransferases (PSPG) motif of 44-amino-acid ... ...

Abstract	Cytokinin glucosyltransferases (CGTs) are key enzymes of plants for regulating the level and function of cytokinins. In a genomic identification of rice CGTs, 41 genes with the plant secondary product glycosyltransferases (PSPG) motif of 44-amino-acid consensus sequence characteristic of plant uridine diphosphate (UDP)-glycosyltransferases (UGTs) were identified. In-silico physicochemical characterisation revealed that, though the CGTs belong to the same subfamily, they display varying molecular weights, ranging from 19.6 kDa to 59.7 kDa. The proteins were primarily acidic (87.8%) and hydrophilic (58.6%) and were observed to be distributed in the plastids (16), plasma membrane (13), mitochondria (5), and cytosol (4). Phylogenetic analysis of the CGTs revealed that their evolutionary relatedness ranged from 70-100%, and they aligned themselves into two major clusters. In a comprehensive analysis of the available transcriptomics data of rice samples representing different growth stages only the CGT,
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11070917
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Article: Leadless Pacemakers: A Review.

Kumar, Vishesh / Sethi, Prince / Yee, Jimmy / Pham, Roman / Pham, Scott

South Dakota medicine : the journal of the South Dakota State Medical Association

2019 Volume 72, Issue 2, Page(s) 60–62

MeSH term(s)	Equipment Design ; Pacemaker, Artificial
Language	English
Publishing date	2019-03-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: Genome-Wide Analysis of von Willebrand Factor A Gene Family in Rice for Its Role in Imparting Biotic Stress Resistance with Emphasis on Rice Blast Disease

Karkute, Suhas Gorakh / Kumar, Vishesh / Tasleem, Mohd / Mishra, Dwijesh Chandra / Chaturvedi, Krishna Kumar / Rai, Anil / Sevanthi, Amitha Mithra / Gaikwad, Kishor / Sharma, Tilak Raj / Solanke, Amolkumar U.

China National Rice Research Institute Rice science. 2022 July, v. 29, no. 4

2022

Abstract: von Willebrand factor A (vWA) genes are well characterized in humans except for few BONZAI genes, but the vWA genes are least explored in plants. Considering the novelty and vital role of vWA genes, this study aimed at characterization of vWA superfamily ...

Abstract	von Willebrand factor A (vWA) genes are well characterized in humans except for few BONZAI genes, but the vWA genes are least explored in plants. Considering the novelty and vital role of vWA genes, this study aimed at characterization of vWA superfamily in rice. Rice genome was found to have 40 vWA genes distributed across all the 12 chromosomes, and 20 of the 40 vWA genes were unique while the remaining shared large fragment similarities with each other, indicating gene duplication. In addition to vWA domain, vWA proteins possess other different motifs or domains, such as ubiquitin interacting motif in protein degradation pathway, and RING finger in protein-protein interaction. Expression analysis of vWA genes in available expression data suggested that they probably function in biotic and abiotic stress responses including hormonal response and signaling. The frequency of transposon elements in the entire 3K rice germplasm was negligible except for 9 vWA genes, indicating the importance of these genes in rice. Structural and functional diversities showed that the vWA genes in a blast-resistant rice variety Tetep had huge variations compared to blast-susceptible rice varieties HP2216 and Nipponbare. qRT-PCR analysis of vWA genes in Magnaporthe oryzae infected rice tissues indicated OsvWA9, OsvWA36, OsvWA37 and OsvWA18 as the optimal candidate genes for disease resistance. This is the first attempt to characterize vWA gene family in plant species.
Keywords	Magnaporthe oryzae ; RING finger domains ; abiotic stress ; biotic stress ; blast disease ; blood coagulation factors ; disease resistance ; gene duplication ; genes ; genome-wide association study ; germplasm ; protein degradation ; protein-protein interactions ; rice ; stress tolerance ; transposons ; ubiquitin
Language	English
Dates of publication	2022-07
Size	p. 375-384.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2406776-3
ISSN	1876-4762 ; 1672-6308
ISSN (online)	1876-4762
ISSN	1672-6308
DOI	10.1016/j.rsci.2021.11.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Transcatheter Aortic Valve Replacement Outcomes in End-Stage Renal Disease Patients on Hemodialysis Requiring Midodrine.

Korngold, Ethan C / Jin, Ruyun / Spinelli, Kateri J / Kumar, Vishesh / Curtis, Brydan / Gafoor, Sameer / Phan, Derek / Spoon, Daniel / Raney, Aidan / McCabe, Lisa / Jones, Brandon

Structural heart : the journal of the Heart Team

2023 Volume 7, Issue 3, Page(s) 100163

Abstract: Background: Patients with dialysis-dependent end-stage renal disease (ESRD) taking midodrine may be at high risk for poor outcomes following transcatheter aortic valve replacement (TAVR). We evaluated dialysis-dependent ESRD patients taking midodrine.!## ...

