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  1. Book ; Thesis: Analysis of transcranial cortical stimulation in mice to alleviate neuropathic pain

    Li, Han / Kuner, Rohini

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Han Li ; Doktormutter: Frau Prof. Dr. Rohini Kuner
    Language English ; German
    Size VIII Blätter, 111 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    Note Text in Englisch, Zusammenfassung in englischer und deutscher Sprache
    HBZ-ID HT030351983
    Database Catalogue ZB MED Medicine, Health

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    2023 E 1210 order for loan Magazin

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  2. Book ; Thesis: Study on the role of BDNF-TrkB signaling in chronic neuropathic pain

    Ding, Ting / Kuner, Rohini

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Ting Ding ; Doktormutter: Prof. Dr. Rohini Kuner
    Language English
    Size 97 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021157008
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Protecting against summation of pain.

    Mauceri, Daniela / Kuner, Rohini

    Neuron

    2022  Volume 110, Issue 16, Page(s) 2513–2515

    Abstract: Temporal summation in the spinal cord is linked to pathological pain. In a translational genetic association study in this issue of Neuron, Trendafilova et al. (2022) identify the sodium-calcium exchanger 3 as a negative regulator of temporal summation ... ...

    Abstract Temporal summation in the spinal cord is linked to pathological pain. In a translational genetic association study in this issue of Neuron, Trendafilova et al. (2022) identify the sodium-calcium exchanger 3 as a negative regulator of temporal summation and hypersensitivity via its modulation of calcium homeostasis.
    MeSH term(s) Humans ; Pain ; Pain Measurement ; Pain Threshold ; Spinal Cord
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2022.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2496: Show issues Location:
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  4. Article ; Online: Sounding out pain.

    Kuner, Rohini / Kuner, Thomas

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6602, Page(s) 155–156

    Abstract: A circuit for sound-induced analgesia has been found in the mouse brain. ...

    Abstract A circuit for sound-induced analgesia has been found in the mouse brain.
    MeSH term(s) Animals ; Audioanalgesia/methods ; Disease Models, Animal ; Mice ; Music Therapy ; Pain/psychology ; Pain Management/methods ; Pain Perception ; Sound
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add0640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Locus revealed: Painlessness via loss of Na

    Simonetti, Manuela / Kuner, Rohini

    Neuron

    2021  Volume 109, Issue 9, Page(s) 1413–1416

    Abstract: How genetic loss of the sodium channel ... ...

    Abstract How genetic loss of the sodium channel Na
    MeSH term(s) Analgesia ; Animals ; Ganglia, Spinal ; Humans ; Mice ; NAV1.7 Voltage-Gated Sodium Channel/genetics ; NAV1.8 Voltage-Gated Sodium Channel ; Pain/genetics ; Sensory Receptor Cells
    Chemical Substances NAV1.7 Voltage-Gated Sodium Channel ; NAV1.8 Voltage-Gated Sodium Channel
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neocortical circuits in pain and pain relief.

    Tan, Linette Liqi / Kuner, Rohini

    Nature reviews. Neuroscience

    2021  Volume 22, Issue 8, Page(s) 458–471

    Abstract: The sensory, associative and limbic neocortical structures play a critical role in shaping incoming noxious inputs to generate variable pain perceptions. Technological advances in tracing circuitry and interrogation of pathways and complex behaviours are ...

    Abstract The sensory, associative and limbic neocortical structures play a critical role in shaping incoming noxious inputs to generate variable pain perceptions. Technological advances in tracing circuitry and interrogation of pathways and complex behaviours are now yielding critical knowledge of neocortical circuits, cellular contributions and causal relationships between pain perception and its abnormalities in chronic pain. Emerging insights into neocortical pain processing suggest the existence of neocortical causality and specificity for pain at the level of subdomains, circuits and cellular entities and the activity patterns they encode. These mechanisms provide opportunities for therapeutic intervention for improved pain management.
    MeSH term(s) Analgesia ; Animals ; Humans ; Neocortex/physiopathology ; Neural Pathways/physiopathology ; Pain/physiopathology ; Pain Management ; Pain Perception/physiology
    Language English
    Publishing date 2021-06-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-021-00468-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy.

