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  1. Book: Protein kinase C

    Kuo, J. F

    1994  

    Author's details edited by J.F. Kuo
    Keywords Protein kinases.
    Language English
    Size x, 326 p. :, ill. ;, 24 cm.
    Publisher Oxford University Press
    Publishing place New York
    Document type Book
    ISBN 0195081013 ; 9780195081015
    Database NAL-Catalogue (AGRICOLA)

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  2. Book: Protein kinase C

    Kuo, J. F

    1994  

    Author's details edited by J.F. Kuo
    MeSH term(s) Protein Kinase C/metabolism
    Language English
    Size x, 326 p. :, ill.
    Publisher Oxford University Press
    Publishing place New York
    Document type Book
    ISBN 9780195081015 ; 0195081013
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: Fracture liaison services for osteoporosis in the Asia-Pacific region: current unmet needs and systematic literature review.

    Chang, Y -F / Huang, C -F / Hwang, J -S / Kuo, J -F / Lin, K -M / Huang, H -C / Bagga, S / Kumar, A / Chen, F -P / Wu, C -H

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2017  Volume 29, Issue 4, Page(s) 779–792

    Abstract: The analysis aimed to identify the treatment gaps in current fracture liaison services (FLS) and to provide recommendations for best practice establishment of future FLS across the Asia-Pacific region. The findings emphasize the unmet need for the ... ...

    Abstract The analysis aimed to identify the treatment gaps in current fracture liaison services (FLS) and to provide recommendations for best practice establishment of future FLS across the Asia-Pacific region. The findings emphasize the unmet need for the implementation of new programs and provide recommendations for the refinement of existing ones. The study's objectives were to evaluate fracture liaison service (FLS) programs in the Asia-Pacific region and provide recommendations for establishment of future FLS programs. A systematic literature review (SLR) of Medline, PubMed, EMBASE, and Cochrane Library (2000-2017 inclusive) was performed using the following keywords: osteoporosis, fractures, liaison, and service. Inclusion criteria included the following: patients ≥ 50 years with osteoporosis-related fractures; randomized controlled trials or observational studies with control groups (prospective or retrospective), pre-post, cross-sectional and economic evaluation studies. Success of direct or indirect interventions was assessed based on patients' understanding of risk, bone mineral density assessment, calcium intake, osteoporosis treatment, re-fracture rates, adherence, and mortality, in addition to cost-effectiveness. Overall, 5663 unique citations were identified and the SLR identified 159 publications, reporting 37 studies in Asia-Pacific. These studies revealed the unmet need for public health education, adequate funding, and staff resourcing, along with greater cooperation between departments and physicians. These actions can help to overcome therapeutic inertia with sufficient follow-up to ensure adherence to recommendations and compliance with treatment. The findings also emphasize the importance of primary care physicians continuing to prescribe treatment and ensure service remains convenient. These findings highlight the limited evidence supporting FLS across the Asia-Pacific region, emphasizing the unmet need for new programs and/or refinement of existing ones to improve outcomes. With the continued increase in burden of fractures in Asia-Pacific, establishment of new FLS and assessment of existing services are warranted to determine the impact of FLS for healthcare professionals, patients, family/caregivers, and society.
    MeSH term(s) Asia/epidemiology ; Australasia/epidemiology ; Bone Density Conservation Agents/therapeutic use ; Cost-Benefit Analysis ; Delivery of Health Care, Integrated/economics ; Delivery of Health Care, Integrated/organization & administration ; Health Care Costs/statistics & numerical data ; Humans ; Needs Assessment/organization & administration ; Osteoporosis/diagnosis ; Osteoporosis/drug therapy ; Osteoporosis/epidemiology ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/prevention & control ; Patient Education as Topic/methods ; Program Evaluation ; Recurrence
    Chemical Substances Bone Density Conservation Agents
    Language English
    Publishing date 2017-12-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-017-4347-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Practical Design Calculation for Groundwater and Soil Remediation

    Kuo, J.-F. J.

    1998  , Page(s) 305

    Abstract: Due to certain differences in educational training, the ability of environmental professionals to perform or review design calculations varies. It bridges the gap with 'Practical Design Calculations for Groundwater and Soil Remediation'. Jeff Kuo's hands- ...

