Article ; Online: Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas.
2023 Volume 9, Issue 30, Page(s) eadf6210
Abstract: KRAS/ERK pathway phosphorylates DICER1, causing its nuclear translocation, and ... ...
Abstract | KRAS/ERK pathway phosphorylates DICER1, causing its nuclear translocation, and phosphomimetic |
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MeSH term(s) | Humans ; Mice ; Animals ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Chromatin/genetics ; MicroRNAs/genetics ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/genetics ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism |
Chemical Substances | Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Chromatin ; MicroRNAs ; DICER1 protein, human (EC 3.1.26.3) ; Ribonuclease III (EC 3.1.26.3) ; DEAD-box RNA Helicases (EC 3.6.4.13) |
Language | English |
Publishing date | 2023-07-26 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2810933-8 |
ISSN | 2375-2548 ; 2375-2548 |
ISSN (online) | 2375-2548 |
ISSN | 2375-2548 |
DOI | 10.1126/sciadv.adf6210 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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