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  1. Article ; Online: Nasal Microbiota Imbalance as a Contributory Link in the Emergence of COVID-19 Associated Mucormycosis.

    Singh, Rachna / Kumari, Anjna

    ACS infectious diseases

    2021  Volume 7, Issue 8, Page(s) 2211–2213

    Abstract: COVID-19 associated mucormycosis (CAM) is being reported at an elevated frequency and has been declared an ongoing epidemic in India. A huge diabetic population, inappropriate corticosteroid usage and environmental mucoralean spore count, along with ... ...

    Abstract COVID-19 associated mucormycosis (CAM) is being reported at an elevated frequency and has been declared an ongoing epidemic in India. A huge diabetic population, inappropriate corticosteroid usage and environmental mucoralean spore count, along with COVID-19 associated glycemic imbalance, hypoxemia, increased iron levels, vascular endothelial injury, as well as the immunosuppressive impact are being considered as important risk factors for CAM. The present viewpoint aims to discuss the plausible role of another important facet, the nasal microbiota imbalance, in the emergence of mucormycosis under the prevailing COVID-19 pandemic conditions.
    MeSH term(s) COVID-19 ; Humans ; Microbiota ; Mucormycosis/epidemiology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00371
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  2. Article: The Indigenous Volatile Inhibitor 2-Methyl-2-butene Impacts Biofilm Formation and Interspecies Interaction of the Pathogenic Mucorale Rhizopus arrhizus

    Kaur, Mahaldeep / Kumari, Anjna / Singh, Rachna

    Microbial ecology. 2022 Feb., v. 83, no. 2

    2022  

    Abstract: 2-Methyl-2-butene has recently been reported to be a quorum-based volatile self-inhibitor of spore germination and growth in pathogenic Mucorale Rhizopus arrhizus. The present study aimed to elucidate if this compound can influence R. arrhizus biofilm ... ...

    Abstract 2-Methyl-2-butene has recently been reported to be a quorum-based volatile self-inhibitor of spore germination and growth in pathogenic Mucorale Rhizopus arrhizus. The present study aimed to elucidate if this compound can influence R. arrhizus biofilm formation and interspecies interaction. The compound was found to significantly decrease R. arrhizus biofilm formation (p < 0.001), with nearly 25% and 50% lesser biomass in the biofilms cultured with exposure to 4 and 32 µg/ml of 2-methyl-2-butene, respectively. The growth of pre-formed biofilms was also impacted, albeit to a lesser extent. Additionally, 2-methyl-2-butene was found to self-limit R. arrhizus growth during interspecies interaction with Staphylococcus aureus and was detected at a substantially greater concentration in the headspace of co-cultures (2338.75 µg/ml) compared with monocultures (69.52 µg/ml). Some of the C5 derivatives of this compound (3-methyl-1-butanol, 2-methyl-2-butanol, and 3-methyl-1-butyne) were also observed to partially mimic its action, such as inhibition of spore germination, but did not impact R. arrhizus biofilm formation. Finally, the treated R. arrhizus displayed changes in fungal morphology suggestive of cytoskeletal alterations, such as filopodia formation, blebs, increased longitudinal folds and/or corrugations, and finger-like and sheet-like surface protrusions, depending upon the concentration of the compound(s) and the planktonic or biofilm growth mode.
    Keywords Rhizopus arrhizus ; Staphylococcus aureus ; biofilm ; biomass ; coculture ; cytoskeleton ; fungal morphology ; headspace analysis ; interspecific competition ; plankton ; pseudopodia ; spore germination
    Language English
    Dates of publication 2022-02
    Size p. 506-512.
    Publishing place Springer US
    Document type Article
    ZDB-ID 1462065-0
    ISSN 1432-184X ; 0095-3628
    ISSN (online) 1432-184X
    ISSN 0095-3628
    DOI 10.1007/s00248-021-01765-0
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  3. Article ; Online: Antibiofilm Activity of Small Molecules Produced by Staphylococcus epidermidis against Staphylococcus aureus.

    Kumari, Anjna / Singh, Rachna

    Applied and environmental microbiology

    2020  Volume 86, Issue 13

    MeSH term(s) Biofilms ; Humans ; Staphylococcal Infections ; Staphylococcus aureus ; Staphylococcus epidermidis
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/AEM.00627-20
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  4. Article ; Online: The Indigenous Volatile Inhibitor 2-Methyl-2-butene Impacts Biofilm Formation and Interspecies Interaction of the Pathogenic Mucorale Rhizopus arrhizus.

    Kaur, Mahaldeep / Kumari, Anjna / Singh, Rachna

    Microbial ecology

    2021  Volume 83, Issue 2, Page(s) 506–512

    Abstract: 2-Methyl-2-butene has recently been reported to be a quorum-based volatile self-inhibitor of spore germination and growth in pathogenic Mucorale Rhizopus arrhizus. The present study aimed to elucidate if this compound can influence R. arrhizus biofilm ... ...

