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  1. Article ; Online: Letter to the Editor. Pseudarthrosis after the bulk floating procedure.

    Kuo, Yi-Hsuan / Wu, Jau-Ching

    Journal of neurosurgery. Spine

    2023  Volume 40, Issue 1, Page(s) 122–123

    MeSH term(s) Humans ; Pseudarthrosis/diagnostic imaging ; Pseudarthrosis/etiology ; Pseudarthrosis/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Retrospective Studies
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Letter
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2023.7.SPINE23777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial. Bulk floating of the ossification of the posterior longitudinal ligament: direct decompression without durotomy.

    Kuo, Yi-Hsuan / Wu, Jau-Ching

    Journal of neurosurgery. Spine

    2022  , Page(s) 1–2

    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Editorial ; Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2021.10.SPINE211195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to Folweiler KA et al., Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes With Distinct Acute Injury Profiles and Long-Term Outcomes (DOI: 10.1089/neu.2019.6705).

    Wang, Ching-Ying / Wu, Jau-Ching / Kuo, Yi-Hsuan

    Journal of neurotrauma

    2023  Volume 41, Issue 1-2, Page(s) 292–293

    MeSH term(s) Humans ; Unsupervised Machine Learning ; Brain Injuries, Traumatic ; Phenotype
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2023.0396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exercise effects on fatigue in breast cancer survivors after treatments: A systematic review and meta-analysis.

    Lin, Hui-Ping / Kuo, Yi-Hsuan / Tai, Wen-Yuan / Liu, Hsueh-Erh

    International journal of nursing practice

    2021  Volume 28, Issue 4, Page(s) e12989

    Abstract: Aim: The aim of this study is to explore the effects of exercise interventions by type, duration and intensity of exercise for fatigue in breast cancer survivors who had completed their treatment.: Background: Most studies found that exercise has ... ...

    Abstract Aim: The aim of this study is to explore the effects of exercise interventions by type, duration and intensity of exercise for fatigue in breast cancer survivors who had completed their treatment.
    Background: Most studies found that exercise has valuable outcomes for cancer survivors. This meta-analysis comprehensively summarizes the benefits of exercise intervention for fatigue in breast cancer patients who had completed their adjuvant treatments.
    Methods: We conducted a meta-analysis on randomized control trials published during 1 January 2000 through 31 December 2019, from PubMed, Cochrane Library databases, EMBASE, Medline (ProQuest), CINAHL, PsycINFO, Chinese Electronic Periodical Service and Wan Fan Data with prespecified searching criteria. Breast cancer patients earlier than stage IIIc and completing adjuvant treatments were included, and the effects of exercise on fatigue were investigated.
    Results: Nine randomized controlled trials (RCTs) were included (N = 581). Patients receiving exercise interventions showed reduced fatigue comparing with those without exercise. Exercise with low-moderate intensity, 20 min/day, three times per week and lasting up to 12 weeks had a significant effect on reducing fatigue for breast cancer survivors.
    Conclusion: Our study suggested that exercise interventions can reduce fatigue for this group of cancer survivors. The duration and intensity of exercise intervention could be prescribed for this specific group of cancer patients as a basic requirement to handle their reported fatigue.
    MeSH term(s) Breast Neoplasms/complications ; Breast Neoplasms/therapy ; Cancer Survivors ; Exercise ; Fatigue/etiology ; Fatigue/therapy ; Female ; Humans ; Quality of Life ; Survivors
    Language English
    Publishing date 2021-07-13
    Publishing country Australia
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1381116-2
    ISSN 1440-172X ; 1322-7114
    ISSN (online) 1440-172X
    ISSN 1322-7114
    DOI 10.1111/ijn.12989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The More Levels, the Better Outcome? Cervical Disk Arthroplasty Outscores Anterior Cervical Diskectomy and Fusion in Multilevel Disease.

    Tu, Tsung-Hsi / Chang, Chih-Chang / Kuo, Yi-Hsuan / Ko, Chin-Chu / Wu, Jau-Ching / Huang, Wen-Cheng / Kuo, Chao-Hung

    World neurosurgery

    2023  Volume 175, Page(s) 155–156

    MeSH term(s) Humans ; Diskectomy ; Treatment Outcome ; Arthroplasty ; Cervical Vertebrae/surgery ; Spinal Fusion ; Intervertebral Disc Degeneration/surgery
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.03.141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comparison of Cortical Bone Trajectory to Pedicle-Based Dynamic Stabilization: An Analysis of 291 Patients.