Abstract	Background: Patients with dialysis-dependent end-stage renal disease (ESRD) taking midodrine may be at high risk for poor outcomes following transcatheter aortic valve replacement (TAVR). We evaluated dialysis-dependent ESRD patients taking midodrine. Methods: We conducted a retrospective analysis of non-clinical trial TAVR patients from February 2012 to December 2020 from 11 facilities in a Western US health system. Patient groups included ESRD patients on midodrine before TAVR (ESRD [+M]), ESRD patients without midodrine (ESRD [-M]), and non-ESRD patients. The endpoints of 30-day and 1-year mortality were represented by Kaplan-Meier survival estimator and compared by log-rank test. Results: Forty-five ESRD (+M), 216 ESRD (-M), and 6898 non-ESRD patients were included. ESRD patients had more comorbid conditions, despite no significant difference in predicted Society of Thoracic Surgeons mortality risk between ESRD (+M) and ESRD (-M) (8.7% vs. 9.2%, Conclusions: Our experience suggests ESRD patients on midodrine are a higher acuity population with worse survival after TAVR, compared to ESRD patients not on midodrine. These findings may help with risk stratification for ESRD patients undergoing TAVR.
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article
ISSN	2474-8714
ISSN (online)	2474-8714
DOI	10.1016/j.shj.2023.100163
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Article: AngioVac System Used as an Adjunct Treatment for Intra-Cardiac Lead and Valvular Vegetations.

Kumar, Vishesh / Malik, Shahbaz A / Sheikh, Maryam / Stys, Adam

South Dakota medicine : the journal of the South Dakota State Medical Association

2018 Volume 71, Issue 1, Page(s) 22–24

Abstract: Infections are known complications of cardiovascular implantable electronic devices (CIEDs). We describe a case of a 62-year-old male who presented with pulseless electrical activity (PEA) cardiac arrest and respiratory failure. He had a history of ... ...

Abstract	Infections are known complications of cardiovascular implantable electronic devices (CIEDs). We describe a case of a 62-year-old male who presented with pulseless electrical activity (PEA) cardiac arrest and respiratory failure. He had a history of cardiac resynchronization device and defibrillator (CRT-D) implantation for nonischemic cardiomyopathy. After resuscitation, he was found to have methicillin sensitive Staphylococcus aureus (MSSA) bacteremia on blood culture and large vegetations on the CRT-D lead and tricuspid valve found on echocardiography. The patient underwent extraction of the leads, but several large vegetations were present adherent to the tricuspid valve on intra-cardiac ultrasound (ICE). Due to comorbidities, the patient was not a candidate for surgical removal of these vegetations. Thus, he underwent percutaneous extraction of tricuspid and right atrial vegetations with the AngioVac device.
MeSH term(s)	Bacteremia/diagnosis ; Bacteremia/microbiology ; Defibrillators, Implantable/microbiology ; Device Removal/instrumentation ; Device Removal/methods ; Echocardiography ; Electric Countershock ; Heart Atria ; Humans ; Male ; Middle Aged ; Staphylococcal Infections/diagnostic imaging ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/therapy ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/isolation & purification ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/microbiology
Language	English
Publishing date	2018-02-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article ; Online: Comparable Outcomes for Transcarotid and Transfemoral Transcatheter Aortic Valve Replacement at a High Volume US Center.

Jones, Brandon M / Kumar, Vishesh / Chiu, Shih Ting / Korngold, Ethan / Hodson, Robert W / Spinelli, Kateri J / Kirker, Eric B

Seminars in thoracic and cardiovascular surgery

2021 Volume 34, Issue 2, Page(s) 467–474

Abstract: With continued growth of transcatheter aortic valve replacement (TAVR), safe alternative access remains important for patients without adequate transfemoral (TF) access. Registry-based outcomes with transcarotid (TC) TAVR are favorable compared to ... ...

Abstract	With continued growth of transcatheter aortic valve replacement (TAVR), safe alternative access remains important for patients without adequate transfemoral (TF) access. Registry-based outcomes with transcarotid (TC) TAVR are favorable compared to transapical or transaxillary/subclavian, but TC vs TF comparisons have not been made. Our objective was to compare outcomes between TF and TC access routes for TAVR at a high-volume United States center. Methods: We retrospectively evaluated all TF and TC TAVR procedures from June 11, 2014 (first TC case) through December 31, 2019. The primary outcomes were 30-day stroke and 30-day mortality. Secondary outcomes were 1-year stroke, 1-year survival, and 30-day and 1-year life-threatening/major bleeding, vascular complications, and myocardial infarction. Propensity score weighted (PSW) models were used to compare risk-adjusted TF and TC outcomes. Of 1,465 TAVR procedures, 1319 (90%) were TF and 146 (10%) were TC. Procedure time and length of stay did not differ between groups. Unadjusted 30-day stroke (TF = 2.0%, TC = 2.7%, P = 0.536) and mortality (TF = 2.1%, TC = 2.7%, P = 0.629) were similar between groups. PSW 30-day stroke (odds ratio (OR) (95% confidence interval (CI)) = 0.8 (0.2-2.8)) and mortality (OR (95% CI) = 0.8 (0.2-3.0)) were similar between groups. Unadjusted and PSW 30-day major/life threatening bleeding, major vascular complications, and myocardial infarction did not differ between groups. Survival at one year was 90% (88%-92%) for TF patients and 87% (81%-93%) for TC patients (unadjusted P = 0.28, PSW hazard ratio = 1.0 (0.6-1.7)). Transcarotid TAVR is associated with similar outcomes compared to transfemoral TAVR at an experienced, high-volume center.
MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Femoral Artery/diagnostic imaging ; Femoral Artery/surgery ; Hemorrhage/surgery ; Humans ; Myocardial Infarction/complications ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stroke/etiology ; Transcatheter Aortic Valve Replacement ; Treatment Outcome ; United States
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038278-1
ISSN	1532-9488 ; 1043-0679
ISSN (online)	1532-9488
ISSN	1043-0679
DOI	10.1053/j.semtcvs.2021.03.009
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