    Abstract 2-Methyl-2-butene has recently been reported to be a quorum-based volatile self-inhibitor of spore germination and growth in pathogenic Mucorale Rhizopus arrhizus. The present study aimed to elucidate if this compound can influence R. arrhizus biofilm formation and interspecies interaction. The compound was found to significantly decrease R. arrhizus biofilm formation (p < 0.001), with nearly 25% and 50% lesser biomass in the biofilms cultured with exposure to 4 and 32 µg/ml of 2-methyl-2-butene, respectively. The growth of pre-formed biofilms was also impacted, albeit to a lesser extent. Additionally, 2-methyl-2-butene was found to self-limit R. arrhizus growth during interspecies interaction with Staphylococcus aureus and was detected at a substantially greater concentration in the headspace of co-cultures (2338.75 µg/ml) compared with monocultures (69.52 µg/ml). Some of the C5 derivatives of this compound (3-methyl-1-butanol, 2-methyl-2-butanol, and 3-methyl-1-butyne) were also observed to partially mimic its action, such as inhibition of spore germination, but did not impact R. arrhizus biofilm formation. Finally, the treated R. arrhizus displayed changes in fungal morphology suggestive of cytoskeletal alterations, such as filopodia formation, blebs, increased longitudinal folds and/or corrugations, and finger-like and sheet-like surface protrusions, depending upon the concentration of the compound(s) and the planktonic or biofilm growth mode.
    MeSH term(s) Alkenes ; Biofilms ; Rhizopus ; Rhizopus oryzae ; Staphylococcus aureus
    Chemical Substances Alkenes ; 2-butene (S1SK37516R)
    Language English
    Publishing date 2021-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1462065-0
    ISSN 1432-184X ; 0095-3628
    ISSN (online) 1432-184X
    ISSN 0095-3628
    DOI 10.1007/s00248-021-01765-0
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  5. Article ; Online: Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals.

    Fatima, Samreen / Kumari, Anjna / Dwivedi, Ved Prakash

    MedComm

    2021  Volume 2, Issue 4, Page(s) 494–513

    Abstract: Eastern countries are a major source of medicinal plants, which set up a rich source of ethnopharmacologically known medicines used in the treatment of various diseases. These traditional medicines have been known as complementary, alternative, or ... ...

    Abstract Eastern countries are a major source of medicinal plants, which set up a rich source of ethnopharmacologically known medicines used in the treatment of various diseases. These traditional medicines have been known as complementary, alternative, or nonconventional therapy across globe for ages. Tuberculosis (TB) poses a huge global burden and leads to maximum number of deaths due to an infectious agent. Treatment of TB using Directly Observed Treatment Short-course (DOTS) therapy comprises multiple antibiotics is quite lengthy and causes serious side-effects in different organs. The length of the TB treatment leads to withdrawal from the patients, which paves the way for the emergence of drug resistance in the bacterial population. These concerns related to therapy need serious and immediate interventions. Traditional medicines using phytochemicals has shown to provide tremendous potential in TB treatment, mainly in the eradication of
    Language English
    Publishing date 2021-08-05
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.82
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  6. Article ; Online: Medically important interactions of staphylococci with pathogenic fungi.

    Kumari, Anjna / Singh, Rachna

    Future microbiology

    2019  Volume 14, Page(s) 1159–1170

    Abstract: Staphylococci are common inhabitants at several human body sites and are also implicated in infections either as primary or opportunistic pathogens. These bacteria can thus both contribute to the host defense being a part of the commensalistic microbiota ...

    Abstract Staphylococci are common inhabitants at several human body sites and are also implicated in infections either as primary or opportunistic pathogens. These bacteria can thus both contribute to the host defense being a part of the commensalistic microbiota or synergize with the other microbes during the infection process. Among fungi, staphylococci interact synergistically with
    MeSH term(s) Fungi/growth & development ; Fungi/immunology ; Fungi/pathogenicity ; Humans ; Microbial Interactions ; Staphylococcus/growth & development ; Staphylococcus/immunology ; Staphylococcus/pathogenicity
    Language English
    Publishing date 2019-09-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb-2019-0155
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  7. Article: Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosis

    Fatima, Samreen / Kumari, Anjna / Agarwal, Meetu / Pahuja, Isha / Yadav, Vinod / Bhaskar, Ashima

    FEBS journal. 2022 July, v. 289, no. 14

    2022  

    Abstract: Epigenetics involves changing the gene function without any change in the sequence of the genes. In the case of tuberculosis (TB) infections, the bacilli, Mycobacterium tuberculosis (M.tb), uses epigenetics as a tool to protect itself from the host ... ...

