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  1. Article ; Online: Tuberculosis Elimination: Myth or Achievable Target?

    Centis, Rosella / D'Ambrosio, Lia / Kurhasani, Xhevat / Solovic, Ivan / Migliori, Giovanni Battista

    Archivos de bronconeumologia

    2023  Volume 59, Issue 11, Page(s) 714–716

    MeSH term(s) Humans ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
    Language Spanish
    Publishing date 2023-09-18
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of Human Development Index in the epidemiology of asthma in adolescents in Kosovo: A cross-sectional multicentre Global Asthma Network (GAN) study.

    Ahmetaj, Luljeta / Martínez-Torres, A Elena / Ahmetaj, Ylli / Ismajli, Ibadete / Gashi, Valbona / Kurhasani, Xhevat / Lokaj-Berisha, Violeta / Lumezi, Besa / Lleshi, Leonora / Pajaziti, Laura / Shahini, Mirsije / Zhjeqi, Valbona / García-Marcos, Luis

    Allergologia et immunopathologia

    2023  Volume 51, Issue 2, Page(s) 59–70

    Abstract: Background: Very limited information is available on the prevalence and risk factors of asthma in adolescents in Kosovo, and no study has previously addressed the role of Human Development Index (HDI) on asthma in the region. The present study addresses ...

    Abstract Background: Very limited information is available on the prevalence and risk factors of asthma in adolescents in Kosovo, and no study has previously addressed the role of Human Development Index (HDI) on asthma in the region. The present study addresses these two issues.
    Methods: Following the Global Asthma Network (GAN) methodology, a cross-sectional survey, through standardised self-completed questionnaires, was conducted in the following six centres of Kosovo: Ferizaj, Gjakova, Gjilan, Peja, Prishtina and Prizren. Current asthma symptoms (CAS) and severe current asthma symptoms (sCAS) were defined according to the GAN standards. Environmental questionnaire inquired about gender, exercise, screening time, siblings, truck traffic, use of paracetamol, pet ownership, and smoking habits. Height and weight were also measured. Multivariate logistic regression analyses were performed in each centre along with meta-analyses to summarise the overall effects of each factor in the centres as a whole. Meta-regression of the prevalence rates was calculated using HDI as a moderator.
    Results: Participation rate was high (80.0-99.9%). Prevalence of CAS ranged from 4.6% to 11.3%, and sCAS from 1.7% to 4.5%. Factors associated with CAS were exercise, computer time, paracetamol use and dog ownership. sCAS was associated with paracetamol use and physical exercise. HDI explained 46% and 80% of prevalence variability of CAS and sCAS between centres, respectively.
    Conclusions: Prevalence of CAS and sCAS in Kosovo varies highly between centres. This variability is explained partly by HDI. Individual risk factors are common, with some determined in other studies conducted in other regions.
    MeSH term(s) Humans ; Adolescent ; Animals ; Dogs ; Acetaminophen/adverse effects ; Cross-Sectional Studies ; Kosovo/epidemiology ; Asthma/epidemiology ; Asthma/chemically induced ; Risk Factors ; Surveys and Questionnaires ; Prevalence
    Chemical Substances Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2023-03-01
    Publishing country Singapore
    Document type Multicenter Study ; Journal Article
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v51i2.781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: History of prevention, diagnosis, treatment and rehabilitation of pulmonary sequelae of tuberculosis.

    Migliori, Giovanni Battista / Caminero Luna, Jose' / Kurhasani, Xhevat / van den Boom, Martin / Visca, Dina / D'Ambrosio, Lia / Centis, Rosella / Tiberi, Simon

    Presse medicale (Paris, France : 1983)

    2022  Volume 51, Issue 3, Page(s) 104112

    Abstract: Tuberculosis (TB), known as the White Plague' is of great significance to humanity for the magnitude of morbidity and mortality it has generated over centuries from the very start of human civilization. In this Review, we will describe the history of ... ...

