Article: Major Bleeding After Paracentesis Associated With Apixaban Use: Two Case Reports.
2022 Volume 58, Issue 1, Page(s) 34–37
Abstract: We report 2 patients with compensated cirrhosis and moderate renal impairment who experienced severe bleeding complications from paracentesis during concurrent therapy with apixaban. While paracentesis has traditionally been considered a low bleeding- ... ...
Abstract | We report 2 patients with compensated cirrhosis and moderate renal impairment who experienced severe bleeding complications from paracentesis during concurrent therapy with apixaban. While paracentesis has traditionally been considered a low bleeding-risk procedure and safe to perform without interruption of therapeutic anticoagulation, the increased concentrations observed in patients with impaired liver function may place these patients at unexpectedly high bleeding risk. Further investigation into the safety of paracentesis in patients with cirrhosis on apixaban may be warranted, as well as additional understanding of the clinical safety of this drug in Child-Pugh B cirrhosis. |
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Language | English |
Publishing date | 2022-07-28 |
Publishing country | United States |
Document type | Case Reports |
ZDB-ID | 1468893-1 |
ISSN | 0018-5787 |
ISSN | 0018-5787 |
DOI | 10.1177/00185787221111741 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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