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  1. AU="Kupferman, Tania"
  2. AU="Fumis, R. R. L."
  3. AU="Monge, Ana"
  4. AU="José Miguel Rodríguez González-Moro"
  5. AU="Lopez-Galmiche, Gisela"
  6. AU="Pitsillides, A A"
  7. AU="Huang, Yumeng"
  8. AU="Frankos, V"
  9. AU="Maus, Anthony D." AU="Maus, Anthony D."
  10. AU="Lane, Robin R"
  11. AU="Amankwah, Georgina"
  12. AU=Wang Hai-Yang
  13. AU="M. Hunter Land"
  14. AU="Ferid Murad"
  15. AU="Mulligan, Lisa P"
  16. AU="El Hakim, Joelle"
  17. AU="DeWeerd, Kim A"
  18. AU="Lu, Weigang"
  19. AU="Bordbar, Farzaneh"
  20. AU="Samarakoon, Upeka"
  21. AU="Dalla, Erica"
  22. AU="van Zanten, Hannah"
  23. AU="Mancebo, Gemma"
  24. AU="Mohammed Shahed Jahan"
  25. AU="Bhatankar, Swaroop"
  26. AU="van Guldener, Coen"
  27. AU=Zhang Yafei
  28. AU="Wright, J. L."
  29. AU="Sharma, Taruna"
  30. AU="Vigl, Julia"
  31. AU="Jiaqi LIU"
  32. AU=Lauterio Andrea
  33. AU=Simon Nathan
  34. AU="Heyba, Mohammed"
  35. AU="Geno, Connie S"
  36. AU=Hussein Ahmed A.
  37. AU="Ringsten, Martin"

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  1. Article ; Online: Case Report: A Cluster of Three Leptospirosis Cases in a New York City Abattoir and an Unusual Complication in the Index Case.

    Kupferman, Tania / Coffee, Megan P / Eckhardt, Benjamin J

    The American journal of tropical medicine and hygiene

    2017  

    Abstract: We report the case of a 46-year-old man abattoir worker who developed myalgias, shortness of breath, and irritability 2 weeks after sustaining a laceration to the hand with a knife at work. During his hospital evaluation for septic shock he was noted to ... ...

    Abstract We report the case of a 46-year-old man abattoir worker who developed myalgias, shortness of breath, and irritability 2 weeks after sustaining a laceration to the hand with a knife at work. During his hospital evaluation for septic shock he was noted to be febrile, hypotensive, profoundly jaundiced with aseptic meningitis, and renal failure, and was diagnosed with
    Language English
    Publishing date 2017-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.17-0545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Choosing wisely initiative for reducing urine cultures for asymptomatic bacteriuria and catheter-associated asymptomatic bacteriuria in an 11-hospital safety net system.

    Krouss, Mona / Alaiev, Daniel / Shin, Da Wi / Talledo, Joseph / Israilov, Sigal / Chandra, Komal / Zaurova, Milana / Manchego, Peter Alacron / Tsega, Surafel / Cohen, Gabriel / Bravo, Nathaniel / Kupferman, Tania / Madaline, Theresa / Cho, Hyung J

    American journal of infection control

    2023  Volume 51, Issue 4, Page(s) 461–465

    Abstract: Background: Treatment of asymptomatic bacteriuria (ASB) is common. Overtreatment of ASB leads to harm, including adverse effects from antibiotics, antibiotic resistance, and increased length of stay.: Methods: This quality improvement initiative ... ...

    Abstract Background: Treatment of asymptomatic bacteriuria (ASB) is common. Overtreatment of ASB leads to harm, including adverse effects from antibiotics, antibiotic resistance, and increased length of stay.
    Methods: This quality improvement initiative targeted inappropriate urine cultures across 11 hospitals in a safety-net setting. A mandatory prompt for appropriate indications for urine culture orders and a best practice advisory (BPA) for urine culture on patients with urinary catheters were created. Urine culture ordering was compared pre-intervention (6/2020 to 10/2021) to post-intervention (12/2021 to 8/2022). Catheter associated urinary tract infections (CAUTI) was compared pre- and post-intervention. Variation in urine culture ordering and CAUTI rates in hospitals were assessed.
    Results: Inpatient urine cultures decreased by 20.9% (p<0.001). Inpatient urine cultures on patients with urinary catheters decreased by 21.6% (p<0.001). CAUTI rates remained unchanged post-intervention. High variation in urine culture ordering and CAUTI rates was seen among hospitals.
    Conclusions: This initiative successfully decreased urine cultures in a large, safety-net system. Further study is needed in assessing variation among hospitals.
    MeSH term(s) Humans ; Bacteriuria/diagnosis ; Bacteriuria/drug therapy ; Bacteriuria/etiology ; Urinary Tract Infections/etiology ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Urinary Catheters/adverse effects ; Catheter-Related Infections/etiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2023.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1773: Show issues Location:
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  3. Article ; Online: Notes from the Field: Severe Bartonella quintana Infections Among Persons Experiencing Unsheltered Homelessness - New York City, January 2020-December 2022.

    Rich, Shannan N / Beeson, Amy / Seifu, Leah / Mitchell, Kara / Wroblewski, Danielle / Juretschko, Stefan / Keller, Marina / Gnanaprakasam, Rachel / Agladze, Mariam / Kodama, Rich / Kupferman, Tania / Bhatnagar, Julu / Martines, Roosecelis B / Reagan-Steiner, Sarah / Slavinski, Sally / Kuehnert, Matthew J / Bergeron-Parent, Camille / Corvese, Gabriella / Marx, Grace E /
    Ackelsberg, Joel

    MMWR. Morbidity and mortality weekly report

    2023  Volume 72, Issue 42, Page(s) 1147–1148

    MeSH term(s) Humans ; Trench Fever ; New York City/epidemiology ; Ill-Housed Persons
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7242a3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial.

    Ortigoza, Mila B / Yoon, Hyunah / Goldfeld, Keith S / Troxel, Andrea B / Daily, Johanna P / Wu, Yinxiang / Li, Yi / Wu, Danni / Cobb, Gia F / Baptiste, Gillian / O'Keeffe, Mary / Corpuz, Marilou O / Ostrosky-Zeichner, Luis / Amin, Amee / Zacharioudakis, Ioannis M / Jayaweera, Dushyantha T / Wu, Yanyun / Philley, Julie V / Devine, Megan S /
    Desruisseaux, Mahalia S / Santin, Alessandro D / Anjan, Shweta / Mathew, Reeba / Patel, Bela / Nigo, Masayuki / Upadhyay, Rabi / Kupferman, Tania / Dentino, Andrew N / Nanchal, Rahul / Merlo, Christian A / Hager, David N / Chandran, Kartik / Lai, Jonathan R / Rivera, Johanna / Bikash, Chowdhury R / Lasso, Gorka / Hilbert, Timothy P / Paroder, Monika / Asencio, Andrea A / Liu, Mengling / Petkova, Eva / Bragat, Alexander / Shaker, Reza / McPherson, David D / Sacco, Ralph L / Keller, Marla J / Grudzen, Corita R / Hochman, Judith S / Pirofski, Liise-Anne / Parameswaran, Lalitha / Corcoran, Anthony T / Rohatgi, Abhinav / Wronska, Marta W / Wu, Xinyuan / Srinivasan, Ranjini / Deng, Fang-Ming / Filardo, Thomas D / Pendse, Jay / Blaser, Simone B / Whyte, Olga / Gallagher, Jacqueline M / Thomas, Ololade E / Ramos, Danibel / Sturm-Reganato, Caroline L / Fong, Charlotte C / Daus, Ivy M / Payoen, Arianne Gisselle / Chiofolo, Joseph T / Friedman, Mark T / Wu, Ding Wen / Jacobson, Jessica L / Schneider, Jeffrey G / Sarwar, Uzma N / Wang, Henry E / Huebinger, Ryan M / Dronavalli, Goutham / Bai, Yu / Grimes, Carolyn Z / Eldin, Karen W / Umana, Virginia E / Martin, Jessica G / Heath, Timothy R / Bello, Fatimah O / Ransford, Daru Lane / Laurent-Rolle, Maudry / Shenoi, Sheela V / Akide-Ndunge, Oscar Bate / Thapa, Bipin / Peterson, Jennifer L / Knauf, Kelly / Patel, Shivani U / Cheney, Laura L / Tormey, Christopher A / Hendrickson, Jeanne E

    JAMA internal medicine

    2021  Volume 182, Issue 2, Page(s) 115–126

    Abstract: Importance: There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19.: Objective: To determine the safety and efficacy of CCP compared with placebo in hospitalized patients with COVID-19 receiving ... ...

    Abstract Importance: There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19.
    Objective: To determine the safety and efficacy of CCP compared with placebo in hospitalized patients with COVID-19 receiving noninvasive supplemental oxygen.
    Design, setting, and participants: CONTAIN COVID-19, a randomized, double-blind, placebo-controlled trial of CCP in hospitalized adults with COVID-19, was conducted at 21 US hospitals from April 17, 2020, to March 15, 2021. The trial enrolled 941 participants who were hospitalized for 3 or less days or presented 7 or less days after symptom onset and required noninvasive oxygen supplementation.
    Interventions: A unit of approximately 250 mL of CCP or equivalent volume of placebo (normal saline).
    Main outcomes and measures: The primary outcome was participant scores on the 11-point World Health Organization (WHO) Ordinal Scale for Clinical Improvement on day 14 after randomization; the secondary outcome was WHO scores determined on day 28. Subgroups were analyzed with respect to age, baseline WHO score, concomitant medications, symptom duration, CCP SARS-CoV-2 titer, baseline SARS-CoV-2 serostatus, and enrollment quarter. Outcomes were analyzed using a bayesian proportional cumulative odds model. Efficacy of CCP was defined as a cumulative adjusted odds ratio (cOR) less than 1 and a clinically meaningful effect as cOR less than 0.8.
    Results: Of 941 participants randomized (473 to placebo and 468 to CCP), 556 were men (59.1%); median age was 63 years (IQR, 52-73); 373 (39.6%) were Hispanic and 132 (14.0%) were non-Hispanic Black. The cOR for the primary outcome adjusted for site, baseline risk, WHO score, age, sex, and symptom duration was 0.94 (95% credible interval [CrI], 0.75-1.18) with posterior probability (P[cOR<1] = 72%); the cOR for the secondary adjusted outcome was 0.92 (95% CrI, 0.74-1.16; P[cOR<1] = 76%). Exploratory subgroup analyses suggested heterogeneity of treatment effect: at day 28, cORs were 0.72 (95% CrI, 0.46-1.13; P[cOR<1] = 93%) for participants enrolled in April-June 2020 and 0.65 (95% CrI, 0.41 to 1.02; P[cOR<1] = 97%) for those not receiving remdesivir and not receiving corticosteroids at randomization. Median CCP SARS-CoV-2 neutralizing titer used in April to June 2020 was 1:175 (IQR, 76-379). Any adverse events (excluding transfusion reactions) were reported for 39 (8.2%) placebo recipients and 44 (9.4%) CCP recipients (P = .57). Transfusion reactions occurred in 2 (0.4) placebo recipients and 8 (1.7) CCP recipients (P = .06).
    Conclusions and relevance: In this trial, CCP did not meet the prespecified primary and secondary outcomes for CCP efficacy. However, high-titer CCP may have benefited participants early in the pandemic when remdesivir and corticosteroids were not in use.
    Trial registration: ClinicalTrials.gov Identifier: NCT04364737.
    MeSH term(s) Adult ; Aged ; Blood Component Transfusion ; COVID-19/therapy ; Critical Illness/therapy ; Double-Blind Method ; Female ; Hospitalization/statistics & numerical data ; Humans ; Immunization, Passive ; Male ; Middle Aged ; Respiration, Artificial/statistics & numerical data ; Treatment Outcome ; United States ; COVID-19 Serotherapy
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.6850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.119: Show issues Location:
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