    Abstract Tuberculosis (TB), known as the White Plague' is of great significance to humanity for the magnitude of morbidity and mortality it has generated over centuries from the very start of human civilization. In this Review, we will describe the history of prevention (vaccination and management of TB infection), diagnosis, treatment and pulmonary rehabilitation of post-treatment sequelae. The article leads the reader through the main discoveries which paved the way to the modern approach to TB prevention and care. The history of Bacille Calmette-Guérin (BCG) vaccine and of the diagnosis and treatment of TB infection are presented, together with that of diagnosis and treatment of TB disease. Pivotal was in 1882 the discovery by Robert Koch of the aetiological agent of TB, and his pioneering work in culturing the bacillus and developing tuberculin. Also of enormous importance was, in 1895, the discovery of the X-rays by Wilhelm Conrad Röntgen, discovery which paved the way to the development of the modern imaging technologies. To complement this, the more recent history of rehabilitation of post-treatment sequelae is summarized, given the importance this issue has on patients' wellbeing and Quality of Life.
    Language English
    Publishing date 2022-02-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2022.104112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Tuberculosis Incidence and Case Notification Rates in Kosovo and the Balkans in 2012: Cross-country Comparison.

    Kurhasani, Xhevat / Hafizi, Hasan / Toci, Ervin / Burazeri, Genc

    Materia socio-medica

    2014  Volume 26, Issue 1, Page(s) 55–58

    Abstract: Aim: Tuberculosis (TB) continues to be a considerable burden especially for millions of young adults and disadvantaged people worldwide. The TB incidence and notification rates are good indicators of TB situation in a country. Our aim was to compare TB ... ...

    Abstract Aim: Tuberculosis (TB) continues to be a considerable burden especially for millions of young adults and disadvantaged people worldwide. The TB incidence and notification rates are good indicators of TB situation in a country. Our aim was to compare TB incidence and notification rates in Kosovo and in seven other Balkan countries.
    Methods: Retrospective epidemiologic analysis of published data on TB incidence and notification rates in eight Balkan countries in 2012. Notification rates were expressed per 100,000 inhabitants and were calculated based on the number of TB cases reported divided by the population of each country under analysis.
    Results: The TB incidence in Kosovo (47/100,000) was considerably higher compared to its four neighboring countries: Albania (16/100,000), Macedonia, Montenegro (18/100,000) and Serbia (23/100,000). The TB notification rates in Kosovo and other countries closely mimicked the incidence rates in these countries.
    Conclusion: The exceptionally high TB incidence rate in Kosovo could be due to many factors including low health and medical-seeking behaviors of the local population, poverty and low education levels. Effective interventions should be adapted to the local context in order to increase the chances of success.
    Language English
    Publishing date 2014-02-20
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 1512-7680
    ISSN 1512-7680
    DOI 10.5455/msm.2014.26.55-58
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid Diagnosis of XDR and Pre-XDR TB: A Systematic Review of Available Tools.

    Saderi, Laura / Puci, Mariangela / Di Lorenzo, Biagio / Centis, Rosella / D'Ambrosio, Lia / Akkerman, Onno W / Alffenaar, Jan-Willem C / Caminero, José A / Chakaya, Jeremiah Muhwa / Denholm, Justin T / Kurhasani, Xhevat / Ong, Catherine W M / Rendon, Adrian / Silva, Denise Rossato / Tiberi, Simon / Zenner, Dominik / Cabibbe, Andrea M / Migliori, Giovanni Battista / Sotgiu, Giovanni

    Archivos de bronconeumologia

    2022  Volume 58, Issue 12, Page(s) 809–820

    Abstract: Introduction: No previous systematic reviews have comprehensively investigated the features of Xpert MTB/XDR and other rapid tests to diagnose pre-XDR/XDR-TB. The aim of this systematic review is to assess existing rapid diagnostics for pre-XDR/XDR-TB ... ...

    Abstract Introduction: No previous systematic reviews have comprehensively investigated the features of Xpert MTB/XDR and other rapid tests to diagnose pre-XDR/XDR-TB. The aim of this systematic review is to assess existing rapid diagnostics for pre-XDR/XDR-TB from a point-of-care perspective and describe their technical characteristics (i.e., sensitivity, specificity, positive and negative predictive values).
    Methods: Embase, PubMed, Scopus, and Web of Science were searched to detect the articles focused on the accuracy of commercially available rapid molecular diagnostic tests for XDR-TB according to PRISMA guidelines. The analysis compared the diagnostic techniques and approaches in terms of sensitivity, specificity, laboratory complexity, time to confirmed diagnosis.
    Results: Of 1298 records identified, after valuating article titles and abstracts, 97 (7.5%) records underwent full-text evaluation and 38 records met the inclusion criteria. Two rapid World Health Organization (WHO)-endorsed tests are available: Xpert MTB/XDR and GenoType MTBDRsl (VER1.0 and VER 2.0). Both tests had similar performance, slightly favouring Xpert, although only 2 studies were available (sensitivity 91.4-94; specificity 98.5-99; accuracy 97.2-97.7; PPV 88.9-99.1; NPV 95.8-98.9).
    Conclusions: Xpert MTB/XDR could be suggested at near-point-of-care settings to be used primarily as a follow-on test for laboratory-confirmed TB, complementing existing rapid tests detecting at least rifampicin-resistance. Both Xpert MTB/XDR and GenoType MTBDRsl are presently diagnosing what WHO defined, in 2021, as pre-XDR-TB.
    MeSH term(s) Humans ; Extensively Drug-Resistant Tuberculosis/diagnosis ; Mycobacterium tuberculosis/genetics ; Rifampin ; Genotype ; Predictive Value of Tests ; Sensitivity and Specificity ; Tuberculosis, Multidrug-Resistant/diagnosis
    Chemical Substances Rifampin (VJT6J7R4TR)
    Language Spanish
    Publishing date 2022-07-28
    Publishing country Spain
    Document type Systematic Review ; Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Country-specific lockdown measures in response to the COVID-19 pandemic and its impact on tuberculosis control: a global study.