    Abstract Due to certain differences in educational training, the ability of environmental professionals to perform or review design calculations varies. It bridges the gap with 'Practical Design Calculations for Groundwater and Soil Remediation'. Jeff Kuo's hands-on experience as a consultant and teacher of soil/groundwater remediation informs this collection of the most practical and relevant working information. Written in a user-friendly, 'cookbook-style' format, readers can promptly access the necessary information. More than 200 equations, coupled with tables and figures, allow a clear understanding of purposes and procedures. 'Practical Design Calculations for Groundwater and Soil Remediation' helps everyone involved in a site restoration project follow the same set of guidelines-for effective results.
    Keywords Grundwasserverunreinigung ; Bodenwasser ; Bodenverunreinigung ; Bodenschutz ; Sanierungsmassnahme ; Verfahrenstechnik ; Verdachtsflaeche ; Grundwasserdekontamination ; Bodendekontamination
    Language English
    Document type Book
    ISBN 1-56670-238-0
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  5. Book: Phospholipids and cellular regulation

    Kuo, J. F

    1985  

    Author's details editor, J.F. Kuo. --
    Keywords Cellular control mechanisms. ; Phospholipids. ; Cell membranes.
    Language English
    Size 2 v. :, ill. ;, 27 cm.
    Publisher CRC Press
    Publishing place Boca Raton, Fla
    Document type Book
    ISBN 0849355370 ; 0849355389 ; 9780849355370 ; 9780849355387
    Database NAL-Catalogue (AGRICOLA)

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  6. Book: Phospholipids and cellular regulation

    Kuo, J. F

    1985  

    Author's details editor, J.F. Kuo
    MeSH term(s) Cell Membrane ; Phospholipids
    Language English
    Size v. :, ill.
    Publisher CRC Press
    Publishing place Boca Raton, Fla
    Document type Book
    ISBN 9780849355370 ; 0849355370 ; 9780849355387 ; 0849355389
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: Protein kinase C phosphorylation of cardiac troponin I and troponin T inhibits Ca(2+)-stimulated MgATPase activity in reconstituted actomyosin and isolated myofibrils, and decreases actin-myosin interactions.

    Noland, T A / Kuo, J F

    Journal of molecular and cellular cardiology

    1993  Volume 25, Issue 1, Page(s) 53–65

    Abstract: The inhibitory effects of the phosphorylation of bovine cardiac troponin I (TnI) and troponin T (TnT) by protein kinase C (PKC) on the activity of Ca(2+)-stimulated MgATPase of reconstituted actomyosin complex, as a function of the concentration of ... ...

    Abstract The inhibitory effects of the phosphorylation of bovine cardiac troponin I (TnI) and troponin T (TnT) by protein kinase C (PKC) on the activity of Ca(2+)-stimulated MgATPase of reconstituted actomyosin complex, as a function of the concentration of myosin or myosin subfragment 1 (S-1), were investigated. Phosphorylation of TnI and/or TnT invariably decreased the Ca(2+)-stimulated enzyme activity of reconstituted actomyosin or actomyosin S-1, regardless of the concentration of whole myosin or S-1. The inhibition due to phosphorylated TnI was partially overcome as the concentration of myosin or S-1 increased, suggesting simple competition of phosphorylated TnI with myosin or S-1 for actin binding sites. Inhibition due to phosphorylated TnT, however, remained constant at all concentrations of myosin or S-1, suggesting that phosphorylated TnT may inhibit full Ca(2+)-activation of the thin filament. Both phosphorylated TnI and TnT inhibited the Ca(2+)-stimulated binding of S-1.ADP to regulated actin, consistent with the notion that the effects of phosphorylation of TnI and TnT affected interactions of the thin filament with the thick filament. Effects of PKC phosphorylation of the contractile components in adult rat cardiac myofibrils were also investigated. PKC phosphorylation of TnI and TnT, as well as other proteins in the contractile complex, resulted in the inhibition of Ca(2+)-stimulated MgATPase activity with little change in the Ca(2+)-sensitivity. Thus, the negative inotropic effects attributable to activation of PKC by phorbol esters, as reported by others, could be explained in part through PKC mediated phosphorylation of components of the contractile apparatus.
    MeSH term(s) Actins/metabolism ; Actomyosin/metabolism ; Animals ; Ca(2+) Mg(2+)-ATPase/metabolism ; In Vitro Techniques ; Myocardium/metabolism ; Myofibrils/metabolism ; Myosins/metabolism ; Phosphorylation ; Protein Kinase C/metabolism ; Rats ; Regression Analysis ; Troponin/metabolism ; Troponin I ; Troponin T
    Chemical Substances Actins ; Troponin ; Troponin I ; Troponin T ; Actomyosin (9013-26-7) ; Protein Kinase C (EC 2.7.11.13) ; Ca(2+) Mg(2+)-ATPase (EC 3.6.1.-) ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 1993-01
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1006/jmcc.1993.1007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 426: Show issues Location:
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  8. Article: Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase.

