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Article ; Online: Association of the Great East Japan Earthquake and the Daiichi Nuclear Disaster in Fukushima City, Japan, With Birth Rates.

Kurita, Noriaki

JAMA network open

2019 Volume 2, Issue 1, Page(s) e187455

Abstract: Importance: The association of the Great East Japan Earthquake and the subsequent Fukushima Daiichi Nuclear Power Plant disaster of March 11 and 12, 2011, in Fukushima, Japan, with birth rates has not been examined appropriately in the existing ... ...

Abstract	Importance: The association of the Great East Japan Earthquake and the subsequent Fukushima Daiichi Nuclear Power Plant disaster of March 11 and 12, 2011, in Fukushima, Japan, with birth rates has not been examined appropriately in the existing literature. Objective: To assess the midterm and long-term associations of the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant disaster with birth rates. Design, setting, and participants: Cohort study in which interrupted time series analyses were used to assess monthly changes in birth rates among residents of Fukushima City, Japan, from March 1, 2011, to December 31, 2017, relative to projected birth rates without the disaster based on predisaster trends. Birth rates from January 1, 2007, to December 31, 2017, in Fukushima City were determined using information from the Fukushima City government office. Exposure: The Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant disaster, expressed via 5 potential models of the association with birth rate: level change, level and slope changes, temporal level change, and temporal level change with 1 or 2 slope change(s). Main outcomes and measures: Birth rate, calculated from monthly data on the number of births and total population. Results: The mean birth rate before the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant disaster was 69.8 per 100 000 people per month; after the disaster, the mean birth rate was 61.9 per 100 000 people per month. Compared with birth rates before the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant disaster, there was an estimated 10% reduction in monthly birth rates in Fukushima City (rate ratio, 0.90; 95% CI, 0.86-0.93) in the first 2 years after the disaster. After that, the birth rate trend was similar to the predisaster trend. The predisaster trend suggested a continuous decrease in birth rate (rate ratio for 1 year, 0.98; 95% CI, 0.98-0.99). This gap model was optimal and parsimonious compared with others. A similar association was found when trimonthly averaged data were analyzed. Conclusions and relevance: The Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant disaster were followed by significant reductions in birth rates for 2 years. There was insufficient evidence to indicate that the trend in the 3 to 7 years after the disaster differed from the predisaster trends. The recovery from the reductions in the birth rate may be indicative of the rebuilding efforts. The continuing long-term decrease in birth rates observed before the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant disaster suggests that continuing measures to support birth planning should be considered at the administrative level.
MeSH term(s)	Birth Rate/trends ; Cohort Studies ; Disasters ; Earthquakes ; Fukushima Nuclear Accident ; Humans ; Interrupted Time Series Analysis ; Japan/epidemiology
Language	English
Publishing date	2019-01-04
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2018.7455
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Article ; Online: Impact of Dysmagnesemia on Atrial Fibrillation in Maintenance Hemodialysis Patients: A Nationwide Study.

Toida, Tatsunori / Kurita, Noriaki / Abe, Masanori / Hanafusa, Norio / Joki, Nobuhiko

Cardiorenal medicine

2024 Volume 14, Issue 1, Page(s) 105–112

Abstract: Introduction: The dose-response relationship between serum magnesium (sMg) and atrial fibrillation (AF) and the contribution of dysmagnesemia to AF among hemodialysis patients remain unknown. Hence, we examined the dose-response correlation between sMg ... ...