    Migliori, Giovanni Battista / Thong, Pei Min / Alffenaar, Jan-Willem / Denholm, Justin / Tadolini, Marina / Alyaquobi, Fatma / Al-Abri, Seif / Blanc, François-Xavier / Buonsenso, Danilo / Chakaya, Jeremiah / Cho, Jin-Gun / Codecasa, Luigi Ruffo / Danila, Edvardas / Duarte, Raquel / Dukpa, Rada / García-García, José-María / Gualano, Gina / Kurhasani, Xhevat / Manika, Katerina /
    Mello, Fernanda Carvalho de Queiroz / Pahl, Kristin / Rendon, Adrian / Sotgiu, Giovanni / Souleymane, Mahamadou Bassirou / Thomas, Tania A / Tiberi, Simon / Kunst, Heinke / Udwadia, Zarir F / Goletti, Delia / Centis, Rosella / D'Ambrosio, Lia / Silva, Denise Rossato

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2022  Volume 48, Issue 2, Page(s) e20220087

    Abstract: The objective of this study was to describe country-specific lockdown measures and tuberculosis indicators collected during the first year of the COVID-19 pandemic. Data on lockdown/social restrictions (compulsory face masks and hand hygiene; ... ...

    Abstract The objective of this study was to describe country-specific lockdown measures and tuberculosis indicators collected during the first year of the COVID-19 pandemic. Data on lockdown/social restrictions (compulsory face masks and hand hygiene; international and local travel restrictions; restrictions to family visits, and school closures) were collected from 24 countries spanning five continents. The majority of the countries implemented multiple lockdowns with partial or full reopening. There was an overall decrease in active tuberculosis, drug-resistant tuberculosis, and latent tuberculosis cases. Although national lockdowns were effective in containing COVID-19 cases, several indicators of tuberculosis were affected during the pandemic.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Communicable Disease Control ; Humans ; Influenza, Human/epidemiology ; Pandemics/prevention & control ; Tuberculosis
    Language Portuguese
    Publishing date 2022-04-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.36416/1806-3756/e20220087
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  7. Article ; Online: Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis.

    Nasiri, Mohammad Javad / Zangiabadian, Moein / Arabpour, Erfan / Amini, Sirus / Khalili, Farima / Centis, Rosella / D'Ambrosio, Lia / Denholm, Justin T / Schaaf, H Simon / van den Boom, Martin / Kurhasani, Xhevat / Dalcolmo, Margareth Pretti / Al-Abri, Seif / Chakaya, Jeremiah / Alffenaar, Jan-Willem / Akkerman, Onno / Silva, Denise Rossato / Muňoz-Torrico, Marcela / Seaworth, Barbara /
    Pontali, Emanuele / Saderi, Laura / Tiberi, Simon / Zumla, Alimuddin / Migliori, Giovanni Battista / Sotgiu, Giovanni

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 124 Suppl 1, Page(s) S90–S103

    Abstract: Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening condition needing long poly-chemotherapy regimens. As no systematic reviews/meta-analysis is available to comprehensively evaluate the role of delamanid (DLM), we evaluated ... ...

