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  1. Article: [PHENOTYPIC CHANGES IN MAST CELLS DURING ALLERGY IMMUNOTHERAPY].

    Sasa, Haruki / Ogata, Hitoshi / Kurashima, Yosuke

    Arerugi = [Allergy

    2023  Volume 72, Issue 8, Page(s) 1026–1031

    MeSH term(s) Humans ; Mast Cells ; Hypersensitivity/therapy
    Language Japanese
    Publishing date 2023-09-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.72.1026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 245: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation.

    Zhang, Zhongwei / Kurashima, Yosuke

    Cells

    2021  Volume 10, Issue 7

    Abstract: It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including-but not limited to-allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated ... ...

    Abstract It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including-but not limited to-allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). MCs highly express receptors of these ligands and proteases (e.g., tryptase, chymase) and cytokines (TNF), and other granular components (e.g., histamine and serotonin) and aggravate the allergic reaction and inflammation. On the other hand, accumulated evidence has revealed that MCs also possess immune-regulatory functions, suppressing chronic inflammation and allergic reactions on some occasions. IL-2 and IL-10 released from MCs inhibit excessive immune responses. Recently, it has been revealed that allergen immunotherapy modulates the function of MCs from their allergic function to their regulatory function to suppress allergic reactions. This evidence suggests the possibility that manipulation of MCs functions will result in a novel approach to the treatment of various MCs-mediated diseases.
    MeSH term(s) Acute Disease ; Animals ; Chronic Disease ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/pathology ; Inflammation/immunology ; Inflammation/pathology ; Mast Cells/immunology ; Mast Cells/pathology ; Models, Biological
    Language English
    Publishing date 2021-06-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10071615
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  3. Article ; Online: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Abstract: Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. ... ...

    Abstract Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.
    Language English
    Publishing date 2024-01-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-023-00999-z
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    Zs.A 1425: Show issues Location:
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  4. Article ; Online: Correction: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-024-01002-z
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  5. Article ; Online: Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases.

    Zhang, Zhongwei / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Frontiers in immunology

    2022  Volume 13, Page(s) 937120

    Abstract: Mast cells (MCs) are immune cells widely distributed in the body, accompanied by diverse phenotypes and functions. Committed mast cell precursors (MCPs) leave the bone marrow and enter the blood circulation, homing to peripheral sites under the control ... ...

    Abstract Mast cells (MCs) are immune cells widely distributed in the body, accompanied by diverse phenotypes and functions. Committed mast cell precursors (MCPs) leave the bone marrow and enter the blood circulation, homing to peripheral sites under the control of various molecules from different microenvironments, where they eventually differentiate and mature. Partly attributable to the unique maturation mechanism, MCs display high functional heterogeneity and potentially plastic phenotypes. High plasticity also means that MCs can exhibit different subtypes to cope with different microenvironments, which we call "the peripheral immune education system". Under the peripheral immune education system, MCs showed a new character from previous cognition in some cases, namely regulation of allergy and inflammation. In this review, we focus on the mucosal tissues, such as the gastrointestinal tract, to gain insights into the mechanism underlying the migration of MCs to the gut or other organs and their heterogeneity, which is driven by different microenvironments. In particular, the immunosuppressive properties of MCs let us consider that positively utilizing MCs may be a new way to overcome inflammatory and allergic disorders.
    MeSH term(s) Cell Differentiation ; Humans ; Hypersensitivity ; Mast Cells ; Phenotype ; Plastics
    Chemical Substances Plastics
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.937120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nasal vaccines: solutions for respiratory infectious diseases.

    Nakahashi-Ouchida, Rika / Fujihashi, Kohtaro / Kurashima, Yosuke / Yuki, Yoshikazu / Kiyono, Hiroshi

    Trends in molecular medicine

    2022  Volume 29, Issue 2, Page(s) 124–140

    Abstract: Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal vaccines ... ...

    Abstract Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal vaccines are considered to be a next-generation tool for preventing respiratory infectious diseases, including COVID-19. However, nasal vaccines must overcome key safety concerns given the anatomic proximity of the central nervous system (CNS) via the olfactory bulbs which lie next to the nasal cavity. This review summarizes current efforts to develop safe and effective nasal vaccines and delivery systems, as well as their clinical applications for the prevention of respiratory infections. We also discuss various concerns regarding the safety of nasal vaccines and introduce a system for evaluating them.
    MeSH term(s) Humans ; Administration, Intranasal ; COVID-19/prevention & control ; Vaccines ; Communicable Diseases ; Respiratory Tract Infections/prevention & control ; Immunity, Mucosal
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4345: Show issues Location:
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  7. Article ; Online: Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas-intestinal barrier axis.

    Zhang, Zhongwei / Tanaka, Izumi / Pan, Zhen / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    European journal of immunology

    2022  Volume 52, Issue 7, Page(s) 1035–1046

    Abstract: The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and ... ...