Abstract	Introduction: The dose-response relationship between serum magnesium (sMg) and atrial fibrillation (AF) and the contribution of dysmagnesemia to AF among hemodialysis patients remain unknown. Hence, we examined the dose-response correlation between sMg and AF and estimated the extent of the contribution of dysmagnesemia to AF in this population. Methods: This was a nationwide cross-sectional study on the Japanese Society for Dialysis Therapy registry, also known as Japanese Renal Data Registry (JRDR), encompassing a nationwide population of dialysis centers, as of the end of 2019. Eligible participants were adult patients undergoing hemodialysis three times per week. The main exposure was sMg, categorized into seven categories (≤1.5, >1.5-≤2, >2-≤2.5, >2.5-≤3, >3-≤3.5, >3.5-≤4, and ≥4.0 mg/dL). The outcome was AF reported by dialysis facilities. The independent contribution to AF was assessed via logistic regression to generate population-attributable fractions, assuming a causal relationship between sMg and AF. Results: Total 165,926 patients from 2,549 facilities were investigated. AF prevalence was 7.9%. Compared with the reference (>2.5-≤3 mg/dL), lower sMg was associated with increased AF (adjusted odds ratios (ORs) (95% confidence interval, CI) of 1.49 (1.19-1.85), 1.24 (1.17-1.32), and 1.11 (1.06-1.16) for sMg of ≤1.5, >1.5-≤2.0, and >2.0-≤2.5 mg/dL categories, respectively). Elevated sMg was associated with fewer AF (adjusted OR 0.87 [95% CI, 0.79-0.96] for sMg of >3.0-≤3.5 mg/dL). The adjusted population-attributable fraction of lower sMg and higher and lower sMg for AF was 7.4% and 6.9%, respectively. An association did indeed exist between lower sMg and AF, with the lowest percentages of AF at sMg levels above the reference range for the general population. Conclusion: Dysmagnesemia may be an important contributor to AF among adult hemodialysis patients. Further, longitudinal studies are warranted to determine whether sMg correction reduces the AF incidence.
MeSH term(s)	Humans ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/complications ; Renal Dialysis/adverse effects ; Female ; Male ; Cross-Sectional Studies ; Aged ; Middle Aged ; Japan/epidemiology ; Magnesium/blood ; Registries ; Prevalence ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/complications ; Risk Factors
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Multicenter Study
ZDB-ID	2595659-0
ISSN	1664-5502 ; 1664-3828
ISSN (online)	1664-5502
ISSN	1664-3828
DOI	10.1159/000536595
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Article ; Online: Contralateral knee pain exacerbation after total knee arthroplasty and its impact on functional activity.

Kamitani, Tsukasa / Wada, Osamu / Mizuno, Kiyonori / Kurita, Noriaki

Archives of orthopaedic and trauma surgery

2023 Volume 144, Issue 4, Page(s) 1713–1720

Abstract: Introduction: The purposes of the present study were to (1) describe the prevalence of contralateral knee pain exacerbation after total knee arthroplasty (TKA), (2) explore the risk factors for pain exacerbation, and (3) verify the association of ... ...

Abstract	Introduction: The purposes of the present study were to (1) describe the prevalence of contralateral knee pain exacerbation after total knee arthroplasty (TKA), (2) explore the risk factors for pain exacerbation, and (3) verify the association of contralateral knee pain with future functional activity. Materials and method: We consecutively recruited outpatients with osteoarthritis of both knees who had primary TKA planned. The contralateral knee pain using a Numerical Rating Scale (NRS) and the functional activities subdomain of the new Knee Society Knee Scoring System (KSS) were assessed preoperatively and at 1, 3, and 6 months postoperatively. Among patients with < 5 NRS points preoperatively, we described the frequency of the contralateral knee pain exacerbation, defined as a ≥ 2-point increase from preoperative pain at each postoperative visit. An exploratory analysis was performed to identify preoperative risk factors for contralateral knee pain exacerbation. A linear mixed model was fit to examine the association of the contralateral knee pain with KSS functional activities at subsequent visits. Results: Among 315 patients, 14.6%, 24.1%, and 27.6% of patients experienced contralateral knee pain exacerbation at 1, 3, and 6 months postoperatively, respectively. The identified preoperative risk factors were low quadriceps strength and higher Kellgren-Lawrence grade on the non-operative knee, along with severe pain on the operative knee. The magnitude of the association between contralateral knee pain and worsening KSS functional activities increased with subsequent visits (p for interaction < 0.001). Conclusion: The frequency and impact of pain exacerbation on the contralateral knee increase after TKA and should be carefully evaluated for a prolonged period of time.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Treatment Outcome ; Knee Joint/surgery ; Osteoarthritis/surgery ; Pain/etiology ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/etiology
Language	English
Publishing date	2023-12-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-023-05163-8
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Conference proceedings ; Online: Seasonal characteristics of the Antarctic inland mass balance as indicated by the AWS onboard snow depth sensor