    Venema, R C / Kuo, J F

    The Journal of biological chemistry

    1993  Volume 268, Issue 4, Page(s) 2705–2711

    Abstract: Phosphorylation of cardiac myofibrillar proteins by protein kinase C (PKC) in isolated adult rat cardiomyocytes has been compared with that mediated by the cAMP-dependent protein kinase (PKA). PKA activation by beta-adrenoreceptor (isoproterenol) ... ...

    Abstract Phosphorylation of cardiac myofibrillar proteins by protein kinase C (PKC) in isolated adult rat cardiomyocytes has been compared with that mediated by the cAMP-dependent protein kinase (PKA). PKA activation by beta-adrenoreceptor (isoproterenol) stimulation results in stoichiometric phosphorylation of troponin I (TnI) and C-protein. PKC activation by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or by alpha-adrenoreceptor (phenylephrine plus propranolol) stimulation results in phosphorylation of the same two proteins to similar extents. Two-dimensional phosphopeptide mapping shows that the same sites in TnI are modified by PKC in vitro and in TPA- or alpha-agonist-stimulated cells. These sites are distinct from those phosphorylated in isoproterenol-stimulated cells or by PKA in vitro. Phosphopeptide mapping analysis of C-protein shows that PKC and PKA phosphorylate identical residues in this protein in vitro and in situ. TPA-stimulated phosphorylation in myocytes is associated with a reduction in maximal activity of myofibrillar Ca(2+)-dependent actomyosin MgATPase. Isoproterenol-stimulated phosphorylation has no effect on maximal activity but reduces the Ca2+ sensitivity of the MgATPase. These data demonstrate that TnI and C-protein are phosphorylated in myocardial cells by both PKA and PKC, resulting in different functional consequences in each case.
    MeSH term(s) Actomyosin/antagonists & inhibitors ; Animals ; Calcium/metabolism ; Electrophoresis, Gel, Two-Dimensional ; Isoproterenol/pharmacology ; Myocardium/enzymology ; Myosins/antagonists & inhibitors ; Peptide Mapping ; Phosphoproteins/chemistry ; Phosphorylation ; Protein Kinase C/metabolism ; Protein Kinases/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha/physiology ; Substrate Specificity ; Tetradecanoylphorbol Acetate/pharmacology ; Troponin/metabolism ; Troponin C ; Troponin I
    Chemical Substances Phosphoproteins ; Receptors, Adrenergic, alpha ; Troponin ; Troponin C ; Troponin I ; Actomyosin (9013-26-7) ; Protein Kinases (EC 2.7.-) ; Protein Kinase C (EC 2.7.11.13) ; Myosins (EC 3.6.4.1) ; Isoproterenol (L628TT009W) ; Tetradecanoylphorbol Acetate (NI40JAQ945) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1993-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Phosphorylation of cardiac myosin light chain 2 by protein kinase C and myosin light chain kinase increases Ca(2+)-stimulated actomyosin MgATPase activity.

    Noland, T A / Kuo, J F

    Biochemical and biophysical research communications

    1993  Volume 193, Issue 1, Page(s) 254–260

    Abstract: Myosin light chain 2 (MLC2) phosphorylation in rat cardiac whole myosin by cardiac myosin light chain kinase (MLCK) or by protein kinase C (PKC) resulted in increased actin-stimulated myosin MgATPase activity. The phosphorylation also increased Ca(2+)- ... ...