    Abstract Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening condition needing long poly-chemotherapy regimens. As no systematic reviews/meta-analysis is available to comprehensively evaluate the role of delamanid (DLM), we evaluated its effectiveness and safety.
    Methods: We reviewed the relevant scientific literature published up to January 20, 2022. The pooled success treatment rate with 95% confidence intervals (CI) was assessed using a random-effect model. We assessed studies for quality and bias, and considered P<0.05 to be statistically significant.
    Results: After reviewing 626 records, we identified 25 studies that met the inclusion criteria, 22 observational and 3 experimental, with 1276 and 411 patients, respectively. In observational studies the overall pooled treatment success rate of DLM-containing regimens was 80.9% (95% CI 72.6-87.2) with no evidence of publication bias (Begg's test; P >0.05). The overall pooled treatment success rate in DLM and bedaquiline-containing regimens was 75.2% (95% CI 68.1-81.1) with no evidence of publication bias (Begg's test; P >0.05). In experimental studies the pooled treatment success rate of DLM-containing regimens was 72.5 (95% CI 44.2-89.8, P <0.001, I
    Conclusions: In MDR-TB patients receiving DLM, culture conversion and treatment success rates were high despite extensive resistance with limited adverse events.
    Language English
    Publishing date 2022-03-02
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.02.043
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  8. Article: DOTS implementation in a post-war, United Nations-administered territory: lessons from Kosovo.

    Tigani, Bahri / Kurhasani, Xhevat / Adams, Lisa V / Zhuri, Gazmend / Mehmeti, Rukije / Cirillo, Daniela / Salfinger, Max / Dev, Alka / Ditiu, Lucica / Migliori, Giovanni Battista

    Respiratory medicine

    2008  Volume 102, Issue 1, Page(s) 121–127

    Abstract: Setting: The WHO-recommended strategy of tuberculosis control (DOTS strategy) has been shown to be effective in reducing tuberculosis incidence in a variety of countries/ settings. Little evidence exists on the implementation, and effectiveness of DOTS ... ...

    Abstract Setting: The WHO-recommended strategy of tuberculosis control (DOTS strategy) has been shown to be effective in reducing tuberculosis incidence in a variety of countries/ settings. Little evidence exists on the implementation, and effectiveness of DOTS in a transitional, post-war setting
    Objective: To describe the process of establishing a National Tuberculosis Control Program (NTP) and implementing DOTS throughout Kosovo, and the outcomes achieved by this international collaboration in a post-war transitional setting during 1999-2005.
    Methods: In 1999, as part of the re-organization of health services, a DOTS-based NTP was established and operationalized through a collaboration of several international partners in Kosovo. Five key steps supported these activities.
    Results: Kosovo has reached the World Health Assembly targets, having achieved 75% case detection rate (sputum smear-positive cases) and 93% treatment success rate. During 2000-2005, new smear-positive tuberculosis case notifications decreased by 44.5% (median annual decrease for all cases: 7.6%).
    Conclusions: Kosovo's success story is a collaborative tale, each partner involved playing a unique role in supporting NTP activities. The Kosovo example provides yet another setting in which DOTS implementation has resulted in successful patient outcomes. The international TB control community would be well-served by formal guidelines for implementing DOTS and the new STOP TB Strategy in these settings.
    MeSH term(s) Health Policy ; Humans ; Primary Health Care/standards ; Program Development ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/prevention & control ; United Nations ; Yugoslavia/epidemiology
    Language English
    Publishing date 2008-01
    Publishing country England
    Document type Evaluation Studies ; Journal Article ; Multicenter Study
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2007.07.027
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  9. Article ; Online: Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort.

    Casco, Nicolas / Jorge, Alberto Levi / Palmero, Domingo Juan / Alffenaar, Jan-Willem / Fox, Greg J / Ezz, Wafaa / Cho, Jin-Gun / Denholm, Justin / Skrahina, Alena / Solodovnikova, Varvara / Arbex, Marcos Abdo / Alves, Tatiana / Rabahi, Marcelo Fouad / Pereira, Giovana Rodrigues / Sales, Roberta / Silva, Denise Rossato / Saffie, Muntasir M / Salinas, Nadia Escobar / Miranda, Ruth Caamaño /
    Cisterna, Catalina / Concha, Clorinda / Fernandez, Israel / Villalón, Claudia / Vera, Carolina Guajardo / Tapia, Patricia Gallegos / Cancino, Viviana / Carbonell, Monica / Cruz, Arturo / Muñoz, Eduardo / Muñoz, Camila / Navarro, Indira / Pizarro, Rolando / Cristina Sánchez, Gloria Pereira / Vergara Riquelme, Maria Soledad / Vilca, Evelyn / Soto, Aline / Flores, Ximena / Garavagno, Ana / Bahamondes, Martina Hartwig / Merino, Luis Moyano / Pradenas, Ana María / Revillot, Macarena Espinoza / Rodriguez, Patricia / Salinas, Angeles Serrano / Taiba, Carolina / Valdés, Joaquín Farías / Subiabre, Jorge Navarro / Ortega, Carlos / Palma, Sofia / Castillo, Patricia Perez / Pinto, Mónica / Bidegain, Francisco Rivas / Venegas, Margarita / Yucra, Edith / Li, Yang / Cruz, Andres / Guelvez, Beatriz / Victoria Plaza, Regina / Tello Hoyos, Kelly Yoana / Cardoso-Landivar, José / Van Den Boom, Martin / Andréjak, Claire / Blanc, François-Xavier / Dourmane, Samir / Froissart, Antoine / Izadifar, Armine / Rivière, Frédéric / Schlemmer, Frédéric / Manika, Katerina / Diallo, Boubacar Djelo / Hassane-Harouna, Souleymane / Artiles, Norma / Mejia, Licenciada Andrea / Gupta, Nitesh / Ish, Pranav / Mishra, Gyanshankar / Patel, Jigneshkumar M / Singla, Rupak / Udwadia, Zarir F / Alladio, Francesca / Angeli, Fabio / Calcagno, Andrea / Centis, Rosella / Codecasa, Luigi Ruffo / De Lauretis, Angelo / Esposito, Susanna M R / Formenti, Beatrice / Gaviraghi, Alberto / Giacomet, Vania / Goletti, Delia / Gualano, Gina / Matteelli, Alberto / Migliori, Giovanni Battista / Motta, Ilaria / Palmieri, Fabrizio / Pontali, Emanuele / Prestileo, Tullio / Riccardi, Niccolò / Saderi, Laura / Saporiti, Matteo / Sotgiu, Giovanni / Spanevello, Antonio / Stochino, Claudia / Tadolini, Marina / Torre, Alessandro / Villa, Simone / Visca, Dina / Kurhasani, Xhevat / Furjani, Mohammed / Rasheed, Najia / Danila, Edvardas / Diktanas, Saulius / Ridaura, Ruy López / Luna López, Fátima Leticia / Torrico, Marcela Muñoz / Rendon, Adrian / Akkerman, Onno W / Chizaram, Onyeaghala / Al-Abri, Seif / Alyaquobi, Fatma / Althohli, Khalsa / Aguirre, Sarita / Teixeira, Rosarito Coronel / De Egea, Viviana / Irala, Sandra / Medina, Angélica / Sequera, Guillermo / Sosa, Natalia / Vázquez, Fátima / Llanos-Tejada, Félix K / Manga, Selene / Villanueva-Villegas, Renzo / Araujo, David / Sales Marques, Raquel DuarteTânia / Socaci, Adriana / Barkanova, Olga / Bogorodskaya, Maria / Borisov, Sergey / Mariandyshev, Andrei / Kaluzhenina, Anna / Vukicevic, Tatjana Adzic / Stosic, Maja / Beh, Darius / Ng, Deborah / Ong, Catherine W M / Solovic, Ivan / Dheda, Keertan / Gina, Phindile / Caminero, José A / De Souza Galvão, Maria Luiza / Dominguez-Castellano, Angel / García-García, José-María / Pinargote, Israel Molina / Fernandez, Sarai Quirós / Sánchez-Montalvá, Adrián / Huguet, Eva Tabernero / Murguiondo, Miguel Zabaleta / Bart, Pierre-Alexandre / Mazza-Stalder, Jesica / D'Ambrosio, Lia / Kamolwat, Phalin / Bakko, Freya / Barnacle, James / Bird, Sophie / Brown, Annabel / Chandran, Shruthi / Killington, Kieran / Man, Kathy / Papineni, Padmasayee / Ritchie, Flora / Tiberi, Simon / Utjesanovic, Natasa / Zenner, Dominik / Hearn, Jasie L / Heysell, Scott / Young, Laura

    The European respiratory journal

    2023  Volume 62, Issue 5

    Abstract: Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.: Methods: We collected data from ...

    Abstract Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.
    Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both.
    Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19
    Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.
    MeSH term(s) Humans ; Male ; COVID-19/complications ; HIV Infections/complications ; Coinfection ; Risk Factors ; Tuberculosis, Miliary ; Retrospective Studies
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00925-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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