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Book ; Online ; E-Book: Cell-derived matrices / Part A /

Caballero, David / Kundu, S. C. / Reis, Rui L.

(Methods in cell biology ; Volume 156)

2020

Author's details	edited by David Caballero, Subhas C. Kundu, Rui Luís Reis
Series title	Methods in cell biology ; Volume 156
Keywords	Tissue engineering ; Extracellular matrix
Subject code	611.0182
Language	English
Size	1 online resource (xvii, 332 pages) :, illustrations.
Publisher	Academic Press
Publishing place	Cambridge, MA
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-12-820172-X ; 978-0-12-820172-5
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Microfluidics and biosensors in cancer research

Caballero, David / Kundu, S. C. / Reis, Rui L.

applications in cancer modeling and theranostics

(Advances in experimental medicine and biology ; 1379)

2022

Author's details	David Caballero, Subhas C. Kundu, Rui L. Reis editors
Series title	Advances in experimental medicine and biology ; 1379
Collection
Keywords	Cancer/Research/Technological innovations ; Biosensors ; Microfluidic devices
Subject code	616.99400285
Language	English
Size	xix, 590 Seiten, Illustrationen, 24 cm
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT021410198
ISBN	978-3-031-04038-2 ; 9783031040399 ; 3-031-04038-4 ; 3031040392
Database	Catalogue ZB MED Medicine, Health

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Book ; Online ; E-Book: Biomaterials for 3D tumor modeling

Kundu, S. C. / Reis, Rui L.

(Materials today)

2020

Author's details	edited by Subhas C. Kundu, Rui L. Reis
Series title	Materials today
Keywords	Tumors ; Three-dimensional imaging in medicine ; Biomedical materials
Subject code	616.994027
Language	English
Size	1 Online-Ressource (753 Seiten), Illustrationen
Publisher	Elsevier
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020670197
ISBN	978-0-12-818129-4 ; 9780128181287 ; 0-12-818129-X ; 0128181281
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: The Tumor Microenvironment: An Introduction to the Development of Microfluidic Devices.

Kundu, B / Caballero, D / Abreu, C M / Reis, R L / Kundu, S C

Advances in experimental medicine and biology

2022 Volume 1379, Page(s) 115–138

Abstract: The tumor microenvironment (TME) is like the Referee of a soccer match who has constant eyes on the activity of all players, such as cells, acellular stroma components, and signaling molecules for the successful completion of the game, that is, ... ...

Abstract	The tumor microenvironment (TME) is like the Referee of a soccer match who has constant eyes on the activity of all players, such as cells, acellular stroma components, and signaling molecules for the successful completion of the game, that is, tumorigenesis. The cooperation among all the "team members" determines the characteristics of tumor, such as the hypoxic and acidic niche, stiffer mechanical properties, or dilated vasculature. Like in soccer, each TME is different. This heterogeneity makes it challenging to fully understand the intratumor dynamics, particularly among different tumor subpopulations and their role in therapeutic response or resistance. Further, during metastasis, tumor cells can disseminate to a secondary organ, a critical event responsible for approximately 90% of the deaths in cancer patients. The recapitulation of the rapidly changing TME in the laboratory is crucial to improve patients' prognosis for unraveling key mechanisms of tumorigenesis and developing better drugs. Hence, in this chapter, we provide an overview of the characteristic features of the TME and how to model them, followed by a brief description of the limitations of existing in vitro platforms. Finally, various attempts at simulating the TME using microfluidic platforms are highlighted. The chapter ends with the concerns that need to be addressed for designing more realistic and predictive tumor-on-a-chip platforms.
MeSH term(s)	Carcinogenesis ; Humans ; Lab-On-A-Chip Devices ; Microfluidics ; Neoplasms/pathology ; Tumor Microenvironment
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-031-04039-9_5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Silk biomaterials for tissue engineering and regenerative medicine

Kundu, S. C

(Woodhead publishing series in biomaterials ; number 74)

2014

Abstract: Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties ... ...

