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  1. Article ; Online: Hand-held electron spin resonance scanner for subcutaneous oximetry using OxyChip.

    Almog, Nir / Zgadzai, Oleg / Kuppusamy, Periannan / Zur, Yehonatan / Baruch, Limor / Machluf, Marcelle / Blank, Aharon

    Magnetic resonance in medicine

    2024  Volume 92, Issue 1, Page(s) 430–439

    Abstract: Purpose: Electron spin resonance (ESR) is used to measure oxygen partial pressure (pO: Methods: We introduce a new scanner, tailored for subcutaneous measurements up to 2 mm beneath the skin's surface. This scanner captures pulsed ESR signals from ... ...

    Abstract Purpose: Electron spin resonance (ESR) is used to measure oxygen partial pressure (pO
    Methods: We introduce a new scanner, tailored for subcutaneous measurements up to 2 mm beneath the skin's surface. This scanner captures pulsed ESR signals from embedded approximate 1-mm oxygen-sensing solid paramagnetic implant, OxyChip. The scanner features a static magnetic field source, producing a uniform region outside its surface, and a compact microwave resonator, for exciting and receiving ESR signals.
    Results: ESR readings derived from an OxyChip, positioned approximately 1.5 mm from the scanner's surface, embedded in ATE phantom, exhibited a linear relation of 1/T
    Conclusion: The compact ESR scanner can report pO
    MeSH term(s) Electron Spin Resonance Spectroscopy ; Phantoms, Imaging ; Oximetry/methods ; Oxygen ; Humans ; Equipment Design ; Skin/diagnostic imaging
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.30066
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  2. Article: Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry.

    Kmiec, M M / Tse, D / Kuppusamy, Periannan

    Advances in experimental medicine and biology

    2021  Volume 1269, Page(s) 259–263

    Abstract: Electron paramagnetic resonance (EPR) oximetry based on lithium naphthalocyanine paramagnetic crystals as oxygen sensors enables direct measurement of the partial pressure of oxygen ( ... ...

    Abstract Electron paramagnetic resonance (EPR) oximetry based on lithium naphthalocyanine paramagnetic crystals as oxygen sensors enables direct measurement of the partial pressure of oxygen (pO
    MeSH term(s) Electron Spin Resonance Spectroscopy ; Oximetry ; Oxygen ; Partial Pressure ; Prostheses and Implants
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-48238-1_41
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  3. Article ; Online: PTEN as a Therapeutic Target in Pulmonary Hypertension Secondary to Left-heart Failure: Effect of HO-3867 and Supplemental Oxygenation.

    Ravi, Yazhini / Sai-Sudhakar, Chittoor B / Kuppusamy, Periannan

    Cell biochemistry and biophysics

    2021  Volume 79, Issue 3, Page(s) 593–607

    Abstract: Pulmonary hypertension (PH) is a condition when the pressure in the lung blood vessels is elevated. This leads to increase in thickness of the blood vessels and increases the workload of the heart and lungs. The incidence and prevalence of PH has been on ...

    Abstract Pulmonary hypertension (PH) is a condition when the pressure in the lung blood vessels is elevated. This leads to increase in thickness of the blood vessels and increases the workload of the heart and lungs. The incidence and prevalence of PH has been on the increase in the last decade. It is estimated that PH affects about 1% of the global population and about 10% of individuals >65 years of age. Of the various types, Group 2 PH is the most common type seen in the elderly population. Fixed PH or PH refractive to therapies is considered a contraindication for heart transplantation; the 30-day mortality in heart transplant recipients is significantly increased in the subset of this population. In general, the pathobiology of PH involves multiple factors including hypoxia, oxidative stress, growth factor receptors, vascular stress, etc. Hence, it is challenging and important to identify specific mechanisms, diagnosis and develop effective therapeutic strategies. The focus of this manuscript is to review some of the important pathobiological processes and mechanisms in the development of PH. Results from our previously reported studies, including targeted treatments along with some new data on PH secondary to left-heart failure, are presented.
    MeSH term(s) Piperidones
    Chemical Substances (3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one) ; Piperidones
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1357904-6
    ISSN 1559-0283 ; 1085-9195
    ISSN (online) 1559-0283
    ISSN 1085-9195
    DOI 10.1007/s12013-021-01010-y
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  4. Article ; Online: Estimation of pO

    Demidenko, Eugene / Kmiec, Maciej M / Kuppusamy, Periannan

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2021  Volume 328, Page(s) 106992

    Abstract: Electron paramagnetic resonance (EPR) oximetry, using oxygen-sensing implant such as OxyChip, is capable of measuring oxygen concentration in vivo - a critical tissue information required for successful medical treatment such as cancer, wound healing and ...

    Abstract Electron paramagnetic resonance (EPR) oximetry, using oxygen-sensing implant such as OxyChip, is capable of measuring oxygen concentration in vivo - a critical tissue information required for successful medical treatment such as cancer, wound healing and diabetes. Typically, EPR oximetry produces one value of the oxygen concentration, expressed as pO
    MeSH term(s) Bayes Theorem ; Electron Spin Resonance Spectroscopy ; Humans ; Neoplasms/diagnostic imaging ; Oximetry ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2021.106992
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  5. Article ; Online: Biocompatibility of Oxygen-Sensing Paramagnetic Implants.

    Tse, Dan / Kuppusamy, Periannan

    Cell biochemistry and biophysics

    2019  Volume 77, Issue 3, Page(s) 197–202

    Abstract: Oxygen-sensing implants, composed of paramagnetic microcrystals embedded in a biocompatible polymer, are increasingly being used for electron paramagnetic resonance (EPR) oximetry in animal models and human subjects. The implants are stable and designed ... ...

    Abstract Oxygen-sensing implants, composed of paramagnetic microcrystals embedded in a biocompatible polymer, are increasingly being used for electron paramagnetic resonance (EPR) oximetry in animal models and human subjects. The implants are stable and designed to stay in the tissues for indefinite periods. However, it is not known whether the crystals that may be exposed on the surface of the implants or leached out from the implants will induce cytotoxicity thereby compromising their biocompatibility over the long term. The goal of the current study was to evaluate the cytotoxicity of the implants and crystalline particulates under in vitro conditions. Apoptosis and cell viability studies were performed using L6, a rat muscle cell line and AsPC-1, a cancer cell line derived from human pancreatic adenocarcinoma. The results indicated that neither the intact implants nor their components elicit cytotoxicity, thus establishing their biocompatibility for use in human subjects.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cell Line ; Cell Survival/drug effects ; Electron Spin Resonance Spectroscopy ; Humans ; Oximetry/instrumentation ; Oximetry/methods ; Oxygen/analysis ; Polymers/chemistry ; Porphyrins/chemistry ; Prostheses and Implants ; Rats
    Chemical Substances Biocompatible Materials ; Polymers ; Porphyrins ; lithium octa-n-butoxynaphthalocyanine ; Oxygen (S88TT14065)
    Language English
    Publishing date 2019-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1357904-6
    ISSN 1559-0283 ; 1085-9195
    ISSN (online) 1559-0283
    ISSN 1085-9195
    DOI 10.1007/s12013-019-00881-6
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  6. Article ; Online: Surface dielectric resonator for in vivo EPR measurements.

    Petryakov, Sergey V / Kmiec, Maciej M / Ubert, Conner S / Kassey, Victor B / Schaner, Philip E / Kuppusamy, Periannan

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2024  Volume 362, Page(s) 107690

    Abstract: This research report describes a novel surface dielectric resonator (SDR) with a flexible connector for in vivo electron paramagnetic resonance (EPR) spectroscopy. Contrary to the conventional cavity or surface loop-gap resonators, the newly developed ... ...

    Abstract This research report describes a novel surface dielectric resonator (SDR) with a flexible connector for in vivo electron paramagnetic resonance (EPR) spectroscopy. Contrary to the conventional cavity or surface loop-gap resonators, the newly developed SDR is constructed from a ceramic dielectric material, and it is tuned to operate at the L-band frequency band (1.15 GHz) in continuous-wave mode. The SDR is designed to be critically coupled and capable of working with both very lossy samples, such as biological tissues, and non-lossy materials. The SDR was characterized using electromagnetic field simulations, assessed for sensitivity with a B
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2024.107690
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  7. Article: Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer.

    Mast, Jesse M / Kuppusamy, Periannan

    Frontiers in oncology

    2018  Volume 8, Page(s) 527

    Abstract: Triple-negative breast cancer (TNBC) refers to a group of biologically aggressive breast cancers that do not express estrogen, progesterone or epidermal growth factor receptor 2 hormone receptors. Each subset of TNBC has a unique molecular profile and ... ...

    Abstract Triple-negative breast cancer (TNBC) refers to a group of biologically aggressive breast cancers that do not express estrogen, progesterone or epidermal growth factor receptor 2 hormone receptors. Each subset of TNBC has a unique molecular profile and may require specific treatments. A combination of surgery and chemotherapy followed by radiation therapy is the standard treatment mode for TNBC patients. Tumor oxygen status (hypoxia) is a key factor that may compromise the effectiveness of radiation treatment, as it is known that hypoxia can confer radiation resistance. In this study, we characterized MDA-MB-231 orthotropic xenograft tumors with respect to tumor oxygen level and their response to supplemental oxygen therapy in combination with paclitaxel and radiation therapy. We observed that the TNBC tumors became severely hypoxic (pO
    Language English
    Publishing date 2018-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2018.00527
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  8. Article ; Online: DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases.