    Abstract The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and bloodstream, respectively. Growing evidence suggests that the roles of the pancreas extend to not only the secretion of digestive enzymes and hormones but also to the regulation of intestinal homeostasis and inflammation (e.g., mucosal defense to pathogens and pathobionts). Organ crosstalk between the pancreas and intestine is linked to a range of physiological, immunological, and pathological activities, such as the regulation of the gut microbiota by the pancreatic proteins and lipids, the retroaction of the gut microbiota on the pancreas, the relationship between inflammatory bowel disease, and pancreatic diseases. We herein discuss the current understanding of the pancreas-intestinal barrier axis and the control of commensal bacteria in intestinal inflammation.
    MeSH term(s) Gastrointestinal Microbiome/physiology ; Homeostasis ; Hormones ; Humans ; Inflammation ; Intestinal Mucosa ; Intestines ; Pancreas
    Chemical Substances Hormones
    Language English
    Publishing date 2022-05-15
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149532
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    Zs.A 489: Show issues Location:
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  8. Article ; Online: Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.

    Kurashima, Yosuke / Kiyono, Hiroshi

    Annual review of immunology

    2017  Volume 35, Page(s) 119–147

    Abstract: The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet, enteroendocrine, and tuft cells as well as other cell populations, all of which contribute properties essential for gastrointestinal homeostasis. The intestinal mucosa is ... ...

    Abstract The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet, enteroendocrine, and tuft cells as well as other cell populations, all of which contribute properties essential for gastrointestinal homeostasis. The intestinal mucosa is covered by mucin, which contains antimicrobial peptides and secretory IgA and prevents luminal bacteria, fungi, and viruses from stimulating intestinal immune responses. Conversely, the transport of luminal microorganisms-mediated by M, dendritic, and goblet cells-into intestinal tissues facilitates the harmonization of active and quiescent mucosal immune responses. The bacterial population within gut-associated lymphoid tissues creates the intratissue cohabitations for harmonized mucosal immunity. Intermolecular and intercellular communication among epithelial, immune, and mesenchymal cells creates an environment conducive for epithelial regeneration and mucosal healing. This review summarizes the so-called intestinal mucosal ecological network-the complex but vital molecular and cellular interactions of epithelial mesenchymal cells, immune cells, and commensal microbiota that achieve intestinal homeostasis, regeneration, and healing.
    MeSH term(s) Animals ; Cell Communication ; Epithelial Cells/physiology ; Gastrointestinal Microbiome/immunology ; Homeostasis ; Humans ; Immunity, Innate ; Immunoglobulin A/metabolism ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Wound Healing
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2017-01-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-051116-052424
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  9. Article ; Online: ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract.

    Inami, Akie / Kiyono, Hiroshi / Kurashima, Yosuke

    International journal of molecular sciences

    2018  Volume 19, Issue 8

    Abstract: Extracellular nucleotides, such as adenosine triphosphate (ATP), are released from host cells including nerve termini, immune cells, injured or dead cells, and the commensal bacteria that reside in the gut lumen. Extracellular ATP interacts with the host ...

    Abstract Extracellular nucleotides, such as adenosine triphosphate (ATP), are released from host cells including nerve termini, immune cells, injured or dead cells, and the commensal bacteria that reside in the gut lumen. Extracellular ATP interacts with the host through purinergic receptors, and promotes intercellular and bacteria-host communication to maintain the tissue homeostasis. However, the release of massive concentrations of ATP into extracellular compartments initiates acute and chronic inflammatory responses through the activation of immunocompetent cells (e.g., T cells, macrophages, and mast cells). In this review, we focus on the functions of ATP as a pathophysiologic mediator that is required for the induction and resolution of inflammation and inter-species communication.
    MeSH term(s) Adenosine Triphosphate/immunology ; Animals ; Bacteria/immunology ; Bacterial Physiological Phenomena/immunology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Host-Pathogen Interactions/immunology ; Humans
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2018-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19082371
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  10. Article ; Online: Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells.

    Kurashima, Yosuke / Tokuhara, Daisuke / Kamioka, Mariko / Inagaki, Yutaka / Kiyono, Hiroshi

    Frontiers in immunology

    2019  Volume 10, Page(s) 1281

    Abstract: The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of ... ...

    Abstract The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial-immune responses at mucosal surfaces is dexterously modulated by intrinsic stromal-mesenchymal cells. First, organogenesis of lymphoid tissues, including Peyer's patches, requires dynamic interplay between lymphoid cells and stromal cells, which have become known as "lymphoid organizers." Second, correct spatiotemporal interaction between these cell populations is essential to generate the infrastructure for gut immune responses. Moreover, immune cells at the intestinal barrier are functionally modulated by stromal cells; one such example is the stromal cell-mediated differentiation of innate immune cells, including innate lymphoid cells and mast cells. Ultimately, mucosal stromal cells orchestrate the destinations of epithelial and immune cells to maintain intestinal immune homeostasis.
    MeSH term(s) Animals ; Epithelial Cells/immunology ; Homeostasis/immunology ; Humans ; Immunity, Innate/immunology ; Intestinal Mucosa/immunology ; Lymphocytes/immunology ; Lymphoid Tissue/immunology ; Mast Cells/immunology ; Stromal Cells/immunology
    Language English
    Publishing date 2019-06-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01281
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