Author's details	edited by S.C. Kundu
Series title	Woodhead publishing series in biomaterials ; number 74
Abstract	"Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area"--From publisher's Web site.
MeSH term(s)	Biocompatible Materials ; Silk/therapeutic use ; Tissue Engineering/methods ; Guided Tissue Regeneration/methods
Language	English
Size	xxiii, 555 pages :, illustrations (some color) ;, 25 cm.
Document type	Book
ISBN	9780857096999 ; 0857096990 ; 9780857097064 ; 0857097067
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Sericin-carboxymethyl cellulose porous matrices as cellular wound dressing material.

Nayak, Sunita / Kundu, S C

Journal of biomedical materials research. Part A

2014 Volume 102, Issue 6, Page(s) 1928–1940

Abstract: In this study, porous three-dimensional (3D) hydrogel matrices are fabricated composed of silk cocoon protein sericin of non-mulberry silkworm Antheraea mylitta and carboxymethyl cellulose. The matrices are prepared via freeze-drying technique followed ... ...

Abstract	In this study, porous three-dimensional (3D) hydrogel matrices are fabricated composed of silk cocoon protein sericin of non-mulberry silkworm Antheraea mylitta and carboxymethyl cellulose. The matrices are prepared via freeze-drying technique followed by dual cross-linking with glutaraldehyde and aluminum chloride. The microstructure of the hydrogel matrices is assessed using scanning electron microscopy and biophysical characterization are carried out using Fourier transform infrared spectroscopy and X-ray diffraction. The transforming growth factor β1 release from the cross-linked matrices as a growth factor is evaluated by immunosorbent assay. Live dead assay and 3-[4,5-dimethylthiazolyl-2]-2,5-diphenyl tetrazolium bromide assay show no cytotoxicity of blended matrices toward human keratinocytes. The matrices support the cell attachment and proliferation of human keratinocytes as observed through scanning electron microscope and confocal images. Gelatin zymography demonstrates the low levels of matrix metalloproteinase 2 (MMP-2) and insignificant amount of MMP-9 in the culture media of cell seeded matrices. Low inflammatory response of the matrices is indicated through tumor necrosis factor alpha release assay. The results indicate that the fabricated matrices constitute 3D cell-interactive environment for tissue engineering applications and its potential use as a future cellular biological wound dressing material.
MeSH term(s)	Animals ; Bandages ; Biocompatible Materials/chemistry ; Carboxymethylcellulose Sodium/chemistry ; Cell Adhesion/drug effects ; Cell Proliferation/drug effects ; Delayed-Action Preparations/chemistry ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Moths/chemistry ; Porosity ; Sericins/chemistry ; Transforming Growth Factor beta1/administration & dosage ; Transforming Growth Factor beta1/pharmacology ; Wound Healing
Chemical Substances	Biocompatible Materials ; Delayed-Action Preparations ; Sericins ; Transforming Growth Factor beta1 ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5) ; Carboxymethylcellulose Sodium (K679OBS311)
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.34865
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Drug loading and release on tumor cells using silk fibroin-albumin nanoparticles as carriers.

Subia, B / Kundu, S C

Nanotechnology

2013 Volume 24, Issue 3, Page(s) 35103

Abstract: Polymeric and biodegradable nanoparticles are frequently used in drug delivery systems. In this study silk fibroin-albumin blended nanoparticles were prepared using the desolvation method without any surfactant. These nanoparticles are easily ... ...

