LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Kunning, Sheryl R"
  2. AU="Durkan, Garrett C"
  3. AU="Barcelona, Laura"
  4. AU="McDonald, Bryan"
  5. AU="Martin, Jacqueline M"
  6. AU="Ingrisch, Doris"
  7. AU="Hanks, Ephraim M"
  8. AU="Ruiz-Narvaez, Edward A"
  9. AU="Krzysztof Kamiński"
  10. AU="Sharma, Ishna"
  11. AU="Warner, Brit"
  12. AU="JOCHEN SCHÖNGART"
  13. AU="Curdy, Nicolas"
  14. AU="Nkfusai, Claude Ngwayu"
  15. AU="Peng, Yonghan"
  16. AU="Decker, Miriam"
  17. AU="Campbell, Kerry"
  18. AU="Le Deley, Marie-Cécile" AU="Le Deley, Marie-Cécile"
  19. AU="Guan, Shu"

Suchergebnis

Treffer 1 - 4 von insgesamt 4

Suchoptionen

  1. Artikel ; Online: Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.

    Shan, Feng / Cillo, Anthony R / Cardello, Carly / Yuan, Daniel Y / Kunning, Sheryl R / Cui, Jian / Lampenfeld, Caleb / Williams, Asia M / McDonough, Alexandra P / Pennathur, Arjun / Luketich, James D / Kirkwood, John M / Ferris, Robert L / Bruno, Tullia C / Workman, Creg J / Benos, Panayiotis V / Vignali, Dario A A

    Science immunology

    2023  Band 8, Heft 87, Seite(n) eadf6717

    Abstract: Human regulatory T cells ( ... ...

    Abstract Human regulatory T cells (T
    Mesh-Begriff(e) Humans ; Autoimmune Diseases ; Basic-Leucine Zipper Transcription Factors/genetics ; Gene Regulatory Networks ; Head and Neck Neoplasms/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; T-Lymphocytes, Regulatory
    Chemische Substanzen Basic-Leucine Zipper Transcription Factors ; BATF protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-09-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adf6717
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes.

    Karapetyan, Lilit / AbuShukair, Hassan M / Li, Aofei / Knight, Andrew / Al Bzour, Ayah Nedal / MacFawn, Ian P / Thompson, Zachary J / Chen, Ann / Yang, Xi / Dadey, Rebekah / Karunamurthy, Arivarasan / De Stefano, Danielle Vargas / Sander, Cindy / Kunning, Sheryl R / Najjar, Yana G / Davar, Diwakar / Luke, Jason J / Gooding, William / Bruno, Tullia C /
    Kirkwood, John M / Storkus, Walter J

    Frontiers in immunology

    2023  Band 14, Seite(n) 1171978

    Abstract: Background: Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the current study, we sought to investigate the prognostic value of TLS-associated ... ...

    Abstract Background: Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the current study, we sought to investigate the prognostic value of TLS-associated chemokines/cytokines (TLS-kines) expression levels in melanoma patients by performing serum protein and tissue transcriptomic analyses, and to then correlate these data with patients clinicopathological and TME characteristics.
    Methods: Levels of TLS-kines in patients' sera were quantitated using a custom Luminex Multiplex Assay. The Cancer Genomic Atlas melanoma cohort (TCGA-SKCM) and a Moffitt Melanoma cohort were used for tissue transcriptomic analyses. Associations between target analytes and survival outcomes, clinicopathological variables, and correlations between TLS-kines were statistically analyzed.
    Results: Serum of 95 patients with melanoma were evaluated; 48 (50%) female, median age of 63, IQR 51-70 years. Serum levels of APRIL/TNFSF13 were positively correlated with levels of both CXCL10 and CXCL13. In multivariate analyses, high levels of serum APRIL/TNFSF13 were associated with improved event-free survival after adjusting for age and stage (HR = 0.64, 95% CI 0.43-0.95; p = 0.03). High expression of
    Conclusion: Serum protein and tumor transcript levels of APRIL/TNFSF13 are associated with improved survival outcomes. Patients exhibiting high coordinate expression of
    Mesh-Begriff(e) Humans ; Female ; Middle Aged ; Aged ; Male ; Prognosis ; Melanoma/genetics ; Cytokines ; Gene Expression Profiling ; Genomics ; Tumor Microenvironment/genetics
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1171978
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma.

    Ruffin, Ayana T / Cillo, Anthony R / Tabib, Tracy / Liu, Angen / Onkar, Sayali / Kunning, Sheryl R / Lampenfeld, Caleb / Atiya, Huda I / Abecassis, Irina / Kürten, Cornelius H L / Qi, Zengbiao / Soose, Ryan / Duvvuri, Umamaheswar / Kim, Seungwon / Oesterrich, Steffi / Lafyatis, Robert / Coffman, Lan G / Ferris, Robert L / Vignali, Dario A A /
    Bruno, Tullia C

    Nature communications

    2021  Band 12, Heft 1, Seite(n) 3349

    Abstract: Current immunotherapy paradigms aim to reinvigorate ... ...

    Abstract Current immunotherapy paradigms aim to reinvigorate CD8
    Mesh-Begriff(e) Analysis of Variance ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes/immunology ; Gene Expression ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/virology ; Humans ; Immunotherapy/methods ; Papillomavirus Infections ; Semaphorins/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/virology ; Survival Analysis ; T-Lymphocytes ; Tertiary Lymphoid Structures/metabolism
    Chemische Substanzen SEMA4A protein, human ; Semaphorins
    Sprache Englisch
    Erscheinungsdatum 2021-06-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-23355-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.

    Chuckran, Christopher A / Cillo, Anthony R / Moskovitz, Jessica / Overacre-Delgoffe, Abigail / Somasundaram, Ashwin S / Shan, Feng / Magnon, Grant C / Kunning, Sheryl R / Abecassis, Irina / Zureikat, Amer H / Luketich, James / Pennathur, Arjun / Sembrat, John / Rojas, Mauricio / Merrick, Daniel T / Taylor, Sarah E / Orr, Brian / Modugno, Francesmary / Buckanovich, Ron /
    Schoen, Robert E / Kim, Seungwon / Duvvuri, Umamaheswar / Zeh, Herbert / Edwards, Robert / Kirkwood, John M / Coffman, Lan / Ferris, Robert L / Bruno, Tullia C / Vignali, Dario A A

    Science translational medicine

    2021  Band 13, Heft 623, Seite(n) eabf8495

    Abstract: Despite the success of immune checkpoint blockade therapy, few strategies sufficiently overcome immunosuppression within the tumor microenvironment (TME). Targeting regulatory T cells ( ... ...

    Abstract Despite the success of immune checkpoint blockade therapy, few strategies sufficiently overcome immunosuppression within the tumor microenvironment (TME). Targeting regulatory T cells (T
    Mesh-Begriff(e) Animals ; Head and Neck Neoplasms ; Humans ; Immunotherapy ; Mice ; Neuropilin-1/metabolism ; Prevalence ; T-Lymphocytes, Regulatory ; Tumor Microenvironment
    Chemische Substanzen Neuropilin-1 (144713-63-3)
    Sprache Englisch
    Erscheinungsdatum 2021-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abf8495
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang