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  1. Article ; Online: Obesity or adipokines-which should be targeted for venous thromboembolism prevention?

    Kunutsor, Setor K

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 2, Page(s) 195–197

    MeSH term(s) Humans ; Adipokines ; Venous Thromboembolism/prevention & control ; Obesity/complications ; Anticoagulants
    Chemical Substances Adipokines ; Anticoagulants
    Language English
    Publishing date 2023-02-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2022.11.008
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  2. Article: The multifaceted benefits of passive heat therapies for extending the healthspan: A comprehensive review with a focus on Finnish sauna.

    Laukkanen, Jari A / Kunutsor, Setor K

    Temperature (Austin, Tex.)

    2024  Volume 11, Issue 1, Page(s) 27–51

    Abstract: Passive heat therapy is characterized by exposure to a high environmental temperature for a brief period. There are several types of passive heat therapy which include hot tubs, Waon therapy, hydrotherapy, sanarium, steam baths, infrared saunas and ... ...

    Abstract Passive heat therapy is characterized by exposure to a high environmental temperature for a brief period. There are several types of passive heat therapy which include hot tubs, Waon therapy, hydrotherapy, sanarium, steam baths, infrared saunas and Finnish saunas. The most commonly used and widely studied till date are the Finnish saunas, which are characterized by high temperatures (ranging from 80-100°C) and dry air with relative humidity varying from 10-20%. The goal of this review is to provide a summary of the current evidence on the impact of passive heat therapies particularly Finnish saunas on various health outcomes, while acknowledging the potential of these therapies to contribute to the extension of healthspan, based on their demonstrated health benefits and disease prevention capabilities. The Finnish saunas have the most consistent and robust evidence regarding health benefits and they have been shown to decrease the risk of health outcomes such as hypertension, cardiovascular disease, thromboembolism, dementia, and respiratory conditions; may improve the severity of musculoskeletal disorders, COVID-19, headache and flu, while also improving mental well-being, sleep, and longevity. Finnish saunas may also augment the beneficial effects of other protective lifestyle factors such as physical activity. The beneficial effects of passive heat therapies may be linked to their anti-inflammatory, cytoprotective and anti-oxidant properties and synergistic effects on neuroendocrine, circulatory, cardiovascular and immune function. Passive heat therapies, notably Finnish saunas, are emerging as potentially powerful and holistic strategies to promoting health and extending the healthspan in all populations.
    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2332-8940
    ISSN 2332-8940
    DOI 10.1080/23328940.2023.2300623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physical activity, exercise and adverse cardiovascular outcomes in individuals with pre-existing cardiovascular disease: a narrative review.

    Kunutsor, Setor K / Laukkanen, Jari A

    Expert review of cardiovascular therapy

    2024  Volume 22, Issue 1-3, Page(s) 91–101

    Abstract: Introduction: The evidence supporting the cardiovascular health benefits of physical activity and/or exercise training is well-established. While the role of physical activity in primary prevention is unequivocal, its significance in secondary ... ...

    Abstract Introduction: The evidence supporting the cardiovascular health benefits of physical activity and/or exercise training is well-established. While the role of physical activity in primary prevention is unequivocal, its significance in secondary prevention (among those with preexisting cardiovascular disease) is less definitive. Though guidelines universally recommend physical activity as part of the secondary preventive strategy, the empirical evidence underpinning these recommendations is not as robust as that for primary prevention.
    Areas covered: This review distills the body of available observational and interventional evidence on the relationship between physical activity, exercise, and adverse cardiovascular outcomes among those with preexisting cardiovascular disease. The postulated biologic mechanisms underlying the relationships, areas of prevailing uncertainty, and potential public health implications are also discussed.
    Expert opinion: A physical activity level of 500 MET-min/week (equivalent to 150 min of moderate-intensity physical activity or 75 min of vigorous-intensity physical activity or an equivalent combination) may be a minimum requirement for patients with preexisting CVD. However, to reap the maximum benefits of physical activity and also minimize adverse effects, physical activity and/or exercise regimens should be tailored to unique factors such as individual's baseline physical activity habits, cardiovascular health status and the specific nature of their cardiovascular disease.
    MeSH term(s) Humans ; Cardiovascular Diseases/prevention & control ; Exercise ; Exercise Therapy ; Secondary Prevention
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2024.2328644
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    Zs.A 6107: Show issues Location:
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  4. Article ; Online: Can a healthy dietary pattern alone prevent venous thromboembolism in the general population?

    Kunutsor, Setor K

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2021  Volume 31, Issue 10, Page(s) 2839–2841

    MeSH term(s) Diet ; Humans ; Risk Factors ; Venous Thromboembolism
    Language English
    Publishing date 2021-07-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2021.07.006
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    Zs.A 3149: Show issues Location:
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  5. Article ; Online: The interplay between circulating high-density lipoprotein, age and fracture risk: a new cohort study and systematic meta-analysis.

    Kunutsor, Setor K / Laukkanen, Jari A

    GeroScience

    2023  Volume 45, Issue 4, Page(s) 2727–2741

    Abstract: Previous findings on the association between high-density lipoprotein cholesterol (HDL-C) and fracture have yielded inconsistent results and it is unclear if the association varies with age and sex. We sought to evaluate the prospective association ... ...