    Abstract Myosin light chain 2 (MLC2) phosphorylation in rat cardiac whole myosin by cardiac myosin light chain kinase (MLCK) or by protein kinase C (PKC) resulted in increased actin-stimulated myosin MgATPase activity. The phosphorylation also increased Ca(2+)-stimulated myofibrillar MgATPase activity upon substitution of the phosphorylated myosin into myofibrils. In addition, phosphorylation of MLC2 in myofibrils by MLCK increased both the Ca(2+)-sensitivity and maximum activity of the myofibrillar Ca(2+)-stimulated MgATPase activity. The latter effect was inhibited by PKC-phosphorylation of troponin I, troponin T and C-protein. A role for both PKC and MLCK in regulating cardiac myofibrillar activity, via phosphorylation of various contractile proteins, is indicated.
    MeSH term(s) Animals ; Ca(2+) Mg(2+)-ATPase/metabolism ; Calcium/metabolism ; Cattle ; Enzyme Activation ; Myocardium/enzymology ; Myocardium/metabolism ; Myosins/metabolism ; Phosphorylation ; Protein Kinase C/metabolism ; Rats
    Chemical Substances Protein Kinase C (EC 2.7.11.13) ; Ca(2+) Mg(2+)-ATPase (EC 3.6.1.-) ; Myosins (EC 3.6.4.1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1993-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1006/bbrc.1993.1617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  10. Article: Synthesis, characterization and platelet adhesion studies of novel ion-containing aliphatic polyurethanes.

    Chen, K Y / Kuo, J F / Chen, C Y

    Biomaterials

    2000  Volume 21, Issue 2, Page(s) 161–171

    Abstract: Two novel ion-containing aliphatic polyurethanes based on 4,4'-methylene dicyclohexyl diisocyanate (H12MDI), polytetramethyl oxide (PTMO) were synthesized using either sulfonated or carboxylated chain extender. The nonionic polyurethane chain extended ... ...

    Abstract Two novel ion-containing aliphatic polyurethanes based on 4,4'-methylene dicyclohexyl diisocyanate (H12MDI), polytetramethyl oxide (PTMO) were synthesized using either sulfonated or carboxylated chain extender. The nonionic polyurethane chain extended with 1,4-butanediol, which is denoted as H-M-BD, was synthesized. Pellethane, a biomedical-grade polyurethane, was also studied for comparison. The polymer's bulk, surface, and platelet-contacting properties were studied using Fourier transform infrared spectrophotometry, differential scanning calorimetry, water absorption analysis, electron spectroscopy for chemical analysis, static contact angle analysis, and in vitro platelet adhesion experiments. The effects of ion incorporation on the morphology, surface properties and blood compatibility are discussed. Unlike MDI-based Pellethane, all H12MDI-based polyurethanes are not composed of crystalline hard segment domain but are amorphous. The ionic polyurethanes exhibit a smaller fraction of hydrogen-bonded carbonyl groups, poorer phase separation, smaller fraction of PTMO residing at the surface, and smaller contact angle; however, significant higher water absorption value than H-M-BD and Pellethane. The in vitro platelet adhesion experiments indicated that ion incorporation, especially for carboxylate, significantly reduced the number and the degree of activation of the adherent platelets.
    MeSH term(s) Absorption ; Alkanes/chemical synthesis ; Alkanes/chemistry ; Alkanes/pharmacology ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Blood Platelets/cytology ; Blood Platelets/drug effects ; Calorimetry, Differential Scanning ; Cyclohexanes/chemistry ; Electron Probe Microanalysis ; Hot Temperature ; Humans ; Molecular Weight ; Nitriles/chemistry ; Oxides/chemistry ; Platelet Adhesiveness/drug effects ; Polyurethanes/chemical synthesis ; Polyurethanes/chemistry ; Polyurethanes/pharmacology ; Spectroscopy, Fourier Transform Infrared ; Surface Properties ; Thermodynamics ; Water/chemistry
    Chemical Substances 4,4'-methylene dicyclohexyl diisocyanate ; Alkanes ; Biocompatible Materials ; Cyclohexanes ; Nitriles ; Oxides ; Polyurethanes ; polytetramethyloxide ; Water (059QF0KO0R)
    Language English
    Publishing date 2000-01
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/s0142-9612(99)00144-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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