Abstract	Polymeric and biodegradable nanoparticles are frequently used in drug delivery systems. In this study silk fibroin-albumin blended nanoparticles were prepared using the desolvation method without any surfactant. These nanoparticles are easily internalized by the cells, reside within perinuclear spaces and act as carriers for delivery of the model drug methotrexate. Methotrexate loaded nanoparticles have better encapsulation efficiency, drug loading ability and less toxicity. The in vitro release behavior of methotrexate from the nanoparticles suggests that about 85% of the drug gets released after 12 days. The encapsulation and loading of a drug would depend on factors such as size, charge and hydrophobicity, which affect drug release. MTT assay and conjugation of particles with FITC demonstrate that the silk fibroin-albumin nanoparticles do not affect the viability and biocompatibility of cells. This blended nanoparticle, therefore, could be a promising nanocarrier for the delivery of drugs and other bioactive molecules.
MeSH term(s)	Animals ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacology ; Bombyx/chemistry ; Breast Neoplasms/drug therapy ; Cell Line ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Female ; Fibroins/chemistry ; Fibroins/toxicity ; Hemolysis/drug effects ; Humans ; Methotrexate/administration & dosage ; Methotrexate/pharmacology ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Nanoparticles/ultrastructure ; Particle Size ; Serum Albumin/chemistry ; Serum Albumin/toxicity ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Antimetabolites, Antineoplastic ; Drug Carriers ; Serum Albumin ; Fibroins (9007-76-5) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2013-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/0957-4484/24/3/035103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bio-inspired fabrication of fibroin cryogels from the muga silkworm Antheraea assamensis for liver tissue engineering.

Kundu, Banani / Kundu, S C

Biomedical materials (Bristol, England)

2013 Volume 8, Issue 5, Page(s) 55003

Abstract: Conventional scaffold fabrication techniques result in narrow pore architectures causing a limited interconnectivity and use of porogens, which affects the bio- or cyto-compatibility. To ameliorate this, cryogels are immensely explored due to their macro- ...

Abstract	Conventional scaffold fabrication techniques result in narrow pore architectures causing a limited interconnectivity and use of porogens, which affects the bio- or cyto-compatibility. To ameliorate this, cryogels are immensely explored due to their macro-porous nature, ease in fabrication, using ice crystals as porogens, the shape property, easy reproducibility and cost-effective fabrication technique. Cryogels in the present study are prepared from nonmulberry Indian muga silk gland protein fibroin of Antheraea assamensis using two different fabrication temperatures (-20 and -80 °C). Anionic surfactant sodium dodecyl sulfate is used to solubilize fibroin, which in turn facilitates gelation by accelerating the ß-sheet formation. Ethanol is employed to stabilize the 3D network and induces bimodal porosity. The gels thus formed demonstrate increased ß-sheet content (FTIR) and a considerable effect of pre-freezing temperatures on 3D micro-architectures. The cryogels are capable of absorbing large amounts of water and withstanding mechanical compression without structure deformation. Further, cell impregnated cryogels well support the viability of human hepatocarcinoma cells (live/dead assay). The formation of cellular aggregates (confocal laser and scanning electron microscope), derivation in metabolic activity and proliferation rate are obtained in constructs fabricated at different temperatures. In summary, the present work reveals promising insights in the development of a biomimetic functional template for biomedical therapeutics and liver tissue engineering.
MeSH term(s)	Animals ; Biocompatible Materials/chemistry ; Biomimetics ; Bombyx ; Cell Survival ; Cryogels/chemistry ; Fibroins/chemistry ; Hep G2 Cells ; Humans ; Liver/pathology ; Microscopy, Confocal ; Microscopy, Electron, Scanning ; Porosity ; Silk/chemistry ; Sodium Dodecyl Sulfate/chemistry ; Spectroscopy, Fourier Transform Infrared ; Surface-Active Agents ; Temperature ; Tissue Engineering ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Cryogels ; Silk ; Surface-Active Agents ; Sodium Dodecyl Sulfate (368GB5141J) ; Fibroins (9007-76-5)
Language	English
Publishing date	2013-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-6041/8/5/055003
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Article ; Online: Silk fibroin promotes mineralization of gellan gum hydrogels.

Kundu, Banani / Brancato, Virginia / Oliveira, J M / Correlo, Vitor M / Reis, Rui L / Kundu, S C

International journal of biological macromolecules

2019 Volume 153, Page(s) 1328–1334

Abstract: Mineralization is a natural process leading to the formation of mineralized tissue such as bone. The chief mineral component of bone is hydroxyapatite (HAp), which is deposited using an organic template like fibrillar Collagen I under physiological ... ...

