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  1. AU="Kun, Lyubomyra"
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  1. Article: Increased Prevalence of Headaches and Migraine in Patients with Psoriatic Arthritis and Axial Spondyloarthritis: Insights from an Italian Cohort Study.

    Marino, Annalisa / Currado, Damiano / Altamura, Claudia / Vomero, Marta / Berardicurti, Onorina / Corberi, Erika / Kun, Lyubomyra / Pilato, Andrea / Biaggi, Alice / Genovali, Irene / Bearzi, Pietro / Minerba, Marco / Orlando, Antonio / Trunfio, Francesca / Quadrini, Maria / Salvolini, Chiara / Di Corcia, Letizia Pia / Saracino, Francesca / Giacomelli, Roberto /
    Navarini, Luca

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Background: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory diseases with shared genetic backgrounds and clinical comorbidities. Headache, a common global health issue, affects over 50% of adults and encompasses various ... ...

    Abstract Background: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory diseases with shared genetic backgrounds and clinical comorbidities. Headache, a common global health issue, affects over 50% of adults and encompasses various types, including migraine, tension-type, and cluster headaches. Migraine, the most prevalent, recurrent, and disabling type, is often associated with other medical conditions such as depression, epilepsy, and psoriasis, but little is known about the relationship between autoimmune disease and the risk of migraine.
    Methods: A cross-sectional study was conducted from July to November 2022, enrolling 286 participants, including 216 with PsA, 70 with axSpA, and 87 healthy controls.
    Results: Headache prevalence was significantly higher in the PsA (39.81%) and axSpA (45.71%) patients compared to the healthy controls. The prevalence of migraine without aura was also significantly higher in both the PsA (18.52%) and axSpA (28.57%) groups compared to the healthy controls.
    Conclusions: These findings underscore the high burden of headache and migraine in PsA and axSpA participants, highlighting the need for improved management and treatment strategies for these patients.
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association between Patient Acceptable Symptom State and disease activity in psoriatic arthritis is disrupted by confounders, including comorbid fibromyalgia.

    Navarini, Luca / Currado, Damiano / Pilato, Andrea / Marino, Annalisa / Biaggi, Alice / Di Donato, Stefano / Berardicurti, Onorina / Vomero, Marta / Kun, Lyubomyra / Arcarese, Luisa / Rigon, Amelia / Vadacca, Marta / Bearzi, Pietro / Ruscitti, Piero / Cipriani, Paola / Iagnocco, Annamaria / Giacomelli, Roberto

    Clinical and experimental rheumatology

    2023  

    Abstract: Objectives: Due to the prevalence of fibromyalgia in psoriatic arthritis (PsA) patients, any evaluation about PsA-specific patient-reported outcomes (PROs) should take in account the possible bias related to this comorbidity. Patient acceptable symptom ... ...

    Abstract Objectives: Due to the prevalence of fibromyalgia in psoriatic arthritis (PsA) patients, any evaluation about PsA-specific patient-reported outcomes (PROs) should take in account the possible bias related to this comorbidity. Patient acceptable symptom state (PASS) is a patient-reported measure evaluating the acceptable and/or satisfactory level of symptoms in rheumatic diseases, which has been proposed as a disease activity index, in patients with PsA. Thus, this study was designed to analyse if the association between PASS and PsA disease activity may be biased by the presence of comorbid fibromyalgia.
    Methods: A multi-centre, cross-sectional, observational study enrolling consecutive PsA participants has been conducted from July 2021 to November 2021. The Disease Activity for Psoriatic Arthritis (DAPSA) was collected; the following formulation of PASS question: 'Think about all the ways your PsA has affected you during the last 48 hours. If you were to remain in the next few months as you were during the last 48 hours, would this be acceptable to you?', was submitted to our participants.
    Results: Multivariable logistic regressions, adjusted for the presence of fibromyalgia, did not show any significant association between PASS and DAPSA low disease activity, DAPSA as nominal variable (remission, low disease activity, moderate disease activity, high disease activity) and DAPSA as continuous variable.
    Conclusions: Our data suggest that fibromyalgia influences the patient's perception of the disease and has a negative impact on PASS status independently of disease activity, thus limiting the utility of this Patient reported outcome in real world clinical practice.
    Language English
    Publishing date 2023-12-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/3bs6em
    Database MEDical Literature Analysis and Retrieval System OnLINE

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