    Chang, Chih-Chang / Chang, Hsuan-Kan / Ko, Chin-Chu / Wu, Ching-Lan / Kuo, Yi-Hsuan / Tu, Tsung-Hsi / Huang, Wen-Cheng / Wu, Jau-Ching

    Neurospine

    2023  Volume 20, Issue 1, Page(s) 308–316

    Abstract: Objective: Pedicle-based dynamic stabilization (DS) has gained popularity outside of America. Although pedicle screw (PS) loosening has always been a concern, it is reportedly innocuous. Cortical bone trajectory (CBT) screw is an emerging option with ... ...

    Abstract Objective: Pedicle-based dynamic stabilization (DS) has gained popularity outside of America. Although pedicle screw (PS) loosening has always been a concern, it is reportedly innocuous. Cortical bone trajectory (CBT) screw is an emerging option with less invasiveness and similar effectiveness to PS in short-segment lumbar fusion. This study aimed to verify the use of CBT for DS by comparing the outcomes between pedicle- and CBT-based DS.
    Methods: Consecutive patients with lumbar spondylosis or low-grade spondylolisthesis who underwent 1- or 2-level DS between L3-5 with a minimum follow-up of 24 months were reviewed. Screw loosening was determined by computed tomography and the incidences were compared.
    Results: A total of 291 patients who underwent Dynesys DS (235 pedicle- and 56 CBT-based, respectively) were compared. The demographics and preoperative conditions were similar. All the clinical outcomes improved at 24-month postoperation, while the CBT-based group had less operation time and blood loss than the pedicle-based group. The rates of screw loosening were lower in the CBT-based (5.4% per screw and 12.5% per patient) than the pedicle-based group (9% per screw and 26.4% per patient). Furthermore, there were no differences in the clinical outcomes and complication profiles.
    Conclusion: The CBT-based DS for 1- or 2-level lumbar degeneration demonstrated equivalent clinical improvement as the pedicle-based DS. The adaption of CBT-based screws for DS could be a less invasive approach (shorter operation time and less blood loss), with lower chances of screw loosening than the conventional PS-based DS.
    Language English
    Publishing date 2023-03-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2244888.444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression.

    Kuo, Yi-Hsuan / Lai, Tsai-Chun / Chang, Chia-Hsin / Hsieh, Han-Ching / Yang, Feng-Ming / Hu, Meng-Chun

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 12621

    Abstract: The effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients. The transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole ( ... ...

    Abstract The effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients. The transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole (DRB), as a selective inhibitor of cyclin-dependent kinase 9, was shown to be effective in inducing apoptosis in various hematopoietic malignancies. However, the anticancer efficacy of DRB against breast cancer is still unclear. Herein, we demonstrated that administration of DRB to the breast cancer cell line led to the inhibition of cellular proliferation and induction of the typical signs of apoptotic cells, including the increases in Annexin V-positive cells, DNA fragmentation, and activation of caspase-7, caspase-9, and poly (ADP ribose) polymerase (PARP). Treatment of DRB resulted in a rapid decline in the myeloid cell leukemia 1 (Mcl-1) protein, whereas levels of other antiapoptotic proteins did not change. Overexpression of Mcl-1 decreased the DRB-induced PARP cleavage, whereas knockdown of Mcl-1 enhanced the effects of DRB on PARP activation, indicating that loss of Mcl-1 accounts for the DRB-mediated apoptosis in MCF-7 cells, but not in T-47D. Furthermore, we found that co-treatment of MCF-7 cells with an inhibitor of AKT (LY294002) or an inhibitor of the proteasome (MG-132) significantly augmented the DRB-induced apoptosis. These data suggested that DRB in combination with LY294002 or MG-132 may have a greater therapeutic potency against breast cancer cells.
    MeSH term(s) Female ; Humans ; Apoptosis ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Dichlororibofuranosylbenzimidazole/pharmacology
    Chemical Substances Myeloid Cell Leukemia Sequence 1 Protein ; Dichlororibofuranosylbenzimidazole (53-85-0)
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39340-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cloward's approach for Pancoast neurogenic tumors: illustrative cases.

    Kuo, Yi-Hsuan / Hsu, Po-Kuei / Wu, Jau-Ching / Huang, Wen-Cheng / Tu, Tsung-Hsi

    Journal of neurosurgery. Case lessons

    2021  Volume 1, Issue 23, Page(s) CASE2065

    Abstract: Background: Pancoast tumors are a wide range of tumors located in the apex of the lung. Traditional surgery for Pancoast neurogenic tumors frequently involves extensive approaches, whether anterior or posterior or a combination, in which osteotomies are ...