    Mandel, Nicolas / Büttner, Michael / Poschet, Gernot / Kuner, Rohini / Agarwal, Nitin

    Cells

    2023  Volume 12, Issue 21

    Abstract: Diabetic peripheral neuropathy (DPN) is the prevalent type of peripheral neuropathy; it primarily impacts extremity nerves. Its multifaceted nature makes the molecular mechanisms of diabetic neuropathy intricate and incompletely elucidated. Several types ...

    Abstract Diabetic peripheral neuropathy (DPN) is the prevalent type of peripheral neuropathy; it primarily impacts extremity nerves. Its multifaceted nature makes the molecular mechanisms of diabetic neuropathy intricate and incompletely elucidated. Several types of post-translational modifications (PTMs) have been implicated in the development and progression of DPN, including phosphorylation, glycation, acetylation and SUMOylation. SUMOylation involves the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to target proteins, and it plays a role in various cellular processes, including protein localization, stability, and function. While the specific relationship between high blood glucose and SUMOylation is not extensively studied, recent evidence implies its involvement in the development of DPN in type 1 diabetes. In this study, we investigated the impact of SUMOylation on the onset and progression of DPN in a type 2 diabetes model using genetically modified mutant mice lacking SUMOylation, specifically in peripheral sensory neurons (SNS-Ubc9
    MeSH term(s) Mice ; Animals ; Reactive Oxygen Species/metabolism ; Diabetic Neuropathies/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Sumoylation ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Sensory Receptor Cells/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12212511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Meet PAIN pictured.

    Kuner, Rohini

    Pain

    2015  Volume 156, Issue 1, Page(s) 3

    MeSH term(s) Humans ; Pain ; Periodicals as Topic/trends
    Language English
    Publishing date 2015-01-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1016/j.pain.0000000000000024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Spinal excitatory mechanisms of pathological pain.

    Kuner, Rohini

    Pain

    2015  Volume 156 Suppl 1, Page(s) S11–S17

    Abstract: An important property of the nociceptive system is its plasticity, ie, the ability to change in an experience-dependent manner, which is implicated in the transition from acute pain to chronic pathological pain. Disease-induced plasticity can occur at ... ...

    Abstract An important property of the nociceptive system is its plasticity, ie, the ability to change in an experience-dependent manner, which is implicated in the transition from acute pain to chronic pathological pain. Disease-induced plasticity can occur at both structural and functional levels and manifests as changes in individual molecules, synapses, cellular function, and network activity. In this short review, the author discusses how synaptic plasticity may mediate pathophysiological alterations linked to chronic pain by virtue of shifting the balance between excitation and inhibition, with a particular emphasis on the spinal dorsal horn. In particular, mechanisms of spinal synaptic potentiation and how these are manifest as nociceptive hypersensitivity represent an avenue with recent advances. Structural remodeling and reorganization represent another exciting area of advance in our understanding of pain. Here, new insights into maladaptive structural plasticity of spinal synapses and molecular determinants thereof will be discussed. Finally, the role of synapse-to-nucleus communication in mediating long-term changes in nociceptive sensitivity is discussed from the view point of pain chronicity.
    MeSH term(s) Animals ; Humans ; Neuronal Plasticity/physiology ; Pain/pathology ; Protein Interaction Maps ; Spinal Cord/pathology ; Spinal Cord/physiopathology ; Synapses/physiology
    Language English
    Publishing date 2015-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000000118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Brainbased interventions for chronic pain

    Flor, Herta / Kuner, Rohini

    Neuroforum

    2022  Volume 28, Issue 2 Spec. Iss., Page(s) 95

    Language German
    Document type Article
    ZDB-ID 1238592-X
    ISSN 0947-0875
    Database Current Contents Medicine

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