Hirasawa, N. / Saito, K. / Motoyama, H. / Sugiura, K. / Kurita, N.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: The Japanese Antarctic Research Expedition (JARE) has been conducting snow stakes observation between Syowa Station and Dome Fuji Station for more than 30 years. This observation has revealed interannual variations in the annual depth of accumulation. In ...

Abstract	The Japanese Antarctic Research Expedition (JARE) has been conducting snow stakes observation between Syowa Station and Dome Fuji Station for more than 30 years. This observation has revealed interannual variations in the annual depth of accumulation. In order to clarify the cause of this interannual variation from field observation, it is necessary to know the date and time of the snow surface change and its magnitude. Therefore, we have installed four AWSs equipped with snow depth sensors from 2016 to 2019. This presentation shows the main results as follows: 1) The temporal changes of surface height include stepwise fluctuations and pulse-like fluctuations, and the rise in surface height is mainly caused by stepwise rises, rather than pulse-like fluctuations. The stepwise fluctuations are likely associated with synoptic-scale disturbances. The pulse-like fluctuations are concentrated more in cold season than warm season. 2) A slow decline in surface height was observed during the warm season. 3) The stepwise fluctuations in the inland plateau areas are concentrated more in warm season than cold season.
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Author Correction: Effect of atherosclerosis on the relationship between atrial fibrillation and ischemic stroke incidence among patients on hemodialysis.

Joki, Nobuhiko / Toida, Tatsunori / Nakata, Kenji / Abe, Masanori / Hanafusa, Norio / Kurita, Noriaki

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3737

Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54023-x
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Article ; Online: Effect of atherosclerosis on the relationship between atrial fibrillation and ischemic stroke incidence among patients on hemodialysis.

Joki, Nobuhiko / Toida, Tatsunori / Nakata, Kenji / Abe, Masanori / Hanafusa, Norio / Kurita, Noriaki

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1330

Abstract: In patients undergoing hemodialysis, the impact of atrial fibrillation (AF) through cardiac thromboembolism on the development of ischemic stroke may be influenced by the severity of atherosclerosis present. However, there are no large-scale reports ... ...

Abstract	In patients undergoing hemodialysis, the impact of atrial fibrillation (AF) through cardiac thromboembolism on the development of ischemic stroke may be influenced by the severity of atherosclerosis present. However, there are no large-scale reports confirming whether the severity of atherosclerosis influences the relationship between AF and stroke development in patients requiring hemodialysis. We aimed to investigate the effects of atherosclerotic disease on the relationship between AF and new-onset ischemic stroke. This nationwide longitudinal study based on dialysis facilities across Japan used data collected from the Japanese Renal Data Registry at the end of 2019 and 2020. The exposure was AF at the end of 2019, identified using a resting 12-lead electrocardiography. The primary outcome was the incidence of cerebral infarction (CI) after 1 year. To examine whether the number of atherosclerotic diseases modified the association between AF and the outcome, we estimated the odds ratios (ORs) using a logistic regression model and then assessed the presence of global interaction using Wald test. Following the study criteria, data from 151,350 patients (mean age, 69 years; men, 65.2%; diabetic patients, 48.7%) were included in the final analysis. A total of 9841 patients had AF (prevalence, 6.5%). Between 2019 and 2020, 4967 patients (3.2%) developed ischemic stroke. The adjusted OR of AF for new-onset CI was 1.5, which showed a decreasing trend with an increasing number of atherosclerotic diseases; the interaction was not significant (P = 0.34). While age, diabetes mellitus, smoking, systolic blood pressure, and serum C-reactive protein concentration were positively associated with CI, intradialytic weight gain, body mass index, and serum albumin level were negatively associated. While we demonstrated the association between AF and new-onset CI among Japanese patients on hemodialysis, we failed to demonstrate the evidence that the association was attenuated with an increasing numbers of atherosclerotic complications.
MeSH term(s)	Male ; Humans ; Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Ischemic Stroke/complications ; Longitudinal Studies ; Incidence ; Risk Factors ; Stroke/complications ; Stroke/epidemiology ; Renal Dialysis/adverse effects ; Atherosclerosis/complications ; Atherosclerosis/epidemiology ; Diabetes Mellitus
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51439-3
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Article ; Online: Japanese clinical practice patterns of rituximab treatment for minimal change disease in adults 2021: A web-based questionnaire survey of certified nephrologists.