    Abstract Background: Pancoast tumors are a wide range of tumors located in the apex of the lung. Traditional surgery for Pancoast neurogenic tumors frequently involves extensive approaches, whether anterior or posterior or a combination, in which osteotomies are sometimes required. In this study, the authors proposed a less invasive surgical strategy using the standard Cloward's approach for complete resection of a schwannoma arising from the T1 nerve root.
    Observations: Two patients, each harboring a large T1 tumor, one on each side, underwent Cloward's approach with and without thoracoscopic surgery. Both patients had complete resection of the tumor. Considering the benign and encapsulated nature of neurogenic tumors, Cloward's approach under neuromonitoring, which is a common procedure for anterior cervical discectomy for most neurosurgeons, is a safe and less invasive alternative for Pancoast neurogenic tumors. For patients whose tumor cannot be removed completely via Cloward's approach, video-assisted thoracoscopic surgery is a viable backup plan with minimal invasiveness.
    Lessons: Cloward's approach is a viable option for Pancoast neurogenic tumors.
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Case Reports
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE2065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Surgical Treatment for a Giant Solitary Plasmacytoma with Skull Erosion.

    Kuo, Yi-Hsuan / Huang, Wen-Cheng / Wu, Jau-Ching

    Cureus

    2018  Volume 10, Issue 11, Page(s) e3535

    Abstract: Solitary plasmacytoma of the skull, a single malignant monoclonal plasma cell proliferation without systemic involvement, is rare and often misdiagnosed by radiological examinations only. In this article, the authors presented a 40-year-old man who had a ...

    Abstract Solitary plasmacytoma of the skull, a single malignant monoclonal plasma cell proliferation without systemic involvement, is rare and often misdiagnosed by radiological examinations only. In this article, the authors presented a 40-year-old man who had a painless protruding mass over the midline of the posterior head region. A brain magnetic resonance imaging (MRI) revealed an enhanced mass lesion over the midline of the parieto-occipital region with skull erosion. Under the tentative diagnosis of meningioma, craniectomy was performed with en bloc tumor resection, and the skull defect was replaced by cranioplasty with bone cement. The final histopathological report revealed plasmacytoma without evidence of multiple myeloma. No further adjuvant radiotherapy was arranged for the patient. The postoperative course was uneventful within a one-year follow-up period. For the skull solitary plasmacytoma, there was no strong evidence that adjuvant radiotherapy was necessary after the primary surgery. Surgical intervention with total tumor resection is an effective option for the patient with solitary plasmacytoma of the skull.
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.3535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Anterior Cervical Discectomy and Fusion for Hirayama Disease: A Case Report and Literature Review.

    Kuo, Yi-Hsuan / Kuo, Chao-Hung / Huang, Wen-Cheng / Wu, Jau-Ching

    Neurospine

    2019  Volume 16, Issue 3, Page(s) 626–630

    Abstract: Hirayama disease, a juvenile muscular atrophy of the distal upper extremity, is a rare form of cervical flexion myelopathy characterized by insidiously progressive weakness of the hands and forearm muscles (i.e., painless amyotrophy). The pathognomonic ... ...

    Abstract Hirayama disease, a juvenile muscular atrophy of the distal upper extremity, is a rare form of cervical flexion myelopathy characterized by insidiously progressive weakness of the hands and forearm muscles (i.e., painless amyotrophy). The pathognomonic finding is a markedly forward-shifted spinal cord during neck flexion, demonstrated by dynamic magnetic resonance imaging (MRI), as in a young man with muscle atrophy in the bilateral distal upper extremities. In this report, the authors describe a 31-year-old man who had the classic radiological and clinical presentations of Hirayama disease. Since prior medical treatment had been ineffective for years, he underwent multilevel instrumented anterior cervical discectomy and fusion (ACDF) to keep his subaxial cervical spine slightly-lordotic (nonflexion). His motor evoked potential amplitude improved immediately during the operation, and there were improvements of myelopathy and a modest reversal of muscle wasting at 1 year postoperatively. Postoperative dynamic cervical spine MRI also demonstrated minimal cord compression and elimination of the venous plexus engorgement dorsal to the thecal sac. Although Hirayama disease is benign in nature and frequently self-limiting, multilevel instrumented ACDF could be a reasonable management option.
    Language English
    Publishing date 2019-01-04
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.1836178.089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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