Abstract	Mineralization is a natural process leading to the formation of mineralized tissue such as bone. The chief mineral component of bone is hydroxyapatite (HAp), which is deposited using an organic template like fibrillar Collagen I under physiological condition. Fibrous silk fibroin is structurally homologous to collagen and acts as nucleation site for HAp mineralization when immersed in simulated body fluid (SBF) or fetal bovine serum (FBS), therefore, considered as popular bone regeneration biomaterial. Hence, the mineralization behavior of silk fibroin self-assembled gellan gum enriched 3D hydrogels is investigated under conditions closer to physiological ones using SBF as well as FBS, and also in presence of cells (e.g. human adipose tissue-derived stem cells, ASCs). Incorporation of silk fibroin induces the mineralization in acellular spongy-like hydrogels in composition dependent manner, confirmed by SEM-EDS analysis. In contrast, ASCs mediated mineralization is found in all hydrogel compositions of 3 weeks post-culture under osteogenic conditions as demonstrated by gene expression profile and Alizarin Red S staining. This is perhaps due to the co-existence of fibroin and FBS together induce cell-mediated mineralization. The blending of fibroin offers cheap alternative strategy to improve or guide the repair of mineralized tissue using gellan gum-based biomaterials.
MeSH term(s)	Adipose Tissue/cytology ; Calcification, Physiologic/drug effects ; Cell Differentiation/drug effects ; Fibroins/chemistry ; Fibroins/pharmacology ; Humans ; Hydrogels/chemistry ; Osteogenesis/drug effects ; Polysaccharides, Bacterial/chemistry ; Stem Cells/cytology ; Stem Cells/drug effects
Chemical Substances	Hydrogels ; Polysaccharides, Bacterial ; gellan gum (7593U09I4D) ; Fibroins (9007-76-5)
Language	English
Publishing date	2019-11-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.10.269
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Article: Silk fibroin promotes mineralization of gellan gum hydrogels

Kundu, Banani / Brancato, Virginia / Oliveira, J.M / Correlo, Vitor M / Reis, Rui L / Kundu, S.C

International journal of biological macromolecules. 2019 Oct. 29,

2019

Abstract	Mineralization is a natural process leading to the formation of mineralized tissue such as bone. The chief mineral component of bone is hydroxyapatite (HAp), which is deposited using an organic template like fibrillar Collagen I under physiological condition. Fibrous silk fibroin is structurally homologous to collagen and acts as nucleation site for HAp mineralization when immersed in simulated body fluid (SBF) or fetal bovine serum (FBS), therefore, considered as popular bone regeneration biomaterial. Hence, the mineralization behavior of silk fibroin self-assembled gellan gum enriched 3D hydrogels is investigated under conditions closer to physiological ones using SBF as well as FBS, and also in presence of cells (e.g. human adipose tissue-derived stem cells, ASCs). Incorporation of silk fibroin induces the mineralization in acellular spongy-like hydrogels in composition dependent manner, confirmed by SEM-EDS analysis. In contrast, ASCs mediated mineralization is found in all hydrogel compositions of 3 weeks post-culture under osteogenic conditions as demonstrated by gene expression profile and Alizarin Red S staining. This is perhaps due to the co-existence of fibroin and FBS together induce cell-mediated mineralization. The blending of fibroin offers cheap alternative strategy to improve or guide the repair of mineralized tissue using gellan gum-based biomaterials.
Keywords	alizarin ; biocompatible materials ; bone formation ; collagen ; energy-dispersive X-ray analysis ; fetal bovine serum ; fibroins ; gellan gum ; gene expression ; hydrogels ; hydroxyapatite ; mineralization ; scanning electron microscopy ; staining ; stem cells
Language	English
Dates of publication	2019-1029
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.10.269
Database	NAL-Catalogue (AGRICOLA)

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