    Nagane, Masaki / Yasui, Hironobu / Kuppusamy, Periannan / Yamashita, Tadashi / Inanami, Osamu

    Journal of radiation research

    2021  Volume 62, Issue 4, Page(s) 564–573

    Abstract: A post-exposure cohort study in Hiroshima and Nagasaki reported that low-dose exposure to radiation heightened the risk of cardiovascular diseases (CVD), such as stroke and myocardial infarction, by 14-18% per Gy. Moreover, the risk of atherosclerosis in ...

    Abstract A post-exposure cohort study in Hiroshima and Nagasaki reported that low-dose exposure to radiation heightened the risk of cardiovascular diseases (CVD), such as stroke and myocardial infarction, by 14-18% per Gy. Moreover, the risk of atherosclerosis in the coronary arteries reportedly increases with radiation therapy of the chest, including breast and lung cancer treatment. Cellular senescence of vascular endothelial cells (ECs) is believed to play an important role in radiation-induced CVDs. The molecular mechanism of age-related cellular senescence is believed to involve genomic instability and DNA damage response (DDR); the chronic inflammation associated with senescence causes cardiovascular damage. Therefore, vascular endothelial cell senescence is believed to induce the pathogenesis of CVDs after radiation exposure. The findings of several prior studies have revealed that ionizing radiation (IR) induces cellular senescence as well as cell death in ECs. We have previously reported that DDR activates endothelial nitric oxide (NO) synthase, and NO production promotes endothelial senescence. Endothelial NO synthase (eNOS) is a major isoform expressed in ECs that maintains cardiovascular homeostasis. Therefore, radiation-induced NO production, a component of the DDR in ECs, may be involved in CVDs after radiation exposure. In this article, we describe the pathology of radiation-induced CVD and the unique radio-response to radiation exposure in ECs.
    MeSH term(s) Aging/pathology ; Animals ; Cardiovascular Diseases/etiology ; DNA Damage ; Endothelium, Vascular/pathology ; Humans ; Nitric Oxide/biosynthesis ; Oxidative Stress ; Radiation Injuries/complications
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 603983-2
    ISSN 1349-9157 ; 0449-3060
    ISSN (online) 1349-9157
    ISSN 0449-3060
    DOI 10.1093/jrr/rrab032
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  9. Article ; Online: Retraction: Loss of Metallothionein Predisposes Mice to Diethylnitrosamine-Induced Hepatocarcinogenesis by Activating NF-κB Target Genes.

    Majumder, Sarmila / Roy, Satavisha / Kaffenberger, Thomas / Wang, Bo / Costinean, Stefan / Frankel, Wendy / Bratasz, Anna / Kuppusamy, Periannan / Hai, Tsonwin / Ghoshal, Kalpana / Jacob, Samson T

    Cancer research

    2024  Volume 83, Issue 24, Page(s) 4179

    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-2367
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    Uh III Zs.135/5: Show issues Location:
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  10. Article ; Online: Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor.

    Kato, Kazuhiro / Yasui, Hironobu / Sato-Akaba, Hideo / Emoto, Miho C / Fujii, Hirotada G / Kmiec, Maciej M / Kuppusamy, Periannan / Mizuno, Yuki / Kuge, Yuji / Nagane, Masaki / Yamashita, Tadashi / Inanami, Osamu

    Free radical biology & medicine

    2024  Volume 218, Page(s) 57–67

    Abstract: Understanding the tumor redox status is important for efficient cancer treatment. Here, we noninvasively detected changes in the redox environment of tumors before and after cancer treatment in the same individuals using a novel compact and portable ... ...

    Abstract Understanding the tumor redox status is important for efficient cancer treatment. Here, we noninvasively detected changes in the redox environment of tumors before and after cancer treatment in the same individuals using a novel compact and portable electron paramagnetic resonance imaging (EPRI) device and compared the results with glycolytic information obtained through autoradiography using 2-deoxy-2-[
    MeSH term(s) Animals ; Oxidation-Reduction ; Humans ; Mice ; Fluorodeoxyglucose F18/metabolism ; Glucose/metabolism ; Multimodal Imaging/methods ; Feasibility Studies ; Electron Spin Resonance Spectroscopy/methods ; Buthionine Sulfoximine/pharmacology ; Autoradiography ; HCT116 Cells ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/pathology ; Radiopharmaceuticals/metabolism ; Positron-Emission Tomography/methods ; Xenograft Model Antitumor Assays ; Glutathione/metabolism ; Mice, Nude
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2) ; Buthionine Sulfoximine (5072-26-4) ; Radiopharmaceuticals ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2024.03.028
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