Koizumi, Masahiro / Ishimoto, Takuji / Shimizu, Sayaka / Sasaki, Sho / Kurita, Noriaki / Wada, Takehiko

PloS one

2024 Volume 19, Issue 3, Page(s) e0299053

Abstract: Background: In Japan, rituximab (RTX) for adult-onset frequently relapsing (FR)/steroid-dependent (SD) minimal change disease (MCD) is not explicitly reimbursed by insurance, and its standard regimen has not been established.: Methods: We conducted a ...

Abstract	Background: In Japan, rituximab (RTX) for adult-onset frequently relapsing (FR)/steroid-dependent (SD) minimal change disease (MCD) is not explicitly reimbursed by insurance, and its standard regimen has not been established. Methods: We conducted a cross-sectional web-based survey between November and December 2021. The participants were nephrologists certified by the Japanese Society of Nephrology and answered 7 items about RTX for adult MCD. Factors related to the experience of RTX administration at their facilities were estimated by generalized estimating equations. Results: Of 380 respondents, 181 (47.6%) reported the experience of RTX use for adult MCD at their current facilities. Those who worked at university hospitals (vs. non-university hospitals, proportion difference 13.7%) and at facilities with frequent kidney biopsies (vs. 0 cases/year, 19.2% for 1-40 cases/year; 37.9% for 41-80 cases/year; 51.9% for ≥ 81 cases/year) used RTX more frequently. Of 181 respondents, 28 (15.5%) answered that there was no insurance coverage for RTX treatment. Of 327 respondents who had the opportunity to treat MCD, which was a possible indication for RTX, 178 (54.4%) indicated withholding of RTX administration. The most common reason was the cost due to lack of insurance coverage (141, 79.2%). Regarding RTX regimens for FR/SD MCD, introduction treatment with a single body surface area-based dose of 375 mg/m2 and maintenance treatment with a 6-month interval were the most common. Conclusion: This survey revealed the nephrologists' characteristics associated with RTX use, the barriers to RTX use, and the variation in the regimens for adult MCD in Japan.
MeSH term(s)	Adult ; Humans ; Rituximab/therapeutic use ; Japan ; Nephrologists ; Nephrosis, Lipoid/drug therapy ; Practice Patterns, Physicians' ; Cross-Sectional Studies ; Steroids/therapeutic use ; Surveys and Questionnaires ; Internet ; Treatment Outcome
Chemical Substances	Rituximab (4F4X42SYQ6) ; Steroids
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299053
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Article ; Online: Nonnegligible Seroprevalence and Predictors of Murine Typhus, Japan (Response)

Aita, Tetsuro / Sando, Eiichiro / Katoh, Shungo / Hamaguchi, Sugihiro / Fujita, Hiromi / Kurita, Noriaki

Emerging infectious diseases

2024 Volume 30, Issue 2, Page(s) 403–404

MeSH term(s)	Mice ; Animals ; Japan/epidemiology ; Typhus, Endemic Flea-Borne ; Seroepidemiologic Studies
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Letter
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3002.231465
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Article ; Online: Associations of vitamin D receptor activators and calcimimetics with falls and effect modifications by physical activity: A prospective cohort study on the Japan Dialysis Outcomes and Practice Patterns Study.

