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  1. Article: The Clinical Efficacy of Different Relaxation Exercises on Intraocular Pressure Reduction: A Meta-Analysis.

    Wu, Bing-Qi / Kuo, Hou-Ting / Hsu, Alan Y / Lin, Chun-Ju / Lai, Chun-Ting / Tsai, Yi-Yu

    Journal of clinical medicine

    2024  Volume 13, Issue 9

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2024-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13092591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical Efficacy of Omidenepag Isopropyl for Primary Open-Angle Glaucoma, Normal Tension Glaucoma, or Ocular Hypertension: A Meta-Analysis.

    Kuo, Hou-Ting / Yeh, Cyuan-Yi / Hsu, Alan Y / Ho, Jennifer Hui-Chun / Lin, Chun-Ju / Tsai, Yi-Yu

    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

    2023  Volume 39, Issue 10, Page(s) 705–715

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Aged ; Low Tension Glaucoma/drug therapy ; Glaucoma, Open-Angle/drug therapy ; Intraocular Pressure ; Glaucoma/drug therapy ; Ocular Hypertension/drug therapy ; Treatment Outcome ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use
    Chemical Substances omidenepag isopropyl (G0G0H52U6K) ; Antihypertensive Agents
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 1237021-6
    ISSN 1557-7732 ; 1080-7683
    ISSN (online) 1557-7732
    ISSN 1080-7683
    DOI 10.1089/jop.2023.0058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2099: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prevalence of uveitis in syphilis patients in Taiwan.

    Chen, Chia-Yun / Kuo, Hou-Ting / Hsu, Alan Y / Lin, Chun-Ju / Hsia, Ning-Yi / Tien, Peng-Tai / Lai, Chun-Ting / Chen, Huan-Sheng / Tsai, Yi-Yu

    Emerging microbes & infections

    2024  Volume 13, Issue 1, Page(s) 2290836

    Abstract: Few population-based studies have looked at the risk of uveitis among syphilis patients. Our study addresses the knowledge gap by reporting on uveitis risk in syphilis patients through a retrospective cohort study. The Taiwan National Health Insurance ... ...

    Abstract Few population-based studies have looked at the risk of uveitis among syphilis patients. Our study addresses the knowledge gap by reporting on uveitis risk in syphilis patients through a retrospective cohort study. The Taiwan National Health Insurance database was used for this study, covering the period from January 1st, 2009, to December 31st, 2020. We created a 1:4 propensity score matched cohort between the syphilis patients and controls, which accounted for gender, age, and comorbidities. The primary endpoint was the incidence of newly recorded uveitis. The assessment of uveitis risk in syphilis patients included the use of the Kaplan-Meier method and multivariate Cox proportional hazard model. A total of 31,597 syphilis patients and 126,379 matched comparisons were recruited. The uveitis incidence rate from our syphilis patients was 1.25 per 1000 person-years. The uveitis incidence rate from our non-syphilis group was 0.8 per 1000 person-years. After matching, the syphilis group was found to have a higher risk of developing uveitis (adjusted hazard ratio (aHR) [95% CI]: 1.57 [1.36-1.81],
    MeSH term(s) Male ; Humans ; Syphilis/epidemiology ; Retrospective Studies ; Risk Factors ; Taiwan/epidemiology ; Prevalence ; Uveitis/epidemiology ; Uveitis/diagnosis ; Incidence
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2290836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association between immune checkpoint inhibitor medication and uveitis: a population-based cohort study utilizing TriNetX database.

    Kuo, Hou-Ting / Chen, Chia-Yun / Hsu, Alan Y / Wang, Yu-Hsun / Lin, Chun-Ju / Hsia, Ning-Yi / Tsai, Yi-Yu / Wei, James Cheng-Chung

    Frontiers in immunology

    2024  Volume 14, Page(s) 1302293

    Abstract: Objective: To explore the associations between the use of immune checkpoint inhibitors (ICIs) and the risk of developing uveitis among cancer patients.: Methods: Cancer patients who received ICI therapy and a comparison group of cancer patients who ... ...

    Abstract Objective: To explore the associations between the use of immune checkpoint inhibitors (ICIs) and the risk of developing uveitis among cancer patients.
    Methods: Cancer patients who received ICI therapy and a comparison group of cancer patients who did not receive ICI therapy were retrospectively recruited from the TriNetX electronic heath-record registry. The outcome of interest was the development of new-onset uveitis. Propensity score matching based on a 1:1 ratio was conducted in order to reduce bias. Multi-variate cox proportional hazard models and Kaplan Meier method were also utilized to assess for the risk of uveitis among cancer patients who received ICI therapy.
    Results: 71931 cancer patients (54.7% male; 76.5% white; mean age at index 63.6 ± 12.2 years) who received ICI treatment (ICI group) and 71931 cancer patients (54.7% male; 77% white; mean age at index 63.5 ± 12.4 years) who never received ICI (comparison group) were recruited. Associated Kaplan-Meier curves showed significantly increased uveitis risk among the ICI group for all follow-up years (p<0.001). The risk of uveitis was also higher among the ICI group during the 144-month follow-up period with a hazard ratio (HR) of 2.39 (95% CI: 2.07-2.75). Increased risk for specific uveitis diseases, such as iridocyclitis, chorioretinal inflammation, retinal vasculitis, unspecified purulent endophthalmitis, pan-uveitis and sympathetic uveitis were found. Subgroup analysis demonstrated an elevated hazard ratio for the development of uveitis among ICI recipients, spanning individuals below the age of 65 as well as those aged 65 and older. The elevated hazard ratio for uveitis development among ICI recipients was also observed across all genders, among those of white and Asian ethnicities, those with smoking history, and those with comorbid conditions such as hypertension and dyslipidemia, in comparison to their non-ICI counterparts. An additional subgroup analysis on monotherapy versus combinatory ICI regimens was also conducted. Individuals who received monotherapy from the class of anti-PD-1 (HR:1.98 [CI: 1.65-2.37]) and anti-CTLA-4 (HR:5.86 [CI:1.99-17.24]) exhibited elevated hazard ratios for uveitis development compared to their non-ICI comparators. Those exposed to combinatory ICI regimens, specifically a combination of anti-PD-1 and anti-CTLA4 (HR: 5.04 [CI:3.55-7.16]), showed increased hazard ratios for uveitis development compared to their non-ICI comparators. In contrast, individuals exposed to a combination of anti-PD-1 and anti-PD-L1 (HR: 2.47 [CI:0.81-7.50]) did not demonstrate an increased risk for uveitis compared to their non-ICI comparators.
    Conclusion: A significantly increased risk for uveitis diseases was found among the ICI group from the first year of follow-up. Increased awareness should be promoted on the occurrence of uveitis among cancer patients receiving ICI therapy.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Aged ; Immune Checkpoint Inhibitors ; Cohort Studies ; Retrospective Studies ; Chorioretinitis ; Anesthetics, Local ; Neoplasms
    Chemical Substances Immune Checkpoint Inhibitors ; Anesthetics, Local
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1302293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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