    Abstract Epigenetics involves changing the gene function without any change in the sequence of the genes. In the case of tuberculosis (TB) infections, the bacilli, Mycobacterium tuberculosis (M.tb), uses epigenetics as a tool to protect itself from the host immune system. TB is a deadly disease‐causing maximum death per year due to a single infectious agent. In the case of TB, there is an urgent need for novel host‐directed therapies which can effectively target the survival and long‐term persistence of the bacteria without developing drug resistance in the bacterial strains while also reducing the duration and toxicity associated with the mainstream anti‐TB drugs. Recent studies have suggested that TB infection has a significant effect on the host epigenome thereby manipulating the host immune response in the favor of the pathogen. M.tb alters the activation status of key genes involved in the immune response against TB to promote its survival and subvert the antibacterial strategies of the host. These changes are reversible and can be exploited to design very efficient host‐directed therapies to fight against TB. This review has been written with the purpose of discussing the role of epigenetic changes in TB pathogenesis and the therapeutic approaches involving epigenetics, which can be utilized for targeting the pathogen.
    Keywords Mycobacterium tuberculosis ; death ; drug resistance ; epigenetics ; epigenome ; genes ; immune response ; immune system ; pathogenesis ; pathogens ; therapeutics ; toxicity ; tuberculosis
    Language English
    Dates of publication 2022-07
    Size p. 4172-4191.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note REVIEW
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16170
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    In stock of ZB MED Bonn / Germany

    Z 2006/704: Show issues

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  8. Article ; Online: Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis.

    Pahuja, Isha / Verma, Akanksha / Ghoshal, Antara / Mukhopadhyay, Suparba / Kumari, Anjna / Shaji, Aishwarya / Chaturvedi, Shivam / Dwivedi, Ved Prakash / Bhaskar, Ashima

    Microbiology spectrum

    2023  Volume 11, Issue 4, Page(s) e0085823

    Abstract: Tuberculosis (TB) still tops the list of global health burdens even after COVID-19. However, it will sooner transcend the current pandemic due to the prevailing risk of reactivation of latent TB in immunocompromised individuals. The indiscriminate misuse ...

    Abstract Tuberculosis (TB) still tops the list of global health burdens even after COVID-19. However, it will sooner transcend the current pandemic due to the prevailing risk of reactivation of latent TB in immunocompromised individuals. The indiscriminate misuse and overuse of antibiotics have resulted in the emergence of deadly drug-resistant variants of Mycobacterium tuberculosis (
    MeSH term(s) Animals ; Mice ; CD8-Positive T-Lymphocytes ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/therapeutic use ; Disease Models, Animal ; COVID-19 ; Tuberculosis/microbiology ; Mycobacterium tuberculosis ; Immunity ; Immunologic Factors
    Chemical Substances biapenem (YR5U3L9ZH1) ; Anti-Bacterial Agents ; Carbapenems ; Immunologic Factors
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00858-23
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  9. Article ; Online: Antagonistic Interaction of

    Kumari, Anjna / Tewari, Rupinder / Singh, Rachna

    ACS infectious diseases

    2019  Volume 5, Issue 11, Page(s) 1887–1895

    Abstract: ... Rhizopus ... ...

    Abstract Rhizopus arrhizus
    MeSH term(s) Acids/chemistry ; Acids/metabolism ; Acids/pharmacology ; Antibiosis ; Antifungal Agents/chemistry ; Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Phenols/chemistry ; Phenols/metabolism ; Phenols/pharmacology ; Rhizopus/drug effects ; Rhizopus/growth & development ; Staphylococcus aureus/chemistry ; Staphylococcus aureus/metabolism ; Staphylococcus epidermidis/chemistry ; Staphylococcus epidermidis/metabolism
    Chemical Substances Acids ; Antifungal Agents ; Phenols
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.9b00205
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  10. Article ; Online: Tuberculosis vaccine: A journey from BCG to present.

    Fatima, Samreen / Kumari, Anjna / Das, Gobardhan / Dwivedi, Ved Prakash

    Life sciences

    2020  Volume 252, Page(s) 117594

    Abstract: Tuberculosis (TB) is the leading cause of death worldwide due to an infectious disease, causing around 1.6 million deaths each year. This situation has become more complicated by the emergence of drug-resistant Mycobacterium tuberculosis (M.tb) and HIV- ... ...

    Abstract Tuberculosis (TB) is the leading cause of death worldwide due to an infectious disease, causing around 1.6 million deaths each year. This situation has become more complicated by the emergence of drug-resistant Mycobacterium tuberculosis (M.tb) and HIV-TB co-infection, which has significantly worsened TB prognosis and treatment. Despite years of intensive research, Bacille Calmette-Guerin (BCG) remains the only licensed vaccine and has variable efficacy. It provides protection against childhood TB but is not effective in adult pulmonary TB. As a result of intense research in understanding TB vaccinology, there are many new vaccine candidates in clinical development and many more in pre-clinical trials which aim either to replace or boost BCG vaccine. This review discusses the history of BCG vaccine development and summarizes limitations of the current vaccine strategy and recent advances in improving BCG immunization along with other new vaccines in clinical trials which are promising candidates for the future tuberculosis vaccinology program.
    MeSH term(s) Adult ; Age Factors ; BCG Vaccine/administration & dosage ; Child ; Humans ; Mycobacterium tuberculosis/immunology ; Tuberculosis/epidemiology ; Tuberculosis/microbiology ; Tuberculosis/prevention & control ; Tuberculosis Vaccines/administration & dosage ; Vaccination
    Chemical Substances BCG Vaccine ; Tuberculosis Vaccines
    Language English
    Publishing date 2020-04-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.117594
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
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