    Abstract Previous findings on the association between high-density lipoprotein cholesterol (HDL-C) and fracture have yielded inconsistent results and it is unclear if the association varies with age and sex. We sought to evaluate the prospective association between HDL-C levels and fracture risk and assess if the association is modified by age and sex. Circulating HDL-C levels were measured at baseline in a population-based sample of 2,448 men aged 42-61 years. Cox regression was used to estimate hazard ratios (HRs) and 95% CIs. Incident fractures (n = 134) occurred during a median follow-up of 25.7 years. In analysis adjusted for several risk factors, the HR (95% CI) for fractures was 1.00 (0.85-1.20) per 1 standard deviation (SD) increase in HDL-C levels. Comparing the extreme tertiles of HDL-C levels, the corresponding adjusted HR (95% CI) was 0.94 (0.62-1.45). In a meta-analysis of eight cohort studies (including the current study) comprising 74,378 participants and 4,621 fracture cases, the fully-adjusted risk estimate (95% CI) for fracture was 1.03 (0.96-1.10) per 1SD increase in HDL-C levels and 1.05 (0.92-1.20) comparing extreme tertiles of HDL-C. The pooled risk estimate (95% CIs) for fracture per 1SD increase were 1.09 (1.01-1.17) and 0.98 (0.93-1.04) for age groups ≥ 60 and < 60 years, respectively, and the corresponding risks comparing the extreme tertiles of HDL-C levels were 1.21 (1.09-1.33) and 0.95 (0.85-1.07) (p-value for interaction < 0.05). Age may modify the association between HDL-C levels and fracture risk - an increased fracture risk associated with increased HDL-C levels is only evident in older age (≥ 60 years).
    MeSH term(s) Male ; Humans ; Cohort Studies ; Lipoproteins, HDL ; Cholesterol, HDL ; Risk Factors ; Proportional Hazards Models
    Chemical Substances Lipoproteins, HDL ; Cholesterol, HDL
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-023-00801-w
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    Zs.A 1502: Show issues Location:
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  6. Article ; Online: Sleep quality and its underrated role: Associations between sleep-related symptoms and cardiovascular biomarkers.

    Laukkanen, Jari A / Kunutsor, Setor K

    International journal of cardiology

    2023  Volume 395, Page(s) 131570

    MeSH term(s) Humans ; Sleep Quality ; Sleep ; Biomarkers ; Cardiovascular System
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131570
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    Zs.A 1673: Show issues Location:
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  7. Article ; Online: Higher cardiorespiratory fitness may mitigate increased heart failure risk in men with elevated systolic blood pressure: a prospective cohort study.

    Kunutsor, Setor K / Laukkanen, Jari A

    European journal of preventive cardiology

    2023  Volume 30, Issue 10, Page(s) e48–e50

    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwad168
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    Zs.A 4686: Show issues Location:
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  8. Article ; Online: Nonsteroidal Anti-Inflammatory Drugs and Type 2 Diabetes: A Recipe for Heart Failure?

    Khan, Hassan / Kunutsor, Setor K

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 15, Page(s) 1471–1473

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Heart Failure/drug therapy
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.02.026
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  9. Article ; Online: Does the Combination of Finnish Sauna Bathing and Other Lifestyle Factors Confer Additional Health Benefits? A Review of the Evidence.

    Kunutsor, Setor K / Laukkanen, Jari A

    Mayo Clinic proceedings

    2023  Volume 98, Issue 6, Page(s) 915–926

    Abstract: Sauna bathing, a tradition deeply rooted in the Finnish culture, has been used for thousands of years for leisure, relaxation, and wellness. Sauna bathing is linked with substantial health benefits beyond its use for leisure and relaxation. Several ... ...

    Abstract Sauna bathing, a tradition deeply rooted in the Finnish culture, has been used for thousands of years for leisure, relaxation, and wellness. Sauna bathing is linked with substantial health benefits beyond its use for leisure and relaxation. Several observational and interventional studies suggest that regular or frequent sauna bathing reduces the incidence of vascular and nonvascular diseases, such as hypertension, cardiovascular disease, dementia, and respiratory conditions; may improve the severity of conditions such as musculoskeletal disorders, COVID-19, headache, and influenza; and increases the life span. The beneficial effects of sauna bathing on adverse outcomes have been linked to its blood pressure-reducing, anti-inflammatory, antioxidant, cytoprotective, and stress-reducing properties and its synergistic effect on neuroendocrine, circulatory, cardiovascular, and immune function. Evidence suggests that frequent sauna bathing is an emerging protective risk factor that may augment the beneficial effects of other protective risk or lifestyle factors, such as physical activity and cardiorespiratory fitness, or attenuate or offset the adverse effects of other risk factors, such as high blood pressure, systemic inflammation, and low socioeconomic status. This review summarizes the available epidemiologic and interventional evidence linking the combined effects of Finnish sauna bathing and other risk factors on vascular outcomes including cardiovascular disease and intermediate cardiovascular phenotypes, nonvascular outcomes, and mortality. We also discuss the mechanistic pathways underlying the joint contributions of Finnish sauna bathing and other risk factors on health outcomes, the public health and clinical implications of the findings, gaps in the existing evidence base, and future directions.
    MeSH term(s) Humans ; Steam Bath/adverse effects ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/etiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/etiology ; Hypertension/etiology ; Inflammation/etiology
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.01.008
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    Ua VI Zs.183: Show issues Location:
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  10. Article ; Online: Further proof of a paradoxical relationship between high-density lipoprotein levels and adverse cardiovascular outcomes: are there implications for cardiovascular disease prevention?

    Kunutsor, Setor K / Laukkanen, Jari A

    European journal of preventive cardiology

    2022  Volume 30, Issue 4, Page(s) 290–292

    MeSH term(s) Male ; Humans ; Female ; Cardiovascular Diseases/prevention & control ; Apolipoprotein A-I ; Cardiovascular System ; Risk Factors ; Lipoproteins, HDL
    Chemical Substances Apolipoprotein A-I ; Lipoproteins, HDL
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwac272
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    Zs.A 4686: Show issues Location:
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