Murashima, Miho / Yamamoto, Ryohei / Kanda, Eiichiro / Kurita, Noriaki / Noma, Hisashi / Hamano, Takayuki / Fukagawa, Masafumi

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2024

Abstract: Introduction: This study aimed to examine the associations of vitamin D receptor activators (VDRA) and calcimimetics use with falls.: Methods: This is a prospective cohort study on hemodialysis patients in the Japan Dialysis Outcomes and Practice ... ...

Abstract	Introduction: This study aimed to examine the associations of vitamin D receptor activators (VDRA) and calcimimetics use with falls. Methods: This is a prospective cohort study on hemodialysis patients in the Japan Dialysis Outcomes and Practice Patterns Study. We excluded those who were unable to walk. The associations of VDRA or calcimimetics use with falls and effect modifications by physical activity were analyzed using marginal structural models. Results: In total, 1875 patients were included. VDRA and calcimimetics use was not associated with falls (risk ratio [95% CI]: 1.13 [0.84-1.51] and 1.02 [0.72-1.44]). The risk ratio for falls associated with VDRA use was lower among those with poor physical activity (p for interaction <0.1). Conclusions: Although vitamin D receptor activators and calcimimetics use was not associated with falls, the lower risk ratio for falls with vitamin D receptor activators use among those with poor physical activity suggests that vitamin D receptor activators use might be beneficial among these patients.
Language	English
Publishing date	2024-03-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.14122
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Article ; Online: In Silico Design of Natural Inhibitors of ApoE4 from the Plant

Shaji, Divya / Nagura, Yoshinobu / Sabishiro, Haruna / Suzuki, Ryo / Kurita, Noriyuki

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 24

Abstract: Alzheimer's disease (AD) is a neurological disease, and its signs and symptoms appear slowly over time. Although current Alzheimer's disease treatments can alleviate symptoms, they cannot prevent the disease from progressing. To accurately diagnose and ... ...

Abstract	Alzheimer's disease (AD) is a neurological disease, and its signs and symptoms appear slowly over time. Although current Alzheimer's disease treatments can alleviate symptoms, they cannot prevent the disease from progressing. To accurately diagnose and treat Alzheimer's disease, it is therefore necessary to establish effective methods for diagnosis. Apolipoprotein E4 (ApoE4), the most frequent genetic risk factor for AD, is expressed in more than half of patients with AD, making it an attractive target for AD therapy. We used molecular docking simulations, classical molecular mechanics optimizations, and ab initio fragment molecular orbital (FMO) calculations to investigate the specific interactions between ApoE4 and the naturally occurring compounds found in the plant Moringa Oleifera. According to the FMO calculations, quercetin had the highest binding affinity to ApoE4 among the sixteen compounds because its hydroxyl groups generated strong hydrogen bonds with the ApoE4 residues Trp11, Asp12, Arg15, and Asp130. As a result, we proposed various quercetin derivatives by introducing a hydroxyl group into quercetin and studied their ApoE4 binding properties. The FMO data clearly showed that adding a hydroxyl group to quercetin improved its binding capacity to ApoE4. Furthermore, ApoE4 Trp11, Asp12, Arg15, and Asp130 residues were discovered to be required for significant interactions between ApoE4 and quercetin derivatives. They had a higher ApoE4 binding affinity than our previously proposed epicatechin derivatives. Accordingly, the current results evaluated using the ab initio FMO method will be useful for designing potent ApoE4 inhibitors that can be used as a candidate agent for AD treatment.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Alzheimer Disease/metabolism ; Moringa oleifera ; Quercetin/pharmacology
Chemical Substances	Apolipoprotein E4 ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28248035
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